Gene: SLC22A6

9356
HOAT1|OAT1|PAHT|ROAT1
solute carrier family 22 member 6
protein-coding
11q12.3
Ensembl:ENSG00000197901 MIM:607582 Vega:OTTHUMG00000167767 UniprotKB:Q4U2R8
NC_000011.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.009e-1 (AD)  6.226e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MMD20.631
TSPAN120.622
PIPOX0.597
C1orf610.592
BTBD170.589
PDLIM30.583
PYGM0.581
AKR7A30.578
LFNG0.578
SLC7A100.575

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HTR1B-0.409
SMPX-0.392
FANCI-0.389
HNF4A-0.384
FGF5-0.377
SLCO4C1-0.376
LRMP-0.374
LRRK1-0.372
MKL2-0.368
FANCD2-0.368

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00091CyclosporineSmall Molecule59865-13-3Approved|InvestigationalTransporter
DB00140RiboflavinSmall Molecule83-88-5Approved|Investigational|NutraceuticalTransporter
DB00158Folic AcidSmall Molecule59-30-3Approved|NutraceuticalTransporter
DB00168AspartameSmall Molecule22839-47-0Approved|NutraceuticalTransporter
DB00175PravastatinSmall Molecule81093-37-0ApprovedTransporter
DB00229CefotiamSmall Molecule61622-34-2Approved|InvestigationalTransporter
DB00254DoxycyclineSmall Molecule564-25-0Approved|InvestigationalTransporter
DB00286Conjugated estrogensSmall Molecule12126-59-9ApprovedTransporter
DB00300Tenofovir disoproxilSmall Molecule201341-05-1Approved|InvestigationalTransporter
DB00311EthoxzolamideSmall Molecule452-35-7WithdrawnTransporter
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTransporter
DB00316AcetaminophenSmall Molecule103-90-2ApprovedTransporter
DB00319PiperacillinSmall Molecule66258-76-2ApprovedTransporter
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalTransporter
DB00345Aminohippuric acidSmall Molecule61-78-9Approved|InvestigationalTransporter
DB00365GrepafloxacinSmall Molecule119914-60-2Approved|Investigational|WithdrawnTransporter
DB00369CidofovirSmall Molecule113852-37-2ApprovedTransporter
DB00432TrifluridineSmall Molecule70-00-8Approved|InvestigationalTransporter
DB00438CeftazidimeSmall Molecule72558-82-8ApprovedTransporter
DB00446ChloramphenicolSmall Molecule56-75-7ApprovedTransporter
DB00456CefalotinSmall Molecule153-61-7Approved|InvestigationalTransporter
DB00493CefotaximeSmall Molecule63527-52-6ApprovedTransporter
DB00495ZidovudineSmall Molecule30516-87-1ApprovedTransporter
DB00500TolmetinSmall Molecule26171-23-3ApprovedTransporter
DB00501CimetidineSmall Molecule51481-61-9Approved|InvestigationalTransporter
DB00520CaspofunginSmall Molecule162808-62-0ApprovedTransporter
DB00529FoscarnetSmall Molecule4428-95-9ApprovedTransporter
DB00554PiroxicamSmall Molecule36322-90-4Approved|InvestigationalTransporter
DB00563MethotrexateSmall Molecule59-05-2ApprovedTransporter
DB00567CephalexinSmall Molecule15686-71-2Approved|InvestigationalTransporter
DB00577ValaciclovirSmall Molecule124832-26-4Approved|InvestigationalTransporter
DB00578CarbenicillinSmall Molecule4697-36-3Approved|InvestigationalTransporter
DB00584EnalaprilSmall Molecule75847-73-3ApprovedTransporter
DB00586DiclofenacSmall Molecule15307-86-5ApprovedTransporter
DB00595OxytetracyclineSmall Molecule79-57-2Approved|InvestigationalTransporter
DB00605SulindacSmall Molecule38194-50-2Approved|InvestigationalTransporter
DB00606CyclothiazideSmall Molecule2259-96-3ApprovedTransporter
DB00607NafcillinSmall Molecule147-52-4Approved|InvestigationalTransporter
DB00649StavudineSmall Molecule3056-17-5Approved|InvestigationalTransporter
DB00672ChlorpropamideSmall Molecule94-20-2Approved|InvestigationalTransporter
DB00678LosartanSmall Molecule114798-26-4ApprovedTransporter
DB00693FluoresceinSmall Molecule2321-07-5ApprovedTransporter
DB00695FurosemideSmall Molecule54-31-9ApprovedTransporter
DB00703MethazolamideSmall Molecule554-57-4ApprovedTransporter
DB00709LamivudineSmall Molecule134678-17-4Approved|InvestigationalTransporter
DB00712FlurbiprofenSmall Molecule5104-49-4Approved|InvestigationalTransporter
DB00718Adefovir DipivoxilSmall Molecule142340-99-6Approved|InvestigationalTransporter
DB00731NateglinideSmall Molecule105816-04-4Approved|InvestigationalTransporter
DB00749EtodolacSmall Molecule41340-25-4Approved|InvestigationalTransporter
DB00759TetracyclineSmall Molecule60-54-8ApprovedTransporter
DB00779Nalidixic AcidSmall Molecule389-08-2Approved|InvestigationalTransporter
DB00787AciclovirSmall Molecule59277-89-3ApprovedTransporter
DB00788NaproxenSmall Molecule22204-53-1ApprovedTransporter
DB00798GentamicinSmall Molecule1403-66-3ApprovedTransporter
DB00812PhenylbutazoneSmall Molecule50-33-9ApprovedTransporter
DB00819AcetazolamideSmall Molecule59-66-5ApprovedTransporter
DB00821CarprofenSmall Molecule53716-49-7Approved|WithdrawnTransporter
DB00827CinoxacinSmall Molecule28657-80-9Approved|Investigational|WithdrawnTransporter
DB00861DiflunisalSmall Molecule22494-42-4Approved|InvestigationalTransporter
DB00880ChlorothiazideSmall Molecule58-94-6ApprovedTransporter
DB00887BumetanideSmall Molecule28395-03-1ApprovedTransporter
DB00900DidanosineSmall Molecule69655-05-6ApprovedTransporter
DB00903Etacrynic acidSmall Molecule58-54-8Approved|InvestigationalTransporter
DB00917DinoprostoneSmall Molecule363-24-6ApprovedTransporter
DB00936Salicylic acidSmall Molecule69-72-7Approved|InvestigationalTransporter
DB00939Meclofenamic acidSmall Molecule644-62-2ApprovedTransporter
DB00943ZalcitabineSmall Molecule7481-89-2Approved|InvestigationalTransporter
DB00945Acetylsalicylic acidSmall Molecule50-78-2ApprovedTransporter
DB00999HydrochlorothiazideSmall Molecule58-93-5ApprovedTransporter
DB01004GanciclovirSmall Molecule82410-32-0Approved|InvestigationalTransporter
DB01009KetoprofenSmall Molecule22071-15-4ApprovedTransporter
DB01016GlyburideSmall Molecule10238-21-8ApprovedTransporter
DB01017MinocyclineSmall Molecule10118-90-8Approved|InvestigationalTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01050IbuprofenSmall Molecule15687-27-1ApprovedTransporter
DB01051NovobiocinSmall Molecule303-81-1Approved|InvestigationalTransporter
DB01053BenzylpenicillinSmall Molecule61-33-6ApprovedTransporter
DB01059NorfloxacinSmall Molecule70458-96-7ApprovedTransporter
DB01060AmoxicillinSmall Molecule26787-78-0ApprovedTransporter
DB01082StreptomycinSmall Molecule57-92-1ApprovedTransporter
DB01124TolbutamideSmall Molecule64-77-7Approved|InvestigationalTransporter
DB01137LevofloxacinSmall Molecule100986-85-4Approved|InvestigationalTransporter
DB01140CefadroxilSmall Molecule50370-12-2Approved|WithdrawnTransporter
DB01147CloxacillinSmall Molecule61-72-3Approved|InvestigationalTransporter
DB01160Dinoprost TromethamineSmall Molecule38562-01-5ApprovedTransporter
DB01165OfloxacinSmall Molecule82419-36-1ApprovedTransporter
DB01197CaptoprilSmall Molecule62571-86-2ApprovedTransporter
DB01212CeftriaxoneSmall Molecule73384-59-5ApprovedTransporter
DB01237BromodiphenhydramineSmall Molecule118-23-0ApprovedTransporter
DB01326CefamandoleSmall Molecule34444-01-4Approved|InvestigationalTransporter
DB01327CefazolinSmall Molecule25953-19-9ApprovedTransporter
DB01329CefoperazoneSmall Molecule62893-19-0Approved|InvestigationalTransporter
DB01333CefradineSmall Molecule38821-53-3ApprovedTransporter
DB01414CefacetrileSmall Molecule10206-21-0ApprovedTransporter
DB01424AminophenazoneSmall Molecule58-15-1Approved|WithdrawnTransporter
DB01435AntipyrineSmall Molecule60-80-0Approved|InvestigationalTransporter
DB01597CilastatinSmall Molecule82009-34-5Approved|InvestigationalTransporter
DB01685TopiroxostatSmall Molecule577778-58-6Approved|InvestigationalTransporter
DB02266Flufenamic AcidSmall Molecule530-78-9ExperimentalTransporter
DB02315Cyclic Guanosine MonophosphateSmall Molecule7665-99-8ExperimentalTransporter
DB02527Cyclic Adenosine MonophosphateSmall Molecule60-92-4ExperimentalTransporter
DB03553Glutaric AcidSmall Molecule110-94-1ExperimentalTransporter
DB03585OxyphenbutazoneSmall Molecule129-20-4Approved|WithdrawnTransporter
DB03783PhenacetinSmall Molecule62-44-2WithdrawnTransporter
DB04133Degraded CephaloridineSmall Molecule-ExperimentalTransporter
DB04348Taurocholic AcidSmall Molecule81-24-3ExperimentalTransporter
DB04519Caprylic acidSmall Molecule124-07-2Approved|Experimental|InvestigationalTransporter
DB06151AcetylcysteineSmall Molecule616-91-1Approved|InvestigationalTransporter
DB08843GS 0573Small Molecule113852-41-8InvestigationalTransporter
DB08844Uric AcidSmall Molecule69-93-2Experimental|InvestigationalTransporter
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTransporter
DB08912DabrafenibSmall Molecule-Approved|InvestigationalTransporter
DB08930DolutegravirSmall Molecule1051375-16-6ApprovedTransporter
DB11817BaricitinibSmall Molecule1187594-09-7Approved|InvestigationalTransporter
DB12332RucaparibSmall Molecule283173-50-2Approved|InvestigationalTransporter
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalTransporter
DB00493CefotaximeSmall Molecule63527-52-6ApprovedTarget
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTarget
DB01212CeftriaxoneSmall Molecule73384-59-5ApprovedTarget
DB05016AtalurenSmall Molecule775304-57-9Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC22A6 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC22A6 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC22A6 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC22A6 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC22A6 mRNA"25510870
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]"28629854
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A6 protein"28629854
C4946072-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acidAdipates inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid]15200431
C4946072-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acidadipic acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog]15284288
C4946072-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acidGlutarates inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid]15200431
C4946072-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acidglutaric acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog]15284288
C4946072-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acidp-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid]15200431
C4946072-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acidp-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog]15284288
C4946072-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acidSLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid15200431
C4946072-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acidSLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog15284288
C0240986-carboxyfluorescein"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]"28629854
C0240986-carboxyfluoresceinglutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]28629854
C0240986-carboxyfluoresceinProbenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]28629854
C0240986-carboxyfluoresceinSLC22A6 protein results in increased import of 6-carboxyfluorescein28629854
C0775807-(deoxyadenosin-N(6)-yl)aristolactam IProbenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]19643159
C0775807-(deoxyadenosin-N(6)-yl)aristolactam I[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I19643159
C0775797-(deoxyguanosin-N(2)-yl)aristolactam IProbenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]19643159
C0775797-(deoxyguanosin-N(2)-yl)aristolactam I[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I19643159
C0633809-((2-phosphonylmethoxy)ethyl)guanine9-((2-phosphonylmethoxy)ethyl)guanine analog inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]23856525
C0633809-((2-phosphonylmethoxy)ethyl)guanineProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine]23856525
C0633809-((2-phosphonylmethoxy)ethyl)guanineQuercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog]23856525
C0633809-((2-phosphonylmethoxy)ethyl)guanineSLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine23856525
C0633809-((2-phosphonylmethoxy)ethyl)guanineSLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog23856525
C0501279-(3-hydroxy-2-phosphonylmethoxypropyl)adenineProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine]23856525
C0501279-(3-hydroxy-2-phosphonylmethoxypropyl)adenineSLC22A6 protein results in increased susceptibility to 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine23856525
D000082AcetaminophenAcetaminophen results in decreased activity of SLC22A6 protein12388633
D000082AcetaminophenAcetaminophen results in decreased expression of SLC22A6 mRNA22230336
D000111Acetylcysteineadipic acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
D000111Acetylcysteinealpha-ketoglutaric acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
D000111AcetylcysteineGlutarates inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]12606766
D000111Acetylcysteinep-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
D000111AcetylcysteineProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
D000111AcetylcysteineProbenecid inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]12606766
D000111AcetylcysteineSLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]12606766
D000111AcetylcysteineSLC22A6 protein results in increased transport of [Acetylcysteine co-treated with Mercury]15908511
D000111AcetylcysteineSLC22A6 protein results in increased transport of [Acetylcysteine co-treated with Methylmercury Compounds]15908511
D000111AcetylcysteineSLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]12606766
C053001adefoviradefovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]23856525
C053001adefovirProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to adefovir]23856525
C053001adefovirquercetin 3'-sulfate inhibits the reaction [SLC22A6 protein affects the susceptibility to adefovir]21244849
C053001adefovirSLC22A6 protein affects the susceptibility to adefovir21244849
C053001adefovirSLC22A6 protein results in increased susceptibility to adefovir23856525
C053001adefovirSLC22A6 protein results in increased uptake of adefovir16857889
C053001adefovirSLC22A6 protein results in increased uptake of and results in increased susceptibility to adefovir25448811
C053001adefovirSLC22A6 protein results in increased uptake of adefovir16857889
D000272AdipatesAdipates inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid]15200431
C029900adipic acidadipic acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
C029900adipic acidadipic acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog]15284288
D000493AllopurinolAllopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]21909718|2286564
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]19605544
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]19605544
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SLC22A6 mRNA28522335
C029743alpha-ketoglutaric acidalpha-ketoglutaric acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
C029743alpha-ketoglutaric acidalpha-ketoglutaric acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
D010130p-Aminohippuric Acid9-((2-phosphonylmethoxy)ethyl)guanine analog inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]23856525
D010130p-Aminohippuric Acidadefovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]23856525
D010130p-Aminohippuric AcidAmitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D010130p-Aminohippuric Acidaristolochic acid I inhibits the reaction [SLC22A6 results in increased uptake of p-Aminohippuric Acid]19643159
D010130p-Aminohippuric Acidaristolochic acid I promotes the reaction [SLC22A6 results in increased export of p-Aminohippuric Acid]19643159
D010130p-Aminohippuric Acidbis(4-hydroxyphenyl)sulfone inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]27989701
D010130p-Aminohippuric Acidbisphenol A promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]27989701
D010130p-Aminohippuric Acidbisphenol F promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]27989701
D010130p-Aminohippuric AcidCefaclor inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
D010130p-Aminohippuric Acidcefdinir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
D010130p-Aminohippuric Acidcefoselis inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
D010130p-Aminohippuric AcidCefotiam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
D010130p-Aminohippuric Acidceftibuten inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
D010130p-Aminohippuric AcidCeftizoxime inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
D010130p-Aminohippuric AcidCephaloridine inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
D010130p-Aminohippuric AcidChlorides promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]17353191
D010130p-Aminohippuric Acidchlorpyrifos-methyl inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D010130p-Aminohippuric AcidCimetidine inhibits the reaction [SLC22A6 protein affects the transport of p-Aminohippuric Acid]15496291
D010130p-Aminohippuric AcidDiazepam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D010130p-Aminohippuric AcidFenitrothion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D010130p-Aminohippuric AcidFluorescein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D010130p-Aminohippuric AcidGlutarates promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]12472777
D010130p-Aminohippuric Acidglutaric acid promotes the reaction [SLC22A6 results in increased export of p-Aminohippuric Acid]19643159
D010130p-Aminohippuric AcidMalathion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D010130p-Aminohippuric AcidMianserin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D010130p-Aminohippuric Acidp-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
D010130p-Aminohippuric Acidp-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid]15200431
D010130p-Aminohippuric Acidp-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog]15284288
D010130p-Aminohippuric Acid"p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]"17255469
D010130p-Aminohippuric Acidp-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]15496291
D010130p-Aminohippuric Acidp-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Uric Acid]12472777
D010130p-Aminohippuric AcidPenicillin G inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D010130p-Aminohippuric AcidProbenecid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]28629854
D010130p-Aminohippuric AcidProbenecid inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689|2156179
D010130p-Aminohippuric Acidquercetin 3'-sulfate inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21244849
D010130p-Aminohippuric AcidQuercetin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]19605544
D010130p-Aminohippuric Acidresveratrol inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]27377006
D010130p-Aminohippuric Acidrhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]28890383
D010130p-Aminohippuric Acidrhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]28890383
D010130p-Aminohippuric AcidSLC22A6 protein affects the transport of p-Aminohippuric Acid15496291
D010130p-Aminohippuric AcidSLC22A6 protein results in increased import of p-Aminohippuric Acid28629854
D010130p-Aminohippuric AcidSLC22A6 protein results in increased secretion of p-Aminohippuric Acid11602689
D010130p-Aminohippuric AcidSLC22A6 protein results in increased uptake of p-Aminohippuric Acid11602689|1247277
D010130p-Aminohippuric AcidSLC22A6 results in increased export of p-Aminohippuric Acid19643159
D010130p-Aminohippuric AcidSLC22A6 results in increased uptake of p-Aminohippuric Acid19643159
D010130p-Aminohippuric AcidSulfobromophthalein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D010130p-Aminohippuric AcidTaurocholic Acid inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D010130p-Aminohippuric AcidTenofovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]23856525
D010130p-Aminohippuric AcidTobacco Smoke Pollution inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]28629854
D010130p-Aminohippuric AcidTriazolam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D010130p-Aminohippuric AcidUnithiol inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D010130p-Aminohippuric AcidUnithiol metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D010130p-Aminohippuric AcidUnithiol metabolite promotes the reaction [SLC22A6 protein results in increased secretion of p-Aminohippuric Acid]11602689
D010130p-Aminohippuric AcidUnithiol promotes the reaction [SLC22A6 protein results in increased secretion of p-Aminohippuric Acid]11602689
D010130p-Aminohippuric AcidSLC22A6 protein affects the transport of p-Aminohippuric Acid18216144
D010130p-Aminohippuric Acid[estrone sulfate co-treated with p-Aminohippuric Acid] inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]15251863
D010130p-Aminohippuric AcidSLC22A6 protein results in increased uptake of p-Aminohippuric Acid15251863
D010130p-Aminohippuric Acidp-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]10336520
D010130p-Aminohippuric Acidperfluorohexanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]19915082
D010130p-Aminohippuric Acidperfluoro-n-heptanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]19915082
D010130p-Aminohippuric Acidperfluorooctanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]19915082
D010130p-Aminohippuric AcidSLC22A6 protein results in increased import of p-Aminohippuric Acid19915082
D000639AmitriptylineAmitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC22A6 mRNA16483693
C011659angelicinangelicin results in increased expression of SLC22A6 protein22173200
D000838AnionsDoxycycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]11855680
D000838AnionsMinocycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]11855680
D000838AnionsOxytetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]11855680
D000838AnionsSLC22A6 protein results in increased uptake of Anions11855680
D000838AnionsTetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]11855680
D000893Anti-Inflammatory AgentsAnti-Inflammatory Agents binds to SLC22A6 protein19378467
C000228aristolochic acid Iaristolochic acid I inhibits the reaction [SLC22A6 results in increased uptake of p-Aminohippuric Acid]19643159
C000228aristolochic acid Iaristolochic acid I promotes the reaction [SLC22A6 results in increased export of p-Aminohippuric Acid]19643159
D034341Aristolochic AcidsProbenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]19643159
D034341Aristolochic AcidsProbenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]19643159
D034341Aristolochic AcidsSLC22A6 results in increased uptake of Aristolochic Acids19643159
D034341Aristolochic Acids[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I19643159
D034341Aristolochic Acids[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I19643159
D034341Aristolochic AcidsAristolochic Acids results in decreased expression of SLC22A6 mRNA19717638|2116726
D001241AspirinAspirin results in decreased activity of SLC22A6 protein12388633
C040896AST 120AST 120 affects the expression of SLC22A6 protein24958931
C000595611aurantio-obtusinaurantio-obtusin results in decreased activity of SLC22A6 protein29045746
D001414BacitracinBacitracin results in decreased expression of SLC22A6 mRNA18289764
D001539BendroflumethiazideBendroflumethiazide results in decreased activity of SLC22A6 protein18216144
D001539BendroflumethiazideSLC22A6 protein results in increased secretion of Bendroflumethiazide18216144
D001553BenzbromaroneBenzbromarone inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]27989701
C006780bisphenol Abisphenol A promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]27989701
C006780bisphenol Abisphenol A results in decreased expression of SLC22A6 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SLC22A6 mRNA17010207
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of SLC22A6 mRNA]19228888
C000611646bisphenol Fbisphenol F promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]27989701
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC22A6 mRNA12160620
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC22A6 mRNA25588984
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC22A6 protein25588984
D002433CefaclorCefaclor inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
C056814cefdinircefdinir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
C056814cefdinirSLC22A6 protein results in increased uptake of cefdinir16098483
C079769cefoseliscefoselis inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
D015310CefotiamCefotiam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
C054360ceftibutenceftibuten inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
C054360ceftibutenSLC22A6 protein results in increased uptake of ceftibuten16098483
D015296CeftizoximeCeftizoxime inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
D015296CeftizoximeSLC22A6 protein results in increased uptake of Ceftizoxime16098483
D002509CephaloridineCephaloridine inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]16098483
D002509CephaloridineSLC22A6 protein results in increased uptake of Cephaloridine16098483
D002509CephaloridineSLC22A6 protein results in increased import of Cephaloridine10594788
D002712ChloridesChlorides promotes the reaction [SLC22A6 protein results in increased uptake of Glutarates]17353191
D002712ChloridesChlorides promotes the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]17353191
D002712ChloridesChlorides promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]17353191
D002712ChloridesChlorides results in increased activity of SLC22A6 protein17353191
C007031chlorpyrifos-methylchlorpyrifos-methyl inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
C027113chrysophanic acidchrysophanic acid results in decreased activity of SLC22A6 protein29045746
C059262cidofovirSLC22A6 protein results in increased susceptibility to cidofovir23856525
C059262cidofovirSLC22A6 protein results in increased uptake of and results in increased susceptibility to cidofovir25448811
D002922CiguatoxinsCiguatoxins affects the expression of SLC22A6 mRNA18353800
D002927Cimetidine1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]15496291
D002927CimetidineCimetidine inhibits the reaction [SLC22A6 protein affects the transport of p-Aminohippuric Acid]15496291
D002927Cimetidinep-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]15496291
D002927CimetidineSLC22A6 protein results in increased uptake of Cimetidine15496291|1600649
D002927CimetidineSLC22A6 protein results in increased uptake of Cimetidine15251863
D002953CitrininCitrinin inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]10336520
D0150842,4-Dichlorophenoxyacetic Acid"p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]"17255469
D0150842,4-Dichlorophenoxyacetic Acid"SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid"16857889|1725546
D0150842,4-Dichlorophenoxyacetic Acid"SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid"16857889
D003975DiazepamDiazepam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D002945CisplatinCisplatin results in decreased expression of SLC22A6 mRNA22992436
D002945CisplatinCisplatin results in decreased expression of SLC22A6 protein22992436
D002945CisplatinJBP 485 inhibits the reaction [Cisplatin results in decreased expression of SLC22A6 mRNA]22992436
D004008DiclofenacDiclofenac results in decreased activity of SLC22A6 protein12388633
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of SLC22A6 mRNA26924002
D0178784,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]"12472777
C024629dimethyl phthalatedimethyl phthalate results in increased expression of SLC22A6 mRNA26924002
D004318DoxycyclineDoxycycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]11855680
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased activity of SLC22A6 protein"29045746
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]"22967667
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]"22967667
D004642EmodinEmodin results in decreased activity of SLC22A6 protein29045746
D004785Environmental Pollutants"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in increased expression of SLC22A6 protein"25588985
C017296estrone sulfateSLC22A6 protein results in increased uptake of estrone sulfate16098483
C017296estrone sulfate[estrone sulfate co-treated with p-Aminohippuric Acid] inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]15251863
D005278FenitrothionFenitrothion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D019793FluoresceinFluorescein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D005492Folic AcidFolic Acid results in decreased expression of SLC22A6 mRNA19552531
D005492Folic AcidFolic Acid results in decreased expression of SLC22A6 protein19552531
D005520Food Preservatives"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in increased expression of SLC22A6 protein"25588985
D002955LeucovorinSLC22A6 protein results in increased uptake of Leucovorin16098483
D002955LeucovorinLeucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A6 protein]16925582
D005632FructoseAllopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]19605544
D005632FructoseAllopurinol inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]19605544
D005632FructoseFructose results in decreased expression of SLC22A6 mRNA19605544
D005632FructoseFructose results in decreased expression of SLC22A6 protein19605544
D005632FructoseQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]19605544
D005632FructoseQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]19605544
D005632FructoseRutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]19605544
D005632FructoseRutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]19605544
D005659Fungicides, Industrial"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in increased expression of SLC22A6 protein"25588985
C039281furanfuran results in increased methylation of SLC22A6 gene22079235
D005665FurosemideFurosemide results in decreased activity of SLC22A6 protein18216144
D005665FurosemideSLC22A6 protein results in increased secretion of Furosemide18216144
D005665FurosemideFurosemide results in increased expression of SLC22A6 protein12897087
D019833GenisteinSLC22A6 protein results in increased uptake of Genistein analog21244849
D019833GenisteinGenistein results in decreased expression of SLC22A6 mRNA21782745
D019833GenisteinGenistein results in increased expression of SLC22A6 mRNA17010207
D005839GentamicinsGentamicins results in decreased expression of SLC22A6 mRNA19967075|2370777
D005839GentamicinsGentamicins results in decreased expression of SLC22A6 protein19967075|2370777
D005839GentamicinsJBP 485 inhibits the reaction [Gentamicins results in decreased expression of SLC22A6 mRNA]23707770
D005839GentamicinsJBP 485 inhibits the reaction [Gentamicins results in decreased expression of SLC22A6 protein]23707770
C030691gluconic acidgluconic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
D005977GlutaratesChlorides promotes the reaction [SLC22A6 protein results in increased uptake of Glutarates]17353191
D005977GlutaratesGlutarates binds to and affects the activity of SLC22A6 protein17353191
D005977GlutaratesGlutarates inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid]15200431
D005977GlutaratesGlutarates inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]12606766
D005977GlutaratesGlutarates promotes the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]12472777
D005977GlutaratesGlutarates promotes the reaction [SLC22A6 protein results in increased uptake of Uric Acid]12472777
D005977GlutaratesSLC22A6 protein results in increased uptake of Glutarates17353191
D005977GlutaratesGlutarates affects the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]15068970
C035736glutaric acidglutaric acid inhibits the reaction [SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog]15284288
C035736glutaric acidglutaric acid promotes the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]28629854
C035736glutaric acidglutaric acid promotes the reaction [SLC22A6 results in increased export of p-Aminohippuric Acid]19643159
C035736glutaric acidglutaric acid results in increased activity of SLC22A6 protein28629854
C035736glutaric acidSLC22A6 protein results in increased import of glutaric acid28629854
D005978GlutathioneSLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Glutathione]12606766
C004312glycidolglycidol results in decreased expression of SLC22A6 mRNA24915197
C412815GW 4064GW 4064 results in increased expression of SLC22A6 mRNA26655953
D006540Herbicides"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in increased expression of SLC22A6 protein"25588985
D006852HydrochlorothiazideHydrochlorothiazide results in increased expression of SLC22A6 protein12897087
D007052IbuprofenIbuprofen results in decreased activity of SLC22A6 protein12388633
D007052IbuprofenSLC22A6 protein results in increased uptake of Ibuprofen12388633
C031534imperatorinimperatorin results in decreased expression of SLC22A6 protein22173200
D007213IndomethacinIndomethacin results in decreased activity of SLC22A6 protein12388633
D007213IndomethacinSLC22A6 protein results in increased uptake of Indomethacin12388633
D007306Insecticides"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in increased expression of SLC22A6 protein"25588985
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC22A6 mRNA25613284
C055542isoimperatorinisoimperatorin results in decreased expression of SLC22A6 protein22173200
C412308JBP 485JBP 485 inhibits the reaction [Cisplatin results in decreased expression of SLC22A6 mRNA]22992436
C412308JBP 485JBP 485 inhibits the reaction [Gentamicins results in decreased expression of SLC22A6 mRNA]23707770
C412308JBP 485JBP 485 inhibits the reaction [Gentamicins results in decreased expression of SLC22A6 protein]23707770
C412308JBP 485JBP 485 results in increased expression of SLC22A6 mRNA22992436
C412308JBP 485JBP 485 results in increased expression of SLC22A6 protein23707770
D007660KetoprofenKetoprofen results in decreased activity of SLC22A6 protein12388633
D007660KetoprofenSLC22A6 protein results in increased uptake of Ketoprofen12388633
D008042Linolenic AcidsLinolenic Acids results in decreased activity of SLC22A6 protein29045746
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SLC22A6 mRNA"24972896
D008294MalathionMalathion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D008528Mefenamic AcidMefenamic Acid results in decreased activity of SLC22A6 protein12388633
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of SLC22A6 mRNA16507785|2853600
D008627Mercuric ChlorideSLC22A6 protein affects the susceptibility to Mercuric Chloride21652719
C019468mercuric oxideadipic acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
C019468mercuric oxidealpha-ketoglutaric acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
C019468mercuric oxideGlutarates inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]12606766
C019468mercuric oxidep-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
C019468mercuric oxideProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
C019468mercuric oxideProbenecid inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]12606766
C019468mercuric oxideSLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]12606766
C019468mercuric oxideSLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Glutathione]12606766
C019468mercuric oxideSLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]12606766
D008628MercurySLC22A6 gene SNP affects the susceptibility to and affects the abundance of Mercury23052037
D008628MercurySLC22A6 protein results in increased transport of [Acetylcysteine co-treated with Mercury]15908511
D008628MercurySLC22A6 protein results in increased uptake of Mercury16081680
D008628MercurySLC22A6 results in increased uptake of Mercury16164645
D008727Methotrexateresveratrol inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]27377006
D008727Methotrexaterhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]28890383
D008727MethotrexateSLC22A6 protein results in increased susceptibility to Methotrexate27377006
D008727MethotrexateSLC22A6 protein results in increased uptake of Methotrexate16098483|2737700
D008727MethotrexateLeucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A6 protein]16925582
D008727MethotrexateMethotrexate results in decreased expression of SLC22A6 protein16925582
D008730MethoxsalenMethoxsalen results in decreased expression of SLC22A6 protein22173200
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SLC22A6 mRNA28536007
D008767Methylmercury CompoundsSLC22A6 protein results in increased transport of [Acetylcysteine co-treated with Methylmercury Compounds]15908511
C030589methylmercury cysteineSLC22A6 protein results in increased transport of methylmercury cysteine16081680
C030589methylmercury cysteineSLC22A6 results in increased transport of methylmercury cysteine16164645
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]15496291
D008803MianserinMianserin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D008911MinocyclineMinocycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]11855680
C517284monomethyl phthalatemonomethyl phthalate affects the expression of SLC22A6 mRNA26924002
C420606mulberroside Amulberroside A inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]22865646
C120401N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine"Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine]"23856525
C120401N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine"Quercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine]"23856525
C120401N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine"SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine"23856525
D009288NaproxenNaproxen results in decreased activity of SLC22A6 protein12388633
C025256nonylphenolnonylphenol results in increased expression of SLC22A6 mRNA17010207
C546709obtusifolinobtusifolin results in decreased activity of SLC22A6 protein29045746
C560681obtusifoline-2-O-beta-D-6-di-O-acetylglucopyranosideobtusifoline-2-O-beta-D-6-di-O-acetylglucopyranoside results in decreased activity of SLC22A6 protein29045746
C025589ochratoxin AChlorides promotes the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]17353191
C025589ochratoxin ASLC22A6 protein results in increased uptake of ochratoxin A16098483|1735319
C025589ochratoxin A[estrone sulfate co-treated with p-Aminohippuric Acid] inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]15251863
C025589ochratoxin ASLC22A6 protein results in increased uptake of ochratoxin A15251863
C025589ochratoxin ACitrinin inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]10336520
C025589ochratoxin AGlutarates affects the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]15068970
C025589ochratoxin Aochratoxin A results in decreased expression of SLC22A6 mRNA12700408|1625148
C025589ochratoxin Aochratoxin A results in decreased expression of SLC22A6 protein19538982
C025589ochratoxin Aochratoxin A results in increased expression of SLC22A6 protein19538982
C025589ochratoxin Aoctanoic acid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]10336520
C025589ochratoxin Ap-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]10336520
C025589ochratoxin APiroxicam inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]10336520
C025589ochratoxin AProbenecid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]10336520
C025589ochratoxin ASLC22A6 protein results in increased uptake of ochratoxin A10336520
D019787Linoleic AcidLinoleic Acid results in decreased activity of SLC22A6 protein29045746
C031492octanoic acidoctanoic acid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]10336520
D009942Organometallic CompoundsOrganometallic Compounds affects the localization of SLC22A6 protein25588984
D009942Organometallic CompoundsOrganometallic Compounds results in decreased expression of SLC22A6 mRNA25588984
D010094Oxonic Acid[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A6 protein19605544
D010118OxytetracyclineOxytetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]11855680
D010269ParaquatParaquat affects the expression of SLC22A6 mRNA15206577
D010269ParaquatParaquat results in increased expression of SLC22A6 mRNA18198484
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of SLC22A6 mRNA"25510870
D010400Penicillin GPenicillin G inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
C479228perfluorohexanoic acidperfluorohexanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]19915082
C101815perfluoro-n-heptanoic acidperfluoro-n-heptanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]19915082
C101815perfluoro-n-heptanoic acidSLC22A6 protein results in increased import of perfluoro-n-heptanoic acid19915082
C584865perfluorononanoic acid"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in increased expression of SLC22A6 protein"25588985
C023036perfluorooctanoic acidperfluorooctanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]19915082
C023036perfluorooctanoic acidSLC22A6 protein results in increased import of perfluorooctanoic acid19915082
D015232DinoprostoneDinoprostone results in decreased expression of SLC22A6 protein19605544
D010615PhenacetinPhenacetin results in decreased activity of SLC22A6 protein12388633
D064209Phytochemicals"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in increased expression of SLC22A6 protein"25588985
C006253pirinixic acidpirinixic acid results in increased expression of SLC22A6 mRNA12832660
D010894PiroxicamPiroxicam results in decreased activity of SLC22A6 protein12388633
D010894PiroxicamPiroxicam inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]10336520
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC22A6 mRNA23557933
D010936Plant ExtractsPlant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]22967667
D010936Plant ExtractsPlant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]22967667
D028321Plant PreparationsPlant Preparations results in decreased expression of SLC22A6 mRNA18047722
D010968Plasticizers"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in increased expression of SLC22A6 protein"25588985
C058229polydatinpolydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]22865646
C489337potassium oxonateAllopurinol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]21909718|2286564
C489337potassium oxonate"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]"22967667
C489337potassium oxonate"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]"22967667
C489337potassium oxonatemulberroside A inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]22865646
C489337potassium oxonatePlant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]22967667
C489337potassium oxonatePlant Extracts inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]22967667
C489337potassium oxonatepolydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]22865646
C489337potassium oxonatepotassium oxonate results in decreased expression of SLC22A6 mRNA21909718|2296766
C489337potassium oxonatepotassium oxonate results in decreased expression of SLC22A6 protein21909718|2286564
C489337potassium oxonateProbenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]22967667
C489337potassium oxonateProbenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]22865646|2296766
C489337potassium oxonateQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]21909718
C489337potassium oxonateQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]21909718
C489337potassium oxonateresveratrol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]22865646
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SLC22A6 mRNA22698814
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]28629854
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]28629854
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine]23856525
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine]23856525
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to adefovir]23856525
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]12606766
D011339Probenecid"Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine]"23856525
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to Tenofovir]23856525
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]12606766
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689|2156179
D011339ProbenecidProbenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]19643159
D011339ProbenecidProbenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]19643159
D011339ProbenecidProbenecid results in decreased activity of SLC22A6 protein28629854|2904574
D011339ProbenecidProbenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]22967667
D011339ProbenecidProbenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]22865646|2296766
D011339ProbenecidProbenecid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]10336520
D011441PropylthiouracilPropylthiouracil results in decreased expression of SLC22A6 mRNA24780913
C005296pyrazinoic acidpyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
D011794QuercetinQuercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog]23856525
D011794Quercetin"Quercetin inhibits the reaction [SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine]"23856525
D011794QuercetinQuercetin inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]19605544
D011794QuercetinQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]21909718
D011794QuercetinQuercetin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]21909718
D011794QuercetinQuercetin affects the expression of SLC22A6 protein24958931
D011794QuercetinQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]19605544
D011794QuercetinQuercetin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]19605544
C531389quercetin 3'-sulfatequercetin 3'-sulfate inhibits the reaction [SLC22A6 protein affects the susceptibility to adefovir]21244849
C531389quercetin 3'-sulfatequercetin 3'-sulfate inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21244849
C531389quercetin 3'-sulfateSLC22A6 protein results in increased uptake of quercetin 3'-sulfate21244849
D011899RanitidineSLC22A6 protein results in increased uptake of Ranitidine16006492
C059514resveratrolresveratrol inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]27377006
C059514resveratrolresveratrol inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]27377006
C059514resveratrolresveratrol inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]22865646
C059514resveratrolresveratrol affects the expression of SLC22A6 protein24958931
C020491rheinrhein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]28890383
C020491rheinrhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of Methotrexate]28890383
C020491rheinrhein metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]28890383
C013672riddelliineriddelliine results in decreased expression of SLC22A6 mRNA18047722
D012431RutinRutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]19605544
D012431RutinRutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]19605544
D012459SalicylatesSalicylates inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
D020156Salicylic AcidSalicylic Acid results in decreased activity of SLC22A6 protein12388633
D020156Salicylic AcidSLC22A6 protein results in increased uptake of Salicylic Acid12388633
C017947sodium arsenitesodium arsenite affects the methylation of SLC22A6 gene28589171
D017693Sodium BicarbonateSodium Bicarbonate results in decreased expression of SLC22A6 mRNA29126803
C016104sodium bichromatesodium bichromate results in increased expression of SLC22A6 mRNA12325037
D013311StreptozocinStreptozocin results in decreased expression of SLC22A6 protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in decreased expression of SLC22A6 protein]19634143
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D013467SulindacSulindac results in decreased activity of SLC22A6 protein12388633
D013473Sunscreening Agents"[perfluorononanoic acid co-treated with [Phytochemicals co-treated with Environmental Pollutants co-treated with Food Preservatives co-treated with Plasticizers co-treated with Sunscreening Agents co-treated with Insecticides co-treated with Fungicides, Industrial co-treated with Herbicides]] results in increased expression of SLC22A6 protein"25588985
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of SLC22A6 mRNA]19228888
D014284TriiodothyronineTriiodothyronine results in decreased expression of SLC22A6 mRNA19228888
D013656Taurocholic AcidTaurocholic Acid inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D000068698TenofovirProbenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to Tenofovir]23856525
D000068698TenofovirSLC22A6 protein results in increased susceptibility to Tenofovir23856525
D000068698TenofovirSLC22A6 protein results in increased uptake of and results in increased susceptibility to Tenofovir25448811
D000068698TenofovirTenofovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]23856525
D013739TestosteroneTestosterone results in increased expression of SLC22A6 protein23389457
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC22A6 mRNA22298810
D013752TetracyclineSLC22A6 protein results in increased export of Tetracycline11855680
D013752TetracyclineSLC22A6 protein results in increased uptake of Tetracycline11855680
D013752TetracyclineTetracycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions]11855680
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC22A6 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]28629854
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased activity of SLC22A6 protein28629854
D014229TriazolamTriazolam inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]21561794
D014266TrientineTrientine inhibits the reaction [Streptozocin results in decreased expression of SLC22A6 protein]19634143
D014494UnithiolUnithiol inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D014494UnithiolUnithiol metabolite inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]11602689
D014494UnithiolUnithiol metabolite promotes the reaction [SLC22A6 protein results in increased secretion of p-Aminohippuric Acid]11602689
D014494UnithiolUnithiol promotes the reaction [SLC22A6 protein results in increased secretion of p-Aminohippuric Acid]11602689
D014527Uric Acid"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]"12472777
D014527Uric Acidalpha-ketoglutaric acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
D014527Uric AcidBenzbromarone inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
D014527Uric Acidgluconic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
D014527Uric AcidGlutarates promotes the reaction [SLC22A6 protein results in increased uptake of Uric Acid]12472777
D014527Uric Acidp-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Uric Acid]12472777
D014527Uric AcidProbenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
D014527Uric Acidpyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
D014527Uric AcidSalicylates inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]12472777
D014527Uric AcidSLC22A6 protein results in increased uptake of Uric Acid12472777
D014527Uric AcidSLC22A6 protein affects the secretion of Uric Acid19605544
D014527Uric Acid[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A6 protein19605544
D014640VancomycinVancomycin results in increased expression of SLC22A6 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SLC22A6 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC22A6 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005452inorganic anion exchanger activity-IDA15037815  
GO:0005515protein binding-IPI16189514  19060904  
GO:0008514organic anion transmembrane transporter activity-IDA9950961  10049739  16024787  
GO:0008514organic anion transmembrane transporter activity-IMP22169006  
GO:0015301anion:anion antiporter activity-TAS-  
GO:0031404chloride ion binding-IEA-  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015698inorganic anion transport-IEA-  
GO:0015711organic anion transport-IDA9950961  10049739  
GO:0015711organic anion transport-IMP22169006  
GO:0015742alpha-ketoglutarate transport-IDA9950961  
GO:0031427response to methotrexate-IEA-  
GO:0051260protein homooligomerization-IEA-  
GO:0097254renal tubular secretion-IMP22169006  
GO:0097254renal tubular secretion-NAS9887087  10049739  
GO:0098656anion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA14749323  
GO:0005901caveola-IEA-  
GO:0016323basolateral plasma membrane-IDA9887087  15037815  
GO:0032991protein-containing complex-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-549132Organic cation/anion/zwitterion transportTAS
R-HSA-561048Organic anion transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24343710Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention. (2014 May)Nicol MRJ Clin Pharmacol