Gene: ITGBL1

9358
OSCP|TIED
integrin subunit beta like 1
protein-coding
13q33.1
Ensembl:ENSG00000198542 MIM:604234 Vega:OTTHUMG00000017296 UniprotKB:O95965
NC_000013.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.956e-1 (AD)  8.711e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9554813chr13:101639227 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs9518426chr13:101509729 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLCB40.846
INPP4B0.809
SLC16A140.795
CHM0.787
BTBD30.786
SKAP20.785
KCND20.781
GNG20.775
CLVS10.775
AFF20.774

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G5-0.439
S100A1-0.43
RBP1-0.409
GPR143-0.409
SLC7A10-0.401
PHF21B-0.396
EYA2-0.395
STON2-0.394
IMPA2-0.394
CYP11A1-0.392

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ITGBL1 mRNA"28973690
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ITGBL1 gene27153756
D000393Air PollutantsAir Pollutants analog results in increased expression of ITGBL1 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ITGBL1 mRNA28522335
C006632arsenic trioxidearsenic trioxide results in decreased expression of ITGBL1 mRNA26705709
C547126AZM551248AZM551248 results in increased expression of ITGBL1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ITGBL1 mRNA20713471
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGBL1 mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ITGBL1 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of ITGBL1 mRNA21795739
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of ITGBL1 mRNA17404688
D004958EstradiolProgesterone inhibits the reaction [Estradiol results in decreased expression of ITGBL1 mRNA]21795739
C006780bisphenol Abisphenol A results in decreased expression of ITGBL1 mRNA25047013
C006780bisphenol Abisphenol A results in decreased expression of ITGBL1 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGBL1 mRNA20938992
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of ITGBL1 mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of ITGBL1 mRNA26577399
D003907DexamethasoneDexamethasone results in increased expression of ITGBL1 mRNA22733784
D002117CalcitriolCalcitriol results in decreased expression of ITGBL1 mRNA26485663
D004237DiuronDiuron results in decreased expression of ITGBL1 mRNA25152437
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGBL1 mRNA20938992
C039281furanfuran results in increased expression of ITGBL1 mRNA27387713
D007052IbuprofenIbuprofen affects the expression of ITGBL1 mRNA17070997
D007545IsoproterenolIsoproterenol results in increased expression of ITGBL1 mRNA20003209
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ITGBL1 mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ITGBL1 mRNA25119042
C008261lead acetatelead acetate results in decreased expression of ITGBL1 mRNA11578147
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGBL1 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of ITGBL1 mRNA24657277
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ITGBL1 mRNA20713471
D015735MifepristoneMifepristone results in decreased expression of ITGBL1 mRNA25972201
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of ITGBL1 mRNA"25554681
D009532NickelNickel results in decreased expression of ITGBL1 mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of ITGBL1 mRNA20971185
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of ITGBL1 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of ITGBL1 mRNA25119042
D010936Plant ExtractsPlant Extracts results in decreased expression of ITGBL1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ITGBL1 mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ITGBL1 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of ITGBL1 mRNA17404688
D011374ProgesteroneProgesterone inhibits the reaction [Estradiol results in decreased expression of ITGBL1 mRNA]21795739
D011374ProgesteroneProgesterone results in increased expression of ITGBL1 mRNA17404688
C005556propionaldehydepropionaldehyde results in increased expression of ITGBL1 mRNA26079696
D012293RifampinRifampin results in decreased expression of ITGBL1 mRNA24552687
C116926rofecoxibrofecoxib affects the expression of ITGBL1 mRNA17070997
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ITGBL1 mRNA25895662
D019821SimvastatinSimvastatin results in decreased expression of ITGBL1 mRNA17428261
D012999SomanSoman results in decreased expression of ITGBL1 mRNA19281266
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ITGBL1 mRNA28065790
C032910triadimefontriadimefon results in decreased expression of ITGBL1 mRNA26705709
D014638VanadatesVanadates results in increased expression of ITGBL1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ITGBL1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ITGBL1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-TAS10051402  
GO:0007160cell-matrix adhesion-IBA21873635  
GO:0007229integrin-mediated signaling pathway-IBA21873635  
GO:0016477cell migration-IBA21873635  
GO:0033627cell adhesion mediated by integrin-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-IBA21873635  
GO:0008305integrin complex-IBA21873635  
GO:0009986cell surface-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878166Transcriptional regulation by RUNX2TAS
R-HSA-8941332RUNX2 regulates genes involved in cell migrationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal