Gene: LONP1

9361
CODASS|LON|LONP|LonHS|PIM1|PRSS15|hLON
lon peptidase 1, mitochondrial
protein-coding
19p13.3
Ensembl:ENSG00000196365 MIM:605490 Vega:OTTHUMG00000180504 UniprotKB:P36776
NG_033142.1
PubMed
0   ANCO-SNPs
ND
0   
9.310e-1 (AD)  NA (ND)   (Frontal_Cortex)
3.018e-1 (AD)  4.198e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22280682chr19:5711875LONP1Gene body3.851e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTBP10.94
CDIPT0.94
YIPF30.936
MRPL40.935
DDRGK10.933
NDUFV10.932
ATP6V0C0.932
MRPL380.931
PUF600.931
POLR2E0.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.768
OR4F29-0.728
KCNJ15-0.389
CXCR2-0.381
IL18RAP-0.378
CEACAM3-0.367
VNN2-0.366
CXCR1-0.356
DNASE1L3-0.354
FCGR3B-0.35

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LONP1 mRNA"25614096
D000082AcetaminophenAcetaminophen results in decreased expression of LONP1 mRNA25704631
D000082AcetaminophenLONP1 gene polymorphism affects the susceptibility to Acetaminophen26104854
D000082AcetaminophenAcetaminophen affects the expression of LONP1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LONP1 mRNA19770486
D000393Air Pollutants[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene27448387
D000393Air Pollutants[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased expression of LONP1 mRNA27448387
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of LONP1 protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LONP1 mRNA16483693
C006780bisphenol Abisphenol A results in increased expression of LONP1 mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of LONP1 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of LONP1 mRNA25181051
C032036bromobenzenebromobenzene results in increased expression of LONP1 mRNA15056800
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in decreased expression of LONP1 protein"23026733
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LONP1 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of LONP1 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in increased expression of LONP1 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in increased expression of LONP1 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased expression of LONP1 mRNA24386269
D003375CoumestrolCoumestrol results in increased expression of LONP1 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of LONP1 mRNA20106945|2556210
D013759DronabinolDronabinol results in increased expression of LONP1 mRNA18163980
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of LONP1 mRNA]27941970
D002945CisplatinCisplatin results in decreased expression of LONP1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of LONP1 mRNA28302478
D018119StavudineStavudine affects the expression of LONP1 protein27041070
C493087diphenylarsinic acidLONP1 mutant form inhibits the reaction [diphenylarsinic acid results in increased degradation of [GLS protein alternative form binds to GLS protein alternative form binds to GLS protein alternative form binds to GLS protein alternative form]]22493432
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LONP1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LONP1 mRNA17942748
D018120FinasterideFinasteride results in increased expression of LONP1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of LONP1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LONP1 gene20938992
D005839GentamicinsGentamicins results in increased expression of LONP1 mRNA22061828
D005839GentamicinsGentamicins results in increased expression of LONP1 protein22061828
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of LONP1 protein17337753
D007657Ketone BodiesKetone Bodies results in increased expression of LONP1 mRNA16807920
D008713MethimazoleMethimazole results in decreased expression of LONP1 mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of LONP1 gene20938992
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of LONP1 protein26558463
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of LONP1 mRNA22776087
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of LONP1 protein22776087
C423917MG 262[MG 262 results in decreased activity of LONP1 protein] which results in increased stability of ALAS1 protein21659532
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in decreased expression of LONP1 protein"23026733
C022838nickel chloridenickel chloride results in increased expression of LONP1 mRNA24612858
D009585Nitrogen Dioxide[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene27448387
D009585Nitrogen Dioxide[Air Pollutants results in increased abundance of Nitrogen Dioxide] which results in increased expression of LONP1 mRNA27448387
D009585Nitrogen Dioxide[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene27448387
D009585Nitrogen Dioxide[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased expression of LONP1 mRNA27448387
D016627OxidopamineOxidopamine results in increased expression of LONP1 mRNA12486162
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of LONP1 mRNA25729387
D010936Plant ExtractsPlant Extracts results in increased expression of LONP1 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of LONP1 mRNA22504374
C010313pseudocumenepseudocumene results in decreased expression of LONP1 protein17337753
C059514resveratrolresveratrol results in increased expression of LONP1 protein25505154
D012834SilverSilver results in increased expression of LONP1 mRNA27131904
D013467SulindacSulindac results in decreased expression of LONP1 mRNA24136188
D000068698TenofovirTenofovir affects the expression of LONP1 protein27041070
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LONP1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LONP1 mRNA22298810
D019284ThapsigarginThapsigargin results in increased expression of LONP1 mRNA22378314
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of LONP1 mRNA25729387
C057693troglitazonetroglitazone results in increased expression of LONP1 protein18495193
D014415TunicamycinTunicamycin results in increased expression of LONP1 mRNA22378314
D014520UrethaneUrethane results in decreased expression of LONP1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of LONP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LONP1 mRNA23179753|2915479
D001335Vehicle Emissions[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in decreased methylation of LONP1 gene27448387
D001335Vehicle Emissions[Vehicle Emissions results in increased abundance of Nitrogen Dioxide] which results in increased expression of LONP1 mRNA27448387
D014800VitalliumVitallium analog results in increased expression of LONP1 mRNA23825117
D024483Vitamin K 3Vitamin K 3 affects the expression of LONP1 mRNA20044591
D015215ZidovudineZidovudine affects the expression of LONP1 protein27041070

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001018mitochondrial promoter sequence-specific DNA binding-IDA9485316  
GO:0001018mitochondrial promoter sequence-specific DNA bindingNOTIDA9485316  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0003697single-stranded DNA binding-IEA-  
GO:0003727single-stranded RNA binding-IDA14739292  
GO:0004176ATP-dependent peptidase activity-IBA21873635  
GO:0004176ATP-dependent peptidase activity-IDA8248235  17420247  
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0005515protein binding-IPI14739292  24520911  
GO:0005524ATP binding-IDA14739292  
GO:0043531ADP binding-IDA14739292  
GO:0043565sequence-specific DNA binding-IDA14739292  
GO:0051880G-quadruplex DNA binding-IDA18174225  
GO:0070182DNA polymerase binding-IPI14739292  
GO ID GO Term Qualifier Evidence PubMed
GO:0000002mitochondrial genome maintenance-NAS17420247  
GO:0001666response to hypoxia-IEP17418790  
GO:0006515protein quality control for misfolded or incompletely synthesized proteins-IBA21873635  
GO:0007005mitochondrion organization-IBA21873635  
GO:0007005mitochondrion organization-IMP15683722  
GO:0007568aging-IEA-  
GO:0009725response to hormone-IEA-  
GO:0010044response to aluminum ion-IEA-  
GO:0032042mitochondrial DNA metabolic process-NAS14739292  
GO:0034599cellular response to oxidative stress-IC12198491  
GO:0034599cellular response to oxidative stress-IDA17420247  
GO:0034622cellular protein-containing complex assembly-IEA-  
GO:0051131chaperone-mediated protein complex assembly-IBA21873635  
GO:0051260protein homooligomerization-IDA14739292  
GO:0051603proteolysis involved in cellular protein catabolic process-IDA8248235  17420247  
GO:0070407oxidation-dependent protein catabolic process-IMP12198491  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IDA8248235  
GO:0005759mitochondrial matrix-IBA21873635  
GO:0005759mitochondrial matrix-IMP12198491  
GO:0005829cytosol-IDA-  
GO:0016020membrane-HDA19946888  
GO:0042645mitochondrial nucleoid-IDA18063578  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal