Gene info: ID 9365

Gene: KL

GENE ID: 9365

Synonyms: -

Description: klotho

Gene type: protein-coding

Location: 13q13.1

dbXrefs: Ensembl:ENSG00000133116 MIM:604824 Vega:OTTHUMG00000017408 UniprotKB:Q9UEF7

RefSeq: NG_011485.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 22

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.141e-1 (AD) 8.344e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PRLR	0.811
MYO3A	0.789
TNFRSF8	0.788
ZBED2	0.774
DRD3	0.772
DGKK	0.764
AMBN	0.764
ANKRD34B	0.762
KCNJ1	0.761
ENTHD1	0.76

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NANOS3	-0.403
SOHLH1	-0.377
PYGM	-0.361
RNF182	-0.351
NXNL1	-0.336
NXPH3	-0.323
HES6	-0.318
TEX29	-0.308
HPSE2	-0.306
RLBP1	-0.305

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C097949	1,25-dihydroxyvitamin D	"KL protein affects the abundance of 1,25-dihydroxyvitamin D"	11796525
C114459	4-phenyl-2-propionamidotetraline	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]	25550330
C114459	4-phenyl-2-propionamidotetraline	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]	25550330
C114459	4-phenyl-2-propionamidotetraline	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]	25550330
C114459	4-phenyl-2-propionamidotetraline	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]	25550330
C114459	4-phenyl-2-propionamidotetraline	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]	25550330
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL mRNA]	21389697
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL protein]	21389697
D000111	Acetylcysteine	Acetylcysteine results in increased expression of KL protein	21389697
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cyclosporine results in decreased expression of KL protein]	23765110
D000111	Acetylcysteine	Acetylcysteine results in increased expression of KL protein	23183129
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of BCL2L1 protein]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of BCL2 protein]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1 mRNA]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1R mRNA]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of CREB1 protein]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of GSK3B protein]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of MAPK1 protein]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of MAPK3 protein]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in increased expression of BAX protein]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in increased expression of CASP3 protein modified form]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in increased phosphorylation of MAPK8 protein]	25309793
D000596	Amino Acids	Amino Acids inhibits the reaction [KL gene mutant form results in increased phosphorylation of MAPK9 protein]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of BCL2L1 protein]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of BCL2 protein]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1 mRNA]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1R mRNA]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of CREB1 protein]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of GSK3B protein]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of MAPK1 protein]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of MAPK3 protein]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased expression of BAX protein]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased expression of CASP3 protein modified form]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased phosphorylation of MAPK8 protein]]	25309793
D000596	Amino Acids	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased phosphorylation of MAPK9 protein]]	25309793
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of KL mRNA	16483693
C027927	androsterone glucuronide	androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
C006632	arsenic trioxide	arsenic trioxide results in increased expression of KL mRNA	27829220
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KL mRNA	19152381
D001564	Benzo(a)pyrene	chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of KL mRNA]	19152381
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of KL mRNA	27195522
C006780	bisphenol A	bisphenol A results in decreased expression of KL mRNA	25181051\|2909715
C006780	bisphenol A	bisphenol A results in increased methylation of KL gene	28505145
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of KL mRNA	18804290
D002104	Cadmium	Cadmium affects the methylation of KL gene	23665422
D019256	Cadmium Chloride	Cadmium Chloride results in increased methylation of KL promoter	22457795
D002118	Calcium	KL protein affects the abundance of Calcium	11796525
D002118	Calcium	KL protein inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] inhibits the reaction [TRPV5 protein results in increased uptake of Calcium]]	23747339
C007020	chlorophyllin	chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of KL mRNA]	19152381
D003042	Cocaine	Cocaine results in increased expression of KL mRNA	15009677
D003471	Cuprizone	Cuprizone results in decreased expression of KL protein	27523638
D003471	Cuprizone	Cuprizone results in increased expression of KL mRNA	26577399
D003471	Cuprizone	Cuprizone results in increased expression of KL protein	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of KL mRNA	27989131
D016572	Cyclosporine	Acetylcysteine inhibits the reaction [Cyclosporine results in decreased expression of KL protein]	23765110
D016572	Cyclosporine	Cyclosporine results in decreased expression of KL protein	23765110
D003687	Dehydroepiandrosterone	Dehydroepiandrosterone analog inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in decreased expression of KL mRNA	26924002
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of KL mRNA	26924002
D004317	Doxorubicin	Doxorubicin results in decreased expression of KL mRNA	20606417
D004317	Doxorubicin	Doxorubicin results in decreased expression of KL protein	20606417
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased expression of KL mRNA]	20606417
D004317	Doxorubicin	EPO protein inhibits the reaction [Doxorubicin results in decreased expression of KL protein]	20606417
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of KL mRNA	24534155
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of KL mRNA	20706672
C025482	estradiol-3-glucuronide	estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
C025482	estradiol-3-glucuronide	KL protein results in increased hydrolysis of estradiol-3-glucuronide	14701853
C022810	estriol 3-glucuronide	estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
C022810	estriol 3-glucuronide	KL protein results in increased hydrolysis of estriol 3-glucuronide	14701853
C015856	estrone-3-glucuronide	estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
C015856	estrone-3-glucuronide	KL protein results in increased hydrolysis of estrone-3-glucuronide	14701853
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of KL mRNA	29097150
D017328	Fosinopril	Fosinopril results in increased expression of KL mRNA	21051829
D017328	Fosinopril	Fosinopril results in increased expression of KL protein	21051829
D019833	Genistein	Genistein results in decreased expression of KL mRNA	20706672
D020719	Glucuronides	androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
D020719	Glucuronides	Dehydroepiandrosterone analog inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
D020719	Glucuronides	estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
D020719	Glucuronides	estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
D020719	Glucuronides	estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
D020719	Glucuronides	KL protein results in increased hydrolysis of Glucuronides	14701853
D020719	Glucuronides	pregnanediol-3 alpha-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
D020719	Glucuronides	Taurocholic Acid inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
D020719	Glucuronides	testosterone glucuronate inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of BCL2L1 protein]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of BCL2 protein]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1 mRNA]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased expression of IGF1R mRNA]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of CREB1 protein]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of GSK3B protein]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of MAPK1 protein]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in decreased phosphorylation of MAPK3 protein]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased expression of BAX protein]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased expression of CASP3 protein modified form]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased phosphorylation of MAPK8 protein]]	25309793
C411572	H 1356	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased phosphorylation of MAPK9 protein]]	25309793
D007200	Indican	Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL mRNA]	21389697
D007200	Indican	Acetylcysteine inhibits the reaction [Indican results in decreased expression of KL protein]	21389697
D007200	Indican	Indican results in decreased expression of KL mRNA	21389697
D007200	Indican	Indican results in decreased expression of KL protein	21389697
D007200	Indican	isohelenin inhibits the reaction [Indican results in decreased expression of KL mRNA]	21389697
D007200	Indican	isohelenin inhibits the reaction [Indican results in decreased expression of KL protein]	21389697
D007200	Indican	pyrrolidine dithiocarbamic acid inhibits the reaction [Indican results in decreased expression of KL mRNA]	21389697
D007200	Indican	pyrrolidine dithiocarbamic acid inhibits the reaction [Indican results in decreased expression of KL protein]	21389697
D007200	Indican	Indican results in decreased expression of KL mRNA	21389697
C103906	isohelenin	isohelenin inhibits the reaction [Indican results in decreased expression of KL mRNA]	21389697
C103906	isohelenin	isohelenin inhibits the reaction [Indican results in decreased expression of KL protein]	21389697
C008261	lead acetate	lead acetate results in decreased expression of KL mRNA	22609695
C008261	lead acetate	lead acetate affects the expression of KL mRNA	21864555
C027820	ligustilide	ligustilide results in increased expression of KL mRNA	23973442
C027820	ligustilide	ligustilide results in increased expression of KL protein	23973442
C027820	ligustilide	ligustilide results in increased expression of KL mRNA	23973442
C027820	ligustilide	ligustilide results in increased expression of KL protein	23973442
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of KL mRNA	12057914
D008315	Malondialdehyde	Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde]	25309793
D008315	Malondialdehyde	H 1356 inhibits the reaction [Amino Acids inhibits the reaction [KL gene mutant form results in increased abundance of Malondialdehyde]]	25309793
D008315	Malondialdehyde	KL gene mutant form results in increased abundance of Malondialdehyde	25309793
D008550	Melatonin	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]	25550330
D008550	Melatonin	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]	25550330
D008550	Melatonin	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]	25550330
D008550	Melatonin	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]	25550330
D008550	Melatonin	4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]	25550330
D008550	Melatonin	Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]	25550330
D008550	Melatonin	Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]	25550330
D008550	Melatonin	Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]	25550330
D008550	Melatonin	Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]	25550330
D008550	Melatonin	Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]	25550330
D008550	Melatonin	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]	25550330
D008550	Melatonin	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]	25550330
D008550	Melatonin	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]	25550330
D008550	Melatonin	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]	25550330
D008550	Melatonin	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]	25550330
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of KL mRNA	22401849
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of KL mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in decreased expression of KL mRNA	15674843
D009569	Nitric Oxide	KL protein results in increased abundance of Nitric Oxide	17709902
D009569	Nitric Oxide	[KL protein results in increased abundance of Nitric Oxide] which results in increased expression of SOD2	17709902
C485800	osajin	osajin results in decreased expression of KL mRNA	20706672
D010269	Paraquat	KL protein results in decreased susceptibility to Paraquat	16186101
C011272	perfosfamide	perfosfamide results in decreased expression of KL mRNA	19429390
D010634	Phenobarbital	Phenobarbital results in decreased expression of KL mRNA	19084549
D010710	Phosphates	KL protein affects the reaction [FGF23 protein affects the abundance of Phosphates]	17710231
D010710	Phosphates	KL protein promotes the reaction [FGF23 protein results in decreased uptake of Phosphates]	27432882
D010758	Phosphorus	KL protein affects the abundance of Phosphorus	11796525
C474837	pomiferin	pomiferin results in decreased expression of KL mRNA	20706672
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of KL mRNA	23608068
C022270	pregnanediol-3 alpha-glucuronide	pregnanediol-3 alpha-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
C005556	propionaldehyde	propionaldehyde results in decreased expression of KL mRNA	26079696
D011429	Propolis	Propolis results in decreased expression of KL mRNA	20706672
C033607	puerarin	puerarin results in decreased expression of KL mRNA	20706672
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Indican results in decreased expression of KL mRNA]	21389697
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [Indican results in decreased expression of KL protein]	21389697
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid results in increased expression of KL protein	21389697
D017382	Reactive Oxygen Species	KL protein inhibits the reaction [AGT protein modified form results in increased abundance of Reactive Oxygen Species]	17709902
C059514	resveratrol	ATF3 protein affects the reaction [resveratrol results in increased expression of KL mRNA]	24911970
C059514	resveratrol	resveratrol results in decreased expression of KL mRNA	20706672
C059514	resveratrol	resveratrol results in increased expression of KL mRNA	24911970
C059514	resveratrol	resveratrol results in increased expression of KL protein	24911970
C059514	resveratrol	resveratrol results in increased expression of KL mRNA	24911970
C059514	resveratrol	resveratrol results in increased expression of KL protein	24911970
C059514	resveratrol	ATF3 protein affects the reaction [resveratrol results in increased expression of KL mRNA]	24911970
C059514	resveratrol	JUN protein affects the reaction [resveratrol results in increased expression of KL]	24911970
C059514	resveratrol	resveratrol promotes the reaction [ATF3 protein binds to KL promoter]	24911970
C059514	resveratrol	resveratrol promotes the reaction [JUN protein binds to KL promoter]	24911970
C059514	resveratrol	resveratrol results in increased expression of KL mRNA	24911970
C059514	resveratrol	resveratrol results in increased expression of KL protein	24911970
C059514	resveratrol	resveratrol promotes the reaction [JUN protein results in increased expression of KL mRNA]	24911970
C009166	retinol acetate	retinol acetate results in increased expression of KL mRNA	16772331
C529148	rosavin	rosavin results in decreased expression of KL mRNA	20706672
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of KL]	24136780
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of KL mRNA	19244175
C424127	SL 327	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]	25550330
C424127	SL 327	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]	25550330
C424127	SL 327	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]	25550330
C424127	SL 327	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]	25550330
C424127	SL 327	SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]	25550330
C032706	sodium chlorate	sodium chlorate results in decreased expression of KL protein	27432882
D013311	Streptozocin	rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of KL]	24136780
D013311	Streptozocin	Streptozocin results in decreased expression of KL	24136780
D013656	Taurocholic Acid	Taurocholic Acid inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
C015529	testosterone glucuronate	testosterone glucuronate inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]	14701853
D014028	Tobacco Smoke Pollution	KL protein inhibits the reaction [Tobacco Smoke Pollution results in increased expression of CDKN1A]	26100223
D014028	Tobacco Smoke Pollution	KL protein results in decreased susceptibility to Tobacco Smoke Pollution	26100223
D014302	Trinitrobenzenesulfonic Acid	KL protein inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV5 protein]	23747339
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of KL protein	23747339
C057693	troglitazone	troglitazone results in increased expression of KL mRNA	11768731
D014635	Valproic Acid	Valproic Acid results in decreased methylation of KL gene	29154799
D000068756	Valsartan	Valsartan results in increased expression of KL mRNA	21051829
D000068756	Valsartan	Valsartan results in increased expression of KL protein	21051829
D014640	Vancomycin	Vancomycin results in increased expression of KL mRNA	18930951
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of KL mRNA	26682919
D014807	Vitamin D	KL protein affects the reaction [FGF23 protein affects the abundance of Vitamin D]	17710231
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of KL mRNA	19244175
D015032	Zinc	Zinc deficiency results in decreased expression of KL mRNA	18356318
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of KL mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004566	beta-glucuronidase activity	-	IEA	-
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005104	fibroblast growth factor receptor binding	-	IBA	21873635
GO:0005179	hormone activity	-	IEA	-
GO:0005499	vitamin D binding	-	IEA	-
GO:0008422	beta-glucosidase activity	-	IBA	21873635
GO:0008422	beta-glucosidase activity	-	TAS	9363890
GO:0016303	1-phosphatidylinositol-3-kinase activity	-	TAS	-
GO:0017134	fibroblast growth factor binding	-	IBA	21873635
GO:0017134	fibroblast growth factor binding	-	IPI	18829467
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0005975	carbohydrate metabolic process	-	IEA	-
GO:0006112	energy reserve metabolic process	-	IEA	-
GO:0007568	aging	-	IMP	11792841
GO:0008286	insulin receptor signaling pathway	-	IEA	-
GO:0008543	fibroblast growth factor receptor signaling pathway	-	IBA	21873635
GO:0008543	fibroblast growth factor receptor signaling pathway	-	TAS	-
GO:0010469	regulation of signaling receptor activity	-	IEA	-
GO:0030501	positive regulation of bone mineralization	-	IMP	12110410
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	-	IEA	-
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:0055074	calcium ion homeostasis	-	IEA	-
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	-	IEA	-
GO:1901657	glycosyl compound metabolic process	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005622	intracellular	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	9464267
GO:0016324	apical plasma membrane	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-109704	PI3K Cascade	TAS
R-HSA-112399	IRS-mediated signalling	TAS
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-190236	Signaling by FGFR	TAS
R-HSA-190242	FGFR1 ligand binding and activation	TAS
R-HSA-190374	FGFR1c and Klotho ligand binding and activation	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	TAS
R-HSA-2428924	IGF1R signaling cascade	TAS
R-HSA-2428928	IRS-related events triggered by IGF1R	TAS
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	TAS
R-HSA-5654687	Downstream signaling of activated FGFR1	TAS
R-HSA-5654688	SHC-mediated cascade:FGFR1	TAS
R-HSA-5654689	PI-3K cascade:FGFR1	TAS
R-HSA-5654693	FRS-mediated FGFR1 signaling	TAS
R-HSA-5654726	Negative regulation of FGFR1 signaling	TAS
R-HSA-5654736	Signaling by FGFR1	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-74751	Insulin receptor signalling cascade	TAS
R-HSA-74752	Signaling by Insulin receptor	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25670894	Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls. (2015)	Ishikawa N	Int J Chron Obstruct Pulmon Dis
22650152	Effects of molecular structural variants on serum Krebs von den Lungen-6 levels in sarcoidosis. (2012 Jul 11)	Shigemura M	J Transl Med
24672586	Sorafenib-induced acute interstitial pneumonia in patients with advanced hepatocellular carcinoma: report of three cases. (2012)	Takeda H	Clin J Gastroenterol
24835074	Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis. (2014 Jul)	Ohshimo S	Respir Med
28943558	The Serum Level of KL-6 Is Associated with the Risk of Insulin Resistance and New-onset Diabetes Mellitus: The Tanno-Sobetsu Study. (2017 Nov 15)	Akasaka H	Intern Med
21900000	Pulmonary alveolar proteinosis: new insights from a single-center cohort of 70 patients. (2011 Dec)	Bonella F	Respir Med
20538446	The radiological patterns of interstitial change at an early phase: over a 4-year follow-up. (2010 Nov)	Tsushima K	Respir Med
27746429	Influence of Smoking in Interstitial Pneumonia Presenting with a Non-Specific Interstitial Pneumonia Pattern. (2016)	Sawata T	Intern Med
12669274	KLOTHO allele status and the risk of early-onset occult coronary artery disease. (2003 May)	Arking DE	Am J Hum Genet
26029566	Improvement in idiopathic nonspecific interstitial pneumonia after smoking cessation. (2015)	Shinohara T	Respir Med Case Rep
26758437	Association of serum KL-6 levels with interstitial lung disease in patients with connective tissue disease: a cross-sectional study. (2016 Mar)	Oguz EO	Clin Rheumatol
21569324	Ageing and long-term smoking affects KL-6 levels in the lung, induced sputum and plasma. (2011 May 11)	Ishikawa N	BMC Pulm Med
21402472	Comparison of biomarkers of subclinical lung injury in obstructive sleep apnea. (2011 Jun)	Aihara K	Respir Med
27117830	Treatment and monitoring of hypersensitivity pneumonitis. (2016 Sep)	Miyazaki Y	Expert Rev Clin Immunol
29712948	G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old. (2018 Apr 30)	Hao Q	Sci Rep
23778023	Serum KL-6 concentrations are associated with molecular sizes and efflux behavior of KL-6/MUC1 in healthy subjects. (2013 Sep 23)	Shigemura M	Clin Chim Acta
25823238	[Combined pulmonary fibrosis and emphysema (CPFE)--limitation of usual lung function test and challenge at practice]. (2014 Dec)	Takai D	Rinsho Byori
21474912	Levels of surfactant proteins A and D and KL-6 are elevated in the induced sputum of chronic obstructive pulmonary disease patients: a sequential sputum analysis. (2011)	Ishikawa N	Respiration
27546601	Effect of Perioperative Pirfenidone Treatment in Lung Cancer Patients With Idiopathic Pulmonary Fibrosis. (2016 Dec)	Iwata T	Ann Thorac Surg
18595202	Serum surfactant protein-A, but not surfactant protein-D or KL-6, can predict preclinical lung damage induced by smoking. (2008 Jun)	Kobayashi H	Biomarkers
29565649	Risk factors for radiation pneumonitis after stereotactic radiation therapy for lung tumours: clinical usefulness of the planning target volume to total lung volume ratio. (2018 Jun)	Ueyama T	Br J Radiol
25244495	Diagnostic Values For Club Cell Secretory Protein (CC16) in Serum of Patients of Combined Pulmonary Fibrosis and Emphysema. (2015 Aug)	Kokuho N	COPD