Gene: ARHGAP18

93663
MacGAP|SENEX|bA307O14.2
Rho GTPase activating protein 18
protein-coding
6q22.33
Ensembl:ENSG00000146376 MIM:613351 Vega:OTTHUMG00000015547 UniprotKB:Q8N392
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.322e-1 (AD)  6.807e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12213388chr6:129711600 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NAA380.805
DAB20.8
CD2AP0.78
KCTD120.771
IKBIP0.764
CAV20.755
CTSC0.751
PRSS230.746
ATP7A0.741
IFNAR20.736

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSF-0.417
PYGM-0.389
NXPH3-0.361
HES6-0.359
ASPDH-0.352
SLC7A10-0.337
CPLX3-0.336
EPHB1-0.334
WNT7A-0.333
BTBD17-0.333

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ARHGAP18 mRNA19933214
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ARHGAP18 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C0293704-toluidine4-toluidine results in increased expression of ARHGAP18 mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ARHGAP18 mRNA21420995
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ARHGAP18 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of ARHGAP18 mRNA27829220
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ARHGAP18 mRNA17905399
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARHGAP18 mRNA20064835|2010694
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ARHGAP18 mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ARHGAP18 mRNA"19150397
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of ARHGAP18 mRNA20404318
C006780bisphenol Abisphenol A results in decreased expression of ARHGAP18 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ARHGAP18 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ARHGAP18 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ARHGAP18 mRNA26472689
D002220CarbamazepineCarbamazepine affects the expression of ARHGAP18 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ARHGAP18 mRNA17484886
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ARHGAP18 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of ARHGAP18 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of ARHGAP18 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of ARHGAP18 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of ARHGAP18 mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of ARHGAP18 mRNA25562108
D000069439DasatinibDasatinib results in decreased expression of ARHGAP18 mRNA20579391
D003703DemecolcineDemecolcine results in decreased expression of ARHGAP18 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ARHGAP18 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ARHGAP18 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of ARHGAP18 mRNA28302478
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGAP18 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ARHGAP18 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ARHGAP18 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ARHGAP18 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ARHGAP18 mRNA23649840
C540355fenamidonefenamidone results in increased expression of ARHGAP18 mRNA27029645
D005557FormaldehydeFormaldehyde results in decreased expression of ARHGAP18 mRNA23649840
C039281furanfuran results in increased expression of ARHGAP18 mRNA25539665
D019833GenisteinGenistein results in decreased methylation of ARHGAP18 gene28505145
D019833GenisteinGenistein results in increased methylation of ARHGAP18 gene28505145
D005839GentamicinsGentamicins results in increased expression of ARHGAP18 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of ARHGAP18 mRNA24136188
D017313FenretinideFenretinide results in increased expression of ARHGAP18 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of ARHGAP18 mRNA18951874
C016517indole-3-carbinolindole-3-carbinol affects the expression of ARHGAP18 mRNA21396975
D007545IsoproterenolIsoproterenol results in decreased expression of ARHGAP18 mRNA20003209
C410337K 7174K 7174 results in decreased expression of ARHGAP18 mRNA24086573
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ARHGAP18 mRNA21641980
D008558MelphalanMelphalan results in decreased expression of ARHGAP18 mRNA22363485
C042720mercuric bromidemercuric bromide results in increased expression of ARHGAP18 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ARHGAP18 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of ARHGAP18 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of ARHGAP18 mRNA21664453
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ARHGAP18 mRNA17905399
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ARHGAP18 mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of ARHGAP18 mRNA20024957
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ARHGAP18 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ARHGAP18 mRNA"25620056
C029938nickel sulfatenickel sulfate results in increased expression of ARHGAP18 mRNA22714537
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ARHGAP18 mRNA26272509
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ARHGAP18 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of ARHGAP18 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ARHGAP18 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARHGAP18 mRNA19710929
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGAP18 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ARHGAP18 mRNA22079256
D011374ProgesteroneProgesterone results in decreased expression of ARHGAP18 mRNA20864642
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ARHGAP18 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of ARHGAP18 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ARHGAP18 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of ARHGAP18 mRNA20371982
C017947sodium arsenitesodium arsenite results in increased expression of ARHGAP18 mRNA22714537
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ARHGAP18 mRNA21641980
D013605T-2 ToxinT-2 Toxin results in decreased expression of ARHGAP18 mRNA26141394
D013629TamoxifenTamoxifen affects the expression of ARHGAP18 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARHGAP18 mRNA20106945
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ARHGAP18 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARHGAP18 mRNA19933214
D013849ThimerosalThimerosal results in decreased expression of ARHGAP18 mRNA27188386
D013853ThioacetamideThioacetamide results in increased expression of ARHGAP18 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ARHGAP18 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of ARHGAP18 mRNA21934132
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ARHGAP18 mRNA17905399
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ARHGAP18 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ARHGAP18 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ARHGAP18 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ARHGAP18 mRNA23179753|2352703
D014638VanadatesVanadates results in increased expression of ARHGAP18 mRNA22714537
D014640VancomycinVancomycin results in increased expression of ARHGAP18 mRNA18930951
D014750VincristineVincristine results in decreased expression of ARHGAP18 mRNA23649840
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGAP18 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of ARHGAP18 mRNA26272509|2718838
C088658zoledronic acidzoledronic acid results in decreased expression of ARHGAP18 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005096GTPase activator activity-IMP21865595  
GO:0005096GTPase activator activity-TAS-  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0007264small GTPase mediated signal transduction-IMP21865595  
GO:0008360regulation of cell shape-IMP21865595  
GO:0030833regulation of actin filament polymerization-IBA21873635  
GO:0030833regulation of actin filament polymerization-IMP21865595  
GO:0032956regulation of actin cytoskeleton organization-IBA21873635  
GO:0032956regulation of actin cytoskeleton organization-IMP21865595  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-IBA21873635  
GO:0051056regulation of small GTPase mediated signal transduction-IMP21865595  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:2000145regulation of cell motility-IMP21865595  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IMP21865595  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal