Gene: SLC22A8

9376
OAT3
solute carrier family 22 member 8
protein-coding
11q12.3
Ensembl:ENSG00000149452 MIM:607581 Vega:OTTHUMG00000167768 UniprotKB:Q8TCC7
NC_000011.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.454e-1 (AD)  7.972e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC13A40.945
CDC20B0.939
GATA60.907
SLC22A20.902
ALX40.894
OR51E10.892
TRABD2B0.88
MYOCD0.87
SLC5A50.862
OGN0.83

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEXI-0.253
SOX15-0.228
FEZF2-0.224
DOK7-0.216
BRINP3-0.211
NANOS3-0.21
DNASE1L2-0.209
TMEM74-0.206
PNPLA7-0.204
CCDC151-0.202

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00139Succinic acidSmall Molecule110-15-6Approved|NutraceuticalTransporter
DB00168AspartameSmall Molecule22839-47-0Approved|NutraceuticalTransporter
DB00175PravastatinSmall Molecule81093-37-0ApprovedTransporter
DB00181BaclofenSmall Molecule1134-47-0ApprovedTransporter
DB00198OseltamivirSmall Molecule196618-13-0ApprovedTransporter
DB00254DoxycyclineSmall Molecule564-25-0Approved|InvestigationalTransporter
DB00279LiothyronineSmall Molecule6893-02-3ApprovedTransporter
DB00286Conjugated estrogensSmall Molecule12126-59-9ApprovedTransporter
DB00300Tenofovir disoproxilSmall Molecule201341-05-1Approved|InvestigationalTransporter
DB00313Valproic AcidSmall Molecule99-66-1Approved|InvestigationalTransporter
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalTransporter
DB00345Aminohippuric acidSmall Molecule61-78-9Approved|InvestigationalTransporter
DB00390DigoxinSmall Molecule20830-75-5ApprovedTransporter
DB00437AllopurinolSmall Molecule315-30-0ApprovedTransporter
DB00456CefalotinSmall Molecule153-61-7Approved|InvestigationalTransporter
DB00469TenoxicamSmall Molecule59804-37-4ApprovedTransporter
DB00493CefotaximeSmall Molecule63527-52-6ApprovedTransporter
DB00495ZidovudineSmall Molecule30516-87-1ApprovedTransporter
DB00501CimetidineSmall Molecule51481-61-9Approved|InvestigationalTransporter
DB00536GuanidineSmall Molecule113-00-8ApprovedTransporter
DB00554PiroxicamSmall Molecule36322-90-4Approved|InvestigationalTransporter
DB00563MethotrexateSmall Molecule59-05-2ApprovedTransporter
DB00567CephalexinSmall Molecule15686-71-2Approved|InvestigationalTransporter
DB00577ValaciclovirSmall Molecule124832-26-4Approved|InvestigationalTransporter
DB00583L-CarnitineSmall Molecule541-15-1Approved|InvestigationalTransporter
DB00584EnalaprilSmall Molecule75847-73-3ApprovedTransporter
DB00586DiclofenacSmall Molecule15307-86-5ApprovedTransporter
DB00595OxytetracyclineSmall Molecule79-57-2Approved|InvestigationalTransporter
DB00624TestosteroneSmall Molecule58-22-0Approved|InvestigationalTransporter
DB00695FurosemideSmall Molecule54-31-9ApprovedTransporter
DB00718Adefovir DipivoxilSmall Molecule142340-99-6Approved|InvestigationalTransporter
DB00759TetracyclineSmall Molecule60-54-8ApprovedTransporter
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalTransporter
DB00787AciclovirSmall Molecule59277-89-3ApprovedTransporter
DB00812PhenylbutazoneSmall Molecule50-33-9ApprovedTransporter
DB00863RanitidineSmall Molecule66357-35-5ApprovedTransporter
DB00887BumetanideSmall Molecule28395-03-1ApprovedTransporter
DB00908QuinidineSmall Molecule56-54-2Approved|InvestigationalTransporter
DB00917DinoprostoneSmall Molecule363-24-6ApprovedTransporter
DB00927FamotidineSmall Molecule76824-35-6ApprovedTransporter
DB00936Salicylic acidSmall Molecule69-72-7Approved|InvestigationalTransporter
DB01004GanciclovirSmall Molecule82410-32-0Approved|InvestigationalTransporter
DB01009KetoprofenSmall Molecule22071-15-4ApprovedTransporter
DB01017MinocyclineSmall Molecule10118-90-8Approved|InvestigationalTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01033MercaptopurineSmall Molecule50-44-2ApprovedTransporter
DB01050IbuprofenSmall Molecule15687-27-1ApprovedTransporter
DB01051NovobiocinSmall Molecule303-81-1Approved|InvestigationalTransporter
DB01053BenzylpenicillinSmall Molecule61-33-6ApprovedTransporter
DB01065MelatoninSmall Molecule73-31-4Approved|NutraceuticalTransporter
DB01092OuabainSmall Molecule630-60-4ApprovedTransporter
DB01140CefadroxilSmall Molecule50370-12-2Approved|WithdrawnTransporter
DB01160Dinoprost TromethamineSmall Molecule38562-01-5ApprovedTransporter
DB01212CeftriaxoneSmall Molecule73384-59-5ApprovedTransporter
DB01326CefamandoleSmall Molecule34444-01-4Approved|InvestigationalTransporter
DB01327CefazolinSmall Molecule25953-19-9ApprovedTransporter
DB01329CefoperazoneSmall Molecule62893-19-0Approved|InvestigationalTransporter
DB01414CefacetrileSmall Molecule10206-21-0ApprovedTransporter
DB01583LiotrixSmall Molecule8065-29-0ApprovedTransporter
DB01597CilastatinSmall Molecule82009-34-5Approved|InvestigationalTransporter
DB01650trans-2-hydroxycinnamic acidSmall Molecule614-60-8ExperimentalTransporter
DB01685TopiroxostatSmall Molecule577778-58-6Approved|InvestigationalTransporter
DB02527Cyclic Adenosine MonophosphateSmall Molecule60-92-4ExperimentalTransporter
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTransporter
DB03553Glutaric AcidSmall Molecule110-94-1ExperimentalTransporter
DB03793Benzoic AcidSmall Molecule65-85-0Approved|InvestigationalTransporter
DB03902Oxalic AcidSmall Molecule144-62-7ExperimentalTransporter
DB04133Degraded CephaloridineSmall Molecule-ExperimentalTransporter
DB04348Taurocholic AcidSmall Molecule81-24-3ExperimentalTransporter
DB04519Caprylic acidSmall Molecule124-07-2Approved|Experimental|InvestigationalTransporter
DB05804Prasterone sulfateSmall Molecule651-48-9InvestigationalTransporter
DB06335SaxagliptinSmall Molecule361442-04-8ApprovedTransporter
DB06710MethyltestosteroneSmall Molecule58-18-4ApprovedTransporter
DB08837TetraethylammoniumSmall Molecule66-40-0Experimental|InvestigationalTransporter
DB08844Uric AcidSmall Molecule69-93-2Experimental|InvestigationalTransporter
DB08912DabrafenibSmall Molecule-Approved|InvestigationalTransporter
DB08930DolutegravirSmall Molecule1051375-16-6ApprovedTransporter
DB09060AvibactamSmall Molecule1192500-31-4ApprovedTransporter
DB09272EluxadolineSmall Molecule864821-90-9Approved|InvestigationalTransporter
DB11817BaricitinibSmall Molecule1187594-09-7Approved|InvestigationalTransporter
DB11901ApalutamideSmall Molecule956104-40-8Approved|InvestigationalTransporter
DB12070LetermovirSmall Molecule917389-32-3Approved|InvestigationalTransporter
DB12332RucaparibSmall Molecule283173-50-2Approved|InvestigationalTransporter
DB13874EnasidenibSmall Molecule1446502-11-9Approved|InvestigationalTransporter
DB13943Testosterone cypionateSmall Molecule58-20-8ApprovedTransporter
DB13944Testosterone enanthateSmall Molecule315-37-7ApprovedTransporter
DB13946Testosterone undecanoateSmall Molecule5949-44-0Approved|InvestigationalTransporter
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalTransporter
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalTransporter
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalTransporter
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalTransporter
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalTransporter
DB00493CefotaximeSmall Molecule63527-52-6ApprovedTarget
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTarget
DB01053BenzylpenicillinSmall Molecule61-33-6ApprovedTarget
DB01212CeftriaxoneSmall Molecule73384-59-5ApprovedTarget
DB05016AtalurenSmall Molecule775304-57-9Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC22A8 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC22A8 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC22A8 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC22A8 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC22A8 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC22A8 mRNA"25510870
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]"28629854
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]"28629854
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A8 protein]"28629854
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A8 protein"28629854
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]"28629854
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A8 protein]"28629854
C0178222-amino-9H-pyrido(2,3-b)indole"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]"28629854
C0178222-amino-9H-pyrido(2,3-b)indole"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A8 protein]"28629854
C0178222-amino-9H-pyrido(2,3-b)indole"2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]"28629854
C0178222-amino-9H-pyrido(2,3-b)indole"2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]"28629854
C0178222-amino-9H-pyrido(2,3-b)indole"2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A8 protein]"28629854
C0178222-amino-9H-pyrido(2,3-b)indole"2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A8 protein"28629854
C0009893,4-dihydroxymandelic acid"3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]"10224140
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]"28629854
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A8 protein"28629854
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of SLC22A8 mRNA"25380136
C0451324-carboxyfluoresceinquercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]21244849
C0451324-carboxyfluoresceinquercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]21244849
C0451324-carboxyfluoresceinquercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]21244849
C0451324-carboxyfluoresceinSLC22A8 protein results in increased transport of 4-carboxyfluorescein21244849
C0017365-methoxyindoleacetic acid5-methoxyindoleacetic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C0005889585-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methylbenzoic acid results in decreased activity of SLC22A8 protein23631744
C0240986-carboxyfluorescein"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]"28629854
C0240986-carboxyfluorescein"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction [2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]"28629854
C0240986-carboxyfluorescein"2-amino-9H-pyrido(2,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]"28629854
C0240986-carboxyfluorescein"2-amino-9H-pyrido(2,3-b)indole promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]]"28629854
C0240986-carboxyfluorescein"3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]"28629854
C0240986-carboxyfluoresceinCadmium Chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]28629854
C0240986-carboxyfluoresceinglutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]28629854
C0240986-carboxyfluoresceinlead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]28629854
C0240986-carboxyfluoresceinProbenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]28629854
C0240986-carboxyfluoresceinSLC22A8 protein results in increased import of 6-carboxyfluorescein28629854
C0240986-carboxyfluoresceinsodium arsenate promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]28629854
C0775807-(deoxyadenosin-N(6)-yl)aristolactam IProbenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]19643159
C0775807-(deoxyadenosin-N(6)-yl)aristolactam I[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I19643159
C0775797-(deoxyguanosin-N(2)-yl)aristolactam IProbenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]19643159
C0775797-(deoxyguanosin-N(2)-yl)aristolactam I[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I19643159
D000082AcetaminophenAcetaminophen affects the expression of SLC22A8 mRNA17562736
D000111AcetylcysteineSLC22A8 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]12606766
C053001adefovirSLC22A8 protein results in increased susceptibility to adefovir25448811
D000242Cyclic AMPSLC22A8 protein affects the transport of Cyclic AMP11306713
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of SLC22A8 mRNA19920212
D000493AllopurinolSLC22A8 protein results in increased transport of Allopurinol15100168
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SLC22A8 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SLC22A8 mRNA21298039
D010130p-Aminohippuric Acidaristolochic acid I promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid]19643159
D010130p-Aminohippuric Acidestrone sulfate promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid]19643159
D010130p-Aminohippuric AcidSLC22A8 protein affects the transport of p-Aminohippuric Acid11306713
D010130p-Aminohippuric AcidSLC22A8 protein results in increased uptake of p-Aminohippuric Acid16098483
D010130p-Aminohippuric AcidSLC22A8 results in increased export of p-Aminohippuric Acid19643159
D010130p-Aminohippuric AcidCimetidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]15100168
D010130p-Aminohippuric AcidEnalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]15100168
D010130p-Aminohippuric AcidFamotidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]15100168
D010130p-Aminohippuric AcidIbuprofen inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]15100168
D010130p-Aminohippuric AcidSLC22A8 protein results in increased uptake of p-Aminohippuric Acid15100168
D010130p-Aminohippuric Acidtenoxicam inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]15100168
D010130p-Aminohippuric Acid[estrone sulfate co-treated with p-Aminohippuric Acid] inhibits the reaction [SLC22A8 protein results in increased uptake of ochratoxin A]15251863
D010130p-Aminohippuric Acidp-Aminohippuric Acid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D010130p-Aminohippuric AcidSLC22A8 protein results in increased uptake of p-Aminohippuric Acid10224140
D010130p-Aminohippuric Aciddonepezil inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]20924140
D010130p-Aminohippuric AcidHydrochlorothiazide inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]20924140
D010130p-Aminohippuric AcidMetoprolol inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]20924140
D010130p-Aminohippuric AcidRanitidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]20924140
D010130p-Aminohippuric AcidSLC22A8 protein results in increased uptake of p-Aminohippuric Acid20924140
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC22A8 mRNA16483693
C011659angelicinangelicin results in decreased expression of SLC22A8 mRNA22173200
C011659angelicinangelicin results in increased expression of SLC22A8 protein22173200
D000838AnionsSLC22A8 protein results in increased uptake of Anions11855680
D000893Anti-Inflammatory AgentsAnti-Inflammatory Agents binds to SLC22A8 protein19378467
C000228aristolochic acid Iaristolochic acid I inhibits the reaction [SLC22A8 results in increased uptake of estrone sulfate]19643159
C000228aristolochic acid Iaristolochic acid I promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid]19643159
D034341Aristolochic AcidsProbenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]19643159
D034341Aristolochic AcidsProbenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]19643159
D034341Aristolochic AcidsSLC22A8 results in increased uptake of Aristolochic Acids19643159
D034341Aristolochic Acids[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I19643159
D034341Aristolochic Acids[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I19643159
D034341Aristolochic AcidsAristolochic Acids results in decreased expression of SLC22A8 mRNA21167265
D034341Aristolochic AcidsAristolochic Acids results in decreased expression of SLC22A8 protein21167265
D001241AspirinAspirin results in increased expression of SLC22A8 mRNA11906190
C040896AST 120AST 120 affects the expression of SLC22A8 protein24958931
D001280AtrazineAtrazine results in increased expression of SLC22A8 mRNA22378314
C000595611aurantio-obtusinaurantio-obtusin results in decreased activity of SLC22A8 protein29045746
D001539BendroflumethiazideBendroflumethiazide results in decreased activity of SLC22A8 protein18216144
D001539BendroflumethiazideSLC22A8 protein results in increased secretion of Bendroflumethiazide18216144
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]27989701
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased activity of SLC22A8 protein27989701
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Phenylephrine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C006780bisphenol Abisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]27989701
C006780bisphenol Abisphenol A results in decreased activity of SLC22A8 protein27989701
C006780bisphenol Abisphenol A results in decreased expression of SLC22A8 mRNA25181051
C000611646bisphenol Fbisphenol F inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]27989701
C000611646bisphenol Fbisphenol F results in decreased activity of SLC22A8 protein27989701
D002034BumetanideBumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
D002034BumetanideBumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
D019256Cadmium ChlorideCadmium Chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]28629854
D019256Cadmium ChlorideCadmium Chloride results in increased activity of SLC22A8 protein28629854
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC22A8 mRNA25588984
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC22A8 protein25588984
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SLC22A8 protein12629582|1754437
D002331CarnitineSLC22A8 protein results in increased transport of Carnitine15100168
D002433CefaclorCefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
D002433CefaclorSLC22A8 protein results in increased uptake of Cefaclor16098483
D002437CefazolinSLC22A8 protein results in increased uptake of Cefazolin16098483
C056814cefdinircefdinir inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
C056814cefdinirSLC22A8 protein results in increased uptake of cefdinir16098483
C079769cefoseliscefoselis inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
C079769cefoselisSLC22A8 protein results in increased uptake of cefoselis16098483
D015310CefotiamCefotiam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
D015310CefotiamSLC22A8 protein results in increased uptake of Cefotiam16098483
C054360ceftibutenceftibuten inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
C054360ceftibutenSLC22A8 protein results in increased uptake of ceftibuten16098483
D015296CeftizoximeCeftizoxime inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
D015296CeftizoximeSLC22A8 protein results in increased uptake of Ceftizoxime16098483
D002509CephaloridineCephaloridine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
D002509CephaloridineSLC22A8 protein results in increased uptake of Cephaloridine16098483
D002511CephalosporinsSLC22A8 protein affects the secretion of Cephalosporins16098483
D020355CholatesCholates inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
C027113chrysophanic acidchrysophanic acid results in decreased activity of SLC22A8 protein29045746
C059262cidofovirSLC22A8 protein results in increased susceptibility to cidofovir25448811
D002927CimetidineCimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]15496291
D002927CimetidineProbenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]16006492
D002927CimetidineSLC22A8 protein affects the transport of Cimetidine11306713
D002927CimetidineSLC22A8 protein results in increased uptake of Cimetidine16006492|1609848
D002927CimetidineProbenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]16291876
D002927CimetidineSLC22A8 protein results in increased uptake of Cimetidine16291876
D002927CimetidineCimetidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]15100168
D002927Cimetidineestrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15251863
D002927CimetidineSLC22A8 protein results in increased uptake of Cimetidine15251863
D002927Cimetidineestradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D002927Cimetidineestrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D002927CimetidineFamotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D002927Cimetidinep-Aminohippuric Acid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D002927CimetidinePenicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D002927CimetidineProbenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]16006492
D002927CimetidineProbenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D002927CimetidineRanitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D002927CimetidineSLC22A8 protein results in increased uptake of Cimetidine10224140|1531934
D003471CuprizoneCuprizone results in increased expression of SLC22A8 mRNA26577399
C004742daidzeinSLC22A8 protein results in increased uptake of daidzein analog21244849
D003687DehydroepiandrosteroneDehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
D019314Dehydroepiandrosterone SulfateSLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate11306713
D019314Dehydroepiandrosterone SulfateSLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate16098483|1725546
D003840Deoxycholic Acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SLC22A8 mRNA16556975
D003907DexamethasoneDexamethasone inhibits the reaction [Freund's Adjuvant results in decreased expression of SLC22A8 mRNA]21149847
D003907DexamethasoneDexamethasone results in decreased expression of SLC22A8 mRNA19922765
D003976DiazinonDiazinon results in increased methylation of SLC22A8 gene22964155
D003994BucladesineBucladesine promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]15238352
D003994BucladesineN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
D002945CisplatinCisplatin results in decreased expression of SLC22A8 mRNA22992436
D002945CisplatinCisplatin results in decreased expression of SLC22A8 protein22992436
D002945CisplatinJBP 485 inhibits the reaction [Cisplatin results in decreased expression of SLC22A8 mRNA]22992436
D004008DiclofenacDiclofenac inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
D004008DiclofenacDiclofenac inhibits the reaction [SLC22A8 protein results in increased uptake of steviol metabolite]26525112
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of SLC22A8 mRNA26924002
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SLC22A8 mRNA19638242
D0151023,4-Dihydroxyphenylacetic Acid"3,4-Dihydroxyphenylacetic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]"10224140
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of SLC22A8 mRNA25380136
C024629dimethyl phthalatedimethyl phthalate results in increased expression of SLC22A8 mRNA26924002
C076946donepezildonepezil inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]20924140
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased activity of SLC22A8 protein"29045746
D004642EmodinEmodin results in decreased activity of SLC22A8 protein29045746
D004656EnalaprilEnalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]15100168
C025483estradiol-17 beta-glucuronideSLC22A8 protein affects the transport of estradiol-17 beta-glucuronide11306713
C025483estradiol-17 beta-glucuronideestradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
C017296estrone sulfatearistolochic acid I inhibits the reaction [SLC22A8 results in increased uptake of estrone sulfate]19643159
C017296estrone sulfatebis(4-hydroxyphenyl)sulfone inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]27989701
C017296estrone sulfatebisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]27989701
C017296estrone sulfatebisphenol F inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]27989701
C017296estrone sulfateBumetanide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
C017296estrone sulfateCefaclor inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
C017296estrone sulfatecefdinir inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
C017296estrone sulfatecefoselis inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
C017296estrone sulfateCefotiam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
C017296estrone sulfateceftibuten inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
C017296estrone sulfateCeftizoxime inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
C017296estrone sulfateCephaloridine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]16098483
C017296estrone sulfateCholates inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
C017296estrone sulfateCimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]15496291
C017296estrone sulfateDehydroepiandrosterone inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
C017296estrone sulfateDiclofenac inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
C017296estrone sulfateestrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]15496291
C017296estrone sulfateestrone sulfate promotes the reaction [SLC22A8 results in increased export of p-Aminohippuric Acid]19643159
C017296estrone sulfateFamotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]15496291
C017296estrone sulfateFurosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
C017296estrone sulfateIbuprofen inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
C017296estrone sulfateIndomethacin inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
C017296estrone sulfateProbenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
C017296estrone sulfateProbenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]28629854
C017296estrone sulfateProbenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]27989701|2889038
C017296estrone sulfateQuercetin inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]19605544
C017296estrone sulfaterhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]28890383
C017296estrone sulfaterhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]28890383
C017296estrone sulfateSLC22A8 protein affects the transport of estrone sulfate11306713|1549629
C017296estrone sulfateSLC22A8 protein results in increased import of estrone sulfate28629854
C017296estrone sulfateSLC22A8 protein results in increased uptake of estrone sulfate16098483|1685788
C017296estrone sulfateSLC22A8 results in increased uptake of estrone sulfate19643159
C017296estrone sulfatetetrabromobisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]27989701
C017296estrone sulfateTobacco Smoke Pollution inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]28629854
C017296estrone sulfateSLC22A8 protein results in increased uptake of estrone sulfate15100168
C017296estrone sulfatebisindolylmaleimide I inhibits the reaction [Phenylephrine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C017296estrone sulfatebisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C017296estrone sulfateBucladesine promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]15238352
C017296estrone sulfateDinoprostone promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]15238352
C017296estrone sulfateEGF protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]15238352
C017296estrone sulfate[estrone sulfate co-treated with p-Aminohippuric Acid] inhibits the reaction [SLC22A8 protein results in increased uptake of ochratoxin A]15251863
C017296estrone sulfateestrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15251863
C017296estrone sulfateN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C017296estrone sulfateN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C017296estrone sulfateN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [EGF protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C017296estrone sulfatePhenylephrine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]15238352
C017296estrone sulfatePTGS1 protein promotes the reaction [EGF protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C017296estrone sulfatePTGS1 protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]15238352
C017296estrone sulfateSC 560 inhibits the reaction [EGF protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C017296estrone sulfateSLC22A8 protein results in increased uptake of estrone sulfate15238352|1525186
C017296estrone sulfateTetradecanoylphorbol Acetate inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]15238352
C017296estrone sulfate"3,4-dihydroxymandelic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]"10224140
C017296estrone sulfate"3,4-Dihydroxyphenylacetic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]"10224140
C017296estrone sulfate5-methoxyindoleacetic acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C017296estrone sulfateBumetanide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C017296estrone sulfateestrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
C017296estrone sulfateFurosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C017296estrone sulfatehexadecafluoro-nonanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]19915082
C017296estrone sulfateHomovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C017296estrone sulfateIndocyanine Green inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C017296estrone sulfatemethoxytryptophol inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C017296estrone sulfatePenicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C017296estrone sulfateperfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]19915082
C017296estrone sulfateperfluoro-n-heptanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]19915082
C017296estrone sulfateperfluorooctanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]19915082
C017296estrone sulfatePiroxicam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C017296estrone sulfateProbenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C017296estrone sulfateSLC22A8 protein affects the transport of estrone sulfate16079298
C017296estrone sulfateSLC22A8 protein results in increased import of estrone sulfate19915082
C017296estrone sulfateSLC22A8 protein results in increased uptake of estrone sulfate10224140|1685788
C017296estrone sulfateSulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C017296estrone sulfateVanilmandelic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
D015738Famotidineestrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]15496291
D015738FamotidineFamotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]15496291
D015738FamotidineProbenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]16006492
D015738FamotidineSLC22A8 protein results in increased uptake of Famotidine15496291|1600649
D015738FamotidineProbenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]16291876
D015738FamotidineSLC22A8 protein results in increased uptake of Famotidine16291876
D015738FamotidineFamotidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]15100168
D015738FamotidineFamotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D015738FamotidinePenicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]15319347
D015738FamotidineProbenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]16006492
D015738FamotidineProbenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]15319347
D015738FamotidineSLC22A8 protein results in increased uptake of Famotidine15319347|1600649
D005363FicusinFicusin results in decreased expression of SLC22A8 mRNA22173200
D005363FicusinFicusin results in increased expression of SLC22A8 protein22173200
D005419FlavonoidsFlavonoids inhibits the reaction [SLC22A8 protein results in increased uptake of steviol metabolite]26525112
D005472FluorouracilSLC22A8 protein results in increased transport of Fluorouracil15100168
D005492Folic AcidFolic Acid results in decreased expression of SLC22A8 mRNA19552531
D005492Folic AcidFolic Acid results in decreased expression of SLC22A8 protein19552531
D002955LeucovorinSLC22A8 protein results in increased uptake of Leucovorin16098483
D002955LeucovorinLeucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A8 protein]16925582
D005620Freund's AdjuvantDexamethasone inhibits the reaction [Freund's Adjuvant results in decreased expression of SLC22A8 mRNA]21149847
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of SLC22A8 mRNA21149847
D005620Freund's AdjuvantPrednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of SLC22A8 mRNA]21149847
C039281furanfuran results in increased methylation of SLC22A8 gene22079235
D005665FurosemideFurosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
D005665FurosemideFurosemide results in decreased activity of SLC22A8 protein18216144
D005665FurosemideSLC22A8 protein results in increased secretion of Furosemide18216144
D005665FurosemideFurosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
D005839GentamicinsGentamicins results in decreased expression of SLC22A8 mRNA19967075|2370777
D005839GentamicinsGentamicins results in decreased expression of SLC22A8 protein19967075|2370777
D005839GentamicinsJBP 485 inhibits the reaction [Gentamicins results in decreased expression of SLC22A8 mRNA]23707770
D005839GentamicinsJBP 485 inhibits the reaction [Gentamicins results in decreased expression of SLC22A8 protein]23707770
C030691gluconic acid[gluconic acid co-treated with Deoxycholic Acid] results in increased expression of SLC22A8 mRNA16556975
D005977GlutaratesSLC22A8 protein affects the transport of Glutarates11306713
C035736glutaric acidglutaric acid promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]28629854
C035736glutaric acidglutaric acid results in increased activity of SLC22A8 protein28629854
C035736glutaric acidSLC22A8 protein results in increased import of glutaric acid28629854
C086566glyciteinSLC22A8 protein results in increased uptake of glycitein analog21244849
C412815GW 4064GW 4064 results in increased expression of SLC22A8 mRNA26655953
C018959hexadecafluoro-nonanoic acidhexadecafluoro-nonanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]19915082
C018959hexadecafluoro-nonanoic acidSLC22A8 protein results in increased import of hexadecafluoro-nonanoic acid19915082
D006719Homovanillic AcidHomovanillic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
D006852HydrochlorothiazideHydrochlorothiazide inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]20924140
D007052IbuprofenIbuprofen inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
D007052IbuprofenIbuprofen inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]15100168
C031534imperatorinimperatorin results in increased expression of SLC22A8 protein22173200
D007208Indocyanine GreenIndocyanine Green inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
D007213IndomethacinIndomethacin inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
C055542isoimperatorinisoimperatorin results in increased expression of SLC22A8 mRNA22173200
C055542isoimperatorinisoimperatorin results in increased expression of SLC22A8 protein22173200
C412308JBP 485JBP 485 inhibits the reaction [Cisplatin results in decreased expression of SLC22A8 mRNA]22992436
C412308JBP 485JBP 485 inhibits the reaction [Gentamicins results in decreased expression of SLC22A8 mRNA]23707770
C412308JBP 485JBP 485 inhibits the reaction [Gentamicins results in decreased expression of SLC22A8 protein]23707770
C412308JBP 485JBP 485 results in increased expression of SLC22A8 mRNA22992436
C412308JBP 485JBP 485 results in increased expression of SLC22A8 protein23707770
C029891lead chloridelead chloride promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]28629854
C029891lead chloridelead chloride results in increased activity of SLC22A8 protein28629854
D000069349LinezolidLinezolid results in decreased expression of SLC22A8 mRNA21296123
D008042Linolenic AcidsLinolenic Acids results in decreased activity of SLC22A8 protein29045746
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SLC22A8 mRNA15205389
D015122MercaptopurineSLC22A8 protein results in increased transport of Mercaptopurine15100168
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of SLC22A8 mRNA27720909
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of and affects the localization of SLC22A8 protein19533102
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of SLC22A8 mRNA19533102
C019468mercuric oxideSLC22A8 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]12606766
D008628MercurySLC22A8 gene SNP affects the susceptibility to and affects the abundance of Mercury23052037
D008727Methotrexateresveratrol inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]27377006
D008727Methotrexaterhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]28890383
D008727MethotrexateSLC22A8 protein affects the transport of Methotrexate11306713
D008727MethotrexateSLC22A8 protein results in increased susceptibility to Methotrexate27377006
D008727MethotrexateSLC22A8 protein results in increased uptake of Methotrexate16098483|2737700
D008727MethotrexateLeucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A8 protein]16925582
D008727MethotrexateMethotrexate results in decreased expression of SLC22A8 protein16925582
D008730MethoxsalenMethoxsalen results in increased expression of SLC22A8 protein22173200
C002465methoxytryptopholmethoxytryptophol inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC22A8 mRNA27720909
D0156551-Methyl-4-phenylpyridiniumSLC22A8 protein results in increased uptake of 1-Methyl-4-phenylpyridinium12675912
D008790MetoprololMetoprolol inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]20924140
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of SLC22A8 mRNA26924002
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [EGF protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of SLC22A8 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of SLC22A8 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of SLC22A8 mRNA24136188
C546709obtusifolinobtusifolin results in decreased activity of SLC22A8 protein29045746
C560681obtusifoline-2-O-beta-D-6-di-O-acetylglucopyranosideobtusifoline-2-O-beta-D-6-di-O-acetylglucopyranoside results in decreased activity of SLC22A8 protein29045746
C025589ochratoxin ASLC22A8 protein affects the transport of ochratoxin A11306713
C025589ochratoxin ASLC22A8 protein results in increased uptake of ochratoxin A16098483
C025589ochratoxin A[estrone sulfate co-treated with p-Aminohippuric Acid] inhibits the reaction [SLC22A8 protein results in increased uptake of ochratoxin A]15251863
C025589ochratoxin ASLC22A8 protein results in increased uptake of ochratoxin A15251863
C025589ochratoxin Aochratoxin A results in decreased expression of SLC22A8 mRNA19538982|2912680
C025589ochratoxin Aochratoxin A results in increased expression of SLC22A8 protein19538982
C025589ochratoxin ASLC22A8 protein results in increased uptake of ochratoxin A10224140
D019787Linoleic AcidLinoleic Acid results in decreased activity of SLC22A8 protein29045746
D009942Organometallic CompoundsOrganometallic Compounds affects the localization of SLC22A8 protein25588984
D009942Organometallic CompoundsOrganometallic Compounds results in decreased expression of SLC22A8 mRNA25588984
D010094Oxonic Acid[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A8 protein19605544
D010098OxycodoneOxycodone results in decreased expression of SLC22A8 mRNA23439660
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC22A8 mRNA"25510870
D010400Penicillin Gresveratrol inhibits the reaction [SLC22A8 protein results in increased uptake of Penicillin G]27377006
D010400Penicillin GSLC22A8 protein results in increased uptake of Penicillin G17255469|2737700
D010400Penicillin GPenicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D010400Penicillin GPenicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
D010400Penicillin GPenicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]15319347
D010400Penicillin GPenicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Ranitidine]15319347
C036567perfluorodecanoic acidperfluorodecanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]19915082
C101815perfluoro-n-heptanoic acidperfluoro-n-heptanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]19915082
C023036perfluorooctanoic acidperfluorooctanoic acid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]19915082
C023036perfluorooctanoic acidSLC22A8 protein affects the transport of perfluorooctanoic acid11879818
C023036perfluorooctanoic acidSLC22A8 protein results in increased import of perfluorooctanoic acid19915082
D015232DinoprostoneSLC22A8 protein affects the transport of Dinoprostone11306713
D015232DinoprostoneSLC22A8 protein results in increased transport of Dinoprostone15100168
D015232DinoprostoneDinoprostone promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]15238352
D015232DinoprostoneN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
D015232DinoprostoneDinoprostone results in decreased expression of SLC22A8 protein19605544
D010656Phenylephrinebisindolylmaleimide I inhibits the reaction [Phenylephrine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
D010656PhenylephrinePhenylephrine inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]15238352
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of SLC22A8 mRNA22484513
C006253pirinixic acidpirinixic acid results in decreased expression of SLC22A8 mRNA20813756
D010894PiroxicamPiroxicam inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
D028321Plant PreparationsPlant Preparations results in decreased expression of SLC22A8 mRNA18047722
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SLC22A8 mRNA23608068
D011239PrednisolonePrednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of SLC22A8 mRNA]21149847
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]16006492
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]11306713
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]16006492
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]28629854
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]28629854
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]27989701|2889038
D011339ProbenecidProbenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]19643159
D011339ProbenecidProbenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]19643159
D011339ProbenecidProbenecid results in decreased activity of SLC22A8 protein28629854|2904574
D011339ProbenecidProbenecid results in decreased expression of SLC22A8 mRNA23129053
D011339ProbenecidProbenecid results in decreased expression of SLC22A8 protein23129053
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]16291876
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]16291876
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]16006492
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]16006492
D011339ProbenecidProbenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
D011339ProbenecidProbenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D011339ProbenecidProbenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]15319347
D011339ProbenecidProbenecid promotes the reaction [SLC22A8 protein results in increased uptake of Ranitidine]15319347
D015237DinoprostSLC22A8 protein results in increased transport of Dinoprost15100168
D011794QuercetinQuercetin inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]19605544
D011794QuercetinQuercetin affects the expression of SLC22A8 protein24958931
D011794QuercetinQuercetin inhibits the reaction [SLC22A8 protein results in increased uptake of steviol metabolite]26525112
C443401quercetin 3-O-glucuronidequercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]21244849
C443401quercetin 3-O-glucuronidequercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]21244849
C443401quercetin 3-O-glucuronideSLC22A8 protein results in increased uptake of quercetin 3-O-glucuronide analog21244849
C531389quercetin 3'-sulfatequercetin 3'-sulfate inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]21244849
D011899RanitidineSLC22A8 protein results in increased uptake of Ranitidine16006492
D011899RanitidineSLC22A8 protein results in increased uptake of Ranitidine16291876
D011899RanitidinePenicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Ranitidine]15319347
D011899RanitidineProbenecid promotes the reaction [SLC22A8 protein results in increased uptake of Ranitidine]15319347
D011899RanitidineRanitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]15319347
D011899RanitidineSLC22A8 protein results in increased uptake of Ranitidine15319347|1600649
D011899RanitidineRanitidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]20924140
C059514resveratrolresveratrol inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]27377006
C059514resveratrolresveratrol inhibits the reaction [SLC22A8 protein results in increased uptake of Penicillin G]27377006
C059514resveratrolresveratrol affects the expression of SLC22A8 protein24958931
C020491rheinrhein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]28890383
C020491rheinrhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]28890383
C020491rheinrhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]28890383
C013672riddelliineriddelliine results in decreased expression of SLC22A8 mRNA18047722
C115461SC 560SC 560 inhibits the reaction [EGF protein promotes the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
C009277sodium arsenatesodium arsenate promotes the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]28629854
C009277sodium arsenatesodium arsenate results in increased activity of SLC22A8 protein28629854
C016104sodium bichromatesodium bichromate results in decreased expression of SLC22A8 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in decreased expression of SLC22A8 mRNA27862939
D012999SomanSoman results in decreased expression of SLC22A8 mRNA19281266
C012042steviolDiclofenac inhibits the reaction [SLC22A8 protein results in increased uptake of steviol metabolite]26525112
C012042steviolFlavonoids inhibits the reaction [SLC22A8 protein results in increased uptake of steviol metabolite]26525112
C012042steviolQuercetin inhibits the reaction [SLC22A8 protein results in increased uptake of steviol metabolite]26525112
C012042steviolSLC22A8 protein results in increased uptake of steviol metabolite26525112
C012042stevioltelmisartan inhibits the reaction [SLC22A8 protein results in increased uptake of steviol metabolite]26525112
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
C016766sulforafansulforafan affects the expression of SLC22A8 protein24958931
D013656Taurocholic AcidSLC22A8 protein affects the transport of Taurocholic Acid11306713
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of SLC22A8 mRNA15885361
C084178telmisartantelmisartan inhibits the reaction [SLC22A8 protein results in increased uptake of steviol metabolite]26525112
D000068698TenofovirSLC22A8 protein results in increased susceptibility to Tenofovir25448811
C032801tenoxicamtenoxicam inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]15100168
D013739TestosteroneTestosterone results in decreased expression of SLC22A8 protein23389457
C020806tetrabromobisphenol Atetrabromobisphenol A inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]27989701
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased activity of SLC22A8 protein27989701
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC22A8 mRNA21215274
D013752TetracyclineSLC22A8 protein results in increased uptake of Tetracycline11855680
D013755Tetradecanoylphorbol Acetatebisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]]15238352
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]15238352
D013853ThioacetamideThioacetamide results in decreased expression of SLC22A8 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]28629854
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased activity of SLC22A8 protein28629854
D014050TolueneToluene affects the expression of SLC22A8 mRNA18653662
D014050TolueneToluene results in increased expression of SLC22A8 mRNA22967744
D014527Uric AcidSLC22A8 protein affects the transport of Uric Acid11306713
D014527Uric Acid[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A8 protein19605544
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of SLC22A8 mRNA15885361
C406224valdecoxibvaldecoxib results in decreased expression of SLC22A8 mRNA24136188
D014635Valproic AcidValproic Acid results in increased methylation of SLC22A8 gene29154799
D014640VancomycinVancomycin results in increased expression of SLC22A8 mRNA18930951
D014642Vanilmandelic AcidVanilmandelic Acid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]10224140
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLC22A8 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of SLC22A8 mRNA19165385
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC22A8 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005452inorganic anion exchanger activity-IDA15037815  
GO:0015301anion:anion antiporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009636response to toxic substance-IEA-  
GO:0015698inorganic anion transport-IEA-  
GO:0098656anion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016323basolateral plasma membrane-IDA15037815  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04976Bile secretion
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-549132Organic cation/anion/zwitterion transportTAS
R-HSA-561048Organic anion transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24343710Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention. (2014 May)Nicol MRJ Clin Pharmacol