Gene: LIPG

9388
EDL|EL|PRO719
lipase G, endothelial type
protein-coding
18q21.1
Ensembl:ENSG00000101670 MIM:603684 Vega:OTTHUMG00000179658 UniprotKB:Q9Y5X9
NC_000018.10
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.318e-1 (AD)  4.294e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDLIM10.717
SUCNR10.717
GALR10.715
BCL2A10.714
PLAU0.707
EMILIN20.705
CTHRC10.702
LILRB20.702
LILRA10.7
KIAA00400.696

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EXTL1-0.434
SCRT1-0.42
CYP46A1-0.417
TMEM143-0.416
KCNIP3-0.416
FUT9-0.409
ASPDH-0.403
BDH1-0.402
KCNA2-0.401
TM7SF2-0.401

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0430511-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholineLIPG protein results in increased hydrolysis of 1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine15953354
C0892151-palmitoyl-2-lysophosphatidylcholine[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of 1-palmitoyl-2-lysophosphatidylcholine24777581
C0839751-palmitoyl-2-oleoyl-sn-glycerolLIPG gene mutant form results in decreased abundance of 1-palmitoyl-2-oleoyl-sn-glycerol24777581
C5246161-stearoyl-2-docosahexaenoylglycerol[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of 1-stearoyl-2-docosahexaenoylglycerol24777581
C0973571-stearoyl-2-linoleoyl-sn-glycerolLIPG gene mutant form results in decreased abundance of 1-stearoyl-2-linoleoyl-sn-glycerol24777581
C0841991-stearoyl-2-oleoyl-sn-glycerol[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of 1-stearoyl-2-oleoyl-sn-glycerol24777581
C0841991-stearoyl-2-oleoyl-sn-glycerolLIPG gene mutant form results in decreased abundance of 1-stearoyl-2-oleoyl-sn-glycerol24777581
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LIPG mRNA"25614096
C04456324-hydroxycholesterol24-hydroxycholesterol results in decreased expression of LIPG mRNA15953354
C04456324-hydroxycholesterol24-hydroxycholesterol results in decreased expression of LIPG protein15953354
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of LIPG mRNA]"19467301
C0005982004-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid"4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of LIPG mRNA"22918042
C0005982004-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid"NR1H4 gene mutant form inhibits the reaction [4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of LIPG mRNA]"22918042
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIPG mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of LIPG mRNA19191707
C1044594-nitro-3-(octanoyloxy)benzoic acidLIPG protein results in increased hydrolysis of 4-nitro-3-(octanoyloxy)benzoic acid24777581
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIPG mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of LIPG mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of LIPG mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of LIPG protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LIPG mRNA27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of LIPG mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LIPG mRNA16483693
D016718Arachidonic Acid[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Arachidonic Acid24777581
D016718Arachidonic AcidLIPG gene mutant form results in decreased abundance of Arachidonic Acid24777581
D001151ArsenicArsenic results in decreased expression of LIPG mRNA19654921
D001507BeclomethasoneBeclomethasone results in increased expression of LIPG mRNA23656298
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LIPG mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LIPG mRNA27195522
D004958EstradiolEstradiol results in decreased expression of LIPG mRNA20106945
D001629BezafibrateBezafibrate results in decreased expression of LIPG mRNA15953354
D001629BezafibrateBezafibrate results in decreased expression of LIPG protein15953354
C006780bisphenol Abisphenol A results in decreased expression of LIPG mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LIPG gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LIPG mRNA24982889
D004390ChlorpyrifosChlorpyrifos results in increased expression of LIPG mRNA21356183
C110341cholesterol stearateLIPG gene mutant form results in decreased abundance of cholesterol stearate24777581
C029382cholesteryl arachidonate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl arachidonate24777581
C029382cholesteryl arachidonateLIPG gene mutant form results in decreased abundance of cholesteryl arachidonate24777581
C021976cholesteryl linoleate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linoleate24777581
C021976cholesteryl linoleateLIPG gene mutant form affects the abundance of cholesteryl linoleate24777581
C095270cholesteryl linolenate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl linolenate24777581
C095270cholesteryl linolenateLIPG gene mutant form results in increased abundance of cholesteryl linolenate24777581
C032561cholesteryl myristate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl myristate24777581
C032561cholesteryl myristateLIPG gene mutant form affects the abundance of cholesteryl myristate24777581
C014409cholesteryl oleate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl oleate24777581
C014409cholesteryl oleateLIPG gene mutant form results in increased abundance of cholesteryl oleate24777581
C026651cholesteryl palmitate[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of cholesteryl palmitate24777581
C026651cholesteryl palmitateLIPG gene mutant form results in increased abundance of cholesteryl palmitate24777581
C032459choline plasmalogens[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of choline plasmalogens24777581
C032459choline plasmalogensLIPG gene mutant form results in increased abundance of choline plasmalogens24777581
D019327Copper SulfateCopper Sulfate results in increased expression of LIPG mRNA19549813
D016572CyclosporineCyclosporine affects the expression of LIPG mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of LIPG mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of LIPG mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LIPG mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of LIPG mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of LIPG mRNA28962523
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of LIPG mRNA]"19467301
D004041Dietary FatsDietary Fats affects the expression of LIPG mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of LIPG mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of LIPG mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of LIPG mRNA]19850644
D002117CalcitriolCalcitriol results in increased expression of LIPG mRNA16002434
C013965diolein[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of diolein24777581
C013965dioleinLIPG gene mutant form results in decreased abundance of diolein24777581
C005071dipalmitin[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of dipalmitin24777581
C005071dipalmitinLIPG gene mutant form results in decreased abundance of dipalmitin24777581
D004281Docosahexaenoic Acids[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Docosahexaenoic Acids24777581
D004281Docosahexaenoic AcidsLIPG gene mutant form results in decreased abundance of Docosahexaenoic Acids24777581
D015118Eicosapentaenoic Acid[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Eicosapentaenoic Acid24777581
D000431EthanolEthanol results in increased expression of LIPG mRNA28986285
C024565ethylene dichlorideethylene dichloride results in decreased expression of LIPG mRNA28189721
D005485FlutamideFlutamide results in increased expression of LIPG mRNA21525395
D005557FormaldehydeFormaldehyde results in increased expression of LIPG mRNA27664576
D005947GlucoseGlucose results in decreased expression of LIPG mRNA17178593
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of LIPG mRNA26846883
C492448ICG 001ICG 001 results in decreased expression of LIPG mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of LIPG mRNA28201806
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of LIPG mRNA26752646
C045463leflunomideleflunomide results in increased expression of LIPG mRNA28988120
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of LIPG mRNA26667767
D008713MethimazoleMethimazole results in increased expression of LIPG mRNA22504374
C002950methylformamidemethylformamide analog results in decreased expression of LIPG mRNA17040096
C002950methylformamidemethylformamide results in decreased expression of LIPG mRNA17040096
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LIPG mRNA26011545
D008942MitoxantroneLIPG protein affects the susceptibility to Mitoxantrone16217747
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of LIPG mRNA22401849
C523799MRK 003MRK 003 results in decreased expression of LIPG mRNA21169257
D019829NevirapineNevirapine metabolite results in decreased expression of LIPG mRNA23947594
D019829NevirapineNevirapine results in decreased expression of LIPG mRNA23947594
D009532NickelNickel results in increased expression of LIPG mRNA24768652|2558310
C097760N-palmitoylsphingosine[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-palmitoylsphingosine24777581
C033173N-stearoylsphingomyelin[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of N-stearoylsphingomyelin24777581
D019787Linoleic Acid[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Linoleic Acid24777581
D019301Oleic Acid[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Oleic Acid24777581
C016340o,p'-DDT"o,p'-DDT results in decreased expression of LIPG mRNA"18204070
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of LIPG mRNA24888373
D010100OxygenOxygen deficiency results in decreased expression of LIPG mRNA20880076
D019308Palmitic Acid[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Palmitic Acid24777581
C033171palmitoylsphingomyelin[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of palmitoylsphingomyelin24777581
C033171palmitoylsphingomyelinLIPG gene mutant form results in increased abundance of palmitoylsphingomyelin24777581
D000073878Palm OilPalm Oil affects the expression of LIPG mRNA19680557
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of LIPG mRNA28049043
C471071perfluorohexanesulfonic acidPPARA gene mutant form inhibits the reaction [perfluorohexanesulfonic acid results in increased expression of LIPG mRNA]28049043
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LIPG mRNA23978341
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of LIPG mRNA28049043
C023036perfluorooctanoic acidPPARA gene mutant form inhibits the reaction [perfluorooctanoic acid results in increased expression of LIPG mRNA]28049043
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of LIPG mRNA17097637
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of LIPG mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of LIPG mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of LIPG mRNA19482888
D010713Phosphatidylcholines[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines24777581
D010713PhosphatidylcholinesLIPG gene mutant form results in increased abundance of Phosphatidylcholines24777581
D010795Phthalic AcidsPhthalic Acids results in decreased expression of LIPG mRNA21061450
C060836pioglitazonepioglitazone results in decreased expression of LIPG mRNA15953354
C060836pioglitazonepioglitazone results in decreased expression of LIPG protein15953354
C006253pirinixic acidpirinixic acid results in increased expression of LIPG mRNA18301758|1844570
D010936Plant ExtractsPlant Extracts results in decreased expression of LIPG mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of LIPG mRNA23370395
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of LIPG mRNA24888373
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of LIPG mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of LIPG mRNA18070364
D011441PropylthiouracilPropylthiouracil results in increased expression of LIPG mRNA22504374
D011794QuercetinQuercetin results in decreased expression of LIPG mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of LIPG mRNA21632981
C031389resorcinolresorcinol results in increased expression of LIPG mRNA22623647
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of LIPG mRNA26667767
C089730rosiglitazonerosiglitazone results in decreased expression of LIPG mRNA25572481
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of LIPG mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of LIPG mRNA25351596
D012834SilverSilver results in decreased expression of LIPG mRNA27131904
C017947sodium arsenitesodium arsenite results in decreased expression of LIPG mRNA20371982
D012969Sodium FluorideSodium Fluoride results in increased expression of LIPG protein28918527
C026564stearoyl alpha-lysolecithin[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin24777581
C037149stearoylarachidonylglycerol[LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoylarachidonylglycerol24777581
C013698tallowtallow affects the expression of LIPG mRNA19680557
D013629TamoxifenTamoxifen affects the expression of LIPG mRNA20937368
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in decreased expression of LIPG mRNA]21079772
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of LIPG mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LIPG mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LIPG mRNA20067830
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LIPG mRNA25975270|2823826
D013893ThiramThiram results in increased expression of LIPG mRNA20530235
C423915TO-901317TO-901317 results in increased expression of LIPG mRNA16142410
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of LIPG mRNA19969065
D014280Triglycerides[LIPC gene mutant form co-treated with LIPG gene mutant form] results in decreased abundance of Triglycerides24777581
D014280TriglyceridesLIPG gene mutant form results in decreased abundance of Triglycerides24777581
D014520UrethaneUrethane results in increased expression of LIPG mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of LIPG mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of LIPG gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of LIPG mRNA16341940
C111237vorinostatvorinostat results in decreased expression of LIPG mRNA27188386
C540004WAY-362450NR1H4 gene mutant form inhibits the reaction [WAY-362450 results in increased expression of LIPG mRNA]22918042
C540004WAY-362450WAY-362450 results in increased expression of LIPG mRNA19136377|2291804
C088658zoledronic acidzoledronic acid results in increased expression of LIPG mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004465lipoprotein lipase activity-EXP19567873  
GO:0004620phospholipase activity-IDA10192396  
GO:0008201heparin binding-IEA-  
GO:0008970phosphatidylcholine 1-acylhydrolase activity-IDA10318835  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-TAS10192396  10318835  
GO:0007584response to nutrient-IEA-  
GO:0008283cell proliferation-IEA-  
GO:0009395phospholipid catabolic process-NAS19136670  
GO:0010983positive regulation of high-density lipoprotein particle clearance-IMP19136670  
GO:0032376positive regulation of cholesterol transport-IDA19136670  
GO:0034375high-density lipoprotein particle remodeling-IMP19136670  
GO:0034375high-density lipoprotein particle remodeling-TAS-  
GO:0042632cholesterol homeostasis-IMP19136670  
GO:0043691reverse cholesterol transport-IMP19136670  
GO:0050746regulation of lipoprotein metabolic process-IEA-  
GO:0055091phospholipid homeostasis-IMP19136670  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA10192396  
GO:0005769early endosome-IDA23918928  
GO:0005794Golgi apparatus-IDA23918928  
GO:0009986cell surface-IDA23918928  
KEGG ID KEGG Term
hsa00561Glycerolipid metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-8963899Plasma lipoprotein remodelingTAS
R-HSA-8964058HDL remodelingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22606049Interactions of several lipid-related gene polymorphisms and cigarette smoking on blood pressure levels. (2012)Yin RXInt J Biol Sci
25550964Association of endothelial lipase genetic polymorphism with lacunar infarction in a Chinese population. (2014)Wang JInt J Clin Exp Med
16023652Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans. (2006 Mar)Hutter CMAtherosclerosis