Gene: CD27

939
S152|S152. LPFS2|T14|TNFRSF7|Tp55
CD27 molecule
protein-coding
12p13.31
Ensembl:ENSG00000139193 MIM:186711 Vega:OTTHUMG00000168316 UniprotKB:P26842
NG_031995.1
PubMed
0   ANCO-SNPs
ND|AD
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.797e-1 (AD)  3.627e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PFAS0.693
ZNF7850.674
PXMP40.673
FAM156B0.672
CCDC1420.669
ZBED40.669
ADCY60.668
N6AMT10.661
CYB561D10.661
ANGEL10.66

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACOT6-0.354
ENDOU-0.339
HIST1H1C-0.326
RAB13-0.309
MT1M-0.305
FXYD3-0.304
HPR-0.301
TRDN-0.301
NOTCH2NL-0.3
MT1A-0.3

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CD27 mRNA"20816883
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CD27 mRNA28070108
D001151ArsenicArsenic affects the expression of CD27 protein24675094
D001151ArsenicArsenic results in decreased methylation of CD27 gene27838757
C006632arsenic trioxidearsenic trioxide results in increased expression of CD27 mRNA17530438
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD27 mRNA21569818
D004958EstradiolEstradiol results in decreased expression of CD27 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of CD27 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of CD27 mRNA18958704
D000069286BortezomibBortezomib results in increased expression of CD27 mRNA17895889
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CD27 mRNA15501611
D003520CyclophosphamideCyclophosphamide results in decreased expression of CD27 mRNA21041162
D003907DexamethasoneDexamethasone results in decreased expression of CD27 mRNA21041162
D002945CisplatinCisplatin results in increased expression of CD27 mRNA26546572
D004041Dietary FatsDietary Fats results in increased expression of CD27 mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CD27 mRNA21041162
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD27 mRNA25613284
D007530IsofluraneIsoflurane results in decreased expression of CD27 mRNA16978161
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD27 mRNA23086925
C008261lead acetatelead acetate results in decreased expression of CD27 mRNA21829687
C008261lead acetatelead acetate results in increased expression of CD27 mRNA20542052
D009151Mustard GasMustard Gas results in increased expression of CD27 mRNA15674843
D009532NickelNickel results in increased expression of CD27 mRNA24768652|2558310
D010269ParaquatParaquat results in decreased expression of CD27 mRNA18836921
D010424PentobarbitalPentobarbital results in decreased expression of CD27 mRNA16978161
D010634PhenobarbitalPhenobarbital affects the expression of CD27 mRNA19136022
C006253pirinixic acidpirinixic acid affects the expression of CD27 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of CD27 mRNA17950772
C443641poly(propyleneimine)poly(propyleneimine) analog results in decreased expression of CD27 mRNA16308212
D019821SimvastatinSimvastatin results in decreased expression of CD27 mRNA18453621
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD27 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD27 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CD27 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD27 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD27 mRNA27913140
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD27 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CD27 mRNA15289447
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CD27 mRNA16137721
D014118Toxins, Biological"Toxins, Biological affects the expression of CD27 mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CD27 protein20530238
C057693troglitazonetroglitazone results in decreased expression of CD27 mRNA17569031
D014635Valproic AcidValproic Acid results in increased methylation of CD27 gene29154799
C088658zoledronic acidzoledronic acid affects the expression of CD27 mRNA19036117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-NAS14556986  
GO:0005515protein binding-IPI9177220  12324477  16683188  25910212  
GO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process-IDA12324477  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-NAS14556986  
GO:0016064immunoglobulin mediated immune response-NAS14556986  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0043066negative regulation of apoptotic process-IDA12324477  
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEA-  
GO:0045471response to ethanol-IEA-  
GO:0045579positive regulation of B cell differentiation-NAS10809378  
GO:0045582positive regulation of T cell differentiation-IEA-  
GO:0046330positive regulation of JNK cascade-ISS-  
GO:0070233negative regulation of T cell apoptotic process-IEA-  
GO:0097191extrinsic apoptotic signaling pathway-IDA9177220  
GO:1901224positive regulation of NIK/NF-kappaB signaling-NAS12324477  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS12624711  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS12324477  
GO:0009897external side of plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19002140Differential effects on T-cell function following exposure to serum from schizophrenia smokers. (2010 Apr)Herberth MMol Psychiatry
29448960Double-negative (CD27(-)IgD(-)) B cells are expanded in NSCLC and inversely correlate with affinity-matured B cell populations. (2018 Feb 15)Centuori SMJ Transl Med
15644129Immunohistochemistry of the B-cell component in lower lip salivary glands of Sjogren's syndrome and healthy subjects. (2005 Jan)Larsson AScand J Immunol
27527002Association of T Cell and Macrophage Activation with Arterial Vascular Health in HIV. (2017 Feb)Grome HNAIDS Res Hum Retroviruses
22652413Increased intraepithelial (CD103+) CD8+ T cells in the airways of smokers with and without chronic obstructive pulmonary disease. (2013 Feb)Mikko MImmunobiology
17050556Modification of surface antigens in blood CD8+ T-lymphocytes in COPD: effects of smoking. (2007 Jan)Koch AEur Respir J
26894484PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit. (2016 May)Aiello AEPsychoneuroendocrinology
18587574Combined automated cell and flow cytometric analysis enables recognition of persistent polyclonal B-cell lymphocytosis (PPBL), a study of 25 patients. (2008 Oct)Schmidt-Hieber MAnn Hematol
24952144Assessment of selected B cells populations in the workers of X-ray departments. (2014 Jun)Klucinski PInt J Occup Med Environ Health
26146763Altered Distribution of Peripheral Blood Maturation-Associated B-Cell Subsets in Chronic Alcoholism. (2015 Aug)Almeida JAlcohol Clin Exp Res