Gene: TGFBRAP1

9392
TRAP-1|TRAP1|VPS3
transforming growth factor beta receptor associated protein 1
protein-coding
2q12.1-q12.2
Ensembl:ENSG00000135966 MIM:606237 Vega:OTTHUMG00000130809 UniprotKB:Q8WUH2
NG_050952.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.765e-1 (AD)  5.527e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14459716chr2:105889560TGFBRAP1Gene body4.527e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBE3C0.951
RALGAPB0.949
LARP10.944
RAPGEF20.944
CAMSAP10.939
PRDM40.939
KPNA60.939
PHLPP20.938
SBNO10.937
UBN10.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.538
OR4F29-0.512
MYL3-0.393
HEY2-0.372
COPZ2-0.364
S100A1-0.356
MTRNR2L10-0.355
CSAG1-0.349
MTRNR2L6-0.345
MTRNR2L9-0.343

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TGFBRAP1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TGFBRAP1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TGFBRAP1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TGFBRAP1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TGFBRAP1 mRNA"25510870
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TGFBRAP1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TGFBRAP1 mRNA22100608
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TGFBRAP1 mRNA21298039
D001280AtrazineAtrazine results in decreased expression of TGFBRAP1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TGFBRAP1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TGFBRAP1 mRNA"20018196
D004958EstradiolEstradiol affects the expression of TGFBRAP1 mRNA21826169
D004958EstradiolEstradiol results in increased expression of TGFBRAP1 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of TGFBRAP1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TGFBRAP1 mRNA21826169
C006780bisphenol Abisphenol A results in increased expression of TGFBRAP1 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of TGFBRAP1 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of TGFBRAP1 mRNA26191083
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGFBRAP1 mRNA20938992
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TGFBRAP1 mRNA17361019|2126653
C000944dicrotophosdicrotophos results in increased expression of TGFBRAP1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of TGFBRAP1 mRNA25016146
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGFBRAP1 mRNA20938992
C492448ICG 001ICG 001 results in increased expression of TGFBRAP1 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of TGFBRAP1 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of TGFBRAP1 mRNA]26733615
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TGFBRAP1 mRNA23086925
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of TGFBRAP1 mRNA]26733615
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGFBRAP1 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TGFBRAP1 mRNA"25554681
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of TGFBRAP1 mRNA]26733615
C496932panobinostatpanobinostat affects the expression of TGFBRAP1 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of TGFBRAP1 mRNA]26733615
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of TGFBRAP1 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of TGFBRAP1 mRNA23892564
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGFBRAP1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGFBRAP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TGFBRAP1 mRNA22298810
D014415TunicamycinTunicamycin results in increased expression of TGFBRAP1 mRNA17127020
D014635Valproic AcidValproic Acid affects the expression of TGFBRAP1 mRNA25979313
C088658zoledronic acidzoledronic acid results in increased expression of TGFBRAP1 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005160transforming growth factor beta receptor binding-IDA11278302  
GO:0005515protein binding-IPI11278302  25266290  26496610  
GO:0046332SMAD binding-IBA21873635  
GO:0046332SMAD binding-IDA11278302  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IDA11278302  
GO:0006886intracellular protein transport-IEA-  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-IDA11278302  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS9545258  
GO:0008333endosome to lysosome transport-IMP25266290  
GO:0034058endosomal vesicle fusion-IMP25266290  
GO ID GO Term Qualifier Evidence PubMed
GO:0005769early endosome-IDA25266290  
GO:0016020membrane-IDA11278302  
GO:0033263CORVET complex-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25466412Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. (2015 Feb)Schaefer ASCirc Cardiovasc Genet