Gene: CD28

940
Tp44
CD28 molecule
protein-coding
2q33.2
Ensembl:ENSG00000178562 MIM:186760 Vega:OTTHUMG00000132878 UniprotKB:P10747
NG_029618.1
PubMed
0   ANCO-SNPs
ND|AD
20   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.248e-1 (AD)  2.316e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR51E10.751
CDC20B0.746
GATA60.743
ALX40.738
FOXC20.731
FOXD20.729
TRABD2B0.714
MYOCD0.709
C1QTNF70.709
BMP50.706

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNPLA7-0.309
FEZF2-0.302
KIAA0930-0.302
SFTPC-0.297
DNAI1-0.286
UBAP1L-0.281
C19orf73-0.275
UCN-0.275
FTCD-0.268
EFNA5-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0793931,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole"1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Calcium]"14607919
C0793931,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole"1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]"14607919
C0793931,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole"1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]"14607919
C5048762-aminoethoxydiphenylborane2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Calcium]14607919
C5048762-aminoethoxydiphenylborane2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]14607919
C5048762-aminoethoxydiphenylborane2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]14607919
C5122365-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide inhibits the reaction [CD28 protein results in increased abundance of Calcium]14607919
C5122365-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]14607919
C5122365-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]14607919
D000082AcetaminophenAcetaminophen affects the expression of CD28 mRNA17562736
C014949acetylhydrazineacetylhydrazine results in decreased expression of CD28 mRNA15282401
D000171AcroleinAcrolein results in increased expression of CD28 mRNA18515264
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of CD28 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD28 mRNA16483693
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of CD28 mRNA18585445
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of CD28 mRNA18585445
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CD28 mRNA21569818
D002118Calcium"1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Calcium]"14607919
D002118Calcium2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Calcium]14607919
D002118Calcium5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide inhibits the reaction [CD28 protein results in increased abundance of Calcium]14607919
D002118CalciumCD28 protein results in increased abundance of Calcium14607919
D002118Calciummanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [CD28 protein results in increased abundance of Calcium]14607919
D002737ChloropreneChloroprene results in decreased expression of CD28 mRNA23125180
D003520CyclophosphamideCyclophosphamide results in decreased expression of CD28 mRNA21041162
D003609DactinomycinDactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein]11465111
D003907Dexamethasone[Dexamethasone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA20363256
D003907DexamethasoneDexamethasone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]20363256
D003907DexamethasoneDexamethasone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]20363256
D003907DexamethasoneDexamethasone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]20363256
D003907DexamethasoneMifepristone inhibits the reaction [[Dexamethasone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]20363256
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]20363256
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]]20363256
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]20363256
D003907DexamethasoneDexamethasone results in decreased expression of CD28 mRNA21041162
D004008DiclofenacDiclofenac results in increased expression of CD28 mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of CD28 mRNA25016146
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of CD28 mRNA21852083
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CD28 mRNA21041162
D002117CalcitriolCalcitriol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]24792400
D002117Calcitriol[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol24792400
D002117CalcitriolKetoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]24792400
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of CD28 mRNA25270620
D005944GlucosamineGlucosamine results in increased expression of CD28 mRNA17109745
D006052Gold Sodium ThiomalateCD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]19077085
D006052Gold Sodium ThiomalateCD28 protein affects the susceptibility to Gold Sodium Thiomalate19077085
C029424hydrazinehydrazine results in decreased expression of CD28 mRNA15282401
D002112CalcifediolCalcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]24792400
D002112CalcifediolKetoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]24792400
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD28 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD28 mRNA22802445
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD28 mRNA25982114
D007654KetoconazoleKetoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]24792400
D007654KetoconazoleKetoconazole inhibits the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased abundance of Calcitriol]24792400
D015636Magnesium ChlorideMagnesium Chloride promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CD28 protein]8662792
C025340manganese chloride[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein8662792
C025340manganese chloridemanganese chloride promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CD28 protein]8662792
C025340manganese chlorideTetradecanoylphorbol Acetate inhibits the reaction [[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein]8662792
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [CD28 protein results in increased abundance of Calcium]14607919
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]14607919
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]14607919
D015122MercaptopurineMercaptopurine inhibits the reaction [CD28 protein results in increased activity of [NFKB1 protein binds to RELA protein]]12697733
D008627Mercuric ChlorideCD28 protein affects the reaction [Mercuric Chloride results in decreased activity of FBL protein]19077085
D008627Mercuric ChlorideCD28 protein affects the susceptibility to Mercuric Chloride19077085
D008727MethotrexateMethotrexate results in decreased expression of CD28 mRNA17400583
D015735MifepristoneMifepristone inhibits the reaction [[Dexamethasone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]20363256
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]20363256
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]]20363256
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]20363256
D015735MifepristoneMifepristone inhibits the reaction [[rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]20363256
D015735MifepristoneMifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]20363256
D015735MifepristoneMifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]]20363256
D015735MifepristoneMifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]20363256
D009151Mustard GasMustard Gas results in increased expression of CD28 mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CD28 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CD28 mRNA"25554681
D009532NickelNickel results in increased expression of CD28 mRNA25583101
D009569Nitric Oxide"1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]"14607919
D009569Nitric Oxide2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]14607919
D009569Nitric Oxide5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]14607919
D009569Nitric OxideCD28 protein results in increased abundance of Nitric Oxide14607919
D009569Nitric Oxidemanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]14607919
D052638Particulate MatterParticulate Matter results in increased expression of CD28 mRNA23638009
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD28 mRNA19710929
D059808PolyphenolsPolyphenols results in decreased expression of CD28 mRNA16293270
D017035PravastatinPravastatin results in decreased expression of CD28 mRNA27225895
D017035PravastatinPravastatin affects the expression of CD28 mRNA27225895
D017382Reactive Oxygen Species"1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]"14607919
D017382Reactive Oxygen Species2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]14607919
D017382Reactive Oxygen Species5-diisopropoxyphosphoryl-5-methyl-1-pyrroline-N-oxide inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]14607919
D017382Reactive Oxygen SpeciesCD28 protein results in increased abundance of Reactive Oxygen Species14607919
D017382Reactive Oxygen Speciesmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species]14607919
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of CD28 mRNA21852083
C013769rimexoloneMifepristone inhibits the reaction [[rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA]20363256
C013769rimexoloneMifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]20363256
C013769rimexoloneMifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]]20363256
C013769rimexoloneMifepristone inhibits the reaction [rimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]]20363256
C013769rimexolone[rimexolone co-treated with CD28 protein] results in increased expression of NFKBIA mRNA20363256
C013769rimexolonerimexolone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]20363256
C013769rimexolonerimexolone inhibits the reaction [CD28 protein results in increased secretion of IL2 protein]20363256
C013769rimexolonerimexolone inhibits the reaction [CD28 protein results in increased secretion of TNF protein]20363256
D012835Silver NitrateCD28 protein affects the reaction [Silver Nitrate results in decreased activity of FBL protein]19077085
D012835Silver NitrateCD28 protein affects the susceptibility to Silver Nitrate19077085
C075117squalestatin 1squalestatin 1 results in increased expression of CD28 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of CD28 mRNA27225895
D019311StaurosporineStaurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein]11465111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CD28 mRNA16102516
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD28 mRNA18684927
D013755Tetradecanoylphorbol AcetateDactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein]11465111
D013755Tetradecanoylphorbol AcetateMagnesium Chloride promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CD28 protein]8662792
D013755Tetradecanoylphorbol Acetatemanganese chloride promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of CD28 protein]8662792
D013755Tetradecanoylphorbol AcetateStaurosporine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein]11465111
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [[manganese chloride co-treated with LCK protein] results in increased phosphorylation of CD28 protein]8662792
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of CD28 protein11465111
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased phosphorylation of and affects the localization of CD28 protein8662792
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD28 mRNA25613284
D013849ThimerosalCD28 affects the susceptibility to Thimerosal15808517
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CD28 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CD28 mRNA19042947

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI12777399  
GO:0005070SH3/SH2 adaptor activity-IDA19641626  
GO:0005515protein binding-IPI7568038  7584133  7807015  8146197  8183372  9417079  
9784967  10820259  11285224  15067037  15554700  
GO:0015026coreceptor activity-TAS9784967  
GO:0019901protein kinase binding-IEA-  
GO:0042802identical protein binding-NAS3159820  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002863positive regulation of inflammatory response to antigenic stimulus-IEA-  
GO:0006959humoral immune response-TAS8717514  
GO:0007166cell surface receptor signaling pathway-TAS9784967  
GO:0010628positive regulation of gene expression-IMP23817958  
GO:0010629negative regulation of gene expression-IMP23817958  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IEA-  
GO:0031295T cell costimulation-TAS8617933  
GO:0032733positive regulation of interleukin-10 production-IDA8617933  
GO:0032753positive regulation of interleukin-4 production-IDA8617933  
GO:0042089cytokine biosynthetic process-TAS8717514  
GO:0042102positive regulation of T cell proliferation-IDA3159820  8617933  
GO:0042102positive regulation of T cell proliferation-ISS-  
GO:0042102positive regulation of T cell proliferation-TAS9784967  
GO:0042110T cell activation-IGI18337562  
GO:0043066negative regulation of apoptotic process-TAS8717514  
GO:0045060negative thymic T cell selection-IEA-  
GO:0045066regulatory T cell differentiation-IDA18641304  
GO:0045070positive regulation of viral genome replication-NAS7492435  
GO:0045086positive regulation of interleukin-2 biosynthetic process-IDA3875683  
GO:0045086positive regulation of interleukin-2 biosynthetic process-ISS-  
GO:0045589regulation of regulatory T cell differentiation-IEA-  
GO:0045727positive regulation of translation-NAS12028592  
GO:0045840positive regulation of mitotic nuclear division-IDA3159820  
GO:0045840positive regulation of mitotic nuclear division-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0046641positive regulation of alpha-beta T cell proliferation-IEA-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048304positive regulation of isotype switching to IgG isotypes-IEA-  
GO:0050690regulation of defense response to virus by virus-TAS-  
GO:0050852T cell receptor signaling pathway-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0097190apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001772immunological synapse-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA11390434  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9784967  
GO:0009897external side of plasma membrane-IDA11390434  
GO:0009986cell surface-IDA15067037  
GO:0098636protein complex involved in cell adhesion-IDA7544393  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04660T cell receptor signaling pathway
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162906HIV InfectionTAS
R-HSA-162909Host Interactions of HIV factorsTAS
R-HSA-1643685DiseaseTAS
R-HSA-164938Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adaptersTAS
R-HSA-164939Nef mediated downregulation of CD28 cell surface expressionTAS
R-HSA-164952The role of Nef in HIV-1 replication and disease pathogenesisTAS
R-HSA-168256Immune SystemTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389356CD28 co-stimulationTAS
R-HSA-389357CD28 dependent PI3K/Akt signalingTAS
R-HSA-389359CD28 dependent Vav1 pathwayTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28847915Arterial Stiffness Is Associated With Cytomegalovirus-Specific Senescent CD8(+) T Cells. (2017 Aug 28)Yu HTJ Am Heart Assoc
23747161Age-related macular degeneration is associated with increased proportion of CD56(+) T cells in peripheral blood. (2013 Nov)Faber COphthalmology
11025487Alcoholic liver cirrhosis is associated with a decreased expression of the CD28 costimulatory molecule, a lower ability of T cells to bind exogenous IL-2, and increased soluble CD8 levels. (2000 Oct 15)Laso FJCytometry
16873770Early manifestations of NNK-induced lung cancer: role of lung immunity in tumor susceptibility. (2007 Jan)Razani-Boroujerdi SAm J Respir Cell Mol Biol
23845919Childhood socioeconomic status, telomere length, and susceptibility to upper respiratory infection. (2013 Nov)Cohen SBrain Behav Immun
29744169Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)Heikkinen AMClin Exp Dent Res
25231450Thyroid autoimmunity. (2014)Wiersinga WMEndocr Dev
22776655Detection of T lymphocyte subsets in the peripheral blood of patients with advanced lung adenocarcinoma. (2012 Jun)Yan XZhongguo Yi Xue Ke Xue Yuan Xue Bao
26894484PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit. (2016 May)Aiello AEPsychoneuroendocrinology
18057064Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking. (2008 Mar)Barcelo BEur Respir J
21711350CD8+ CD28- and CD8+ CD57+ T cells and their role in health and disease. (2011 Sep)Strioga MImmunology
21669243CTLA-4, CD28, and ICOS gene polymorphism associations with non-small-cell lung cancer. (2011 Oct)Karabon LHum Immunol
10783938The expression of lymphocyte surface antigens in bronchial biopsies, bronchoalveolar lavage cells and blood cells in healthy smoking and never-smoking men, 60 years old. (2000 Mar)Ekberg-Jansson ARespir Med
19252239[Recent advances in the pathogenesis of rheumatoid arthritis]. (2009 Mar)Kawabata KClin Calcium
19002140Differential effects on T-cell function following exposure to serum from schizophrenia smokers. (2010 Apr)Herberth MMol Psychiatry
10351927Expression of costimulatory molecules on alveolar macrophages in hypersensitivity pneumonitis. (1999 Jun)Israel-Assayag EAm J Respir Crit Care Med
19711824The relationship between cell surface markers, cytokines, ageing, and cigarette smoking. (2009)Horvathova MBratisl Lek Listy
29371709Association of single nucleotide polymorphism in CD28(C/T-I3 + 17) and CD40 (C/T-1) genes with the Graves' disease. (2018 Jan)Mustafa SJ Pak Med Assoc
21910726Role of increased CD8/CD28(null) T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease. (2011 Oct)Hodge GClin Exp Immunol
17050556Modification of surface antigens in blood CD8+ T-lymphocytes in COPD: effects of smoking. (2007 Jan)Koch AEur Respir J