Gene info: ID 9400

Gene: RECQL5

GENE ID: 9400

Synonyms: RECQ5

Description: RecQ like helicase 5

Gene type: protein-coding

Location: 17q25.1

dbXrefs: Ensembl:ENSG00000108469 MIM:603781 Vega:OTTHUMG00000179795 UniprotKB:O94762

RefSeq: NG_029617.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.943e-1 (AD) 5.620e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg03721291	chr17:73649149	RECQL5		1.300e-13	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
POLL	0.93
ANAPC2	0.914
PPOX	0.904
TMEM175	0.902
INTS3	0.898
STRADA	0.897
IFT172	0.897
PPP1R3E	0.895
NUMA1	0.893
SPPL2B	0.892

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.533
OR4F29	-0.494
MTRNR2L9	-0.417
MTRNR2L6	-0.411
PABPC4L	-0.373
MTRNR2L10	-0.37
KLRB1	-0.342
KCNJ15	-0.339
MTRNR2L8	-0.334
MTRNR2L2	-0.33

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of RECQL5 mRNA"	21346803
D000082	Acetaminophen	Acetaminophen results in decreased expression of RECQL5 mRNA	17585979
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of RECQL5 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RECQL5 mRNA]	17585979
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of RECQL5 gene	27153756
C006780	bisphenol A	bisphenol A affects the expression of RECQL5 mRNA	21786754
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of RECQL5 mRNA	17585979
D002994	Clofibrate	Clofibrate results in increased expression of RECQL5 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RECQL5 mRNA]	17585979
D016572	Cyclosporine	Cyclosporine results in increased expression of RECQL5 mRNA	22147139
D003561	Cytarabine	Cytarabine results in decreased expression of RECQL5 mRNA	19194470
C014347	decitabine	decitabine results in decreased expression of RECQL5 mRNA	19194470
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of RECQL5 mRNA	18936297
C039281	furan	furan results in increased methylation of RECQL5 gene	22079235
C544151	jinfukang	jinfukang results in increased expression of RECQL5 mRNA	27392435
C045463	leflunomide	leflunomide results in decreased expression of RECQL5 mRNA	28988120
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of RECQL5 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of RECQL5 mRNA	26011545
C046012	pentanal	pentanal results in decreased expression of RECQL5 mRNA	26079696
C006253	pirinixic acid	pirinixic acid results in decreased expression of RECQL5 mRNA	17426115
D011374	Progesterone	Progesterone results in decreased expression of RECQL5 mRNA	19690047
D012643	Selenium	Selenium results in increased expression of RECQL5 mRNA	19244175
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RECQL5 mRNA	21570461
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of RECQL5 mRNA	28065790
D014212	Tretinoin	Tretinoin results in decreased expression of RECQL5 mRNA	16604517
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of RECQL5 mRNA	19042947
D014635	Valproic Acid	Valproic Acid affects the expression of RECQL5 mRNA	25979313
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of RECQL5 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000993	RNA polymerase II core binding	-	IBA	21873635
GO:0000993	RNA polymerase II core binding	-	IDA	23748380
GO:0003677	DNA binding	-	IBA	21873635
GO:0003678	DNA helicase activity	-	IDA	22013166
GO:0003678	DNA helicase activity	-	NAS	10710432
GO:0005524	ATP binding	-	IEA	-
GO:0009378	four-way junction helicase activity	-	IBA	21873635
GO:0042802	identical protein binding	-	IBA	21873635
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000070	mitotic sister chromatid segregation	-	IBA	21873635
GO:0000278	mitotic cell cycle	-	IMP	22013166
GO:0000724	double-strand break repair via homologous recombination	-	IBA	21873635
GO:0006259	DNA metabolic process	-	NAS	10710432
GO:0006260	DNA replication	-	IBA	21873635
GO:0006260	DNA replication	-	IMP	22013166
GO:0006281	DNA repair	-	IBA	21873635
GO:0006281	DNA repair	-	IMP	22973052
GO:0006310	DNA recombination	-	IBA	21873635
GO:0010165	response to X-ray	-	IBA	21873635
GO:0032508	DNA duplex unwinding	-	IBA	21873635
GO:0032508	DNA duplex unwinding	-	IEA	-
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	-	IBA	21873635
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	-	IDA	23748380
GO:0045930	negative regulation of mitotic cell cycle	-	IBA	21873635
GO:0051301	cell division	-	IEA	-
GO:0051304	chromosome separation	-	IMP	22013166
GO:0072757	cellular response to camptothecin	-	IEA	-
GO:1990414	replication-born double-strand break repair via sister chromatid exchange	-	IBA	21873635
GO:1990414	replication-born double-strand break repair via sister chromatid exchange	-	IEA	-
GO:2000042	negative regulation of double-strand break repair via homologous recombination	-	IBA	21873635
GO:2000042	negative regulation of double-strand break repair via homologous recombination	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	22013166
GO:0005654	nucleoplasm	-	NAS	10710432
GO:0005694	chromosome	-	IBA	21873635
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	NAS	10710432
GO:0005829	cytosol	-	IDA	-
GO:0016591	DNA-directed RNA polymerase II, holoenzyme	-	IDA	22231121

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23050049	Genetic and lifestyle influence on telomere length and subsequent risk of colon cancer in a case control study. (2012)	Pellatt AJ	Int J Mol Epidemiol Genet