| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| KIAA0319L | 0.947 |
| DDB1 | 0.945 |
| VPS39 | 0.934 |
| PSMD2 | 0.932 |
| OS9 | 0.931 |
| GANAB | 0.931 |
| NLGN2 | 0.931 |
| TMUB2 | 0.93 |
| RIC8A | 0.93 |
| AP3D1 | 0.928 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| OR4F5 | -0.68 |
| OR4F29 | -0.623 |
| MTRNR2L6 | -0.385 |
| CTNNA3 | -0.361 |
| MTRNR2L9 | -0.357 |
| MTRNR2L10 | -0.332 |
| PPBP | -0.327 |
| KLRB1 | -0.323 |
| CST7 | -0.321 |
| TFPI2 | -0.32 |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| C111118 | 2',3,3',4',5-pentachloro-4-hydroxybiphenyl | "2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PIGS mRNA" | 19114083 |
| C016403 | 2,4-dinitrotoluene | "2,4-dinitrotoluene affects the expression of PIGS mRNA" | 21346803 |
| C023514 | 2,6-dinitrotoluene | "2,6-dinitrotoluene affects the expression of PIGS mRNA" | 21346803 |
| D004958 | Estradiol | [Dieldrin co-treated with Estradiol] results in decreased expression of PIGS mRNA | 23041725 |
| C044887 | beta-methylcholine | beta-methylcholine affects the expression of PIGS mRNA | 21179406 |
| C006780 | bisphenol A | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIGS mRNA | 28628672 |
| C006780 | bisphenol A | bisphenol A results in increased expression of PIGS mRNA | 25181051 |
| C018475 | butyraldehyde | butyraldehyde results in decreased expression of PIGS mRNA | 26079696 |
| D002392 | Catechin | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PIGS mRNA | 24763279 |
| D019327 | Copper Sulfate | Copper Sulfate results in decreased expression of PIGS mRNA | 19549813 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of PIGS mRNA | 20106945 |
| D003907 | Dexamethasone | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIGS mRNA | 28628672 |
| D003993 | Dibutyl Phthalate | Dibutyl Phthalate results in decreased expression of PIGS mRNA | 21266533 |
| D004026 | Dieldrin | [Dieldrin co-treated with Estradiol] results in decreased expression of PIGS mRNA | 23041725 |
| D004026 | Dieldrin | Dieldrin results in increased expression of PIGS mRNA | 20438755 |
| D004041 | Dietary Fats | Dietary Fats results in decreased expression of PIGS mRNA | 18042831 |
| C511402 | Grape Seed Proanthocyanidins | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PIGS mRNA | 24763279 |
| D017313 | Fenretinide | Fenretinide results in decreased expression of PIGS mRNA | 28973697 |
| D006830 | Hydralazine | [Hydralazine co-treated with Valproic Acid] results in increased expression of PIGS mRNA | 17183730 |
| D007213 | Indomethacin | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIGS mRNA | 28628672 |
| D007213 | Indomethacin | Indomethacin results in increased expression of PIGS mRNA | 28201806 |
| D015056 | 1-Methyl-3-isobutylxanthine | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIGS mRNA | 28628672 |
| D000073878 | Palm Oil | Palm Oil results in decreased expression of PIGS mRNA | 18042831 |
| D012822 | Silicon Dioxide | Silicon Dioxide analog results in decreased expression of PIGS mRNA | 25895662 |
| C066340 | tolcapone | tolcapone binds to PIGS protein | 19783845 |
| D014050 | Toluene | Toluene results in increased expression of PIGS mRNA | 22967744 |
| D014635 | Valproic Acid | [Hydralazine co-treated with Valproic Acid] results in increased expression of PIGS mRNA | 17183730 |
| D014635 | Valproic Acid | Valproic Acid affects the expression of PIGS mRNA | 25979313 |
| D014635 | Valproic Acid | Valproic Acid results in increased expression of PIGS mRNA | 23179753|2718838 |
| D014638 | Vanadates | Vanadates results in decreased expression of PIGS mRNA | 22714537 |
| D001335 | Vehicle Emissions | Vehicle Emissions affects the methylation of PIGS gene | 25560391 |
| C025643 | vinclozolin | vinclozolin results in decreased expression of PIGS mRNA | 23034163 |
| C025643 | vinclozolin | vinclozolin results in increased expression of PIGS mRNA | 22570695 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0003923 | GPI-anchor transamidase activity | contributes_to | TAS | 11483512 |
| GO:0005515 | protein binding | - | IPI | 11483512 25416956 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0016255 | attachment of GPI anchor to protein | - | TAS | 11483512 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005789 | endoplasmic reticulum membrane | - | TAS | - |
| GO:0016020 | membrane | - | HDA | 19946888 |
| GO:0042765 | GPI-anchor transamidase complex | - | TAS | 15713669 |
| KEGG ID | KEGG Term |
|---|---|
| hsa00563 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
| hsa01100 | Metabolic pathways |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-162791 | Attachment of GPI anchor to uPAR | TAS |
| R-HSA-163125 | Post-translational modification: synthesis of GPI-anchored proteins | TAS |
| R-HSA-392499 | Metabolism of proteins | TAS |
| R-HSA-597592 | Post-translational protein modification | TAS |
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 22741523 | High-frequency viscoelastic shear properties of vocal fold tissues: implications for vocal fold tissue engineering. (2012 Oct) | Teller SS | Tissue Eng Part A |
| 25447846 | Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis. (2015 Feb) | Maleth J | Gastroenterology |
| 12176158 | Consequences of maternal cocaine on cerebral microvascular functions in piglets. (2002 Aug 30) | Yakubu MA | Brain Res |
| 17692509 | The effect of smoking cessation and steroid treatment on emphysema in guinea pigs. (2007 Nov) | Milot J | Respir Med |
| 11588007 | Chronic smoking enhances tachykinin synthesis and airway responsiveness in guinea pigs. (2001 Sep) | Kwong K | Am J Respir Cell Mol Biol |
| 26915460 | Protection from cigarette smoke-induced vascular injury by recombinant human relaxin-2 (serelaxin). (2016 May) | Pini A | J Cell Mol Med |
| 25228925 | A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD. (2014) | Davidsen PK | Genome Med |
| 27864296 | A mechanistic investigation of thrombotic microangiopathy associated with IV abuse of Opana ER. (2017 Feb 16) | Hunt R | Blood |
| 21997333 | Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease. (2012 Jan 1) | Churg A | Am J Respir Crit Care Med |
| 25560588 | The effect of carvacrol on systemic inflammation in guinea pigs model of COPD induced by cigarette smoke exposure. (2015 Feb) | Mahtaj LG | Pharmacol Rep |
| 11751203 | Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response. (2002 Jan) | Meshi B | Am J Respir Cell Mol Biol |
| 19682386 | Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig. (2009 Aug 14) | Ferrer E | Respir Res |
| 21697995 | Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process. (2011) | Geraghty P | Int J Chron Obstruct Pulmon Dis |
| 20467194 | Vitamin C prevents cigarette smoke induced atherosclerosis in guinea pig model. (2010 Aug 31) | Ray T | J Atheroscler Thromb |
| 17300721 | Black tea prevents cigarette smoke-induced apoptosis and lung damage. (2007 Feb 14) | Banerjee S | J Inflamm (Lond) |
| 15193959 | Protease-activated receptor 2 in regulation of bronchomotor tone: effect of tobacco smoking. (2004 Jul 9) | Risse PA | Life Sci |
| 22063434 | The interaction between calpastatin and RYR1 genes for some pork quality traits. (2003 Oct) | Kocwin-Podsiadla M | Meat Sci |
| 12740284 | Matrix metalloproteinases inhibition attenuates tobacco smoke-induced emphysema in Guinea pigs. (2003 May) | Selman M | Chest |
| 25881210 | Lung inflammation changes and oxidative stress induced by cigarette smoke exposure in guinea pigs affected by Zataria multiflora and its constituent, carvacrol. (2015 Mar 3) | Boskabady MH | BMC Complement Altern Med |
| 23192463 | Differential responses of hippocampal neurons and astrocytes to nicotine and hypoxia in the fetal guinea pig. (2013 Jul) | Blutstein T | Neurotox Res |
| 24043489 | Functional characterization of a porcine emphysema model. (2013 Dec) | Bruun CS | Lung |
| 23615073 | Vitamin C forestalls cigarette smoke induced NF-kappaB activation in alveolar epithelial cells. (2013 Jun 20) | Das B | Toxicol Lett |
| 6099452 | [Cigarette smoking and lung metabolism--effect of cigarette smoke exposure on blood levels of histamine, serotonin and ACE activity in guinea pigs]. (1984 Nov) | Kitamura S | Nihon Kyobu Shikkan Gakkai Zasshi |
| 10744060 | Chronic prenatal exposure to carbon monoxide results in a reduction in tyrosine hydroxylase-immunoreactivity and an increase in choline acetyltransferase-immunoreactivity in the fetal medulla: implications for Sudden Infant Death Syndrome. (2000 Mar) | Tolcos M | J Neuropathol Exp Neurol |
| 17151354 | Chronic ethanol perturbs testicular folate metabolism and dietary folate deficiency reduces sex hormone levels in the Yucatan micropig. (2007 Mar) | Wallock-Montelius LM | Biol Reprod |
| 6771806 | Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary. (1980) | Schulz R | Psychopharmacology (Berl) |
| 15653167 | In vivo evaluation of 3-O-alkyl ester transdermal prodrugs of naltrexone in hairless guinea pigs. (2005 Feb 2) | Valiveti S | J Control Release |
| 18321686 | In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs. (2008 Apr 23) | Kiptoo PK | Eur J Pharm Sci |