Gene: RECQL4

9401
RECQ4
RecQ like helicase 4
protein-coding
8q24.3
Ensembl:ENSG00000160957 MIM:603780 Vega:OTTHUMG00000165178 UniprotKB:O94761
NG_016430.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.822e-1 (AD)  7.363e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANKRD13B0.887
ANKRD240.871
ULK30.869
ZDHHC80.865
ARMC50.863
ABCB60.862
CDK100.859
KLHL170.858
MEN10.856
SEMA6C0.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AGTR1-0.469
PROK2-0.469
TFPI2-0.465
RGS22-0.46
H3F3C-0.457
CD48-0.453
KCNJ15-0.451
C9orf135-0.45
KLRB1-0.449
IL18RAP-0.44

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RECQL4 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RECQL4 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RECQL4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RECQL4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RECQL4 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RECQL4 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RECQL4 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RECQL4 mRNA"21346803
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of RECQL4 mRNA21298039
C006780bisphenol Abisphenol A results in decreased expression of RECQL4 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of RECQL4 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of RECQL4 mRNA20977926
C584509C646 compoundC646 compound results in decreased expression of RECQL4 mRNA26191083
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of RECQL4 mRNA24763279
D002509CephaloridineCephaloridine results in increased expression of RECQL4 mRNA18500788
D002994ClofibrateClofibrate results in decreased expression of RECQL4 mRNA16081524
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of RECQL4 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of RECQL4 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of RECQL4 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of RECQL4 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of RECQL4 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of RECQL4 mRNA26577399
D016572CyclosporineCyclosporine results in decreased methylation of RECQL4 promoter27989131
D003976DiazinonDiazinon results in increased methylation of RECQL4 gene22964155
D002945CisplatinCisplatin results in decreased expression of RECQL4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of RECQL4 mRNA27594783
D002117CalcitriolCalcitriol results in decreased expression of RECQL4 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of RECQL4 mRNA21592394
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of RECQL4 mRNA18242016
D004237DiuronDiuron results in decreased expression of RECQL4 mRNA21551480
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of RECQL4 mRNA27776689
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of RECQL4 mRNA]15016801
C039281furanfuran results in increased methylation of RECQL4 gene22079235
D005944GlucosamineGlucosamine results in increased expression of RECQL4 mRNA17178593
C004312glycidolglycidol results in increased expression of RECQL4 mRNA24915197
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of RECQL4 mRNA24763279
C031927hydroquinonehydroquinone results in increased expression of RECQL4 mRNA15452088
C492448ICG 001ICG 001 results in decreased expression of RECQL4 mRNA26191083
C544151jinfukangjinfukang results in increased expression of RECQL4 mRNA27392435
D007854LeadLead results in decreased expression of RECQL4 mRNA19921347
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of RECQL4 mRNA"24972896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of RECQL4 mRNA26011545
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of RECQL4 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RECQL4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RECQL4 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of RECQL4 mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of RECQL4 mRNA23358140
D010081OxazoloneOxazolone results in increased expression of RECQL4 mRNA18242016
D010100OxygenOxygen deficiency results in decreased expression of RECQL4 mRNA26516004
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of RECQL4 mRNA"25510870
D010936Plant ExtractsPlant Extracts results in decreased expression of RECQL4 mRNA23557933
C005556propionaldehydepropionaldehyde results in decreased expression of RECQL4 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of RECQL4 mRNA24780913
D011794QuercetinQuercetin results in increased expression of RECQL4 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of RECQL4 mRNA19167446
D012834SilverSilver results in decreased expression of RECQL4 mRNA22576574
D012834SilverSilver results in increased expression of RECQL4 mRNA27131904
D053260SootSoot results in increased expression of RECQL4 mRNA26551751
C025462sulindac sulfidesulindac sulfide results in decreased expression of RECQL4 mRNA16184548
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of RECQL4 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of RECQL4 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RECQL4 mRNA16962184
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of RECQL4 mRNA"18242016
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RECQL4 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of RECQL4 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of RECQL4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of RECQL4 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RECQL4 gene25560391
D014750VincristineVincristine results in decreased expression of RECQL4 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000405bubble DNA binding-IBA21873635  
GO:0000405bubble DNA binding-IDA19177149  
GO:0003677DNA binding-IBA21873635  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0004386helicase activity-TAS22039056  
GO:0005515protein binding-IBA21873635  
GO:0005515protein binding-IPI21044950  22039056  
GO:0005524ATP binding-IBA21873635  
GO:0005524ATP binding-IDA19177149  
GO:0009378four-way junction helicase activity-IBA21873635  
GO:0032357oxidized purine DNA binding-IBA21873635  
GO:0032357oxidized purine DNA binding-IDA22039056  
GO:0036310annealing helicase activity-IBA21873635  
GO:0036310annealing helicase activity-IDA19177149  
GO:0043140ATP-dependent 3'-5' DNA helicase activity-IBA21873635  
GO:0043140ATP-dependent 3'-5' DNA helicase activity-IMP19177149  
GO:0061821telomeric D-loop binding-IBA21873635  
GO:0061821telomeric D-loop binding-IDA22039056  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IMP22039056  
GO:0000724double-strand break repair via homologous recombination-IBA21873635  
GO:0000733DNA strand renaturation-IDA19177149  
GO:0006260DNA replication-IBA21873635  
GO:0006260DNA replication-IDA19177149  
GO:0006260DNA replication-IMP22039056  
GO:0006281DNA repair-IBA21873635  
GO:0006281DNA repair-TAS9878247  
GO:0006284base-excision repair-IBA21873635  
GO:0006310DNA recombination-IBA21873635  
GO:0007275multicellular organism development-TAS10319867  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0010971positive regulation of G2/M transition of mitotic cell cycle-IBA21873635  
GO:0032508DNA duplex unwinding-IBA21873635  
GO:0032508DNA duplex unwinding-IDA19177149  
GO:0032508DNA duplex unwinding-TAS22039056  
GO:0045740positive regulation of DNA replication-IBA21873635  
GO:0061820telomeric D-loop disassembly-IBA21873635  
GO:0061820telomeric D-loop disassembly-IDA22039056  
GO:0061820telomeric D-loop disassembly-IGI22039056  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric region-IBA21873635  
GO:0000781chromosome, telomeric region-IMP22039056  
GO:0005634nucleus-IBA21873635  
GO:0005694chromosome-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18449888Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers. (2008 Jul 15)Danoy PInt J Cancer