Gene: TTYH2

94015
C17orf29
tweety family member 2
protein-coding
17q25.1
Ensembl:ENSG00000141540 MIM:608855 Vega:OTTHUMG00000166018 UniprotKB:Q9BSA4
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.682e-1 (AD)  7.570e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSPA20.936
ELOVL10.914
PHLDB10.901
LAMP20.895
COL4A50.891
ERBB30.891
PRR180.889
TMEM63A0.889
PLEKHG30.887
PLEKHH10.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.364
OR4F29-0.354
PRTN3-0.323
NPBWR1-0.314
PNOC-0.304
CALB2-0.298
SHISA8-0.297
CHRNA2-0.297
AVPR2-0.296
CHRNA6-0.291

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TTYH2 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TTYH2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTYH2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTYH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTYH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTYH2 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of TTYH2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TTYH2 gene27153756
D001280AtrazineAtrazine results in increased expression of TTYH2 mRNA25929836
C547126AZM551248AZM551248 results in increased expression of TTYH2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TTYH2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTYH2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TTYH2 mRNA22300585
C006780bisphenol Abisphenol A affects the expression of TTYH2 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of TTYH2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of TTYH2 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of TTYH2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TTYH2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TTYH2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TTYH2 mRNA27392435
C118739entinostatentinostat results in increased expression of TTYH2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TTYH2 mRNA"27188386
C540355fenamidonefenamidone results in increased expression of TTYH2 mRNA27029645
D005472FluorouracilFluorouracil results in decreased expression of TTYH2 mRNA16510598
D005557FormaldehydeFormaldehyde results in increased expression of TTYH2 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of TTYH2 mRNA19167457
D007213IndomethacinIndomethacin results in decreased expression of TTYH2 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TTYH2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TTYH2 mRNA23086925
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TTYH2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TTYH2 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of TTYH2 mRNA24810058
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of TTYH2 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TTYH2 mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of TTYH2 mRNA24136188
C028007nickel monoxidenickel monoxide results in decreased expression of TTYH2 mRNA19167457
C012655nimesulidenimesulide results in decreased expression of TTYH2 mRNA24136188
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TTYH2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of TTYH2 mRNA26272509
D011374ProgesteroneProgesterone results in decreased expression of TTYH2 mRNA23012394
C045950propiconazolepropiconazole results in decreased expression of TTYH2 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of TTYH2 mRNA26079696
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TTYH2 mRNA27029645
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TTYH2 mRNA25895662
D013739TestosteroneTestosterone results in increased expression of TTYH2 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TTYH2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TTYH2 mRNA19933214
D013849ThimerosalThimerosal results in decreased expression of TTYH2 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TTYH2 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of TTYH2 mRNA18087596
D014212TretinoinTretinoin results in decreased expression of TTYH2 mRNA21934132
D014520UrethaneUrethane results in increased expression of TTYH2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TTYH2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TTYH2 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of TTYH2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of TTYH2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of TTYH2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TTYH2 mRNA21126777
D014750VincristineVincristine results in increased expression of TTYH2 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005229intracellular calcium activated chloride channel activity-IBA21873635  
GO:0005254chloride channel activity-IEA-  
GO:0005515protein binding-IPI18577513  
GO:0072320volume-sensitive chloride channel activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:1902476chloride transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IEA-  
GO:0034707chloride channel complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26752167A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction. (2016 Jan 11)Taylor JYSci Rep