Gene: HTRA3

94031
Prsp|Tasp
HtrA serine peptidase 3
protein-coding
4p16.1
Ensembl:ENSG00000170801 MIM:608785 Vega:OTTHUMG00000090561 UniprotKB:P83110
NC_000004.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.022e-1 (AD)  1.081e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPX80.801
MARVELD20.788
NPR10.778
VEGFC0.775
SIX10.772
PABPC4L0.767
FOXD20.764
CHMP4C0.762
BMX0.759
SVIL0.756

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OMG-0.469
EFNA5-0.42
TMEM191C-0.418
CNNM1-0.414
BCL11A-0.412
SEC14L5-0.407
FUT9-0.405
NME9-0.405
AMER3-0.404
MYADML2-0.404

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0127962-butenal2-butenal results in increased expression of HTRA3 mRNA20471460
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA3 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of HTRA3 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA3 mRNA"27188386
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of HTRA3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HTRA3 mRNA]17585979
D000393Air PollutantsAir Pollutants results in increased expression of HTRA3 mRNA23649983
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of HTRA3 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of HTRA3 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HTRA3 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of HTRA3 mRNA19128835
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of HTRA3 mRNA21714911|2231617
C006780bisphenol Abisphenol A results in decreased expression of HTRA3 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of HTRA3 mRNA24586524
D002737ChloropreneChloroprene results in increased expression of HTRA3 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HTRA3 mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of HTRA3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HTRA3 mRNA]17585979
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of HTRA3 mRNA23052192
D019327Copper SulfateCopper Sulfate results in increased expression of HTRA3 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of HTRA3 mRNA22077320
D003671DEET[fipronil co-treated with DEET] results in increased expression of HTRA3 mRNA27091632
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HTRA3 mRNA21266533
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of HTRA3 mRNA26924002
D004026DieldrinDieldrin results in increased expression of HTRA3 mRNA20438755
D004237DiuronDiuron results in decreased expression of HTRA3 mRNA21551480|2515243
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HTRA3 mRNA17942748
C082360fipronil[fipronil co-treated with DEET] results in increased expression of HTRA3 mRNA27091632
C082360fipronilfipronil results in increased expression of HTRA3 mRNA27091632
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HTRA3 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of HTRA3 mRNA19167457
C039281furanfuran results in increased expression of HTRA3 mRNA27387713
D017313FenretinideFenretinide results in decreased expression of HTRA3 mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of HTRA3 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HTRA3 mRNA26644586
D015122MercaptopurineMercaptopurine results in increased expression of HTRA3 mRNA23358152
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of HTRA3 mRNA20938992
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of HTRA3 mRNA22129749
D008777MethyltestosteroneMethyltestosterone results in increased expression of HTRA3 mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate affects the expression of HTRA3 mRNA26924002
D009532NickelNickel results in increased expression of HTRA3 mRNA24768652|2558310
D010100OxygenOxygen deficiency results in increased expression of HTRA3 mRNA20880076
C006253pirinixic acidpirinixic acid results in increased expression of HTRA3 mRNA18301758|2081375
D010938Plant OilsPlant Oils results in increased expression of HTRA3 mRNA23370395
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of HTRA3 mRNA21334430
D012715Sesame OilSesame Oil results in decreased expression of HTRA3 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HTRA3 mRNA25895662
D012834SilverSilver results in increased expression of HTRA3 mRNA26014281
D012906SmokeSmoke results in increased expression of HTRA3 mRNA21095227
C017947sodium arsenitesodium arsenite results in increased expression of HTRA3 mRNA20371982|2549360
D012999SomanSoman results in decreased expression of HTRA3 mRNA19281266
D012999SomanSoman results in increased expression of HTRA3 mRNA19281266
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of HTRA3 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HTRA3 mRNA21998131
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HTRA3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HTRA3 promoter]19654925
C009495titanium dioxidetitanium dioxide results in decreased expression of HTRA3 mRNA23557971
D014050TolueneToluene results in increased expression of HTRA3 mRNA22967744
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of HTRA3 mRNA23052192
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA3 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of HTRA3 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of HTRA3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of HTRA3 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-IDA18387192  
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0005515protein binding-IPI22229724  
GO:0005520insulin-like growth factor binding-IEA-  
GO:0008236serine-type peptidase activity-IDA22229724  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-IEA-  
GO:0006508proteolysis-IDA18387192  22229724  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-ISS-  
GO:0030514negative regulation of BMP signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20068077Methylation induced gene silencing of HtrA3 in smoking-related lung cancer. (2010 Jan 15)Beleford DClin Cancer Res