Gene: CD80

941
B7|B7-1|B7.1|BB1|CD28LG|CD28LG1|LAB7
CD80 molecule
protein-coding
3q13.33
Ensembl:ENSG00000121594 MIM:112203 Vega:OTTHUMG00000159419 UniprotKB:P33681
NC_000003.12
PubMed
0   ANCO-SNPs
ND|AD
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.787e-1 (AD)  4.793e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRT750.904
CYP19A10.892
C15orf480.873
ETV70.87
CCL80.852
GBP50.847
IL4I10.844
AIM20.838
HIST1H2AJ0.837
RHOH0.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNX22-0.354
MYADML2-0.342
HCN2-0.341
SCRT1-0.338
ATP6V1E2-0.331
OMG-0.327
KCNIP3-0.326
ASIC1-0.322
TMEM179-0.322
KCNN1-0.322

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01281AbataceptBiotechDrug332348-12-6ApprovedTarget
DB04901GaliximabBiotechDrug357613-77-5InvestigationalTarget
DB06681BelataceptBiotechDrug706808-37-9Approved|InvestigationalTarget
DB11714DurvalumabBiotechDrug1428935-60-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CD80 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CD80 mRNA"27291303
C02835824,25-epoxycholesterol"24,25-epoxycholesterol results in decreased expression of CD80 protein"17475839
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CD80 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CD80 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CD80 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CD80 mRNA"25510870
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [alitretinoin results in decreased expression of CD80 protein]17475839
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide results in decreased expression of CD80 protein17475839
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of CD80 mRNA16788091
C0541893,5-di-tert-butylchalcone 4'-carboxylic acid"3,5-di-tert-butylchalcone 4'-carboxylic acid results in decreased expression of CD80 protein"17475839
C0255664-methylhistamine4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]12538815
D000119Acetylmuramyl-Alanyl-Isoglutamine[Acetylmuramyl-Alanyl-Isoglutamine co-treated with FK 565] results in increased expression of CD80 protein16299289
D000119Acetylmuramyl-Alanyl-Isoglutamine[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD80 protein16299289
D000119Acetylmuramyl-Alanyl-IsoglutamineAcetylmuramyl-Alanyl-Isoglutamine results in increased expression of CD80 protein16299289
C022571adenosine 5'-O-(3-thiotriphosphate)adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD80 protein15944274
D037361Adenylate Cyclase ToxinAdenylate Cyclase Toxin results in increased expression of CD80 protein14977963
D037361Adenylate Cyclase ToxinPolymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD80 protein]14977963
C103303alitretinoin2-chloro-5-nitrobenzanilide inhibits the reaction [alitretinoin results in decreased expression of CD80 protein]17475839
C103303alitretinoin[alitretinoin co-treated with rosiglitazone] results in decreased expression of CD80 protein17475839
C103303alitretinoinalitretinoin results in decreased expression of CD80 protein17475839
C103303alitretinoinHX 630 inhibits the reaction [alitretinoin results in decreased expression of CD80 protein]17475839
D000534Alum CompoundsAlum Compounds inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD80 protein]18390722
D000536Aluminum HydroxideAluminum Hydroxide inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD80 protein]18390722
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD80 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD80 mRNA24449571
D001151ArsenicArsenic affects the expression of CD80 protein24675094
C547126AZM551248AZM551248 results in increased expression of CD80 mRNA22323515
D004958EstradiolEstradiol promotes the reaction [Lipopolysaccharides results in increased expression of CD80 protein]28811679
D004958Estradiol[Estradiol results in increased susceptibility to CpG ODN 1826] which results in increased expression of CD80 protein28811679
D004958EstradiolEstradiol results in decreased expression of CD80 mRNA17823450
D047071beta-Glucansbeta-Glucans results in increased expression of CD80 protein17572156
C006780bisphenol Abisphenol A results in decreased expression of CD80 mRNA25181051
D002211CapsaicinCapsaicin results in increased expression of CD80 protein22150557
D002211CapsaicinNaproxen affects the reaction [Capsaicin results in increased expression of CD80 protein]22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] affects the reaction [Capsaicin results in increased expression of CD80 protein]22150557
D002211CapsaicinSumatriptan affects the reaction [Capsaicin results in increased expression of CD80 protein]22150557
D002330CarmustineCarmustine results in increased expression of CD80 mRNA15980968
D002858Chromium AlloysChromium Alloys results in decreased secretion of CD80 protein19844976
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of CD8017026843
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of CD80 mRNA28219650
D002990ClobetasolClobetasol results in decreased expression of CD80 protein15086553
D004002Clodronic AcidClodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD80 protein]15892581
C423449CpG ODN 1826[Estradiol results in increased susceptibility to CpG ODN 1826] which results in increased expression of CD80 protein28811679
C004742daidzeindaidzein inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]21945492
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CD80 mRNA23640034
C014347decitabinedecitabine results in increased expression of CD80 protein19401350
D013759DronabinolDronabinol results in decreased expression of CD80 protein23727458
D003703DemecolcineDemecolcine results in increased expression of CD80 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in increased expression of CD80 mRNA21074547
C451162Dermatophagoides pteronyssinus antigen p 1CD80 protein affects the reaction [Particulate Matter analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
C451162Dermatophagoides pteronyssinus antigen p 1CD80 protein affects the reaction [Vehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
D003994BucladesineBucladesine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]12538815
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CD80 mRNA20360939
D002117CalcitriolCalcitriol results in decreased expression of CD80 protein10679076
D002117Calcitriol[CD40LG protein co-treated with Calcitriol] results in decreased expression of CD80 protein19186073
C012125diisononyl phthalatediisononyl phthalate results in increased expression of CD80 protein20064775
D017259DimapritDimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]12538815
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of CD80 mRNA28219650
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CD80 protein"15894585
D004365Drugs, Chinese Herbal"helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD80 protein]"15894585
D004964EstriolEstriol results in increased expression of CD80 protein21317386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CD80 mRNA23649840
D015738FamotidineFamotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]12538815
C039537FK 565[Acetylmuramyl-Alanyl-Isoglutamine co-treated with FK 565] results in increased expression of CD80 protein16299289
C039537FK 565[FK 565 co-treated with Lipopolysaccharides] results in increased expression of CD80 protein16299289
C039537FK 565FK 565 results in increased expression of CD80 protein16299289
D005419FlavonoidsFlavonoids results in increased expression of CD80 mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of CD80 mRNA23649840
D062610Fungal PolysaccharidesFungal Polysaccharides results in increased expression of CD80 protein28235615
D062610Fungal Polysaccharidespyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased expression of CD80 protein]28235615
C546771gardiquimodgardiquimod results in increased expression of CD80 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD80 mRNA]28003376
D019833Genistein"Genistein analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD80 protein]"25447760
C027478glucuronoxylomannanglucuronoxylomannan results in increased expression of CD80 protein12864811
C001329helenalin"helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD80 protein]"15894585
C001329helenalinhelenalin inhibits the reaction [Polysaccharides results in increased expression of CD80 protein]15894585
D006632HistamineFamotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]12538815
D006632HistamineHistamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]12538815
D006632HistamineRanitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]12538815
C422175HX 630HX 630 inhibits the reaction [alitretinoin results in decreased expression of CD80 protein]17475839
C422175HX 630HX 630 results in increased expression of CD80 protein17475839
D006854HydrocortisoneHydrocortisone results in decreased expression of CD80 protein15241357
D006854HydrocortisoneHydrocortisone results in decreased expression of CD80 protein15086553
C031927hydroquinonehydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]19148301
C020755hydroxycitronellalhydroxycitronellal results in increased expression of CD80 mRNA17936526
C474021indirubin-3'-monoximeindirubin-3'-monoxime promotes the reaction [Lipopolysaccharides results in increased expression of CD80 protein]21948866
C474021indirubin-3'-monoximeindirubin-3'-monoxime results in increased expression of CD80 protein21948866
C474021indirubin-3'-monoxime[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased expression of CD80 protein21948866
C016517indole-3-carbinolindole-3-carbinol promotes the reaction [Lipopolysaccharides results in increased expression of CD80 protein]21948866
C016517indole-3-carbinolindole-3-carbinol results in increased expression of CD80 protein21948866
C016517indole-3-carbinol[Lipopolysaccharides co-treated with indole-3-carbinol] results in increased expression of CD80 protein21948866
C051890irinotecanirinotecan metabolite results in increased expression of CD80 mRNA15956246
C051890irinotecanirinotecan results in increased expression of CD80 mRNA15956246
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]25725100
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD80 mRNA26387944
C008261lead acetate[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD80 protein17512567
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CD80 protein"17630318|2545848
C440499lipopolysaccharide, Escherichia coli O111 B4"Genistein analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD80 protein]"25447760
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD80 protein"23353651|2544776
C440499lipopolysaccharide, Escherichia coli O111 B4"Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD80 protein]"23353651
C440499lipopolysaccharide, Escherichia coli O111 B4"TOLLIP protein affects the reaction [Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD80 protein]]"23353651
D008070Lipopolysaccharides4-methylhistamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]12538815
D008070Lipopolysaccharides[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD80 protein16299289
D008070LipopolysaccharidesBucladesine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]12538815
D008070LipopolysaccharidesCD80 protein affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]12538815
D008070LipopolysaccharidesCSF2 protein affects the reaction [Lipopolysaccharides results in increased expression of CD80 protein]25725100
D008070LipopolysaccharidesDimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]12538815
D008070LipopolysaccharidesFamotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]12538815
D008070Lipopolysaccharides[FK 565 co-treated with Lipopolysaccharides] results in increased expression of CD80 protein16299289
D008070LipopolysaccharidesHistamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]12538815
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]25725100
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CD80 protein18390722
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CD80 protein11884429|1253881
D008070LipopolysaccharidesRanitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]12538815
D008070Lipopolysaccharidesdaidzein inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]21945492
D008070LipopolysaccharidesEstradiol promotes the reaction [Lipopolysaccharides results in increased expression of CD80 protein]28811679
D008070Lipopolysaccharideshydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]19148301
D008070Lipopolysaccharidesindirubin-3'-monoxime promotes the reaction [Lipopolysaccharides results in increased expression of CD80 protein]21948866
D008070Lipopolysaccharidesindole-3-carbinol promotes the reaction [Lipopolysaccharides results in increased expression of CD80 protein]21948866
D008070LipopolysaccharidesLipopolysaccharides affects the expression of CD80 protein24561310
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with CSF2 protein] results in increased expression of CD80 protein17512567
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in increased expression of CD80 protein21948866
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with indole-3-carbinol] results in increased expression of CD80 protein21948866
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD80 protein17512567
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CD80 mRNA22169119
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CD80 protein19148301|2034823
D008070LipopolysaccharidesNiclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein]24561310
D008070Lipopolysaccharidesprocyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA]22169119
D008070LipopolysaccharidesRaloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]16081843
D008070LipopolysaccharidesTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]20348231
C480546lupanelupane results in increased expression of CD80 protein16388738
C078795LW 50020LW 50020 results in increased expression of CD80 protein15246609
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CD80 mRNA21641980
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CD80 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CD80 mRNA"20188158
C089950MF59 oil emulsionMF59 oil emulsion inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD80 protein]18390722
C085192molybdenum chloridemolybdenum chloride results in increased secretion of CD80 protein19844976
C523799MRK 003CD80 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CD80 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD80 mRNA"25554681
D009288NaproxenNaproxen affects the reaction [Capsaicin results in increased expression of CD80 protein]22150557
D009288Naproxen[Naproxen co-treated with Sumatriptan] affects the reaction [Capsaicin results in increased expression of CD80 protein]22150557
D009532NickelNickel results in increased expression of CD80 mRNA25583101
D009532NickelCD80 protein results in increased susceptibility to Nickel19844976
C022838nickel chloridenickel chloride results in increased expression of CD80 protein25458486
C029938nickel sulfatenickel sulfate results in increased expression of CD80 protein25673294
D009534NiclosamideNiclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein]24561310
D009761NystatinNystatin results in increased expression of CD80 protein16374455
D010269ParaquatParaquat results in increased expression of CD80 mRNA18198484
D052638Particulate MatterCD80 protein affects the reaction [Particulate Matter analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
D052638Particulate MatterGSTM1 mutant form promotes the reaction [Particulate Matter results in increased expression of CD80]21169129
D052638Particulate MatterHBA1 alternative form promotes the reaction [Particulate Matter results in increased expression of CD80]21169129
D052638Particulate MatterParticulate Matter results in increased expression of CD8021169129
D052638Particulate MatterParticulate Matter results in increased expression of CD80 protein17630318
D052638Particulate MatterParticulate Matter results in increased expression of CD80 mRNA23638009
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of CD80 mRNA"25510870
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of CD80 mRNA21984479
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of CD80 mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CD80 mRNA21984479
D010936Plant ExtractsPlant Extracts results in increased expression of CD80 protein23108216
D028321Plant PreparationsPlant Preparations results in increased expression of CD80 protein25019244
D011070Poly I-CPoly I-C results in increased expression of CD80 protein15246609
D011112Polymyxin BPolymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD80 protein]14977963
D011134Polysaccharideshelenalin inhibits the reaction [Polysaccharides results in increased expression of CD80 protein]15894585
D011134PolysaccharidesPolysaccharides results in increased expression of CD80 protein15894585
D011134PolysaccharidesPolysaccharides results in increased expression of CD80 protein23108216|2501924
C479581procyanidin B3procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 mRNA]22169119
D011374ProgesteroneProgesterone results in decreased expression of CD80 protein21856019
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD80 mRNA]28003376
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased expression of CD80 protein]28235615
D011794Quercetin"Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD80 protein]"23353651
D011794Quercetin"TOLLIP protein affects the reaction [Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD80 protein]]"23353651
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]16081843
D011899RanitidineRanitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]12538815
C059514resveratrolresveratrol results in decreased expression of CD80 mRNA22962611
C059514resveratrolresveratrol results in decreased expression of CD80 protein14996416
C059514resveratrolresveratrol inhibits the reaction [IFNG protein results in increased expression of CD80 protein]15135313
C034206RibomunylRibomunyl results in increased expression of CD80 protein15246609
C089730rosiglitazone[alitretinoin co-treated with rosiglitazone] results in decreased expression of CD80 protein17475839
C089730rosiglitazonerosiglitazone results in decreased expression of CD80 protein17475839
D019821SimvastatinSimvastatin results in decreased expression of CD80 mRNA22305382
D020123SirolimusSirolimus results in decreased expression of CD80 protein12531798
D013311StreptozocinClodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD80 protein]15892581
D013311StreptozocinStreptozocin results in increased expression of CD80 protein15892581
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CD80 mRNA21641980
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] affects the reaction [Capsaicin results in increased expression of CD80 protein]22150557
D018170SumatriptanSumatriptan affects the reaction [Capsaicin results in increased expression of CD80 protein]22150557
D016559TacrolimusTacrolimus results in decreased expression of CD80 protein15241357
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of CD80 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [BCL6 protein binds to CD80 enhancer]25543051
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased expression of BCL6 protein] which results in decreased expression of CD80 protein25543051
D013749TetrachlorodibenzodioxinAHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD80 mRNA]23999131
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD80 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of CD80 protein]21807014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]20348231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD80 mRNA23999131
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CD80 protein21097750
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin results in increased expression of BCL6 protein] which results in decreased expression of CD80 protein27546522
D013853ThioacetamideThioacetamide results in increased expression of CD80 mRNA23411599
D014118Toxins, Biological"Toxins, Biological affects the expression of CD80 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of CD80 protein15454112
C001899triptolidetriptolide results in decreased expression of CD80 protein15663903
D017974Uranium CompoundsUranium Compounds results in increased expression of CD80 mRNA19654044
D014635Valproic AcidValproic Acid affects the expression of CD80 mRNA17963808
D001335Vehicle EmissionsCD80 protein affects the reaction [Vehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]12023397
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CD80 protein17630318
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CD80 gene25560391
C025643vinclozolinvinclozolin results in increased expression of CD80 mRNA23869203
D014750VincristineVincristine results in increased expression of CD80 mRNA23649840
C088658zoledronic acidzoledronic acid results in increased expression of CD80 protein19446661

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005515protein binding-IPI9915850  11279502  18585785  21982860  
GO:0015026coreceptor activity-NAS9915850  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006955immune response-IBA21873635  
GO:0007165signal transduction-IBA21873635  
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0009967positive regulation of signal transduction-NAS9915850  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0031295T cell costimulation-IBA21873635  
GO:0031295T cell costimulation-TAS-  
GO:0035556intracellular signal transduction-NAS9915850  
GO:0042102positive regulation of T cell proliferation-IBA21873635  
GO:0042130negative regulation of T cell proliferation-IBA21873635  
GO:0045086positive regulation of interleukin-2 biosynthetic process-NAS9915850  
GO:0045425positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process-NAS9915850  
GO:0045627positive regulation of T-helper 1 cell differentiation-NAS9915850  
GO:0045893positive regulation of transcription, DNA-templated-NAS9915850  
GO:0046718viral entry into host cell-IEA-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA9915850  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0071222cellular response to lipopolysaccharide-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0009986cell surface-HDA23981064  
GO:0009986cell surface-IBA21873635  
GO:0016021integral component of membrane-IEA-  
GO:0098636protein complex involved in cell adhesion-IDA7544393  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04620Toll-like receptor signaling pathway
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05320Autoimmune thyroid disease
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05416Viral myocarditis
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389356CD28 co-stimulationTAS
R-HSA-389357CD28 dependent PI3K/Akt signalingTAS
R-HSA-389359CD28 dependent Vav1 pathwayTAS
R-HSA-389513CTLA4 inhibitory signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6783783Interleukin-10 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11025487Alcoholic liver cirrhosis is associated with a decreased expression of the CD28 costimulatory molecule, a lower ability of T cells to bind exogenous IL-2, and increased soluble CD8 levels. (2000 Oct 15)Laso FJCytometry
18203971Function-associated surface molecules on airway dendritic cells in cigarette smokers. (2008 Jun)Bratke KAm J Respir Cell Mol Biol
29309749Patients with idiopathic endplate inflammation displayed aberrant Th17 responses resulting in proinflammatory monocyte activation. (2018 Feb 1)Wang JExp Cell Res
15031634Relationships of differential leukocyte and lymphocyte subpopulations with carotid atherosclerosis in elderly men. (2003 Nov)Tanigawa TJ Clin Immunol
21910726Role of increased CD8/CD28(null) T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease. (2011 Oct)Hodge GClin Exp Immunol
27058955Cigarette Smoke Decreases the Maturation of Lung Myeloid Dendritic Cells. (2016)Arellano-Orden EPLoS One
27692140Bronchoalveolar lavage for the diagnosis of Pulmonary Langerhans cell histiocytosis. (2016 Oct)Lommatzsch MRespir Med
17925605Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro. (2007 Nov)Dopheide JFCoron Artery Dis
27526110Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung. (2016 Aug 15)Yamada HYOncogenesis
18453581Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice. (2008 May 15)Robbins CSJ Immunol
10351927Expression of costimulatory molecules on alveolar macrophages in hypersensitivity pneumonitis. (1999 Jun)Israel-Assayag EAm J Respir Crit Care Med
20732370CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. (2010 Nov)Liu YHum Immunol
28574651Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells. (2017 Aug)Mulligan JKInt Forum Allergy Rhinol
16907910Different inflammatory cell pattern and macrophage phenotype in chronic obstructive pulmonary disease patients, smokers and non-smokers. (2006 Sep)Lofdahl JMClin Exp Immunol