Gene: ORMDL3

94103
-
ORMDL sphingolipid biosynthesis regulator 3
protein-coding
17q21.1
Ensembl:ENSG00000172057 MIM:610075 Vega:OTTHUMG00000133249 UniprotKB:Q8N138
NC_000017.11
PubMed
0   ANCO-SNPs
ND
4   
9.096e-1 (AD)  5.894e-1 (ND)   (Frontal_Cortex)
9.789e-1 (AD)  7.284e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB5C0.894
MED290.89
EMC100.883
PFKL0.876
FAM213A0.876
ECHS10.871
TSPAN30.869
PUF600.867
ENO10.865
TUFM0.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.799
OR4F29-0.794
MTRNR2L6-0.266
MTRNR2L9-0.248
C17orf112-0.23
KRTAP4-9-0.204
SULT1E1-0.202
KRTAP3-2-0.201
SLC6A14-0.198
SFTPA1-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ORMDL3 mRNA"19850644|2890350
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ORMDL3 mRNA]"19850644
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of ORMDL3 mRNA"20713471
D000082AcetaminophenAcetaminophen results in decreased expression of ORMDL3 mRNA21420995|2223033
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]27784618
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ORMDL3 protein20106945
D001151ArsenicArsenic affects the methylation of ORMDL3 gene25304211
D001280AtrazineAtrazine results in decreased expression of ORMDL3 mRNA22378314
D001542BenomylAcetylcysteine inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]27784618
D001542BenomylBenomyl results in increased expression of ORMDL3 protein27784618
D001542BenomylMitoTEMPO inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]27784618
D001542BenomylORMDL3 protein affects the reaction [Benomyl results in increased expression of ADAM33 protein]27784618
D001542BenomylORMDL3 protein affects the reaction [Benomyl results in increased expression of CCL17 mRNA]27784618
D001542BenomylORMDL3 protein affects the reaction [Benomyl results in increased expression of CXCL8 mRNA]27784618
D001542BenomylORMDL3 protein affects the reaction [Benomyl results in increased expression of MMP2 protein]27784618
D001542BenomylORMDL3 protein affects the reaction [Benomyl results in increased expression of TSLP mRNA]27784618
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ORMDL3 mRNA19770486
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ORMDL3 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ORMDL3 mRNA25181051
D002922CiguatoxinsCiguatoxins affects the expression of ORMDL3 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of ORMDL3 mRNA17585979
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ORMDL3 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ORMDL3 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ORMDL3 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of ORMDL3 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ORMDL3 mRNA19850644
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ORMDL3 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ORMDL3 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ORMDL3 mRNA17942748
D005839GentamicinsGentamicins results in decreased expression of ORMDL3 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of ORMDL3 mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ORMDL3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ORMDL3 mRNA28628672
D007649KetamineKetamine results in increased expression of ORMDL3 mRNA20080153
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ORMDL3 mRNA22776087
C555916MitoTEMPOMitoTEMPO inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]27784618
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ORMDL3 mRNA"25620056
C028007nickel monoxidenickel monoxide results in increased expression of ORMDL3 mRNA19167457
D000073878Palm OilPalm Oil results in decreased expression of ORMDL3 mRNA18042831
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital results in increased expression of ORMDL3 mRNA]19850644
D010634PhenobarbitalPhenobarbital affects the expression of ORMDL3 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ORMDL3 mRNA19850644
C006253pirinixic acidpirinixic acid results in increased expression of ORMDL3 mRNA18301758|1844570
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of ORMDL3 mRNA]19850644
D011192Potassium DichromatePotassium Dichromate results in increased expression of ORMDL3 protein23718831
C059514resveratrolresveratrol results in increased expression of ORMDL3 protein25505154
D013629TamoxifenTamoxifen affects the expression of ORMDL3 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ORMDL3 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ORMDL3 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ORMDL3 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ORMDL3 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ORMDL3 mRNA18796159|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ORMDL3 mRNA17942748
C009495titanium dioxidetitanium dioxide results in decreased expression of ORMDL3 mRNA23557971
C483909torcetrapibtorcetrapib results in increased expression of ORMDL3 mRNA23228038
C012589trichostatin Atrichostatin A affects the expression of ORMDL3 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ORMDL3 mRNA"26179874
D014520UrethaneUrethane results in increased expression of ORMDL3 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ORMDL3 mRNA25979313
C029297vinylidene chloridevinylidene chloride results in increased expression of ORMDL3 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20182505  
GO ID GO Term Qualifier Evidence PubMed
GO:0006672ceramide metabolic process-IBA21873635  
GO:0006672ceramide metabolic process-IMP20182505  
GO:0043312neutrophil degranulation-TAS-  
GO:0090156cellular sphingolipid homeostasis-IBA21873635  
GO:1900060negative regulation of ceramide biosynthetic process-IBA21873635  
GO:1900060negative regulation of ceramide biosynthetic process-IMP25691431  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA12093374  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030667secretory granule membrane-TAS-  
GO:0035339SPOTS complex-IBA21873635  
GO:0035339SPOTS complex-IDA20182505  25691431  
GO:0035579specific granule membrane-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1660661Sphingolipid de novo biosynthesisTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24347560DENND1B gene variants associate with elevated exhaled nitric oxide in healthy high-risk neonates. (2015 Feb)Chawes BLPediatr Pulmonol
2262659217q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom. (2012 Jun)Marinho SAnn Allergy Asthma Immunol
20008879Genome-wide association studies: what do they teach us about asthma and chronic obstructive pulmonary disease? (2009 Dec)Boezen HMProc Am Thorac Soc
2362200517q12-21 and asthma: interactions with early-life environmental exposures. (2013 May)Blekic MAnn Allergy Asthma Immunol