Gene: SYTL3

94120
SLP3
synaptotagmin like 3
protein-coding
6q25.3
Ensembl:ENSG00000164674 Vega:OTTHUMG00000015916 UniprotKB:Q4VX76
NG_029794.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.756e-1 (AD)  5.831e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPRC0.805
SLC11A10.804
TFEC0.797
BTK0.796
CD860.792
MSR10.791
LILRA20.786
LAIR10.786
KLHL60.786
TLR20.785

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPLX3-0.358
KCNIP3-0.349
WNT7A-0.342
ARSF-0.338
HES5-0.334
MARCH4-0.313
TMEM179-0.302
NEUROD6-0.3
SCRT1-0.294
WFDC1-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of SYTL3 mRNA"26377693
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SYTL3 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SYTL3 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SYTL3 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SYTL3 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SYTL3 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of SYTL3 mRNA25181051
D003703DemecolcineDemecolcine results in increased expression of SYTL3 mRNA23649840
D002117CalcitriolCalcitriol results in decreased expression of SYTL3 mRNA26485663
C039281furanfuran results in increased expression of SYTL3 mRNA25539665
C412815GW 4064GW 4064 results in increased expression of SYTL3 mRNA26655953
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SYTL3 mRNA23086925
C008261lead acetatelead acetate results in decreased expression of SYTL3 mRNA21829687
C008261lead acetatelead acetate results in increased expression of SYTL3 mRNA22609695
D008727MethotrexateMethotrexate results in increased expression of SYTL3 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SYTL3 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SYTL3 mRNA"25554681
D009532NickelNickel results in increased expression of SYTL3 mRNA24768652|2558310
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SYTL3 mRNA22714537
C005556propionaldehydepropionaldehyde results in increased expression of SYTL3 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SYTL3 mRNA25895662
D018038Sodium SeleniteSodium Selenite results in increased expression of SYTL3 mRNA18175754
D053260SootSoot affects the expression of SYTL3 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SYTL3 promoter]19654925
D013853ThioacetamideThioacetamide results in increased expression of SYTL3 mRNA23411599
D014212TretinoinTretinoin results in increased expression of SYTL3 mRNA23724009|2383079
D014635Valproic AcidValproic Acid results in increased expression of SYTL3 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of SYTL3 gene29154799
D014638VanadatesVanadates results in increased expression of SYTL3 mRNA22714537
D014750VincristineVincristine results in increased expression of SYTL3 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017137Rab GTPase binding-IEA-  
GO:0019905syntaxin binding-IBA21873635  
GO:0030276clathrin binding-IBA21873635  
GO:0042043neurexin family protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IEA-  
GO:0006906vesicle fusion-IBA21873635  
GO:0016079synaptic vesicle exocytosis-IBA21873635  
GO:0017158regulation of calcium ion-dependent exocytosis-IBA21873635  
GO:0048791calcium ion-regulated exocytosis of neurotransmitter-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0019897extrinsic component of plasma membrane-IEA-  
GO:0070382exocytic vesicle-IBA21873635  
GO:0098793presynapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22361517Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. (2012 May)Wassel CLAtherosclerosis