Gene info: ID 9415

Gene: FADS2

GENE ID: 9415

Synonyms: D6D|DES6|FADSD6|LLCDL2|SLL0262|TU13

Description: fatty acid desaturase 2

Gene type: protein-coding

Location: 11q12.2

dbXrefs: Ensembl:ENSG00000134824 MIM:606149 Vega:OTTHUMG00000163794 UniprotKB:O95864

RefSeq: NC_000011.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.481e-1 (AD) 8.766e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP1B2	0.844
SLC9A3R1	0.839
CD81	0.835
FADS1	0.833
PLCD3	0.83
HADHB	0.827
ITM2C	0.814
MLC1	0.813
ZFAND3	0.812
FXYD1	0.809

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.576
OR4F29	-0.562
TYRP1	-0.316
ZNF860	-0.305
CCDC178	-0.293
OR51Q1	-0.288
CCDC68	-0.284
TDRD1	-0.277
ROPN1L	-0.274
KLHL38	-0.267

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00132	Alpha-Linolenic Acid	Small Molecule	463-40-1	Approved\|Nutraceutical	Target
DB13168	Omega-6 fatty acids	Small Molecule		Nutraceutical	Enzyme

ID	Drug Name	Action	PubMed
C078632	1-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine	"FADS2 protein affects the reaction [Amiodarone results in increased uptake of 1-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine]"	21123845
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of FADS2 mRNA"	25614096
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of FADS2 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of FADS2 mRNA"	21346803
C457499	2-chloro-5-nitrobenzanilide	[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Amiodarone results in increased expression of FADS2 mRNA]	21123845
C575631	4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile	"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of FADS2 mRNA"	21218783
D000082	Acetaminophen	Acetaminophen results in decreased expression of FADS2 mRNA	21420995
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FADS2 mRNA	22129741
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FADS2 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of FADS2 mRNA	19770486
D000638	Amiodarone	[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Amiodarone results in increased expression of FADS2 mRNA]	21123845
D000638	Amiodarone	Amiodarone affects the expression of FADS2 mRNA	29248575
D000638	Amiodarone	Amiodarone results in increased expression of FADS2 mRNA	21123845
D000638	Amiodarone	"FADS2 protein affects the reaction [Amiodarone results in increased uptake of 1-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine]"	21123845
D000638	Amiodarone	Amiodarone affects the expression of FADS2 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FADS2 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of FADS2 mRNA	24449571
D016718	Arachidonic Acid	Arachidonic Acid results in decreased expression of FADS2 mRNA	21457203
D001151	Arsenic	Arsenic results in decreased expression of FADS2 mRNA	18315880
D001374	Azacitidine	Azacitidine results in decreased expression of FADS2 mRNA	20823114
D001553	Benzbromarone	Benzbromarone affects the expression of FADS2 mRNA	19483382
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FADS2 mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FADS2 mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FADS2 mRNA"	20382639
D004958	Estradiol	Estradiol affects the expression of FADS2 mRNA	23557687
D004958	Estradiol	Estradiol affects the expression of FADS2 mRNA	22574217
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of FADS2 mRNA	20823114
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid affects the expression of FADS2 mRNA	18192240
C095105	bexarotene	bexarotene results in increased expression of FADS2 mRNA	17630414
C095105	bexarotene	[Tamoxifen co-treated with bexarotene] results in increased expression of FADS2 mRNA	17630414
D001629	Bezafibrate	Bezafibrate results in increased activity of FADS2 protein	7606338
C006780	bisphenol A	bisphenol A affects the expression of FADS2 mRNA	23557687
C006780	bisphenol A	bisphenol A results in increased expression of FADS2 mRNA	26364221
C006780	bisphenol A	bisphenol A results in increased expression of FADS2 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of FADS2 mRNA	25270620
C006780	bisphenol A	bisphenol A results in decreased expression of FADS2 mRNA	24534842
C006780	bisphenol A	bisphenol A affects the expression of FADS2 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of FADS2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of FADS2 gene	28505145
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FADS2 mRNA	28628672
D000069286	Bortezomib	Bortezomib results in decreased expression of FADS2 mRNA	20977926
D002065	Buspirone	Buspirone results in decreased expression of FADS2 mRNA	24136188
C018475	butyraldehyde	butyraldehyde results in decreased expression of FADS2 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of FADS2 mRNA	24982889
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of FADS2 mRNA	25993096
D002220	Carbamazepine	Carbamazepine results in decreased expression of FADS2 mRNA	21123845
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of FADS2 mRNA	15963578
D002738	Chloroquine	Chloroquine results in decreased expression of FADS2 mRNA	19393257
D002788	Cholesterol Esters	[troglitazone results in decreased expression of FADS2 mRNA] which affects the abundance of Cholesterol Esters	11916926
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FADS2 gene	20938992
C043561	chrysin	chrysin results in decreased expression of FADS2 mRNA	20816778
D002994	Clofibrate	Clofibrate affects the expression of FADS2 mRNA	19483382
D002994	Clofibrate	Clofibrate results in decreased expression of FADS2 protein	6821269
D002994	Clofibrate	Clofibrate results in increased activity of FADS2 protein	7606338
D002994	Clofibrate	Clofibrate results in increased expression of FADS2 mRNA	12851107
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of FADS2 mRNA	19320972\|1937684
D003300	Copper	Copper results in decreased expression of FADS2 mRNA	22465980
C551994	crizotinib	crizotinib results in increased expression of FADS2 mRNA	23707608
D003474	Curcumin	Curcumin affects the expression of FADS2 mRNA	27208389
D003474	Curcumin	Curcumin results in decreased expression of FADS2 mRNA	27208389
C057862	cyanoginosin LR	cyanoginosin LR results in decreased expression of FADS2 protein	26984711
C093628	cyproconazole	cyproconazole affects the expression of FADS2 mRNA	21621602
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FADS2 mRNA]	27941970
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FADS2 mRNA	28628672
C016366	dibenzothiophene	dibenzothiophene results in decreased expression of FADS2 mRNA	23656968
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of FADS2 mRNA	21266533
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of FADS2 mRNA	20823114
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of FADS2 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of FADS2 mRNA	27594783
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA	16931933
D019259	Lamivudine	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA	16931933
D004041	Dietary Fats	Dietary Fats affects the expression of FADS2 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in increased expression of FADS2 mRNA	16357043
D019422	Dietary Sucrose	Dietary Sucrose results in increased activity of FADS2 protein	15763435
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of FADS2 mRNA	15763435
D019422	Dietary Sucrose	troglitazone inhibits the reaction [Dietary Sucrose results in increased activity of FADS2 protein]	15763435
D019422	Dietary Sucrose	troglitazone inhibits the reaction [Dietary Sucrose results in increased expression of FADS2 mRNA]	15763435
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of FADS2 mRNA	19245819\|1985064
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of FADS2 mRNA]	19850644
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of FADS2 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of FADS2 mRNA	19638242
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FADS2 mRNA	22129741
C042080	diisodecyl phthalate	diisodecyl phthalate results in increased expression of FADS2 mRNA	25825955
D004237	Diuron	Diuron results in increased expression of FADS2 mRNA	21551480
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of FADS2 mRNA	20064776
D000431	Ethanol	Ethanol results in increased expression of FADS2 mRNA	19167417
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of FADS2 mRNA	16488489
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of FADS2 mRNA	17108234
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of FADS2 mRNA	23550701
D005001	Ethionine	Ethionine affects the expression of FADS2 mRNA	19483382
C034096	ethoxyacetic acid	ethoxyacetic acid affects the expression of FADS2 mRNA	21621602
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of FADS2 mRNA	28189721
D005228	Fatty Acids, Essential	"Fatty Acids, Essential deficiency results in increased expression of FADS2 mRNA"	23333450
D005228	Fatty Acids, Essential	"NR1H2 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of FADS2 mRNA]"	23333450
D005228	Fatty Acids, Essential	"NR1H3 gene mutant form inhibits the reaction [Fatty Acids, Essential deficiency results in increased expression of FADS2 mRNA]"	23333450
D005231	Fatty Acids, Unsaturated	"[Paliperidone Palmitate results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated"	21458237
D005231	Fatty Acids, Unsaturated	"[Risperidone results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated"	21458237
D005395	Fish Oils	Fish Oils results in decreased expression of FADS2 mRNA	15654130
C061365	flusilazole	flusilazole affects the expression of FADS2 mRNA	21621602
D005485	Flutamide	Flutamide results in decreased expression of FADS2 mRNA	24136188
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FADS2 gene	20938992
D015248	Gemfibrozil	Gemfibrozil results in increased activity of FADS2 protein	7606338
D019833	Genistein	Genistein results in decreased expression of FADS2 mRNA	20816778
D005897	Glafenine	Glafenine results in decreased expression of FADS2 mRNA	24136188
D017313	Fenretinide	Fenretinide results in increased expression of FADS2 mRNA	28973697
D019469	Indinavir	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA	16931933
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of FADS2 mRNA	21396975
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FADS2 mRNA	22129741
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FADS2 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of FADS2 mRNA	28628672
D007529	Isoflavones	Isoflavones results in increased expression of FADS2 mRNA	17374662
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of FADS2 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of FADS2 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of FADS2 mRNA	26752646
C410337	K 7174	K 7174 results in decreased expression of FADS2 mRNA	24086573
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of FADS2 mRNA	20359477
D008383	Margarine	FADS2 gene SNP affects the susceptibility to Margarine	21793953
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of FADS2 mRNA	20823114
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of FADS2 mRNA	20353558
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FADS2 gene	20938992
D008727	Methotrexate	FADS2 protein affects the susceptibility to Methotrexate	16217747
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of FADS2 mRNA	21621602
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of FADS2 mRNA	23458150
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of FADS2 protein	26558463
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of FADS2 mRNA	23649840
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of FADS2 mRNA	29191790
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of FADS2 protein	24625837
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of FADS2 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of FADS2 mRNA"	25620056
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of FADS2 mRNA	19812364
C051752	nefazodone	nefazodone results in decreased expression of FADS2 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of FADS2 mRNA	24768652
C022838	nickel chloride	nickel chloride results in decreased expression of FADS2 mRNA	24612858
C012655	nimesulide	nimesulide results in decreased expression of FADS2 mRNA	24136188
D019787	Linoleic Acid	[Linoleic Acid co-treated with Testosterone] results in increased expression of FADS2 mRNA	21457203
D019787	Linoleic Acid	Linoleic Acid results in increased expression of FADS2 mRNA	21457203
D019787	Linoleic Acid	Linoleic Acid results in increased expression of FADS2 protein	21457203
D019787	Linoleic Acid	FADS2 protein inhibits the reaction [Linoleic Acid results in increased activity of LOX protein]	26240151
D015525	Fatty Acids, Omega-3	"Fatty Acids, Omega-3 results in decreased expression of FADS2 mRNA"	23333450
D015525	Fatty Acids, Omega-3	"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of FADS2 mRNA]"	23333450
D015525	Fatty Acids, Omega-3	"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Omega-3 results in decreased expression of FADS2 mRNA]"	23333450
D009853	Omeprazole	Omeprazole affects the expression of FADS2 mRNA	19483382
C016340	o,p'-DDT	"o,p'-DDT results in decreased expression of FADS2 mRNA"	18204070
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of FADS2 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of FADS2 mRNA	25729387
D000068882	Paliperidone Palmitate	Paliperidone Palmitate results in increased expression of FADS2 mRNA	21458237
D000068882	Paliperidone Palmitate	"[Paliperidone Palmitate results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated"	21458237
D000073878	Palm Oil	Palm Oil affects the expression of FADS2 mRNA	19680557
D010269	Paraquat	Paraquat results in decreased expression of FADS2 mRNA	21371552
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of FADS2 mRNA	18692542
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of FADS2 protein	26879310
C031181	phenanthrene	phenanthrene results in increased expression of FADS2 mRNA	19457238
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of FADS2 mRNA	26678675
D010634	Phenobarbital	Phenobarbital affects the expression of FADS2 mRNA	19136022
C415326	phenoxyacetic acid	phenoxyacetic acid affects the expression of FADS2 mRNA	21621602
D010743	Phospholipids	[troglitazone results in decreased expression of FADS2 mRNA] which affects the abundance of Phospholipids	11916926
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of FADS2 mRNA	15728792
D010840	Phytosterols	APOE gene mutant form affects the reaction [Phytosterols results in increased expression of FADS2 mRNA]	18155511
C014153	pirimiphos methyl	pirimiphos methyl results in decreased expression of FADS2 mRNA	27845199
C006253	pirinixic acid	pirinixic acid affects the expression of FADS2 mRNA	19136022
C006253	pirinixic acid	pirinixic acid results in increased expression of FADS2 mRNA	16357043\|1830175
C006253	pirinixic acid	pirinixic acid affects the expression of FADS2 mRNA	19483382
C006253	pirinixic acid	pirinixic acid results in increased expression of FADS2 mRNA	15654130\|2248451
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of FADS2 mRNA	22714537
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of FADS2 mRNA	28903501
D011374	Progesterone	Progesterone results in increased expression of FADS2 mRNA	20631399\|2301239
D011374	Progesterone	Progesterone results in increased expression of FADS2 mRNA	18070364
D011441	Propylthiouracil	Propylthiouracil affects the expression of FADS2 mRNA	19483382
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of FADS2 mRNA	24780913
C030984	pyrene	pyrene results in decreased expression of FADS2 mRNA	23656968
C030984	pyrene	pyrene results in increased expression of FADS2 mRNA	15963578
C502851	quinocetone	quinocetone results in increased expression of FADS2 mRNA	27046791
D015474	Isotretinoin	Isotretinoin results in decreased expression of FADS2 mRNA	20436886
D018967	Risperidone	Risperidone results in increased expression of FADS2 mRNA	21458237
D018967	Risperidone	"[Risperidone results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated"	21458237
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of FADS2 mRNA	21427059
D019258	Saquinavir	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA	16931933
C009250	sevoflurane	sevoflurane affects the expression of FADS2 mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of FADS2 mRNA	25895662
D012906	Smoke	Smoke affects the expression of FADS2 mRNA	23693141
C009277	sodium arsenate	sodium arsenate results in decreased expression of FADS2 mRNA	23922661
C016104	sodium bichromate	sodium bichromate results in decreased expression of FADS2 mRNA	25993096
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of FADS2 protein	28918527
C473478	sunitinib	sunitinib results in increased expression of FADS2 mRNA	23707608
D014284	Triiodothyronine	Triiodothyronine results in increased expression of FADS2 mRNA	15953391
C013698	tallow	tallow affects the expression of FADS2 mRNA	19680557
D013629	Tamoxifen	Tamoxifen results in decreased expression of FADS2 mRNA	25123088
D013629	Tamoxifen	[Tamoxifen co-treated with bexarotene] results in increased expression of FADS2 mRNA	17630414
D013629	Tamoxifen	Tamoxifen results in decreased expression of FADS2 mRNA	17630414
C030141	taurine-ursodeoxycholate conjugate	taurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of FADS2 mRNA]	21079772
D013739	Testosterone	[Linoleic Acid co-treated with Testosterone] results in increased expression of FADS2 mRNA	21457203
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FADS2 mRNA	21998131\|2623829
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FADS2 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of FADS2 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FADS2 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FADS2 mRNA	18796159\|2629044
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of FADS2 mRNA	21724226
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of FADS2 mRNA	21215274
D013849	Thimerosal	Thimerosal results in decreased expression of FADS2 mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of FADS2 mRNA	19483382
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of FADS2 mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of FADS2 mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of FADS2 mRNA	25729387
D014204	Trenbolone Acetate	Trenbolone Acetate results in increased expression of FADS2 mRNA	16488489
D014212	Tretinoin	Tretinoin results in decreased expression of FADS2 mRNA	20530235
D014241	Trichloroethylene	Trichloroethylene results in increased expression of FADS2 mRNA	25549359
C012589	trichostatin A	trichostatin A results in decreased expression of FADS2 mRNA	27188386
D014280	Triglycerides	[troglitazone results in decreased expression of FADS2 mRNA] which affects the abundance of Triglycerides	11916926
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of FADS2 mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of FADS2 mRNA	11916926
C057693	troglitazone	[troglitazone results in decreased expression of FADS2 mRNA] which affects the abundance of Cholesterol Esters	11916926
C057693	troglitazone	[troglitazone results in decreased expression of FADS2 mRNA] which affects the abundance of Phospholipids	11916926
C057693	troglitazone	[troglitazone results in decreased expression of FADS2 mRNA] which affects the abundance of Triglycerides	11916926
C057693	troglitazone	troglitazone results in decreased expression of FADS2 mRNA	28973697
C057693	troglitazone	troglitazone inhibits the reaction [Dietary Sucrose results in increased activity of FADS2 protein]	15763435
C057693	troglitazone	troglitazone inhibits the reaction [Dietary Sucrose results in increased expression of FADS2 mRNA]	15763435
D014520	Urethane	Urethane results in decreased expression of FADS2 mRNA	28818685
C406224	valdecoxib	valdecoxib results in decreased expression of FADS2 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of FADS2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of FADS2 mRNA	23179753\|2718838
D014635	Valproic Acid	Valproic Acid results in decreased expression of FADS2 mRNA	21427059
C025643	vinclozolin	vinclozolin results in increased expression of FADS2 mRNA	22570695
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of FADS2 mRNA	26682919
C111237	vorinostat	vorinostat results in decreased expression of FADS2 mRNA	27188386
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of FADS2 mRNA	16931933
D015215	Zidovudine	[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA	16931933
C088658	zoledronic acid	zoledronic acid results in increased expression of FADS2 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004768	stearoyl-CoA 9-desaturase activity	-	IEA	-
GO:0016213	linoleoyl-CoA desaturase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006636	unsaturated fatty acid biosynthetic process	-	IEA	-
GO:0036109	alpha-linolenic acid metabolic process	-	TAS	-
GO:0043651	linoleic acid metabolic process	-	TAS	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	9867867
GO:0016020	membrane	-	HDA	19946888

KEGG ID	KEGG Term
hsa00592	alpha-Linolenic acid metabolism
hsa01040	Biosynthesis of unsaturated fatty acids
hsa03320	PPAR signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	IEA
R-HSA-1430728	Metabolism	TAS
R-HSA-2046104	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	IEA
R-HSA-2046104	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	TAS
R-HSA-2046105	Linoleic acid (LA) metabolism	TAS
R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	IEA
R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	TAS
R-HSA-556833	Metabolism of lipids	IEA
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-8978868	Fatty acid metabolism	IEA
R-HSA-8978868	Fatty acid metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24346170	Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). (2014 Jan 29)	Meyers KJ	Invest Ophthalmol Vis Sci
22743310	Circulating and dietary alpha-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study. (2012 Aug)	Lemaitre RN	Am J Clin Nutr
21040914	FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease. (2011 Jan)	Kwak JH	Atherosclerosis