Gene info: ID 942

Gene: CD86

GENE ID: 942

Synonyms: B7-2|B7.2|B70|CD28LG2|LAB72

Description: CD86 molecule

Gene type: protein-coding

Location: 3q13.33

dbXrefs: Ensembl:ENSG00000114013 MIM:601020 Vega:OTTHUMG00000159482 UniprotKB:P42081

RefSeq: NG_029928.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 19

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.220e-1 (AD) 9.544e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C3AR1	0.934
BTK	0.933
SYK	0.922
LAPTM5	0.921
CLEC7A	0.92
DOCK2	0.918
NCKAP1L	0.915
PTPRC	0.915
IL18	0.913
TFEC	0.911

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP2C2	-0.411
KCNIP3	-0.393
WNT7A	-0.381
CPLX3	-0.366
ZNF835	-0.365
MAGIX	-0.365
CHRNA4	-0.349
ST6GAL2	-0.345
MARCH4	-0.343
ZSCAN1	-0.342

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00098	Antithymocyte immunoglobulin (rabbit)	BiotechDrug		Approved	Target
DB01281	Abatacept	BiotechDrug	332348-12-6	Approved	Target
DB06681	Belatacept	BiotechDrug	706808-37-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C025205	1,10-phenanthroline	"1,10-phenanthroline results in increased expression of CD86 mRNA"	19641517
C025205	1,10-phenanthroline	"Acetylcysteine inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]"	19641517
C025205	1,10-phenanthroline	"SB 203580 inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]"	19641517
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of CD86 mRNA"	19162173
C033020	1-aminobenzotriazole	1-aminobenzotriazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CD86 protein]	21742781
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CD86 protein	21097750
C028358	24,25-epoxycholesterol	"24,25-epoxycholesterol results in increased expression of CD86 protein"	17475839
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [alitretinoin results in increased expression of CD86 protein]	17475839
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in increased expression of CD86 protein]	17475839
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of CD86 protein	19033392
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	19148301
C054189	3,5-di-tert-butylchalcone 4'-carboxylic acid	"3,5-di-tert-butylchalcone 4'-carboxylic acid results in increased expression of CD86 protein"	17475839
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CD86 mRNA"	25380136
C005969	4,4'-diphenylmethane diisocyanate	"4,4'-diphenylmethane diisocyanate results in increased expression of CD86 protein"	19665512
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of CD86 mRNA	19191707
C029728	4-phenylenediamine	4-phenylenediamine results in increased expression of CD86 protein	12423654\|1903339
C029728	4-phenylenediamine	bisindolylmaleimide I inhibits the reaction [4-phenylenediamine results in increased expression of CD86 protein]	24136171
C111855	6-formylindolo(3,2-b)carbazole	"6-formylindolo(3,2-b)carbazole results in decreased expression of CD86 protein"	27783115
C111855	6-formylindolo(3,2-b)carbazole	"[Lipopolysaccharides co-treated with 6-formylindolo(3,2-b)carbazole] results in decreased expression of CD86 protein"	27783115
C111855	6-formylindolo(3,2-b)carbazole	"6-formylindolo(3,2-b)carbazole results in increased expression of CD86 protein"	20350561\|2109775
D000082	Acetaminophen	Acetaminophen results in decreased expression of CD86 mRNA	17585979
D000082	Acetaminophen	Acetaminophen affects the expression of CD86 mRNA	19784758
D000082	Acetaminophen	Acetaminophen results in decreased expression of CD86 mRNA	19784758
D000082	Acetaminophen	Acetaminophen results in increased expression of CD86 mRNA	19784758
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	21628959
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Eugenol results in increased expression of CD86 protein]	21628959
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [phenylacetaldehyde results in increased expression of CD86 protein]	21628959
D000111	Acetylcysteine	"Acetylcysteine inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]"	19641517
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	19033392\|2041722
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]	20417223\|2045721
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CD86 protein]	20417223
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]	20417223
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Thimerosal results in increased expression of CD86 protein]	20417223\|2045721
D000119	Acetylmuramyl-Alanyl-Isoglutamine	[Acetylmuramyl-Alanyl-Isoglutamine co-treated with FK 565] results in increased expression of CD86 protein	16299289
D000119	Acetylmuramyl-Alanyl-Isoglutamine	[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD86 protein	16299289
D000119	Acetylmuramyl-Alanyl-Isoglutamine	Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of CD86 protein	16299289
C022571	adenosine 5'-O-(3-thiotriphosphate)	adenosine 5'-O-(3-thiotriphosphate) results in increased expression of CD86 protein	15944274
D037361	Adenylate Cyclase Toxin	Adenylate Cyclase Toxin results in increased expression of CD86 protein	14977963
D037361	Adenylate Cyclase Toxin	Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD86 protein]	14977963
D000276	Adjuvants, Immunologic	"Adjuvants, Immunologic results in increased expression of CD86 protein"	11160013
D015766	Albendazole	[Albendazole co-treated with CYP3A4 protein] results in increased expression of CD86 protein	22785256
C103303	alitretinoin	2-chloro-5-nitrobenzanilide inhibits the reaction [alitretinoin results in increased expression of CD86 protein]	17475839
C103303	alitretinoin	[alitretinoin co-treated with rosiglitazone] results in increased expression of CD86 protein	17475839
C103303	alitretinoin	alitretinoin results in increased expression of CD86 protein	17475839
C103303	alitretinoin	HX 630 inhibits the reaction [alitretinoin results in increased expression of CD86 protein]	17475839
C005197	alternariol	alternariol results in increased expression of CD86 protein	26341179
C005197	alternariol	alternariol results in increased expression of CD86 protein	26341179
D000534	Alum Compounds	Alum Compounds promotes the reaction [CSF2 protein results in increased expression of CD86 protein]	18390722
D000534	Alum Compounds	Alum Compounds results in increased expression of CD86 protein	18390722
D000536	Aluminum Hydroxide	Aluminum Hydroxide promotes the reaction [CSF2 protein results in increased expression of CD86 protein]	18390722
D000536	Aluminum Hydroxide	Aluminum Hydroxide results in increased expression of CD86 protein	11160013\|1839072
D000638	Amiodarone	[Amiodarone co-treated with CYP3A4 protein] results in increased expression of CD86 protein	22785256
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of CD86 mRNA	16483693
C018453	ammonium hexachloroplatinate	ammonium hexachloroplatinate results in increased expression of CD86 protein	19665512
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CD86 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of CD86 mRNA	15761015
C006632	arsenic trioxide	arsenic trioxide results in increased expression of CD86 mRNA	20458559
C015001	arsenite	arsenite results in decreased expression of CD86 mRNA	18191166
D001194	Asbestos	Asbestos affects the expression of CD86 mRNA	17297452
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in decreased expression of CD86 protein	16387846
C547126	AZM551248	AZM551248 results in increased expression of CD86 mRNA	22323515
C051597	Bandrowski's base	Bandrowski's base affects the expression of CD86 mRNA	18202158
C051597	Bandrowski's base	Bandrowski's base results in increased expression of CD86 protein	19665512\|2174278
C416282	BAY 11-7085	BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]	17636246
D001554	Benzene	Benzene results in increased expression of CD86 mRNA	19162166
D001564	Benzo(a)pyrene	1-aminobenzotriazole inhibits the reaction [Benzo(a)pyrene results in increased expression of CD86 protein]	21742781
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CD86 protein	21742781
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CD86 mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CD86 mRNA	22228805
C013409	benzoyl chloride	benzoyl chloride results in increased expression of CD86 protein	19665512
C020711	beryllium sulfate	beryllium sulfate results in increased expression of CD86 protein	19665512
D004958	Estradiol	Estradiol affects the expression of CD86 mRNA	22574217
D004958	Estradiol	Estradiol promotes the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	28811679
D004958	Estradiol	Estradiol results in increased expression of CD86 protein	28811679
D004958	Estradiol	[Estradiol results in increased susceptibility to CpG ODN 1826] which results in increased expression of CD86 protein	28811679
D047071	beta-Glucans	beta-Glucans results in increased expression of CD86 protein	17572156
D001624	Betamethasone Valerate	Betamethasone Valerate results in decreased expression of CD86 protein	15940147
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [4-phenylenediamine results in increased expression of CD86 protein]	24136171
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein]	24136171
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	24136171
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of CD86 mRNA	18958704
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of CD86 protein	20457211
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CD86 mRNA	20360939
C005563	captax	captax results in increased expression of CD86 protein	12423654
D002248	Carbon Monoxide	Carbon Monoxide results in decreased expression of CD86 protein	12201358
C469298	CEP-11004	CEP-11004 inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	17698565
C469298	CEP-11004	CEP-11004 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]	17698565
D002509	Cephaloridine	Cephaloridine results in increased expression of CD86 mRNA	18500788
C016300	chloramine-T	chloramine-T results in increased expression of CD86 protein	19665512
D002746	Chlorpromazine	Chlorpromazine results in increased expression of CD86 protein	19665512
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of CD86 protein	23994500
D002858	Chromium Alloys	Chromium Alloys results in decreased secretion of CD86 protein	19844976
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of CD86	17026843
C017133	chromous chloride	chromous chloride results in increased expression of CD86 protein	16099135
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of CD86 mRNA	19524605
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of CD86 protein	19665512\|2048824
C012843	cinnamic aldehyde	cinnamic aldehyde results in decreased expression of CD86 mRNA	28219650
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of CD86 protein	11244134
D002990	Clobetasol	Clobetasol results in decreased expression of CD86 protein	15086553
D004002	Clodronic Acid	Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD86 protein]	15892581
C055162	clopidogrel	clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA]	19172522
C018021	cobaltous chloride	cobaltous chloride results in increased expression of CD86 protein	19665512
C018021	cobaltous chloride	cobaltous chloride results in increased secretion of CD86 protein	19844976
C423449	CpG ODN 1826	CpG ODN 1826 results in increased expression of CD86 protein	16890772
C423449	CpG ODN 1826	Particulate Matter analog inhibits the reaction [CpG ODN 1826 results in increased expression of CD86 protein]	16890772
C423449	CpG ODN 1826	Vehicle Emissions analog inhibits the reaction [CpG ODN 1826 results in increased expression of CD86 protein]	16890772
C423449	CpG ODN 1826	[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of CD86 protein	21097750
C423449	CpG ODN 1826	[Estradiol results in increased susceptibility to CpG ODN 1826] which results in increased expression of CD86 protein	28811679
C423449	CpG ODN 1826	Tetrachlorodibenzodioxin promotes the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of CD86 protein]	21097750
C025390	creosol	creosol results in increased expression of CD86 protein	21742781
D003545	Cysteine	Cysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	20457211
D003545	Cysteine	Cysteine inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]	20457211
D003545	Cysteine	Cysteine inhibits the reaction [Thimerosal results in increased expression of CD86 protein]	20457211
C004742	daidzein	daidzein inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	21945492
D003634	DDT	"DDT inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein]"	28412309
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CD86 protein	22972382
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of CD86 mRNA	23914054
C014347	decitabine	decitabine results in increased expression of CD86 protein	19401350
D003703	Demecolcine	Demecolcine results in increased expression of CD86 mRNA	23649840
C007262	deoxynivalenol	deoxynivalenol results in increased expression of CD86 mRNA	21074547
C451162	Dermatophagoides pteronyssinus antigen p 1	CD86 protein affects the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]	12023397
C451162	Dermatophagoides pteronyssinus antigen p 1	CD86 protein affects the reaction [Particulate Matter analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]	12023397
C451162	Dermatophagoides pteronyssinus antigen p 1	CD86 protein affects the reaction [Vehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]	12023397
D003976	Diazinon	Diazinon results in increased expression of CD86 protein	28119078
D002945	Cisplatin	Cisplatin results in increased expression of CD86 mRNA	27594783
D003633	Dichlorodiphenyl Dichloroethylene	"Dichlorodiphenyl Dichloroethylene inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein]"	28412309
D001728	Dicumarol	[Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]	21742781
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in increased expression of CD86 mRNA	17490981
C014476	diethyl maleate	bisindolylmaleimide I inhibits the reaction [diethyl maleate results in increased expression of CD86 protein]	24136171
C014476	diethyl maleate	diethyl maleate results in increased expression of CD86 protein	24136171
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of CD86 mRNA	20360939
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of CD86 protein	15794588
D002117	Calcitriol	Calcitriol results in decreased expression of CD86 protein	10679076
D002117	Calcitriol	Calcitriol results in increased expression of CD86 mRNA	16002434
D002117	Calcitriol	[CD40LG protein co-treated with Calcitriol] results in decreased expression of CD86 protein	19186073
C012125	diisononyl phthalate	diisononyl phthalate results in increased expression of CD86 protein	20064775
D004117	Dimethoate	Dimethoate results in increased expression of CD86 protein	23994500
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of CD86 mRNA	25380136
D004137	Dinitrochlorobenzene	Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	21628959
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CD86 protein	21628959
D004137	Dinitrochlorobenzene	Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	19033392\|2041722
D004137	Dinitrochlorobenzene	bisindolylmaleimide I inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	24136171
D004137	Dinitrochlorobenzene	Cysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	20457211
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CD86 mRNA	17374397
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CD86 protein	12423654\|1573719
D004137	Dinitrochlorobenzene	Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	20457211
D004137	Dinitrochlorobenzene	Vitamin E inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	20457211
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene affects the expression of CD86 mRNA	28219650
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene promotes the reaction [TNF protein results in increased expression of CD86 protein]	17636246
D004137	Dinitrochlorobenzene	TNF protein promotes the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	17636246
D004139	Dinitrofluorobenzene	Dinitrofluorobenzene results in increased expression of CD86 protein	21362464
C062963	diphenylcarboxylate	diphenylcarboxylate results in increased expression of CD86 protein	19665512
D004237	Diuron	Diuron results in decreased expression of CD86 mRNA	21551480
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of CD86 protein"	15894585
D004365	Drugs, Chinese Herbal	"helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD86 protein]"	15894585
C044101	endotoxin, Escherichia coli	"DDT inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein]"	28412309
C044101	endotoxin, Escherichia coli	"Dichlorodiphenyl Dichloroethylene inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein]"	28412309
C044101	endotoxin, Escherichia coli	"endotoxin, Escherichia coli results in increased expression of CD86 protein"	28412309
C044101	endotoxin, Escherichia coli	"Nandrolone promotes the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein]"	28412309
D060754	Equol	Equol inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	21945492
D004964	Estriol	Estriol results in increased expression of CD86 protein	21317386
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of CD86 mRNA	17942748
C004919	ethylene dimethacrylate	ethylene dimethacrylate results in increased expression of CD86 protein	19665512
D005034	Ethylmercuric Chloride	Acetylcysteine inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]	20417223\|2045721
D005034	Ethylmercuric Chloride	Cysteine inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]	20457211
D005034	Ethylmercuric Chloride	Ethylmercuric Chloride results in increased expression of CD86 protein	20417223\|2045721
D005034	Ethylmercuric Chloride	Glutathione inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]	20457211
D005034	Ethylmercuric Chloride	Vitamin E inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]	20457211
D005054	Eugenol	Acetylcysteine inhibits the reaction [Eugenol results in increased expression of CD86 protein]	21628959
D005054	Eugenol	Eugenol results in increased expression of CD86 protein	21628959
D005054	Eugenol	[Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]	21742781
D005054	Eugenol	Eugenol results in increased expression of CD86 protein	12423654\|2048824
C039537	FK 565	[Acetylmuramyl-Alanyl-Isoglutamine co-treated with FK 565] results in increased expression of CD86 protein	16299289
C039537	FK 565	[FK 565 co-treated with Lipopolysaccharides] results in increased expression of CD86 protein	16299289
C039537	FK 565	FK 565 results in increased expression of CD86 protein	16299289
D005411	Flame Retardants	Flame Retardants analog results in increased expression of CD86 protein	22972382
D016650	Fluorescein-5-isothiocyanate	Fluorescein-5-isothiocyanate results in increased expression of CD86 protein	19665512
D005557	Formaldehyde	Formaldehyde results in increased expression of CD86 mRNA	23649840\|2766457
C460864	FSL-1 lipoprotein, synthetic	"FSL-1 lipoprotein, synthetic results in increased expression of CD86 protein"	16890772
C460864	FSL-1 lipoprotein, synthetic	"Particulate Matter analog inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of CD86 protein]"	16890772
C460864	FSL-1 lipoprotein, synthetic	"Vehicle Emissions analog inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of CD86 protein]"	16890772
D062610	Fungal Polysaccharides	Fungal Polysaccharides results in increased expression of CD86 protein	28235615
D062610	Fungal Polysaccharides	pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased expression of CD86 protein]	28235615
C039281	furan	furan results in increased expression of CD86 mRNA	27387713
D019833	Genistein	"Genistein analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein]"	25447760
D019833	Genistein	Genistein inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	21945492
C027478	glucuronoxylomannan	glucuronoxylomannan results in increased expression of CD86 protein	12864811
D005976	Glutaral	Glutaral results in increased expression of CD86 protein	19665512
D005978	Glutathione	Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	20457211
D005978	Glutathione	Glutathione inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]	20457211
D005978	Glutathione	Glutathione inhibits the reaction [Thimerosal results in increased expression of CD86 protein]	20457211
C001329	helenalin	"helenalin inhibits the reaction [Drugs, Chinese Herbal results in increased expression of CD86 protein]"	15894585
C001329	helenalin	helenalin inhibits the reaction [Polysaccharides results in increased expression of CD86 protein]	15894585
C089796	hexabromocyclododecane	hexabromocyclododecane results in increased expression of CD86 protein	22972382
C422175	HX 630	HX 630 inhibits the reaction [alitretinoin results in increased expression of CD86 protein]	17475839
D006854	Hydrocortisone	Hydrocortisone results in decreased expression of CD86 protein	15241357
D006854	Hydrocortisone	Hydrocortisone results in decreased expression of CD86 protein	15086553
D006861	Hydrogen Peroxide	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CD86 protein]	20417223
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of CD86 protein	20417223\|2045721
C031927	hydroquinone	hydroquinone results in increased expression of CD86 protein	19665512
C031927	hydroquinone	hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	19148301
C056493	imiquimod	[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein	21097750
C056493	imiquimod	Tetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein]	21097750
C474021	indirubin-3'-monoxime	AHR protein affects the susceptibility to [indirubin-3'-monoxime results in decreased expression of CD86 protein]	21948866
C474021	indirubin-3'-monoxime	indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	21948866
C474021	indirubin-3'-monoxime	indirubin-3'-monoxime results in decreased expression of CD86 protein	21948866
C474021	indirubin-3'-monoxime	[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD86 protein	21948866
C016517	indole-3-carbinol	indole-3-carbinol results in decreased expression of CD86 protein	27783115
C016517	indole-3-carbinol	[Lipopolysaccharides co-treated with indole-3-carbinol] results in decreased expression of CD86 protein	27783115
C016517	indole-3-carbinol	AHR protein affects the susceptibility to [indole-3-carbinol results in increased expression of CD86 protein]	21948866
C016517	indole-3-carbinol	indole-3-carbinol promotes the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	21948866
C016517	indole-3-carbinol	indole-3-carbinol results in decreased expression of CD86 protein	21948866
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of CD86 protein	21948866
C016517	indole-3-carbinol	[Lipopolysaccharides co-treated with indole-3-carbinol] results in increased expression of CD86 protein	21948866
D007455	Iodine	Iodine results in increased expression of CD86 mRNA	19035182
D015759	Ionomycin	Ionomycin results in decreased expression of CD86 protein	23376802
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of CD86 mRNA	15618438
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	25725100
D007612	Kanamycin	Kanamycin results in increased expression of CD86 protein	19665512
C008261	lead acetate	[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD86 protein	17512567
C017461	lead nitrate	lead nitrate results in increased expression of CD86 protein	23376802
C018584	linalool	linalool metabolite results in increased expression of CD86 protein	29029310
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CD86 protein"	17630318\|2567329
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CD86 protein"	23624183
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 mRNA]"	12794122
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 mRNA"	12794122
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Genistein analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein]"	25447760
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein"	23353651\|2544776
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein]"	23353651
C440499	lipopolysaccharide, Escherichia coli O111 B4	"TOLLIP protein affects the reaction [Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein]]"	23353651
D008070	Lipopolysaccharides	[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD86 protein	16299289
D008070	Lipopolysaccharides	CD86 protein affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]	12538815
D008070	Lipopolysaccharides	CEP-11004 inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	17698565
D008070	Lipopolysaccharides	CSF2 protein affects the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	25725100
D008070	Lipopolysaccharides	[FK 565 co-treated with Lipopolysaccharides] results in increased expression of CD86 protein	16299289
D008070	Lipopolysaccharides	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	25725100
D008070	Lipopolysaccharides	"[Lipopolysaccharides co-treated with 6-formylindolo(3,2-b)carbazole] results in decreased expression of CD86 protein"	27783115
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with indole-3-carbinol] results in decreased expression of CD86 protein	27783115
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CD86 protein	27783115
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of CD86 mRNA	18192897
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD86 protein	11884429\|1253881
D008070	Lipopolysaccharides	NFE2L2 protein affects the reaction [Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]]	16890772
D008070	Lipopolysaccharides	NFE2L2 protein affects the reaction [Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]]	16890772
D008070	Lipopolysaccharides	Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	16890772
D008070	Lipopolysaccharides	[resveratrol co-treated with Lipopolysaccharides] results in increased expression of CD86 protein	15135313
D008070	Lipopolysaccharides	SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	17698565
D008070	Lipopolysaccharides	Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	16890772
D008070	Lipopolysaccharides	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	19148301
D008070	Lipopolysaccharides	clopidogrel inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 mRNA]	19172522
D008070	Lipopolysaccharides	daidzein inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	21945492
D008070	Lipopolysaccharides	Equol inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	21945492
D008070	Lipopolysaccharides	Estradiol promotes the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	28811679
D008070	Lipopolysaccharides	Genistein inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	21945492
D008070	Lipopolysaccharides	hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	19148301
D008070	Lipopolysaccharides	indirubin-3'-monoxime inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	21948866
D008070	Lipopolysaccharides	indole-3-carbinol promotes the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	21948866
D008070	Lipopolysaccharides	Lipopolysaccharides affects the expression of CD86 protein	24561310
D008070	Lipopolysaccharides	[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of CD86 protein	21097750
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with CSF2 protein] results in increased expression of CD86 protein	17512567
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with indirubin-3'-monoxime] results in decreased expression of CD86 protein	21948866
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with indole-3-carbinol] results in increased expression of CD86 protein	21948866
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with lead acetate co-treated with CSF2 protein] results in increased expression of CD86 protein	17512567
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD86 mRNA	22024136
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD86 protein	15618177\|1689077
D008070	Lipopolysaccharides	Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein]	24561310
D008070	Lipopolysaccharides	Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	16890772
D008070	Lipopolysaccharides	pyrithione inhibits the reaction [Lipopolysaccharides results in increased expression of CD86]	17126599
D008070	Lipopolysaccharides	Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	16081843
D008070	Lipopolysaccharides	Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	20348231
D008070	Lipopolysaccharides	Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of CD86 protein]	21097750
D008070	Lipopolysaccharides	Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	16890772
C480546	lupane	lupane results in increased expression of CD86 protein	16388738
C078795	LW 50020	LW 50020 results in increased expression of CD86 protein	15246609
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CD86 mRNA	26378955
C025340	manganese chloride	manganese chloride results in increased expression of CD86 protein	15737199
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of CD86 protein	20417223\|2045721
D008727	Methotrexate	Methotrexate results in decreased expression of CD86 mRNA	17400583
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CD86 protein	20417223\|2045721
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CD86 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of CD86 promoter"	26251327
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of CD86 protein	26254549
D015655	1-Methyl-4-phenylpyridinium	TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CD86 protein]	26254549
C089950	MF59 oil emulsion	MF59 oil emulsion promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD86 protein]	18390722
C089950	MF59 oil emulsion	MF59 oil emulsion promotes the reaction [CSF2 protein results in increased expression of CD86 protein]	18390722
C089950	MF59 oil emulsion	MF59 oil emulsion results in increased expression of CD86 protein	18390722
C523799	MRK 003	CD86 results in increased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of CD86 mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CD86 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CD86 mRNA"	25554681
D009355	Neomycin	Neomycin results in increased expression of CD86 protein	19665512
D009532	Nickel	Nickel results in increased expression of CD86 mRNA	24768652\|2558310
D009532	Nickel	Nickel results in increased expression of CD86 protein	19033392\|2362423
D009532	Nickel	CD86 protein results in increased susceptibility to Nickel	19844976
C022838	nickel chloride	nickel chloride results in increased expression of CD86 protein	15737199\|1966551
C022838	nickel chloride	nickel chloride results in increased secretion of CD86 protein	19844976
C029938	nickel sulfate	Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]	20417223
C029938	nickel sulfate	BAY 11-7085 inhibits the reaction [nickel sulfate results in increased expression of CD86 protein]	17636246
C029938	nickel sulfate	nickel sulfate affects the expression of CD86 mRNA	18202158
C029938	nickel sulfate	nickel sulfate results in increased expression of CD86 mRNA	16780908\|1737439
C029938	nickel sulfate	nickel sulfate results in increased expression of CD86 protein	16099135\|1763624
D009534	Niclosamide	Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein]	24561310
D009538	Nicotine	Nicotine results in increased expression of CD86 mRNA	27782041
D009569	Nitric Oxide	Nitric Oxide results in decreased expression of CD86 protein	13678430
D020030	Nitric Oxide Donors	Nitric Oxide Donors results in decreased expression of CD86 protein	13678430
D026422	S-Nitrosoglutathione	S-Nitrosoglutathione results in decreased expression of CD86 protein	13678430
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CD86 protein"	16892068
D016912	Levonorgestrel	[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of CD86 mRNA	19074003
D009277	Nandrolone	"Nandrolone promotes the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein]"	28412309
D009761	Nystatin	Nystatin results in increased expression of CD86 protein	16374455
C025589	ochratoxin A	ochratoxin A results in increased expression of CD86 mRNA	24792326
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of CD86 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of CD86 mRNA	25729387
D010081	Oxazolone	Oxazolone results in increased expression of CD86 mRNA	17374397
D010081	Oxazolone	Oxazolone results in increased expression of CD86 protein	24136171
D010100	Oxygen	Oxygen deficiency results in decreased expression of CD86 mRNA	24205000
D010126	Ozone	Ozone results in increased expression of CD86 protein	15036748
D010269	Paraquat	Paraquat results in decreased expression of CD86 mRNA	28467894
D010269	Paraquat	Paraquat results in increased expression of CD86 mRNA	24521700
D052638	Particulate Matter	CD86 protein affects the reaction [Particulate Matter analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]	12023397
D052638	Particulate Matter	GSTM1 mutant form promotes the reaction [Particulate Matter results in increased expression of CD86]	21169129
D052638	Particulate Matter	HBA1 alternative form promotes the reaction [Particulate Matter results in increased expression of CD86]	21169129
D052638	Particulate Matter	NFE2L2 protein affects the reaction [Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]]	16890772
D052638	Particulate Matter	Particulate Matter analog inhibits the reaction [CpG ODN 1826 results in increased expression of CD86 protein]	16890772
D052638	Particulate Matter	"Particulate Matter analog inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of CD86 protein]"	16890772
D052638	Particulate Matter	Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	16890772
D052638	Particulate Matter	Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein]	16890772
D052638	Particulate Matter	Particulate Matter results in increased expression of CD86	21169129
D052638	Particulate Matter	Particulate Matter results in increased expression of CD86 protein	17630318
D052638	Particulate Matter	Particulate Matter analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	16890772
D052638	Particulate Matter	Particulate Matter results in increased expression of CD86 mRNA	23638009
C008776	pelargonic acid	pelargonic acid results in increased expression of CD86 protein	19665512
D010400	Penicillin G	Penicillin G results in increased expression of CD86 protein	19665512
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of CD86 protein	22972382
C025080	Peruvian balsam	Peruvian balsam results in increased expression of CD86 protein	19665512
C040601	phenanthridone	phenanthridone results in decreased expression of CD86 mRNA	17579050
C040601	phenanthridone	phenanthridone results in decreased expression of CD86 protein	17579050
C013192	phenylacetaldehyde	Acetylcysteine inhibits the reaction [phenylacetaldehyde results in increased expression of CD86 protein]	21628959
C013192	phenylacetaldehyde	phenylacetaldehyde results in increased expression of CD86 protein	21628959
C006253	pirinixic acid	pirinixic acid results in decreased expression of CD86 mRNA	20813756
D010936	Plant Extracts	Plant Extracts results in increased expression of CD86	23246459
D010936	Plant Extracts	Plant Extracts results in increased expression of CD86 protein	23108216
D010938	Plant Oils	Plant Oils results in increased expression of CD86 mRNA	23370395
D028321	Plant Preparations	Plant Preparations results in increased expression of CD86 protein	25019244
D011070	Poly I-C	CEP-11004 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]	17698565
D011070	Poly I-C	Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein]	16890772
D011070	Poly I-C	[Poly I-C co-treated with IFNG protein] results in increased secretion of CD86 protein	16224278
D011070	Poly I-C	Poly I-C results in increased expression of CD86 protein	15246609\|1689077
D011070	Poly I-C	SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]	17698565
D011070	Poly I-C	Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein]	16890772
D011112	Polymyxin B	Polymyxin B results in increased expression of CD86 protein	15671028
D011112	Polymyxin B	Polymyxin B inhibits the reaction [Adenylate Cyclase Toxin results in increased expression of CD86 protein]	14977963
D011134	Polysaccharides	helenalin inhibits the reaction [Polysaccharides results in increased expression of CD86 protein]	15894585
D011134	Polysaccharides	Polysaccharides results in increased expression of CD86 protein	15894585
D011134	Polysaccharides	Polysaccharides results in increased expression of CD86	23246459
D011134	Polysaccharides	Polysaccharides results in increased expression of CD86 protein	23108216\|2501924
D011136	Polysorbates	Polysorbates results in increased expression of CD86 protein	19665512
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of CD86 protein	16099135
C009005	potassium mercuric thiocyanate	potassium mercuric thiocyanate results in increased expression of CD86 protein	20457211
D011374	Progesterone	Progesterone results in decreased expression of CD86 protein	21856019
D011435	Propyl Gallate	Propyl Gallate results in increased expression of CD86 protein	19665512
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Fungal Polysaccharides results in increased expression of CD86 protein]	28235615
C023666	pyridine	pyridine results in increased expression of CD86 protein	19665512
C008704	pyrithione	pyrithione inhibits the reaction [Lipopolysaccharides results in increased expression of CD86]	17126599
D011794	Quercetin	"Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein]"	23353651
D011794	Quercetin	"TOLLIP protein affects the reaction [Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CD86 protein]]"	23353651
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	16081843
C059514	resveratrol	[resveratrol co-treated with Lipopolysaccharides] results in increased expression of CD86 protein	15135313
C059514	resveratrol	resveratrol results in increased expression of CD86 protein	15135313
C059514	resveratrol	resveratrol results in decreased expression of CD86 mRNA	22962611
C059514	resveratrol	resveratrol results in decreased expression of CD86 protein	14996416
C059514	resveratrol	[resveratrol co-treated with Streptozocin] results in increased expression of CD86 mRNA	25905778
C059514	resveratrol	resveratrol results in increased expression of CD86 mRNA	15827377\|2590577
C059514	resveratrol	resveratrol results in increased expression of CD86 protein	15827377
C059514	resveratrol	resveratrol inhibits the reaction [IFNG protein results in increased expression of CD86 protein]	15135313
C034206	Ribomunyl	IFNG protein promotes the reaction [Ribomunyl results in increased expression of CD86 protein]	11924914
C034206	Ribomunyl	[Ribomunyl co-treated with IFNG protein] results in increased secretion of CD86 protein	16224278
C034206	Ribomunyl	Ribomunyl results in increased expression of CD86 protein	11924914\|1524660
C089730	rosiglitazone	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in increased expression of CD86 protein]	17475839
C089730	rosiglitazone	[alitretinoin co-treated with rosiglitazone] results in increased expression of CD86 protein	17475839
C089730	rosiglitazone	rosiglitazone results in increased expression of CD86 protein	17475839
C093642	SB 203580	"SB 203580 inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]"	19641517
C093642	SB 203580	SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	17698565
C093642	SB 203580	SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]	17698565
C093642	SB 203580	SB 203580 inhibits the reaction [Zymosan results in increased expression of CD86 protein]	17698565
C078903	seocalcitol	seocalcitol results in increased expression of CD86 mRNA	12040012
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CD86 mRNA	23806026
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CD86 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CD86 mRNA	19073995
D019821	Simvastatin	Simvastatin results in decreased expression of CD86 protein	16387846
D020123	Sirolimus	Sirolimus results in decreased expression of CD86 protein	12531798
D012967	Sodium Dodecyl Sulfate	Sodium Dodecyl Sulfate results in increased expression of CD86 protein	19665512
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of CD86 mRNA	27257137
D012999	Soman	Soman results in increased expression of CD86 mRNA	19281266
D053260	Soot	Soot results in increased expression of CD86 mRNA	26551751
D013311	Streptozocin	Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD86 protein]	15892581
D013311	Streptozocin	Streptozocin results in increased expression of CD86 protein	15892581
D013311	Streptozocin	[resveratrol co-treated with Streptozocin] results in increased expression of CD86 mRNA	25905778
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CD86 mRNA	26378955
D016559	Tacrolimus	Tacrolimus results in decreased expression of CD86 protein	15241357
C043062	tesmilifene	tesmilifene results in decreased expression of CD86 protein	11306145
C010792	testosterone undecanoate	[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of CD86 mRNA	19074003
C010792	testosterone undecanoate	testosterone undecanoate results in increased expression of CD86 mRNA	19074003
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of CD86 protein	22972382
D013749	Tetrachlorodibenzodioxin	[Lipopolysaccharides co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CD86 protein	27783115
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [CD40LG protein results in increased expression of CD86 protein]	21807014
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [CD40LG protein results in increased expression of CD86 protein]	21807014
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CD86 mRNA	17101203
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CD86 protein	27783115
D013749	Tetrachlorodibenzodioxin	AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CD86 mRNA]	23999131
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CD86 protein]	20350561\|2109775
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	20348231
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased expression of CD86 protein]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased expression of CD86 protein]	21097750
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CD86 mRNA	18684927
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CD86 mRNA	17942748\|2399913
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CD86 protein	17681673\|2021193
C036919	tetrachloroplatinate	tetrachloroplatinate results in increased expression of CD86 protein	12423654\|1970243
C475227	thieno(2,3-c)isoquinolin-5-one	"thieno(2,3-c)isoquinolin-5-one results in decreased expression of CD86 mRNA"	17579050
C475227	thieno(2,3-c)isoquinolin-5-one	"thieno(2,3-c)isoquinolin-5-one results in decreased expression of CD86 protein"	17579050
D013849	Thimerosal	Acetylcysteine inhibits the reaction [Thimerosal results in increased expression of CD86 protein]	20417223\|2045721
D013849	Thimerosal	Cysteine inhibits the reaction [Thimerosal results in increased expression of CD86 protein]	20457211
D013849	Thimerosal	Glutathione inhibits the reaction [Thimerosal results in increased expression of CD86 protein]	20457211
D013849	Thimerosal	Thimerosal results in increased expression of CD86 protein	15737199\|2041722
D013849	Thimerosal	Vitamin E inhibits the reaction [Thimerosal results in increased expression of CD86 protein]	20457211
D013853	Thioacetamide	Thioacetamide results in increased expression of CD86 mRNA	19784758
D008063	Thioctic Acid	Thioctic Acid results in increased expression of CD86 protein	19033392
D013893	Thiram	Thiram results in increased expression of CD86 protein	19665512
C040654	titanium nickelide	titanium nickelide analog results in increased expression of CD86	22287114
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CD86 mRNA	28065790
D014028	Tobacco Smoke Pollution	[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of CD86 mRNA	24096154
D014028	Tobacco Smoke Pollution	[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of CD86 protein	24096154
D014028	Tobacco Smoke Pollution	NFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of CD86 mRNA]	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CD86 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of CD86 protein]	24096154
C024746	tobacco tar	tobacco tar results in decreased expression of CD86 mRNA	19559774
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of CD86 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of CD86 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of CD86 protein	15454112
C001899	triptolide	triptolide results in decreased expression of CD86 protein	15663903
C057693	troglitazone	troglitazone results in increased expression of CD86 mRNA	28973697
D001335	Vehicle Emissions	CD86 protein affects the reaction [Vehicle Emissions analog promotes the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased expression of CCL22 protein]]	12023397
D001335	Vehicle Emissions	NFE2L2 protein affects the reaction [Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]]	16890772
D001335	Vehicle Emissions	Vehicle Emissions analog inhibits the reaction [CpG ODN 1826 results in increased expression of CD86 protein]	16890772
D001335	Vehicle Emissions	"Vehicle Emissions analog inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of CD86 protein]"	16890772
D001335	Vehicle Emissions	Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	16890772
D001335	Vehicle Emissions	Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein]	16890772
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of CD86 protein	19900534
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of CD86 protein	17630318
D001335	Vehicle Emissions	Vehicle Emissions analog inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]	16890772
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of CD86 gene	25560391
D014750	Vincristine	Vincristine results in increased expression of CD86 mRNA	23649840
D014810	Vitamin E	Vitamin E inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]	20457211
D014810	Vitamin E	Vitamin E inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]	20457211
D014810	Vitamin E	Vitamin E inhibits the reaction [Thimerosal results in increased expression of CD86 protein]	20457211
C016837	zinc chloride	zinc chloride results in decreased expression of CD86 protein	24284788
C088658	zoledronic acid	zoledronic acid results in increased expression of CD86 protein	19446661
D015054	Zymosan	SB 203580 inhibits the reaction [Zymosan results in increased expression of CD86 protein]	17698565
D015054	Zymosan	Zymosan results in increased expression of CD86 protein	17698565
D015054	Zymosan	Zymosan results in increased expression of CD86 protein	15618177

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001618	virus receptor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	9915850 11279501 21982860 25241761
GO:0015026	coreceptor activity	-	NAS	9915850
GO:0038023	signaling receptor activity	-	TAS	7694363
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002250	adaptive immune response	-	IEA	-
GO:0006955	immune response	-	IBA	21873635
GO:0006955	immune response	-	TAS	7694363
GO:0007165	signal transduction	-	IBA	21873635
GO:0007166	cell surface receptor signaling pathway	-	IBA	21873635
GO:0008284	positive regulation of cell proliferation	-	TAS	7513726
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0031295	T cell costimulation	-	IBA	21873635
GO:0031295	T cell costimulation	-	TAS	-
GO:0042102	positive regulation of T cell proliferation	-	IBA	21873635
GO:0042130	negative regulation of T cell proliferation	-	IBA	21873635
GO:0043017	positive regulation of lymphotoxin A biosynthetic process	-	NAS	9915850
GO:0045086	positive regulation of interleukin-2 biosynthetic process	-	NAS	9915850
GO:0045404	positive regulation of interleukin-4 biosynthetic process	-	NAS	9915850
GO:0045630	positive regulation of T-helper 2 cell differentiation	-	NAS	9915850
GO:0045893	positive regulation of transcription, DNA-templated	-	NAS	9915850
GO:0046718	viral entry into host cell	-	IEA	-
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:0071222	cellular response to lipopolysaccharide	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0009897	external side of plasma membrane	-	IBA	21873635
GO:0009986	cell surface	-	HDA	23981064
GO:0009986	cell surface	-	IBA	21873635
GO:0016021	integral component of membrane	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	20458337
GO:0070062	extracellular exosome	-	IDA	15908444

KEGG ID	KEGG Term
hsa04514	Cell adhesion molecules (CAMs)
hsa04620	Toll-like receptor signaling pathway
hsa04672	Intestinal immune network for IgA production
hsa04940	Type I diabetes mellitus
hsa05320	Autoimmune thyroid disease
hsa05322	Systemic lupus erythematosus
hsa05323	Rheumatoid arthritis
hsa05330	Allograft rejection
hsa05332	Graft-versus-host disease
hsa05416	Viral myocarditis

Reactome ID	Reactome Term	Evidence
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-168256	Immune System	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-388841	Costimulation by the CD28 family	TAS
R-HSA-389356	CD28 co-stimulation	TAS
R-HSA-389357	CD28 dependent PI3K/Akt signaling	TAS
R-HSA-389359	CD28 dependent Vav1 pathway	TAS
R-HSA-389513	CTLA4 inhibitory signaling	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-6783783	Interleukin-10 signaling	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22821131	CD86 gene variants and susceptibility to pancreatic cancer. (2012 Dec)	Xiang H	J Cancer Res Clin Oncol
17893969	Blood concentrations of hydroxychloroquine and its desethyl derivative correlate negatively with the percentage of CD45RO+ cells among CD4+ lymphocytes in hydroxychloroquine-treated lupus patients. (2007 Jun)	Sailler L	Ann N Y Acad Sci
27058955	Cigarette Smoke Decreases the Maturation of Lung Myeloid Dendritic Cells. (2016)	Arellano-Orden E	PLoS One
28951634	Effect of IRAK-M on Airway Inflammation Induced by Cigarette Smoking. (2017)	Gong H	Mediators Inflamm
29089751	Characteristics and potential role of M2 macrophages in COPD. (2017)	He S	Int J Chron Obstruct Pulmon Dis
29309749	Patients with idiopathic endplate inflammation displayed aberrant Th17 responses resulting in proinflammatory monocyte activation. (2018 Feb 1)	Wang J	Exp Cell Res
16907910	Different inflammatory cell pattern and macrophage phenotype in chronic obstructive pulmonary disease patients, smokers and non-smokers. (2006 Sep)	Lofdahl JM	Clin Exp Immunol
28755749	Increased expression of M1 and M2 phenotypic markers in isolated microglia after four-day binge alcohol exposure in male rats. (2017 Aug)	Peng H	Alcohol
22833663	Recovery from workplace-induced airway inflammation 1 year after cessation of exposure. (2012 Oct)	Sikkeland LI	Occup Environ Med
19635922	Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way. (2009 Aug 15)	Robays LJ	J Immunol
25689051	Beryllium increases the CD14(dim)CD16+ subset in the lung of chronic beryllium disease. (2015)	Li L	PLoS One
22399514	Increased expression of TSH receptor by fibrocytes in thyroid-associated ophthalmopathy leads to chemokine production. (2012 May)	Gillespie EF	J Clin Endocrinol Metab
18453581	Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice. (2008 May 15)	Robbins CS	J Immunol
17925605	Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro. (2007 Nov)	Dopheide JF	Coron Artery Dis
20732370	CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. (2010 Nov)	Liu Y	Hum Immunol
29127016	Enhanced activation of circulating plasmacytoid dendritic cells in patients with Chronic Obstructive Pulmonary Disease and experimental smoking-induced emphysema. (2017 Nov 8)	Qiu SL	Clin Immunol
10351927	Expression of costimulatory molecules on alveolar macrophages in hypersensitivity pneumonitis. (1999 Jun)	Israel-Assayag E	Am J Respir Crit Care Med
28574651	Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells. (2017 Aug)	Mulligan JK	Int Forum Allergy Rhinol
18203971	Function-associated surface molecules on airway dendritic cells in cigarette smokers. (2008 Jun)	Bratke K	Am J Respir Cell Mol Biol