Gene: HAND1

9421
Hxt|Thing1|bHLHa27|eHand
heart and neural crest derivatives expressed 1
protein-coding
5q33.2
Ensembl:ENSG00000113196 MIM:602406 Vega:OTTHUMG00000130193 UniprotKB:O96004
NG_052889.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.004e-1 (AD)  7.588e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TEX13A0.407
HAND20.387
PRSS80.36
KRTAP24-10.349
TRIM430.336
CCIN0.336
LHB0.334
IRX40.331
CXCL110.324
VHLL0.322

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C2orf27A-0.287
TDO2-0.257
LRRC17-0.241
ZFP2-0.228
IFNA21-0.224
GGT1-0.218
PARPBP-0.217
GABRA6-0.208
C12orf50-0.206
ABCA10-0.205

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of HAND1 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HAND1 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
D000438AlcoholsAlcohols promotes the reaction [vorinostat results in increased expression of HAND1 mRNA]24857828
D000438AlcoholsAlcohols results in increased expression of HAND1 mRNA24857828
D000438AlcoholsCurcumin inhibits the reaction [Alcohols results in increased expression of HAND1 mRNA]24857828
D000438Alcoholsvorinostat promotes the reaction [Alcohols results in increased expression of HAND1 mRNA]24857828
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HAND1 mRNA16483693
D001104ArbutinArbutin results in increased expression of HAND1 mRNA17103032
C015001arsenitearsenite results in increased methylation of HAND1 promoter23974009
C006780bisphenol Abisphenol A affects the methylation of HAND1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of HAND1 mRNA25181051
D003042CocaineCocaine affects the expression of HAND1 mRNA20187946
D003474CurcuminCurcumin inhibits the reaction [Alcohols results in increased expression of HAND1 mRNA]24857828
D003474CurcuminCurcumin results in decreased expression of HAND1 mRNA24857828
D003561CytarabineCytarabine results in decreased expression of HAND1 mRNA21198554
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of HAND1 mRNA22105179
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of HAND1 mRNA22105179
C118739entinostatentinostat results in increased expression of HAND1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of HAND1 mRNA23550701
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of HAND1 mRNA]15016801
C069837fullerene C60fullerene C60 results in decreased expression of HAND1 mRNA19167457
C011890kojic acidkojic acid results in increased expression of HAND1 mRNA16595896
C045463leflunomideleflunomide results in increased expression of HAND1 mRNA28988120
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HAND1 mRNA23179753
C028007nickel monoxidenickel monoxide results in decreased expression of HAND1 mRNA19167457
D009538NicotineNicotine results in decreased expression of HAND1 mRNA24368670
D009538NicotineNicotine results in decreased expression of HAND1 protein24368670
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
D010416PentachlorophenolPentachlorophenol results in increased expression of HAND1 mRNA23892564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HAND1 mRNA26139165
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HAND1 mRNA24058054
D014212TretinoinTretinoin results in decreased expression of HAND1 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased expression of HAND1 mRNA25847060
C012589trichostatin Atrichostatin A results in decreased expression of HAND1 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAND1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HAND1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HAND1 mRNA23527032|2438349
D014635Valproic AcidValproic Acid results in decreased expression of HAND1 mRNA15901671
C111237vorinostatAlcohols promotes the reaction [vorinostat results in increased expression of HAND1 mRNA]24857828
C111237vorinostatvorinostat promotes the reaction [Alcohols results in increased expression of HAND1 mRNA]24857828
C111237vorinostatvorinostat results in increased expression of HAND1 mRNA24857828

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11802795  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA11802795  
GO:0003713transcription coactivator activity-IC11802795  
GO:0003713transcription coactivator activity-IDA16043483  
GO:0003714transcription corepressor activity-IC11802795  
GO:0005515protein binding-IPI16043483  
GO:0008134transcription factor binding-IPI16043483  
GO:0019899enzyme binding-IEA-  
GO:0042802identical protein binding-ISS-  
GO:0042803protein homodimerization activity-NAS16043483  
GO:0043425bHLH transcription factor binding-IPI11802795  
GO:0044212transcription regulatory region DNA bindingcontributes_toIDA11802795  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA11802795  
GO:0001525angiogenesis-ISS-  
GO:0001707mesoderm formation-IEA-  
GO:0001824blastocyst development-IEP11802795  
GO:0001829trophectodermal cell differentiation-IEP11802795  
GO:0001947heart looping-ISS-  
GO:0003144embryonic heart tube formation-IEA-  
GO:0003218cardiac left ventricle formation-IMP18276607  
GO:0003219cardiac right ventricle formation-IMP18276607  
GO:0006366transcription by RNA polymerase II-IDA11802795  
GO:0007507heart development-ISS-  
GO:0035050embryonic heart tube development-ISS-  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA11802795  
GO:0045892negative regulation of transcription, DNA-templated-IDA11802795  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16043483  
GO:0055010ventricular cardiac muscle tissue morphogenesis-IMP18276607  
GO:0060411cardiac septum morphogenesis-IMP19586923  
GO:0060485mesenchyme development-IEA-  
GO:0060536cartilage morphogenesis-IEA-  
GO:0060707trophoblast giant cell differentiation-IEA-  
GO:1903026negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding-IDA11802795  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11802795  
GO:0005654nucleoplasm-IEA-  
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-IDA11802795  
GO:0090575RNA polymerase II transcription factor complex-IDA11802795  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24368670Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies. (2014 Feb 15)Holloway ACAm J Physiol Endocrinol Metab