Gene info: ID 9423

Gene: NTN1

GENE ID: 9423

Synonyms: NTN1L

Description: netrin 1

Gene type: protein-coding

Location: 17p13.1

dbXrefs: Ensembl:ENSG00000065320 MIM:601614 Vega:OTTHUMG00000130257 UniprotKB:O95631

RefSeq: NC_000017.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.854e-1 (AD) 4.409e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GALNT10	0.769
ARHGEF40	0.744
EPS8	0.734
CTDSP1	0.729
SYDE1	0.726
LIMD1	0.726
MPZL1	0.723
CMTM3	0.721
FAM129B	0.72
TCF7L1	0.716

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KCNB2	-0.513
ZNF385B	-0.508
CTXN2	-0.499
SDR16C5	-0.493
SPTSSB	-0.49
CPNE4	-0.488
VSTM5	-0.487
AGBL4	-0.486
CDCA5	-0.484
IPCEF1	-0.479

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of NTN1 mRNA"	27567155
D000082	Acetaminophen	Acetaminophen results in increased expression of NTN1 mRNA	26690555\|2906747
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of NTN1 mRNA	22100608
D000447	Aldehydes	Aldehydes results in increased expression of NTN1 mRNA	25014914
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of NTN1 mRNA	16483693
D001151	Arsenic	Arsenic results in increased expression of NTN1 mRNA	24019935
D001280	Atrazine	Atrazine results in decreased expression of NTN1 mRNA	25929836
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NTN1 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NTN1 mRNA	27858113
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of NTN1 mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NTN1 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to NTN1 promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of NTN1 mRNA	21569818
D004958	Estradiol	[Estradiol co-treated with Plant Preparations] results in decreased expression of NTN1 mRNA	26945725
C006780	bisphenol A	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTN1 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of NTN1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of NTN1 gene	28505145
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTN1 mRNA	28628672
C018475	butyraldehyde	butyraldehyde results in increased expression of NTN1 mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of NTN1 mRNA	24376830
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of NTN1 mRNA	17484886
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NTN1 mRNA	27858113
D003042	Cocaine	Cocaine results in decreased expression of NTN1 mRNA	17898221
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTN1 mRNA	28628672
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTN1 mRNA	28628672
D003976	Diazinon	Diazinon affects the expression of NTN1 mRNA	22546817
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of NTN1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of NTN1 mRNA	27392435
D004026	Dieldrin	Dieldrin affects the expression of NTN1 mRNA	22546817
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of NTN1 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of NTN1 mRNA	24535843
D004317	Doxorubicin	Doxorubicin results in increased expression of NTN1 mRNA	25896364
C063007	exoenzyme C3, Clostridium botulinum	"exoenzyme C3, Clostridium botulinum inhibits the reaction [lead titanate zirconate results in decreased expression of NTN1 protein]"	24203571
D005947	Glucose	NTN1 protein inhibits the reaction [Glucose results in decreased phosphorylation of MAPK1 protein]	29059224
D005947	Glucose	NTN1 protein inhibits the reaction [Glucose results in decreased phosphorylation of MAPK3 protein]	29059224
D005947	Glucose	NTN1 protein inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]	29059224
D005947	Glucose	NTN1 protein inhibits the reaction [Glucose results in increased activity of CASP3 protein]	29059224
D017313	Fenretinide	Fenretinide results in increased expression of NTN1 mRNA	28973697
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTN1 mRNA	28628672
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTN1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTN1 mRNA	28628672
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTN1 mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of NTN1 mRNA	27392435
D007608	Kainic Acid	Kainic Acid results in increased expression of NTN1 mRNA	19700661
C065536	lead titanate zirconate	"exoenzyme C3, Clostridium botulinum inhibits the reaction [lead titanate zirconate results in decreased expression of NTN1 protein]"	24203571
C065536	lead titanate zirconate	lead titanate zirconate results in decreased expression of NTN1 protein	24203571
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of NTN1 mRNA	23527032
D008344	Maneb	[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA	23017109
D008344	Maneb	[Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA	23017109
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of NTN1 mRNA	24810058
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of NTN1 mRNA	29191790
D008999	Monocrotophos	Monocrotophos affects the expression of NTN1 mRNA	28645554
C022838	nickel chloride	nickel chloride affects the expression of NTN1 mRNA	22546817
D010269	Paraquat	[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA	23017109
D010269	Paraquat	[Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA	23017109
C046012	pentanal	pentanal results in increased expression of NTN1 mRNA	26079696
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of NTN1 mRNA	24535843
C006253	pirinixic acid	pirinixic acid results in decreased expression of NTN1 mRNA	20813756
D028321	Plant Preparations	[Estradiol co-treated with Plant Preparations] results in decreased expression of NTN1 mRNA	26945725
C005556	propionaldehyde	propionaldehyde results in increased expression of NTN1 mRNA	26079696
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of NTN1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of NTN1 mRNA	23806026
D012834	Silver	Silver results in decreased expression of NTN1 mRNA	27131904
C017947	sodium arsenite	sodium arsenite affects the methylation of NTN1 gene	28589171
D013311	Streptozocin	[NTN1 protein co-treated with Streptozocin] results in increased expression of ARG1 protein	29059224
D013311	Streptozocin	NTN1 protein inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]	29059224
D013311	Streptozocin	NTN1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN2A mRNA]	29059224
D013311	Streptozocin	NTN1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN2A protein]	29059224
D013311	Streptozocin	NTN1 protein inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]	29059224
D013311	Streptozocin	NTN1 protein inhibits the reaction [Streptozocin results in increased expression of RELA protein]	29059224
D013311	Streptozocin	NTN1 protein inhibits the reaction [Streptozocin results in increased expression of TRP53 mRNA]	29059224
D013311	Streptozocin	NTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC mRNA]	29059224
D013311	Streptozocin	NTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC protein]	29059224
D013311	Streptozocin	Streptozocin promotes the reaction [NTN1 protein results in increased phosphorylation of MAPK1 protein]	29059224
D013311	Streptozocin	Streptozocin promotes the reaction [NTN1 protein results in increased phosphorylation of MAPK3 protein]	29059224
D013311	Streptozocin	Streptozocin results in decreased expression of NTN1 protein	29059224
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NTN1 promoter]	19654925
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of NTN1 mRNA	28065790
C012589	trichostatin A	trichostatin A results in increased expression of NTN1 mRNA	24935251
C057693	troglitazone	troglitazone results in decreased expression of NTN1 mRNA	28973697
D014635	Valproic Acid	Valproic Acid results in increased expression of NTN1 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of NTN1 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of NTN1 mRNA	24896083
C070417	Win 55212-2	Win 55212-2 results in increased expression of NTN1 mRNA	12237329
C088658	zoledronic acid	zoledronic acid results in increased expression of NTN1 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	10102268 19196994 19721007 20434207 26190107

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001764	neuron migration	-	IEA	-
GO:0006915	apoptotic process	-	IEA	-
GO:0006930	substrate-dependent cell migration, cell extension	-	ISS	-
GO:0007097	nuclear migration	-	IEA	-
GO:0007265	Ras protein signal transduction	-	ISS	-
GO:0007411	axon guidance	-	TAS	-
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0030334	regulation of cell migration	-	IEA	-
GO:0030517	negative regulation of axon extension	-	IEA	-
GO:0032488	Cdc42 protein signal transduction	-	ISS	-
GO:0033564	anterior/posterior axon guidance	-	IEA	-
GO:0042472	inner ear morphogenesis	-	IEA	-
GO:0045773	positive regulation of axon extension	-	ISS	-
GO:0060603	mammary gland duct morphogenesis	-	IEA	-
GO:0098609	cell-cell adhesion	-	IEA	-
GO:2000147	positive regulation of cell motility	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005604	basement membrane	-	IEA	-
GO:0005737	cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04360	Axon guidance

Reactome ID	Reactome Term	Evidence
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1266738	Developmental Biology	IEA
R-HSA-373752	Netrin-1 signaling	TAS
R-HSA-373752	Netrin-1 signaling	IEA
R-HSA-376172	DSCAM interactions	IEA
R-HSA-376176	Signaling by ROBO receptors	IEA
R-HSA-418885	DCC mediated attractive signaling	TAS
R-HSA-418885	DCC mediated attractive signaling	IEA
R-HSA-418886	Netrin mediated repulsion signals	IEA
R-HSA-418890	Role of second messengers in netrin-1 signaling	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-422475	Axon guidance	IEA
R-HSA-428542	Regulation of commissural axon pathfinding by SLIT and ROBO	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23512105	Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)	Beaty TH	Hum Genet