Gene: NTN1

9423
NTN1L
netrin 1
protein-coding
17p13.1
Ensembl:ENSG00000065320 MIM:601614 Vega:OTTHUMG00000130257 UniprotKB:O95631
NC_000017.11
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.854e-1 (AD)  4.409e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GALNT100.769
ARHGEF400.744
EPS80.734
CTDSP10.729
SYDE10.726
LIMD10.726
MPZL10.723
CMTM30.721
FAM129B0.72
TCF7L10.716

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNB2-0.513
ZNF385B-0.508
CTXN2-0.499
SDR16C5-0.493
SPTSSB-0.49
CPNE4-0.488
VSTM5-0.487
AGBL4-0.486
CDCA5-0.484
IPCEF1-0.479

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of NTN1 mRNA"27567155
D000082AcetaminophenAcetaminophen results in increased expression of NTN1 mRNA26690555|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of NTN1 mRNA22100608
D000447AldehydesAldehydes results in increased expression of NTN1 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NTN1 mRNA16483693
D001151ArsenicArsenic results in increased expression of NTN1 mRNA24019935
D001280AtrazineAtrazine results in decreased expression of NTN1 mRNA25929836
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NTN1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NTN1 mRNA27858113
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of NTN1 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NTN1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NTN1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NTN1 mRNA21569818
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in decreased expression of NTN1 mRNA26945725
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTN1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of NTN1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of NTN1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTN1 mRNA28628672
C018475butyraldehydebutyraldehyde results in increased expression of NTN1 mRNA26079696
D002104CadmiumCadmium results in increased expression of NTN1 mRNA24376830
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NTN1 mRNA17484886
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of NTN1 mRNA27858113
D003042CocaineCocaine results in decreased expression of NTN1 mRNA17898221
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTN1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTN1 mRNA28628672
D003976DiazinonDiazinon affects the expression of NTN1 mRNA22546817
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NTN1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of NTN1 mRNA27392435
D004026DieldrinDieldrin affects the expression of NTN1 mRNA22546817
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of NTN1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of NTN1 mRNA24535843
D004317DoxorubicinDoxorubicin results in increased expression of NTN1 mRNA25896364
C063007exoenzyme C3, Clostridium botulinum"exoenzyme C3, Clostridium botulinum inhibits the reaction [lead titanate zirconate results in decreased expression of NTN1 protein]"24203571
D005947GlucoseNTN1 protein inhibits the reaction [Glucose results in decreased phosphorylation of MAPK1 protein]29059224
D005947GlucoseNTN1 protein inhibits the reaction [Glucose results in decreased phosphorylation of MAPK3 protein]29059224
D005947GlucoseNTN1 protein inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]29059224
D005947GlucoseNTN1 protein inhibits the reaction [Glucose results in increased activity of CASP3 protein]29059224
D017313FenretinideFenretinide results in increased expression of NTN1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTN1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTN1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NTN1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of NTN1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NTN1 mRNA27392435
D007608Kainic AcidKainic Acid results in increased expression of NTN1 mRNA19700661
C065536lead titanate zirconate"exoenzyme C3, Clostridium botulinum inhibits the reaction [lead titanate zirconate results in decreased expression of NTN1 protein]"24203571
C065536lead titanate zirconatelead titanate zirconate results in decreased expression of NTN1 protein24203571
D018021Lithium ChlorideLithium Chloride results in decreased expression of NTN1 mRNA23527032
D008344Maneb[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA23017109
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA23017109
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NTN1 mRNA24810058
D008777MethyltestosteroneMethyltestosterone results in decreased expression of NTN1 mRNA29191790
D008999MonocrotophosMonocrotophos affects the expression of NTN1 mRNA28645554
C022838nickel chloridenickel chloride affects the expression of NTN1 mRNA22546817
D010269Paraquat[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA23017109
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA23017109
C046012pentanalpentanal results in increased expression of NTN1 mRNA26079696
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of NTN1 mRNA24535843
C006253pirinixic acidpirinixic acid results in decreased expression of NTN1 mRNA20813756
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in decreased expression of NTN1 mRNA26945725
C005556propionaldehydepropionaldehyde results in increased expression of NTN1 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of NTN1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NTN1 mRNA23806026
D012834SilverSilver results in decreased expression of NTN1 mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of NTN1 gene28589171
D013311Streptozocin[NTN1 protein co-treated with Streptozocin] results in increased expression of ARG1 protein29059224
D013311StreptozocinNTN1 protein inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]29059224
D013311StreptozocinNTN1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN2A mRNA]29059224
D013311StreptozocinNTN1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN2A protein]29059224
D013311StreptozocinNTN1 protein inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]29059224
D013311StreptozocinNTN1 protein inhibits the reaction [Streptozocin results in increased expression of RELA protein]29059224
D013311StreptozocinNTN1 protein inhibits the reaction [Streptozocin results in increased expression of TRP53 mRNA]29059224
D013311StreptozocinNTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC mRNA]29059224
D013311StreptozocinNTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC protein]29059224
D013311StreptozocinStreptozocin promotes the reaction [NTN1 protein results in increased phosphorylation of MAPK1 protein]29059224
D013311StreptozocinStreptozocin promotes the reaction [NTN1 protein results in increased phosphorylation of MAPK3 protein]29059224
D013311StreptozocinStreptozocin results in decreased expression of NTN1 protein29059224
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NTN1 promoter]19654925
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NTN1 mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of NTN1 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of NTN1 mRNA28973697
D014635Valproic AcidValproic Acid results in increased expression of NTN1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of NTN1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of NTN1 mRNA24896083
C070417Win 55212-2Win 55212-2 results in increased expression of NTN1 mRNA12237329
C088658zoledronic acidzoledronic acid results in increased expression of NTN1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10102268  19196994  19721007  20434207  26190107  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0006930substrate-dependent cell migration, cell extension-ISS-  
GO:0007097nuclear migration-IEA-  
GO:0007265Ras protein signal transduction-ISS-  
GO:0007411axon guidance-TAS-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0030334regulation of cell migration-IEA-  
GO:0030517negative regulation of axon extension-IEA-  
GO:0032488Cdc42 protein signal transduction-ISS-  
GO:0033564anterior/posterior axon guidance-IEA-  
GO:0042472inner ear morphogenesis-IEA-  
GO:0045773positive regulation of axon extension-ISS-  
GO:0060603mammary gland duct morphogenesis-IEA-  
GO:0098609cell-cell adhesion-IEA-  
GO:2000147positive regulation of cell motility-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IEA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-373752Netrin-1 signalingTAS
R-HSA-373752Netrin-1 signalingIEA
R-HSA-376172DSCAM interactionsIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-418885DCC mediated attractive signalingTAS
R-HSA-418885DCC mediated attractive signalingIEA
R-HSA-418886Netrin mediated repulsion signalsIEA
R-HSA-418890Role of second messengers in netrin-1 signalingIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-428542Regulation of commissural axon pathfinding by SLIT and ROBOIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23512105Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (2013 Jul)Beaty THHum Genet