Gene: TP53INP1

94241
SIP|TP53DINP1|TP53INP1A|TP53INP1B|Teap|p53DINP1
tumor protein p53 inducible nuclear protein 1
protein-coding
8q22.1
Ensembl:ENSG00000164938 MIM:606185 Vega:OTTHUMG00000164697 UniprotKB:Q96A56
NC_000008.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.891e-1 (AD)  1.050e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARP40.869
REST0.848
BNIP20.848
IRAK40.842
SFT2D20.841
C2orf680.825
FAM114A10.823
CARD80.811
ELF10.81
NEDD10.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAS1-0.586
RTP1-0.547
FBLN7-0.546
ABCC12-0.546
ADRA1D-0.544
KCNB2-0.541
SLC7A4-0.539
LRRC73-0.53
CDH22-0.525
MARCH4-0.524

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of TP53INP1 mRNA25596134
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of TP53INP1 mRNA25596134
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of TP53INP1 mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TP53INP1 mRNA"19167446
D000082AcetaminophenAcetaminophen affects the expression of TP53INP1 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of TP53INP1 mRNA22230336
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of TP53INP1 mRNA25596134
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of TP53INP1 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TP53INP1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TP53INP1 mRNA21632981|2164198
D000393Air PollutantsAir Pollutants analog results in decreased expression of TP53INP1 mRNA21757418
D000638AmiodaroneAmiodarone affects the expression of TP53INP1 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TP53INP1 mRNA16483693
D001151ArsenicArsenic results in increased expression of TP53INP1 mRNA19945496
C050510arsenic trichloride[arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to TP53INP1 3' UTR] which results in decreased expression of TP53INP1 protein]21750348|2175034
C006632arsenic trioxidearsenic trioxide affects the expression of TP53INP1 mRNA19763917
D001507BeclomethasoneBeclomethasone results in increased expression of TP53INP1 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TP53INP1 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TP53INP1 mRNA"20382639|2623829
D004958EstradiolEstradiol results in decreased expression of TP53INP1 mRNA16202921|1916744
D004958Estradiol[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TP53INP1 mRNA21185374
C006780bisphenol Abisphenol A affects the expression of TP53INP1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of TP53INP1 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of TP53INP1 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of TP53INP1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of TP53INP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TP53INP1 gene28505145
D019256Cadmium ChlorideCadmium Chloride affects the expression of TP53INP1 mRNA25596134
D002220CarbamazepineCarbamazepine affects the expression of TP53INP1 mRNA25979313
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of TP53INP1 mRNA19395590
C035377chlorendic acidchlorendic acid results in increased expression of TP53INP1 mRNA22584684
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of TP53INP1 mRNA25596134
D002746ChlorpromazineChlorpromazine affects the expression of TP53INP1 mRNA25064622
C059262cidofovircidofovir affects the expression of TP53INP1 mRNA25596134
D004002Clodronic AcidClodronic Acid results in increased expression of TP53INP1 mRNA25596134
D003300CopperCopper results in increased expression of TP53INP1 mRNA16391388
D019327Copper SulfateCopper Sulfate results in increased expression of TP53INP1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of TP53INP1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of TP53INP1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of TP53INP1 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of TP53INP1 mRNA27523638
D016572CyclosporineCyclosporine affects the expression of TP53INP1 mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of TP53INP1 mRNA25596134
D000069439DasatinibDasatinib results in increased expression of TP53INP1 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of TP53INP1 mRNA23914054
C014347decitabine[[decitabine co-treated with trichostatin A] affects the methylation of TP53INP1 promoter] which affects the expression of TP53INP1 mRNA18803327|1880332
D003703DemecolcineDemecolcine results in increased expression of TP53INP1 mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TP53INP1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TP53INP1 mRNA19561079|2153299
D002945CisplatinCisplatin results in increased expression of TP53INP1 mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of TP53INP1 mRNA28302478
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of TP53INP1 mRNA20886546
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of TP53INP1 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of TP53INP1 mRNA21233418
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TP53INP1 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TP53INP1 mRNA20170705
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TP53INP1 mRNA20170705
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TP53INP1 mRNA23649840
D011345FenofibrateFenofibrate results in decreased expression of TP53INP1 mRNA25596134
D011345FenofibrateFenofibrate affects the expression of TP53INP1 mRNA25596134
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of TP53INP1 mRNA22584684
D005472FluorouracilFluorouracil results in increased expression of TP53INP1 mRNA16510598|1655759
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of TP53INP1 mRNA]15016801
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of TP53INP1 mRNA]16557594|1798267
C065180fluvastatin[zoledronic acid co-treated with fluvastatin] results in increased expression of TP53INP1 mRNA16996129
D005557FormaldehydeFormaldehyde results in increased expression of TP53INP1 mRNA23649840
C039281furanfuran results in increased expression of TP53INP1 mRNA25539665|2619464
C056507gemcitabinegemcitabine results in increased expression of TP53INP1 mRNA16570353|1703926
D019833GenisteinGenistein results in decreased expression of TP53INP1 mRNA23019147|2686566
D019833GenisteinGenistein results in increased expression of TP53INP1 mRNA18847459
C568713GSK1210151AGSK1210151A results in increased expression of TP53INP1 mRNA24952595
C568713GSK1210151AGSK1210151A results in increased expression of TP53INP1 protein24952595
D017313FenretinideFenretinide results in increased expression of TP53INP1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of TP53INP1 mRNA20044591|2117940
C031927hydroquinonehydroquinone results in increased expression of TP53INP1 mRNA23416264
D007052IbuprofenIbuprofen results in decreased expression of TP53INP1 mRNA25596134
D007069IfosfamideIfosfamide results in increased expression of TP53INP1 mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TP53INP1 mRNA25613284
C051890irinotecanirinotecan analog results in increased expression of TP53INP1 mRNA18927307
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TP53INP1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TP53INP1 mRNA24796395|2495259
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TP53INP1 protein24952595
D008154LucanthoneLucanthone results in increased expression of TP53INP1 mRNA21148553
C018091maduramicinmaduramicin results in increased expression of TP53INP1 mRNA29128925
D008687MetforminMetformin results in decreased expression of TP53INP1 mRNA25596134
D008687MetforminMetformin results in increased expression of TP53INP1 mRNA25596134
D008727MethotrexateMethotrexate results in increased expression of TP53INP1 mRNA21678067
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of TP53INP1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TP53INP1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TP53INP1 mRNA23649840
D009151Mustard GasMustard Gas results in increased expression of TP53INP1 mRNA25102026
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TP53INP1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of TP53INP1 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of TP53INP1 mRNA25596134
D010269ParaquatParaquat affects the expression of TP53INP1 mRNA25064622
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of TP53INP1 mRNA28973697
D010634PhenobarbitalPhenobarbital affects the expression of TP53INP1 mRNA19159669
D010936Plant ExtractsPlant Extracts results in increased expression of TP53INP1 mRNA21920417
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TP53INP1 mRNA22714537
D011794QuercetinQuercetin results in increased expression of TP53INP1 mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TP53INP1 mRNA21185374
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of TP53INP1 mRNA19167446
C059514resveratrolresveratrol results in increased expression of TP53INP1 mRNA15767336|2634129
C089730rosiglitazonerosiglitazone results in decreased expression of TP53INP1 mRNA25596134
C089730rosiglitazonerosiglitazone results in decreased expression of TP53INP1 mRNA25596134
D012402RotenoneRotenone results in decreased expression of TP53INP1 mRNA27979718
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TP53INP1 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of TP53INP1 mRNA28595984
C017947sodium arsenitesodium arsenite results in increased expression of TP53INP1 mRNA20477944
C017947sodium arseniteTRP73 protein affects the reaction [sodium arsenite results in increased expression of TP53INP1 mRNA]20477944
D018038Sodium SeleniteSodium Selenite results in increased expression of TP53INP1 mRNA24383545
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of TP53INP1 mRNA26496021
D013752TetracyclineTetracycline affects the expression of TP53INP1 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TP53INP1 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of TP53INP1 mRNA25064622
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TP53INP1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of TP53INP1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of TP53INP1 mRNA21934132|2383079
C012589trichostatin Atrichostatin A results in increased expression of TP53INP1 mRNA15901671
C012589trichostatin A[[decitabine co-treated with trichostatin A] affects the methylation of TP53INP1 promoter] which affects the expression of TP53INP1 mRNA18803327|1880332
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of TP53INP1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of TP53INP1 mRNA29024780
D014520UrethaneUrethane results in increased expression of TP53INP1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of TP53INP1 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of TP53INP1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of TP53INP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of TP53INP1 mRNA29154799
C025643vinclozolinvinclozolin results in decreased expression of TP53INP1 mRNA23034163
D014750VincristineVincristine results in increased expression of TP53INP1 mRNA23649840
C088658zoledronic acid[zoledronic acid co-treated with fluvastatin] results in increased expression of TP53INP1 mRNA16996129

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI22421968  22470510  
GO:0016209antioxidant activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0007050cell cycle arrest-TAS22421968  
GO:0008285negative regulation of cell proliferation-ISS-  
GO:0009408response to heat-IEA-  
GO:0010508positive regulation of autophagy-IMP22421968  22470510  
GO:0010629negative regulation of gene expression-IEA-  
GO:0030336negative regulation of cell migration-ISS-  
GO:0034644cellular response to UV-IEA-  
GO:0042981regulation of apoptotic process-TAS-  
GO:0045893positive regulation of transcription, DNA-templated-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-IDA22470510  
GO:0048102autophagic cell death-IMP22421968  
GO:0048147negative regulation of fibroblast proliferation-IEA-  
GO:0071361cellular response to ethanol-IEA-  
GO:0071447cellular response to hydroperoxide-IEA-  
GO:0072703cellular response to methyl methanesulfonate-IEA-  
GO:0098869cellular oxidant detoxification-IEA-  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:1904761negative regulation of myofibroblast differentiation-IEA-  
GO:2001235positive regulation of apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA22470510  
GO:0005654nucleoplasm-TAS-  
GO:0005776autophagosome-IBA21873635  
GO:0005776autophagosome-IDA22421968  22470510  
GO:0005829cytosol-IDA22470510  
GO:0016605PML body-IEA-  
GO:0031410cytoplasmic vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5633008TP53 Regulates Transcription of Cell Death GenesTAS
R-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29518490Association of 48 type 2 diabetes susceptibility loci with fasting plasma glucose and lipid levels in Chinese Hans. (2018 May)Liu JDiabetes Res Clin Pract