Gene: PPP1R14A

94274
CPI-17|CPI17|PPP1INL
protein phosphatase 1 regulatory inhibitor subunit 14A
protein-coding
19q13.2
Ensembl:ENSG00000167641 MIM:608153 Vega:OTTHUMG00000181892 UniprotKB:Q96A00
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.566e-1 (AD)  9.114e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S1PR50.922
NKX6-20.911
RNASE10.895
NINJ20.892
PLLP0.881
TSPAN150.879
FOLH10.877
RBP70.876
MOG0.875
GJB10.872

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.485
NEUROD1-0.472
CNGB1-0.413
LTK-0.408
HTR3A-0.408
TRERF1-0.404
HCN4-0.404
PCDH8-0.39
TAF7L-0.39
GPR83-0.388

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4590922-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine"2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein]"18986333
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of PPP1R14A mRNA16788091
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of PPP1R14A mRNA18544908
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP1R14A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP1R14A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP1R14A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP1R14A mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PPP1R14A mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of PPP1R14A mRNA18544908
D000109AcetylcholineAcetylcholine results in increased phosphorylation of PPP1R14A protein18577381
D000109AcetylcholineBeclomethasone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein]18577381
D000109AcetylcholinePrednisolone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein]18577381
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PPP1R14A mRNA16483693
D001151ArsenicArsenic affects the methylation of PPP1R14A gene25304211
D001280AtrazineAtrazine results in increased expression of PPP1R14A mRNA25929836
D001280AtrazineAtrazine results in increased expression of PPP1R14A mRNA22378314
D001507BeclomethasoneBeclomethasone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein]18577381
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PPP1R14A mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of PPP1R14A mRNA20660070
D004958EstradiolEstradiol results in increased expression of PPP1R14A mRNA20068009
D002065BuspironeBuspirone results in decreased expression of PPP1R14A mRNA24136188
C018475butyraldehydebutyraldehyde results in increased expression of PPP1R14A mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of PPP1R14A mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PPP1R14A mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1R14A gene20938992
D003471CuprizoneCuprizone results in decreased expression of PPP1R14A mRNA26577399|2752363
C014347decitabinedecitabine affects the expression of PPP1R14A mRNA23300844
D002945CisplatinCisplatin affects the expression of PPP1R14A mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PPP1R14A mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of PPP1R14A mRNA18042831|2501614
D004237DiuronDiuron results in increased expression of PPP1R14A mRNA21551480
C118739entinostatentinostat results in increased expression of PPP1R14A mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP1R14A mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PPP1R14A mRNA17557909
D005419FlavonoidsFlavonoids results in decreased expression of PPP1R14A mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1R14A gene20938992
C017338geranylgeraniolgeranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]24449418
D005897GlafenineGlafenine results in increased expression of PPP1R14A mRNA24136188
D017313FenretinideFenretinide results in increased expression of PPP1R14A mRNA28973697
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PPP1R14A mRNA27392435
C544151jinfukangjinfukang results in increased expression of PPP1R14A mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PPP1R14A mRNA26644586
D064704LevofloxacinLevofloxacin results in decreased expression of PPP1R14A mRNA24136188
D008694MethamphetamineMethamphetamine results in decreased expression of PPP1R14A mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PPP1R14A gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PPP1R14A mRNA27188386
D009151Mustard GasMustard Gas results in increased expression of PPP1R14A mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PPP1R14A mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PPP1R14A mRNA"25620056
D009532NickelNickel results in decreased expression of PPP1R14A mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of PPP1R14A mRNA19167457
D000073878Palm OilPalm Oil results in increased expression of PPP1R14A mRNA18042831
C046012pentanalpentanal results in increased expression of PPP1R14A mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PPP1R14A mRNA16221955
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PPP1R14A mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of PPP1R14A mRNA19482888
D010656Phenylephrinegeranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]24449418
D010656PhenylephrinePhenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]24449418
D010656PhenylephrinePhenylephrine results in increased phosphorylation of PPP1R14A protein24449418
D010656PhenylephrineSimvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]24449418
D010656PhenylephrineSimvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]24449418
D015240Phorbol 12,13-Dibutyrate"2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein]"18986333
D015240Phorbol 12,13-Dibutyrate"Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein"18986333
D015240Phorbol 12,13-Dibutyrate"Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein]"18986333
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PPP1R14A mRNA23608068
D011239PrednisolonePrednisolone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein]18577381
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of PPP1R14A mRNA20660070
C045950propiconazolepropiconazole results in decreased expression of PPP1R14A mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of PPP1R14A mRNA24780913
C064758Ro 31-8220"Ro 31-8220 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased phosphorylation of PPP1R14A protein]"18986333
D019821Simvastatingeranylgeraniol inhibits the reaction [Simvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]]24449418
D019821SimvastatinSimvastatin inhibits the reaction [Phenylephrine promotes the reaction [RHOA protein results in increased phosphorylation of PPP1R14A protein]]24449418
D019821SimvastatinSimvastatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R14A protein]24449418
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PPP1R14A mRNA15716485
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPP1R14A mRNA15652763
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PPP1R14A mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of PPP1R14A mRNA28973375
D013849ThimerosalThimerosal results in decreased expression of PPP1R14A mRNA27188386
D014050TolueneToluene results in decreased expression of PPP1R14A mRNA22166486
D014050TolueneToluene results in increased expression of PPP1R14A mRNA22166486
D014212TretinoinTretinoin results in decreased expression of PPP1R14A mRNA18230668
D014212TretinoinTretinoin results in decreased expression of PPP1R14A mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of PPP1R14A mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of PPP1R14A mRNA24935251|2670570
C080163trovafloxacintrovafloxacin results in decreased expression of PPP1R14A mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of PPP1R14A mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PPP1R14A mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PPP1R14A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PPP1R14A mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of PPP1R14A gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of PPP1R14A mRNA19165385
C111237vorinostatvorinostat results in increased expression of PPP1R14A mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004864protein phosphatase inhibitor activity-IEA-  
GO:0004865protein serine/threonine phosphatase inhibitor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0032515negative regulation of phosphoprotein phosphatase activity-IEA-  
GO:0035304regulation of protein dephosphorylation-IBA21873635  
GO:0035690cellular response to drug-IEA-  
GO:0042325regulation of phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04270Vascular smooth muscle contraction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5625740RHO GTPases activate PKNsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer