Gene: TNFRSF8

943
CD30|D1S166E|Ki-1
TNF receptor superfamily member 8
protein-coding
1p36.22
Ensembl:ENSG00000120949 MIM:153243 Vega:OTTHUMG00000001827 UniprotKB:P28908
NG_029573.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.413e-2 (AD)  1.087e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg22428027chr1:12128827TNFRSF81.400e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENTHD10.934
GPR1010.927
SAG0.924
DRD30.917
DGKK0.912
MYO3A0.905
AMBN0.898
TMPRSS60.898
PRLR0.894
GPR10.891

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC17A7-0.491
GALNT9-0.451
SOHLH1-0.432
NEUROD2-0.429
NANOS3-0.42
TBR1-0.412
NXPH3-0.405
TESPA1-0.392
KCNC2-0.377
PVALB-0.376

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08870Brentuximab vedotinBiotechDrug914088-09-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNFRSF8 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNFRSF8 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNFRSF8 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNFRSF8 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNFRSF8 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF8 mRNA"27188386
C0343434-aminobenzhydrazide4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of TNFRSF8 mRNA]24530881
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in decreased expression of TNFRSF8 mRNA21882252
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in decreased expression of TNFRSF8 mRNA]21882252
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF8 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TNFRSF8 mRNA22230336
D000643Ammonium ChlorideAmmonium Chloride affects the expression of TNFRSF8 mRNA16483693
D016590AphidicolinAphidicolin results in increased expression of TNFRSF8 protein12441127
D001151ArsenicArsenic results in increased expression of TNFRSF8 mRNA19962721
C006632arsenic trioxidearsenic trioxide results in increased expression of TNFRSF8 mRNA22521957
C006632arsenic trioxidearsenic trioxide results in decreased expression of TNFRSF8 mRNA19730151
C015001arsenitearsenite results in increased methylation of TNFRSF8 promoter23974009
D001564Benzo(a)pyrene[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in decreased expression of TNFRSF8 mRNA21882252
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of TNFRSF8 gene25435355
D001564Benzo(a)pyreneCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in decreased expression of TNFRSF8 mRNA]21882252
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNFRSF8 protein21467743
C006780bisphenol Abisphenol A results in decreased expression of TNFRSF8 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TNFRSF8 mRNA12160620
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of TNFRSF8 mRNA15501611
D002392CatechinCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in decreased expression of TNFRSF8 mRNA]21882252
D002392CatechinCatechin results in decreased expression of TNFRSF8 mRNA15465739
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNFRSF8 mRNA]11007951
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in decreased expression of TNFRSF8 mRNA20705681
D019422Dietary SucroseDietary Sucrose results in increased expression of TNFRSF8 mRNA26033743
D002117CalcitriolCalcitriol results in decreased expression of TNFRSF8 protein12441127
C118739entinostatentinostat results in increased expression of TNFRSF8 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNFRSF8 mRNA"27188386
D000431EthanolEthanol promotes the reaction [FOXO3 protein results in increased expression of TNFRSF8 mRNA]26470730
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TNFRSF8 mRNA23649840
D005665FurosemideFurosemide affects the expression of TNFRSF8 mRNA17497460
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of TNFRSF8 mRNA21782745
C013038hydroxyhydroquinone4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of TNFRSF8 mRNA]24530881
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of TNFRSF8 mRNA24530881
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNFRSF8 mRNA25613284
D007530IsofluraneIsoflurane results in decreased expression of TNFRSF8 mRNA16978161
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNFRSF8 mRNA24796395
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TNFRSF8 mRNA12057914
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of TNFRSF8 mRNA21782745
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNFRSF8 mRNA23649840
C028007nickel monoxidenickel monoxide results in increased expression of TNFRSF8 mRNA19167457
D005996NitroglycerinNitroglycerin results in decreased expression of TNFRSF8 mRNA12102619
C014707nitrosobenzylmethylamine[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of TNFRSF8 mRNA12517797
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in decreased expression of TNFRSF8 mRNA20705681
D010269ParaquatParaquat results in increased expression of TNFRSF8 mRNA18198484
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TNFRSF8 mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of TNFRSF8 mRNA23602845
C006253pirinixic acidNCF1 protein promotes the reaction [pirinixic acid results in decreased expression of TNFRSF8 mRNA]17950772
C006253pirinixic acidpirinixic acid results in decreased expression of TNFRSF8 mRNA17950772
D011070Poly I-CPoly I-C results in increased expression of TNFRSF8 mRNA19563882
D011802QuinidineQuinidine results in decreased expression of TNFRSF8 protein12441127
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNFRSF8 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFRSF8 mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNFRSF8 mRNA14718646|1531085
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNFRSF8 mRNA25613284
D014118Toxins, Biological"Toxins, Biological affects the expression of TNFRSF8 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of TNFRSF8 protein12441127
D014241TrichloroethyleneTrichloroethylene results in decreased expression of TNFRSF8 protein20530238
D014635Valproic AcidValproic Acid affects the expression of TNFRSF8 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of TNFRSF8 gene29154799
D015032Zinc[Zinc deficiency promotes the reaction [TRP53 gene mutant form results in increased susceptibility to nitrosobenzylmethylamine]] which results in increased expression of TNFRSF8 mRNA12517797

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS1310894  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS10192335  
GO:0008285negative regulation of cell proliferation-TAS10192335  
GO:0033209tumor necrosis factor-mediated signaling pathway-TAS-  
GO:0042535positive regulation of tumor necrosis factor biosynthetic process-IDA16108830  
GO:0043065positive regulation of apoptotic process-IDA16108830  
GO:0045556positive regulation of TRAIL biosynthetic process-IDA16108830  
GO:0071260cellular response to mechanical stimulus-IEP19593445  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-5668541TNFR2 non-canonical NF-kB pathwayTAS
R-HSA-5669034TNFs bind their physiological receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24098343Genome-wide association study of gene by smoking interactions in coronary artery calcification. (2013)Polfus LMPLoS One