Gene: NCR1

9437
CD335|LY94|NK-p46|NKP46
natural cytotoxicity triggering receptor 1
protein-coding
19q13.42
Ensembl:ENSG00000189430 MIM:604530 Vega:OTTHUMG00000183212 UniprotKB:O76036
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.696e-1 (AD)  7.729e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLRD10.812
IL2RB0.781
PRF10.775
SLAMF60.758
TRAT10.75
KLRB10.745
TBX210.743
GZMB0.731
ERVV-20.728
FCRL30.719

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SVOP-0.433
PRKCZ-0.432
THY1-0.43
MAGIX-0.427
CDS1-0.426
SCN2B-0.424
ATP2B3-0.423
HCN1-0.422
CYP46A1-0.418
C11orf87-0.414

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile results in decreased expression of NCR1 protein19229052
D000082AcetaminophenAcetaminophen results in increased expression of NCR1 mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of NCR1 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NCR1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of NCR1 mRNA24449571
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of NCR1 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of NCR1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NCR1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NCR1 promoter]19654925
C006780bisphenol Abisphenol A results in decreased expression of NCR1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of NCR1 protein19229052
D002211CapsaicinCapsaicin results in increased expression of NCR1 mRNA16278290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of NCR1 mRNA12734012
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of NCR1 mRNA24763279
D002737ChloropreneChloroprene results in decreased expression of NCR1 mRNA23125180
D019327Copper SulfateCopper Sulfate results in decreased expression of NCR1 mRNA19549813
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of NCR1 mRNA28085963
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of NCR1 mRNA24763279
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in decreased expression of NCR1 mRNA17183730
D009173Mycophenolic AcidMycophenolic Acid results in decreased expression of NCR120736080
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NCR1 mRNA"25554681
D009532NickelNickel affects the expression of NCR1 mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of NCR1 mRNA]14575637
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of NCR1 mRNA25729387
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of NCR1 protein"19822075
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NCR1 mRNA26377647
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of NCR1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of NCR1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of NCR1 protein17107666
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of NCR1 gene27618143
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of NCR1 mRNA]14575637
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in decreased expression of NCR1 mRNA17183730

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17056548  28480349  
GO ID GO Term Qualifier Evidence PubMed
GO:0006968cellular defense response-TAS9730896  
GO:0007165signal transduction-TAS9730896  
GO:0030101natural killer cell activation-NAS9730896  
GO:0042269regulation of natural killer cell mediated cytotoxicity-TAS15654827  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS9730896  
GO:0016514SWI/SNF complex-ISS-  
KEGG ID KEGG Term
hsa04650Natural killer cell mediated cytotoxicity
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23681825Heme-related gene expression signatures of meat intakes in lung cancer tissues. (2014 Jul)Lam TKMol Carcinog