Gene: GSTO1

9446
GSTO 1-1|GSTTLp28|HEL-S-21|P28|SPG-R
glutathione S-transferase omega 1
protein-coding
10q25.1
Ensembl:ENSG00000148834 MIM:605482 Vega:OTTHUMG00000019001 UniprotKB:P78417
NG_023362.1
PubMed
0   ANCO-SNPs
ND
16   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.598e-1 (AD)  9.418e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMB30.946
H2AFZ0.942
NDUFV20.939
PSMA60.934
SS18L20.93
PSMB40.929
PSMB60.925
ARPC30.924
PPA10.922
EMC40.921

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.748
OR4F29-0.714
P2RY14-0.271
KCNK5-0.239
KIAA0754-0.201
NKAIN3-0.2
SLC26A5-0.197
VNN3-0.196
PRDM14-0.196
TAS2R41-0.195

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
DB00163Vitamin ESmall Molecule59-02-9Approved|NutraceuticalEnzyme
DB14001alpha-Tocopherol succinateSmall Molecule4345-03-3Approved|NutraceuticalEnzyme
DB14002D-alpha-Tocopherol acetateSmall Molecule58-95-7Approved|NutraceuticalEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of GSTO1 mRNA"28903501
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of GSTO1 mRNA"20453058
C0230353,4,5,3',4'-pentachlorobiphenyl"[epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of GSTO1 mRNA"22521609
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GSTO1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GSTO1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of GSTO1 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of GSTO1 mRNA11793227|2142099
D020106AcrylamideAcrylamide results in increased expression of GSTO1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GSTO1 gene27153756
D000638AmiodaroneAmiodarone affects the expression of GSTO1 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GSTO1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GSTO1 mRNA24449571
D001151ArsenicArsenic affects the reaction [GSTO1 gene alternative form results in increased expression of APAF1 mRNA]22293942
D001151ArsenicArsenic affects the reaction [GSTO1 gene alternative form results in increased expression of CXCL8 mRNA]22293942
D001151ArsenicGSTO1 gene polymorphism affects the abundance of Arsenic metabolite24239724
D001151ArsenicGSTO1 gene polymorphism affects the metabolism of and affects the susceptibility to Arsenic14680363|1754869
D001151ArsenicGSTO1 gene polymorphism affects the reaction [PNP gene polymorphism affects the susceptibility to Arsenic]21605854
D001151ArsenicGSTO1 gene SNP affects the metabolism of Arsenic21094982
D001151ArsenicGSTO1 protein polymorphism results in decreased metabolism of Arsenic15901998
D001151ArsenicGSTO1 protein results in increased metabolism of Arsenic16638819|1841463
C025657arsenic acidGSTO1 protein results in increased reduction of arsenic acid16930657
C015001arseniteGSTO1 protein results in increased chemical synthesis of arsenite16930657
C015001arsenitearsenite results in increased expression of GSTO1 mRNA18929588
D001241AspirinAspirin results in decreased expression of GSTO1 mRNA14976132
D001280AtrazineAtrazine results in increased expression of GSTO1 mRNA25929836
C041512benzo(b)fluorene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of GSTO1 mRNA22120849
D053119Benzophenanthridines[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of GSTO1 mRNA22120849
D053119BenzophenanthridinesBenzophenanthridines analog results in increased expression of GSTO1 mRNA22120849
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GSTO1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GSTO1 protein22138271
D001564Benzo(a)pyreneMethionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSTO1 protein]22138271
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GSTO1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GSTO1 mRNA20127859|2373587
D004958EstradiolEstradiol affects the expression of GSTO1 mRNA15598610
D004958EstradiolEstradiol results in increased expression of GSTO1 mRNA15289156
C006780bisphenol Abisphenol A results in decreased expression of GSTO1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of GSTO1 mRNA25047013
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GSTO1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of GSTO1 mRNA12075121|2518105
C006780bisphenol Abisphenol A results in increased expression of GSTO1 protein22649256
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of GSTO1 mRNA18723825
D002085ButylhydroxybutylnitrosamineButylhydroxybutylnitrosamine results in increased expression of GSTO1 protein24998975
D002104CadmiumCadmium results in increased expression of GSTO1 mRNA21276481
D002104CadmiumCadmium results in increased expression of GSTO1 mRNA23369406
D002104CadmiumCadmium results in increased expression of GSTO1 mRNA19744577
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of GSTO1 mRNA19840844
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of GSTO1 mRNA]16221973
D002110CaffeineCaffeine results in decreased expression of GSTO1 mRNA11793227
C100187chloropicrinchloropicrin results in increased expression of GSTO1 mRNA26352163
D002737ChloropreneChloroprene results in increased expression of GSTO1 mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of GSTO1 mRNA25064622
D004390ChlorpyrifosChlorpyrifos results in increased expression of GSTO1 mRNA19440498
D002994ClofibrateClofibrate results in decreased expression of GSTO1 mRNA19952500
D002995Clofibric AcidClofibric Acid affects the expression of GSTO1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in increased expression of GSTO1 mRNA24612858
D003042CocaineCocaine affects the expression of GSTO1 protein19393250
D019327Copper SulfateCopper Sulfate results in decreased expression of GSTO1 mRNA19549813
C065868COSS-86 protocolGSTO1 results in decreased susceptibility to COSS-86 protocol14767549
C029892cupric chloridecupric chloride results in increased expression of GSTO1 mRNA23707386
D016572CyclosporineCyclosporine affects the expression of GSTO1 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of GSTO1 mRNA20106945
C014347decitabinedecitabine affects the expression of GSTO1 mRNA23300844
C014347decitabinedecitabine results in increased expression of GSTO1 mRNA24998975
C014347decitabinedecitabine results in increased expression of GSTO1 protein24998975
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of GSTO1 mRNA19444856
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GSTO1 mRNA28628672
D003976DiazinonDiazinon results in increased expression of GSTO1 mRNA19440498
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GSTO1 mRNA21266533
D002945CisplatinCisplatin affects the expression of GSTO1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GSTO1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of GSTO1 mRNA27392435
D002945CisplatinGSTO1 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinGSTO1 results in decreased susceptibility to Cisplatin21636539
D004026DieldrinDieldrin results in increased expression of GSTO1 mRNA19440498
C014476diethyl maleatediethyl maleate results in increased expression of GSTO1 mRNA25270620
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of GSTO1 mRNA17394237
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of GSTO1 mRNA15289156
D004237DiuronDiuron results in decreased expression of GSTO1 mRNA21551480
D004317DoxorubicinDoxorubicin affects the expression of GSTO1 mRNA25529476
D004785Environmental PollutantsGSTO1 polymorphism affects the susceptibility to Environmental Pollutants19686770
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of GSTO1 mRNA24534155
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GSTO1 protein23301498
C045651epigallocatechin gallate"[epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of GSTO1 mRNA"22521609
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of GSTO1 mRNA22521609
C045651epigallocatechin gallateNFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA]22521609
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GSTO1 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GSTO1 mRNA12075121|1557682
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in increased expression of GSTO1 mRNA22711419
C436526EUK-189EUK-189 inhibits the reaction [SOD2 gene mutant form results in increased expression of GSTO1 mRNA]15964507
D005411Flame RetardantsFlame Retardants results in decreased expression of GSTO1 protein18550172
D005480FlurbiprofenFlurbiprofen results in increased expression of GSTO1 mRNA16949054
D019833GenisteinGenistein results in increased expression of GSTO1 mRNA15289156
D019833GenisteinGenistein results in increased expression of GSTO1 mRNA12075121
D005839GentamicinsGentamicins results in increased expression of GSTO1 mRNA22061828
C492448ICG 001ICG 001 results in decreased expression of GSTO1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GSTO1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of GSTO1 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of GSTO1 mRNA21335049
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GSTO1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of GSTO1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of GSTO1 mRNA12832151
C008261lead acetatelead acetate results in increased expression of GSTO1 mRNA11578147
C031895lead chromatelead chromate results in increased expression of GSTO1 mRNA23584427
D008715MethionineMethionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSTO1 protein]22138271
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GSTO1 mRNA20061341
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of GSTO1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of GSTO1 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTO1 mRNA19840844
D052998MicrocystinsMicrocystins affects the expression of GSTO1 mRNA19790251
D052998MicrocystinsMicrocystins results in decreased expression of GSTO1 mRNA19790251
C540575MK2i peptide[TGFB1 protein co-treated with MK2i peptide] results in decreased expression of GSTO1 protein20864298
C020300monomethylarsonic acid[GSTO1 protein results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of monomethylarsonous acid12928150
C020300monomethylarsonic acidGSTO1 protein results in increased reduction of monomethylarsonic acid15929903
C406082monomethylarsonous acidGSTO1 protein results in increased chemical synthesis of monomethylarsonous acid12928150|1693065
C406082monomethylarsonous acid[GSTO1 protein results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of monomethylarsonous acid12928150
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of GSTO1 mRNA18524450
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GSTO1 mRNA"25620056
C498045NCX 4040NCX 4040 results in increased expression of GSTO1 mRNA20188076
D009532NickelNickel results in decreased expression of GSTO1 mRNA19440498
C028007nickel monoxidenickel monoxide results in increased expression of GSTO1 mRNA19167457
C025589ochratoxin Aochratoxin A results in decreased expression of GSTO1 mRNA19287073
C025589ochratoxin Aochratoxin A results in decreased expression of GSTO1 protein19287073
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of GSTO1 mRNA19840844
D010269ParaquatParaquat affects the expression of GSTO1 mRNA25064622
D010269ParaquatParaquat results in increased expression of GSTO1 mRNA16128001
D052638Particulate MatterParticulate Matter results in increased expression of GSTO1 mRNA24769257
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of GSTO1 protein18550172
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of GSTO1 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GSTO1 mRNA17560707
D010634PhenobarbitalPhenobarbital results in increased expression of GSTO1 mRNA19952500
D010672PhenytoinPhenytoin results in decreased expression of GSTO1 mRNA14741686
D010795Phthalic AcidsPhthalic Acids results in decreased expression of GSTO1 mRNA15728792
D010936Plant ExtractsPlant Extracts results in increased expression of GSTO1 mRNA28315776
D011374ProgesteroneProgesterone results in decreased expression of GSTO1 mRNA23012394
D011374ProgesteroneProgesterone results in increased expression of GSTO1 mRNA22238285
C059514resveratrolresveratrol results in increased expression of GSTO1 mRNA22610192
C059514resveratrolresveratrol results in increased expression of GSTO1 protein25505154
C447880retene[Benzophenanthridines analog co-treated with benzo(b)fluorene co-treated with retene] results in increased expression of GSTO1 mRNA22120849
D012402RotenoneRotenone results in increased expression of GSTO1 mRNA17657281
C527914S-(4-nitrophenacyl)glutathioneGSTO1 protein results in increased reduction of S-(4-nitrophenacyl)glutathione18571971
C527914S-(4-nitrophenacyl)glutathioneGSTO1 protein results in increased reduction of S-(4-nitrophenacyl)glutathione26496421
D012834SilverSilver analog results in increased expression of GSTO1 mRNA21276481
C009277sodium arsenatesodium arsenate results in increased expression of GSTO1 mRNA16882884
C017947sodium arsenitesodium arsenite results in decreased expression of GSTO1 mRNA12634122
C017947sodium arsenitesodium arsenite results in increased expression of GSTO1 mRNA28595984
C017947sodium arsenitesodium arsenite results in increased expression of GSTO1 protein15725613
C017947sodium arseniteNFE2L1 protein alternative form inhibits the reaction [sodium arsenite results in increased expression of GSTO1 mRNA]28549828
C017947sodium arsenitesodium arsenite results in decreased expression of GSTO1 mRNA17450228
C017947sodium arsenitesodium arsenite results in increased expression of GSTO1 mRNA26473898|2716563
C016104sodium bichromatesodium bichromate results in decreased expression of GSTO1 mRNA24612858
D018038Sodium SeleniteSodium Selenite results in decreased expression of GSTO1 mRNA16705456
C061133tamibarotenetamibarotene results in increased expression of GSTO1 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GSTO1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GSTO1 mRNA21041162
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GSTO1 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of GSTO1 mRNA28973375
D013752TetracyclineTetracycline affects the expression of GSTO1 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTO1 mRNA19840844
D013853ThioacetamideThioacetamide affects the expression of GSTO1 mRNA25064622
D013853ThioacetamideThioacetamide results in decreased expression of GSTO1 mRNA11793227
C009495titanium dioxidetitanium dioxide results in decreased expression of GSTO1 mRNA23557971
D014028Tobacco Smoke PollutionGSTO1 gene SNP affects the susceptibility to Tobacco Smoke Pollution23937118
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of GSTO1 mRNA24096154
D024505TocopherolsTocopherols results in decreased activity of GSTO1 protein16781109
D014212TretinoinTretinoin results in increased expression of GSTO1 mRNA15498508
D014241TrichloroethyleneTrichloroethylene results in increased expression of GSTO1 mRNA19109764|2135165
D014241TrichloroethyleneTrichloroethylene results in increased expression of GSTO1 protein19109764
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of GSTO1 mRNA]15363585
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GSTO1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of GSTO1 mRNA24935251|2627250
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of GSTO1 mRNA19444856
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of GSTO1 mRNA29024780
D014520UrethaneUrethane results in decreased expression of GSTO1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of GSTO1 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of GSTO1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GSTO1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of GSTO1 mRNA23527032
D014638VanadatesVanadates results in increased expression of GSTO1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of GSTO1 gene25560391
D024483Vitamin K 3Vitamin K 3 affects the expression of GSTO1 mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-IDA11511179  
GO:0004364glutathione transferase activity-TAS-  
GO:0005515protein binding-IPI25277244  
GO:0016491oxidoreductase activity-IDA11511179  
GO:0045174glutathione dehydrogenase (ascorbate) activity-IBA21873635  
GO:0045174glutathione dehydrogenase (ascorbate) activity-IDA11511179  
GO:0050610methylarsonate reductase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum-IDA11035031  
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-IC11035031  
GO:0014810positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion-IC11035031  
GO:0019852L-ascorbic acid metabolic process-IDA11511179  
GO:0032259methylation-TAS-  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0042178xenobiotic catabolic process-IDA12928150  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO:0060315negative regulation of ryanodine-sensitive calcium-release channel activity-IDA11035031  
GO:0060316positive regulation of ryanodine-sensitive calcium-release channel activity-IDA11035031  
GO:0071243cellular response to arsenic-containing substance-IDA11511179  
GO:0098869cellular oxidant detoxification-IEA-  
GO:1901687glutathione derivative biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA11511179  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
KEGG ID KEGG Term
hsa00480Glutathione metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156581MethylationTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-168256Immune SystemTAS
R-HSA-196836Vitamin C (ascorbate) metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-9020591Interleukin-12 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19686770A significantly joint effect between arsenic and occupational exposures and risk genotypes/diplotypes of CYP2E1, GSTO1 and GSTO2 on risk of urothelial carcinoma. (2009 Nov 15)Wang YHToxicol Appl Pharmacol
25716313GSTO1*C/GSTO2*G haplotype is associated with risk of transitional cell carcinoma of urinary bladder. (2015 Apr)Djukic TInt Urol Nephrol
20472488GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population. (2010 Aug)Kiyohara CParkinsonism Relat Disord
25967284Metals exposure and risk of small-for-gestational age birth in a Canadian birth cohort: The MIREC study. (2015 Jul)Thomas SEnviron Res
23819933Association between glutathione S-transferase omega 1 A140D polymorphism in the Turkish population and susceptibility to non-small cell lung cancer. (2013 Jun)Ada TGArh Hig Rada Toksikol
23086268Association of glutathione S-transferase omega gene polymorphisms with progression of head and neck cancer. (2012 Dec)Sanguansin SMol Biol Rep
25103078Combined effects of GSTO1 and SULT1A1 polymorphisms and cigarette smoking on urothelial carcinoma risk in a Taiwanese population. (2014 Sep)Tung MCJ Formos Med Assoc
23927022Glutathione S-transferase omega-2 polymorphism Asn142Asp modifies the risk of age-related cataract in smokers and subjects exposed to ultraviolet irradiation. (2014 Apr)Stamenkovic MClin Exp Ophthalmol
18647550Lack of association of GSTT1, GSTM1, GSTO1, GSTP1 and CYP1A1 polymorphisms for susceptibility and outcome in Brazilian prostate cancer patients. (2008)Lima MM JrFolia Biol (Praha)
17194543Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease. (2007 Feb 21)Wahner ADNeurosci Lett
18414193Polymorphisms of glutathione S-transferase A1 and O1 and breast cancer among postmenopausal Danish women. (2008 Jun)Olsen AEur J Cancer Prev
19859803No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (2010 Jun)Andonova IEBreast Cancer Res Treat
27327299Association between polymorphisms in arsenic metabolism genes and urinary arsenic methylation profiles in girls and boys chronically exposed to arsenic. (2016 Aug)Recio-Vega REnviron Mol Mutagen
19513904Association of glutathione-S-transferase omega haplotypes with susceptibility to chronic obstructive pulmonary disease. (2009 Aug)Yanbaeva DGFree Radic Res
17158763Smoking and susceptibility to thyroid cancer: an inverse association with CYP1A1 allelic variants. (2006 Dec)Bufalo NEEndocr Relat Cancer
25892883Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients. (2015 Apr 14)Qu KWorld J Gastroenterol