Gene: AIM2

9447
PYHIN4
absent in melanoma 2
protein-coding
1q23.1-q23.2
Ensembl:ENSG00000163568 MIM:604578 Vega:OTTHUMG00000037183 UniprotKB:O14862
NC_000001.11
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.488e-1 (AD)  9.282e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD800.838
GBP50.82
CYP19A10.819
ETV70.818
RHOH0.812
DDX60L0.805
NMI0.803
LAMP30.803
KRT750.795
CCL80.794

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.388
EXTL1-0.376
SCRT1-0.364
B3GALT2-0.359
ATP2C2-0.358
GABRA5-0.357
FEZF2-0.355
FOXRED2-0.355
SOHLH1-0.354
MYADML2-0.354

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of AIM2 mRNA"23195993
C006780bisphenol Abisphenol A affects the expression of AIM2 mRNA25181051
D000069286BortezomibBortezomib results in increased expression of AIM2 mRNA20977926
D003300CopperCopper deficiency results in increased expression of AIM2 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of AIM2 mRNA26577399
D003703DemecolcineDemecolcine results in increased expression of AIM2 mRNA23649840
D004008DiclofenacDiclofenac results in increased expression of AIM2 mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of AIM2 mRNA25016146
D005557FormaldehydeFormaldehyde results in increased expression of AIM2 mRNA23649840
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of AIM2 mRNA23086925
D008070LipopolysaccharidesLipopolysaccharides affects the expression of AIM2 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of AIM2 mRNA]28070326
D008070LipopolysaccharidesAIM2 protein promotes the reaction [[Lipopolysaccharides co-treated with Poly dA-dT] results in increased secretion of IL1B protein]24158569
D008555MelittenAIM2 protein promotes the reaction [Melitten results in increased expression of IL18 protein]22973906
D008555MelittenAIM2 protein promotes the reaction [Melitten results in increased expression of IL1B protein]22973906
D008727MethotrexateAIM2 protein affects the susceptibility to Methotrexate16217747
D009532NickelNickel results in decreased expression of AIM2 mRNA23195993
D009532NickelNickel results in increased expression of AIM2 mRNA25583101
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of AIM2 mRNA]28070326
D011067Poly dA-dTAIM2 protein promotes the reaction [[Lipopolysaccharides co-treated with Poly dA-dT] results in increased secretion of IL1B protein]24158569
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AIM2 mRNA21570461
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of AIM2 gene25560391
D014750VincristineVincristine results in increased expression of AIM2 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003690double-stranded DNA binding-IDA19158675  
GO:0005515protein binding-IPI19158675  19158676  22286270  22801494  24237704  24630722  
GO:0042802identical protein binding-IPI19158676  24630722  
GO ID GO Term Qualifier Evidence PubMed
GO:0002218activation of innate immune response-IDA19158675  19158676  19158679  
GO:0002230positive regulation of defense response to virus by host-ISS-  
GO:0006915apoptotic process-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-TAS9242382  
GO:0032088negative regulation of NF-kappaB transcription factor activity-IDA16432157  
GO:0032461positive regulation of protein oligomerization-IDA19158676  
GO:0032731positive regulation of interleukin-1 beta production-IDA19158675  19158676  19158679  
GO:0033209tumor necrosis factor-mediated signaling pathway-IDA16432157  
GO:0035458cellular response to interferon-beta-IEA-  
GO:0035690cellular response to drug-IDA19158679  
GO:0045087innate immune response-IEA-  
GO:0050702interleukin-1 beta secretion-IMP19158679  
GO:0050718positive regulation of interleukin-1 beta secretion-IDA19158679  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IDA19158675  
GO:0070269pyroptosis-IDA19158675  19158676  
GO:2001056positive regulation of cysteine-type endopeptidase activity-IDA19158676  19158679  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA19158676  
GO:0005739mitochondrion-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0097169AIM2 inflammasome complex-IDA19158676  19158679  
KEGG ID KEGG Term
hsa04623Cytosolic DNA-sensing pathway
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysIEA
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-622312InflammasomesIEA
R-HSA-622312InflammasomesTAS
R-HSA-844615The AIM2 inflammasomeIEA
R-HSA-844615The AIM2 inflammasomeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28463821Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome. (2017 Aug)Hoyt LRRedox Biol