Gene: CD33

945
SIGLEC-3|SIGLEC3|p67
CD33 molecule
protein-coding
19q13.41
Ensembl:ENSG00000105383 MIM:159590 Vega:OTTHUMG00000182891 UniprotKB:P20138
NC_000019.10
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.838e-1 (AD)  9.713e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DOCK20.933
CD840.929
NCKAP1L0.928
SYK0.927
TLR60.917
WDFY40.917
CYBB0.916
SLC7A70.913
PTAFR0.908
TBXAS10.908

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.405
ASPDH-0.396
TMEM191C-0.391
KCNIP3-0.389
HAGHL-0.384
ZSCAN1-0.378
BDH1-0.369
RTN4R-0.368
TMEM179-0.365
REEP6-0.364

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00056Gemtuzumab ozogamicinBiotechDrug220578-59-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CD33 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CD33 mRNA24449571
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CD33 mRNA25270620
D002273CarcinogensCarcinogens results in decreased expression of CD33 mRNA22269147
D004390ChlorpyrifosChlorpyrifos results in decreased expression of CD33 protein23994500
D003471CuprizoneCuprizone results in increased expression of CD33 mRNA27523638
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CD33 protein18951874
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CD33 mRNA25982114
D009153MutagensMutagens results in decreased expression of CD33 mRNA22269147
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CD33 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CD33 mRNA"25554681
D009532NickelNickel results in increased expression of CD33 mRNA24768652|2558310
C005556propionaldehydepropionaldehyde results in increased expression of CD33 mRNA26079696
D053260SootSoot results in increased expression of CD33 mRNA22461453
C021751tanshinonetanshinone results in decreased expression of CD33 protein16009009
C043062tesmilifenetesmilifene results in decreased expression of CD33 protein11306145
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CD33 protein18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CD33 mRNA20133372
D014212TretinoinCSF3 protein promotes the reaction [Tretinoin results in increased expression of CD33 protein]12627849
D014212TretinoinTretinoin results in increased expression of CD33 protein12627849
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CD33 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10206955  10556798  17947393  25416956  
GO:0030246carbohydrate binding-IEA-  
GO:0038023signaling receptor activity-TAS10611343  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-TAS10611343  
GO:0007267cell-cell signaling-TAS10611343  
GO:0008285negative regulation of cell proliferation-TAS10611343  
GO:0043312neutrophil degranulation-TAS-  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS3139766  
GO:0009897external side of plasma membrane-IDA20660734  
GO:0035579specific granule membrane-TAS-  
GO:0070821tertiary granule membrane-TAS-  
KEGG ID KEGG Term
hsa04640Hematopoietic cell lineage
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget
25430025[Identification and clinical significance of myeloid-derived suppressor cells in peripheral blood of small-cell lung cancer patients]. (2014 Aug)Cheng YZhonghua Zhong Liu Za Zhi
8181314Expression of surface markers on alveolar macrophages from symptomatic patients with HIV infection as detected by flow cytometry. (1994 May)Wasserman KChest
23993707Differential effects of smoking and COPD upon circulating myeloid derived suppressor cells. (2013 Dec)Scrimini SRespir Med
26122358Expansion of myeloid-derived suppressor cells in chronic obstructive pulmonary disease and lung cancer: potential link between inflammation and cancer. (2015 Oct)Scrimini SCancer Immunol Immunother