Gene: LY86

9450
MD-1|MD1|MMD-1|dJ80N2.1
lymphocyte antigen 86
protein-coding
6p25.1
Ensembl:ENSG00000112799 MIM:605241 Vega:OTTHUMG00000014190 UniprotKB:O95711
NC_000006.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.155e-1 (AD)  2.927e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LST10.931
AIF10.929
C30.922
SYK0.911
RNASE60.91
HLA-DMB0.904
RGS100.903
CSF1R0.898
BIN20.898
APBB1IP0.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HES5-0.347
ST6GAL2-0.337
ATP2C2-0.336
KCNIP3-0.336
CHRNA4-0.326
WNT7A-0.32
YBX2-0.32
KREMEN2-0.317
SDK2-0.306
CPLX3-0.306

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of LY86 mRNA"19162173
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LY86 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LY86 mRNA"25380136
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of LY86 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of LY86 mRNA17562736
D000082AcetaminophenLY86 gene polymorphism results in increased susceptibility to Acetaminophen19416960
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of LY86 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of LY86 mRNA21298039
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of LY86 mRNA"22863853
D001151ArsenicArsenic affects the methylation of LY86 gene25304211
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of LY86 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LY86 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LY86 mRNA22228805
D004958EstradiolEstradiol results in increased expression of LY86 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of LY86 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of LY86 mRNA25993096
D002185CannabidiolCannabidiol results in decreased expression of LY86 mRNA21542829
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LY86 mRNA27339419
D002737ChloropreneChloroprene results in decreased expression of LY86 mRNA23125180
D002737ChloropreneChloroprene results in decreased expression of LY86 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LY86 mRNA20938992
D003471CuprizoneCuprizone results in increased expression of LY86 mRNA27523638
D013759DronabinolDronabinol results in decreased expression of LY86 mRNA21542829
D016264Dextran SulfateDextran Sulfate results in increased expression of LY86 mRNA23894361
D003976DiazinonDiazinon affects the expression of LY86 mRNA22546817
D004041Dietary FatsDietary Fats affects the expression of LY86 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of LY86 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of LY86 mRNA22609946
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of LY86 mRNA21658437
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LY86 mRNA25380136
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of LY86 mRNA12072388
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of LY86 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LY86 mRNA20938992
D004397FonofosFonofos results in increased methylation of LY86 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of LY86 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of LY86 mRNA22061828
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of LY86 mRNA17183730
D048628KetolidesKetolides analog results in increased expression of LY86 mRNA24967691
C045463leflunomideleflunomide results in decreased expression of LY86 mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LY86 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LY86 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of LY86 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of LY86 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LY86 mRNA"25620056
D019829NevirapineNevirapine results in decreased expression of LY86 mRNA23947594
D009532NickelNickel results in increased expression of LY86 mRNA24768652|2558310
D010098OxycodoneOxycodone results in decreased expression of LY86 mRNA23439660
D010126OzoneOzone results in decreased expression of LY86 mRNA12763052
D000073878Palm OilPalm Oil results in decreased expression of LY86 mRNA18042831
D010278ParathionParathion results in increased methylation of LY86 promoter22847954
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LY86 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of LY86 mRNA19162173
D017035PravastatinPravastatin results in decreased expression of LY86 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of LY86 mRNA27225895
D011341ProbucolProbucol promotes the reaction [APOE gene mutant form results in increased expression of LY86 mRNA]19394937
D011374ProgesteroneProgesterone results in increased expression of LY86 mRNA21549006
D011441PropylthiouracilPropylthiouracil results in increased expression of LY86 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in decreased expression of LY86 mRNA23221170
D018038Sodium SeleniteSodium Selenite results in increased expression of LY86 mRNA18175754
C075117squalestatin 1squalestatin 1 results in increased expression of LY86 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of LY86 mRNA27225895
C013698tallowtallow affects the expression of LY86 mRNA19680557
C012568terbufosterbufos results in increased methylation of LY86 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LY86 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of LY86 gene26431795
C009495titanium dioxidetitanium dioxide results in decreased expression of LY86 mRNA27760801
C009495titanium dioxidetitanium dioxide results in increased expression of LY86 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of LY86 mRNA20133372
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of LY86 mRNA17982090
C057693troglitazonetroglitazone results in decreased expression of LY86 mRNA17569031
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of LY86 mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of LY86 mRNA17292431|1796380
C025643vinclozolinvinclozolin results in increased expression of LY86 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of LY86 mRNA26682919
D015034Zinc OxideZinc Oxide analog results in decreased expression of LY86 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of LY86 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21857663  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-TAS9763566  
GO:0006954inflammatory response-IEA-  
GO:0006959humoral immune response-TAS9763566  
GO:0008283cell proliferation-TAS9763566  
GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway-IGI10880523  
GO:0045087innate immune response-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005886plasma membrane-TAS9763566  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes