Gene info: ID 9451

Gene: EIF2AK3

GENE ID: 9451

Synonyms: PEK|PERK|WRS

Description: eukaryotic translation initiation factor 2 alpha kinase 3

Gene type: protein-coding

Location: 2p11.2

dbXrefs: Ensembl:ENSG00000172071 MIM:604032 Vega:OTTHUMG00000155046 UniprotKB:Q9NZJ5

RefSeq: NG_016424.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|ND

# Publications: 2

Sherlock p-value : 4.135e-1 (AD) 1.764e-1 (ND) (Frontal_Cortex)

Pascal p-value : 5.734e-1 (AD) 8.831e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DHX15	0.868
SEC24A	0.851
BIRC2	0.85
RIOK3	0.848
NAA15	0.847
ATP11B	0.843
DDX18	0.842
SCYL2	0.84
TBC1D23	0.84
ESCO1	0.837

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.493
OR4F29	-0.463
HES5	-0.274
BTBD17	-0.266
OR4F16	-0.253
NXNL1	-0.251
RERGL	-0.221
MUSTN1	-0.218
PTGDR2	-0.217
C16orf74	-0.212

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C552530	1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane	"1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased phosphorylation of EIF2AK3 protein"	26035713
C561619	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Palmitates results in increased phosphorylation of EIF2AK3 protein]	23576437
C561619	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]	23576437
C561619	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats inhibits the reaction [EPHX2 gene mutant form results in decreased phosphorylation of EIF2AK3 protein]]	23576437
C561619	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased phosphorylation of EIF2AK3 protein]	23576437
C561619	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]	23576437
C561619	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea results in decreased phosphorylation of EIF2AK3 protein	23576437
C025603	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in increased expression of EIF2AK3 protein"	28181380
C025603	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	"[fisetin co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased expression of EIF2AK3 protein"	28181380
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]"	26609140
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]"	22959925
C049325	1,2-dithiol-3-thione	"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]]"	22959925
C049325	1,2-dithiol-3-thione	"Bortezomib inhibits the reaction [1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]]"	22959925
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of EIF2AK3 mRNA"	19162173
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of EIF2AK3 mRNA	28329830
C119546	1-palmitoyl-2-(5-oxovaleroyl)phosphatidylcholine	1-palmitoyl-2-(5-oxovaleroyl)phosphatidylcholine results in increased phosphorylation of EIF2AK3 protein	19041636
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of EIF2AK3 protein]	25827057
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of EIF2AK3 mRNA"	19095052
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2AK3 protein"	25639565
C511295	2,2',4,4'-tetrabromodiphenyl ether	"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2AK3 protein]]"	25639565
C511295	2,2',4,4'-tetrabromodiphenyl ether	"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2AK3 protein]"	25639565
C587734	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of EIF2AK3 protein"	25950987
C587734	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	"2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of EIF2AK3 protein modified form"	25950987
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in increased phosphorylation of EIF2AK3 protein"	21703327
C000599093	2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide	2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [arsenic trioxide results in increased expression of EIF2AK3 protein modified form]	27638049
C000599093	2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide	2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide results in decreased activity of EIF2AK3 protein	27638049
C109986	2-aminoethoxydiphenyl borate	2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]	26609140
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]	25341683
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EIF2AK3 mRNA"	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased phosphorylation of EIF2AK3 protein"	19561079
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]	22226148\|2327070
C400084	4-chlorobenzyltetrahydroberberine	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein]	22226148\|2327070
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased phosphorylation of EIF2AK3 protein	19041636
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein]	28245985
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]	28063906
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 mRNA]	27470132
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 protein]	27470132
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]	28063906
C075773	4-phenylbutyric acid	4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form]	27484784
C075773	4-phenylbutyric acid	4-phenylbutyric acid results in decreased expression of EIF2AK3 protein modified form	27484784
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EIF2AK3 mRNA"	27188386
C121465	6-methyl-2-(phenylethynyl)pyridine	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]	17303341
D000082	Acetaminophen	Acetaminophen affects the expression of EIF2AK3 mRNA	17562736
C056165	acetovanillone	acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]	23270704
C056165	acetovanillone	acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein]	23270704
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]	27784618
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]	25341683
D000111	Acetylcysteine	Acetylcysteine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein	19722195
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein]	25451595
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form]	27484784
D000111	Acetylcysteine	Acetylcysteine results in decreased expression of EIF2AK3 protein modified form	27484784
D000171	Acrolein	Acrolein results in increased phosphorylation of EIF2AK3 protein	19041636
D020106	Acrylamide	Acrylamide results in decreased expression of EIF2AK3 mRNA	28959563
D006710	Homocysteine	Homocysteine results in decreased phosphorylation of EIF2AK3 protein	22964297
D000638	Amiodarone	Amiodarone results in increased expression of EIF2AK3 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of EIF2AK3 mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of EIF2AK3 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in increased expression of EIF2AK3 mRNA	17963750
C006632	arsenic trioxide	arsenic trioxide results in increased expression of EIF2AK3 protein modified form	22922937
C006632	arsenic trioxide	sulforafan promotes the reaction [arsenic trioxide results in increased expression of EIF2AK3 protein modified form]	22922937
C006632	arsenic trioxide	2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [arsenic trioxide results in increased expression of EIF2AK3 protein modified form]	27638049
C006632	arsenic trioxide	"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased expression of EIF2AK3 protein modified form]"	27638049
C006632	arsenic trioxide	arsenic trioxide results in increased expression of EIF2AK3 protein modified form	27638049
C006632	arsenic trioxide	ATF4 protein promotes the reaction [arsenic trioxide results in increased expression of EIF2AK3 protein modified form]	27638049
D000069059	Atorvastatin Calcium	EIF2AK3 mutant form inhibits the reaction [Atorvastatin Calcium results in increased phosphorylation of EIF2S1 protein]	20876807
D000069059	Atorvastatin Calcium	EIF2AK3 results in increased susceptibility to Atorvastatin Calcium	20876807
C017037	aurin	aurin results in increased phosphorylation of EIF2AK3 protein	25477506
C406592	azaspiracid	azaspiracid results in increased expression of EIF2AK3 mRNA	28939011
D001542	Benomyl	Acetylcysteine inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]	27784618
D001542	Benomyl	Benomyl results in increased expression of EIF2AK3 protein	27784618
D001542	Benomyl	MitoTEMPO inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]	27784618
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of EIF2AK3 mRNA"	20382639
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]]"	22959925
D004958	Estradiol	Estradiol results in decreased expression of EIF2AK3 mRNA	19167446
D004958	Estradiol	Estradiol results in increased expression of EIF2AK3 mRNA	20106945
D001663	Bilirubin	Bilirubin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein	20196124
D001663	Bilirubin	EIF2AK3 mRNA promotes the reaction [Bilirubin results in increased expression of CXCL8 mRNA]	27578021
C109992	bis(isopropyl methyl)phosphonate	bis(isopropyl methyl)phosphonate results in increased phosphorylation of EIF2AK3 protein	27665771
C006780	bisphenol A	bisphenol A results in increased expression of EIF2AK3 mRNA	29027980
C006780	bisphenol A	bisphenol A affects the expression of EIF2AK3 mRNA	22574217
C006780	bisphenol A	bisphenol A results in decreased expression of EIF2AK3 mRNA	26063408
C006780	bisphenol A	bisphenol A results in increased expression of EIF2AK3 mRNA	28938450
C006780	bisphenol A	bisphenol A results in increased expression of EIF2AK3 mRNA	18180321\|2518105
D001786	Blood Glucose	Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]	26747958
D001786	Blood Glucose	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]	26747958
D001786	Blood Glucose	Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]	26747958
D001786	Blood Glucose	[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein	26747958
D001786	Blood Glucose	[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein	26747958
D001786	Blood Glucose	zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]	26747958
D001786	Blood Glucose	zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]	26747958
D000069286	Bortezomib	Bortezomib results in increased phosphorylation of EIF2AK3 protein	15509775\|1692868
D000069286	Bortezomib	EIF2AK3 mutant form inhibits the reaction [Bortezomib results in increased phosphorylation of EIF2S1 protein]	20022965
D000069286	Bortezomib	EIF2AK3 results in decreased susceptibility to Bortezomib	20022965
D000069286	Bortezomib	"Bortezomib inhibits the reaction [1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]]"	22959925
D000069286	Bortezomib	Bortezomib results in increased phosphorylation of EIF2AK3 protein	15509775
D020126	Brefeldin A	Brefeldin A results in increased expression of EIF2AK3 protein	24865413
C022777	bufalin	bufalin results in decreased phosphorylation of EIF2AK3 protein	23949904
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]	25341683
D002104	Cadmium	Cadmium results in increased phosphorylation of EIF2AK3 protein	20600546
D002104	Cadmium	Cadmium results in decreased phosphorylation of EIF2AK3 protein	27658547
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of EIF2AK3 protein modified form	21325019
D019256	Cadmium Chloride	Cadmium Chloride results in increased phosphorylation of EIF2AK3 protein	17464326
D002118	Calcium	Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]	26609140
D002193	Cantharidin	Cantharidin results in increased expression of EIF2AK3 protein	27113412
D002220	Carbamazepine	Carbamazepine affects the expression of EIF2AK3 mRNA	24752500
D002220	Carbamazepine	Carbamazepine results in increased activity of EIF2AK3 protein	24752500
D002251	Carbon Tetrachloride	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of EIF2AK3 protein]	25827057
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased phosphorylation of EIF2AK3 protein	25827057
D002251	Carbon Tetrachloride	[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of EIF2AK3 protein modified form	20097184
C006972	chloroacetic acid	Acetylcysteine inhibits the reaction [chloroacetic acid results in increased phosphorylation of EIF2AK3 protein]	25451595
C006972	chloroacetic acid	chloroacetic acid results in increased phosphorylation of EIF2AK3 protein	25451595
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EIF2AK3 gene	20938992
C512471	chromium (D-Phenylalanine)3	chromium (D-Phenylalanine)3 results in decreased expression of EIF2AK3 protein modified form	18388893
C039671	ciglitazone	ciglitazone promotes the reaction [Niflumic Acid results in increased phosphorylation of EIF2AK3 protein]	21067863
C039671	ciglitazone	ciglitazone results in increased phosphorylation of EIF2AK3 protein	21067863
C039671	ciglitazone	Niflumic Acid promotes the reaction [ciglitazone results in increased phosphorylation of EIF2AK3 protein]	21067863
D002995	Clofibric Acid	Clofibric Acid affects the expression of EIF2AK3 mRNA	17602206
D003042	Cocaine	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]	17303341
D003042	Cocaine	Cocaine results in increased expression of EIF2AK3 protein	17303341
D003042	Cocaine	Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]	17303341
D003042	Cocaine	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]	17303341
D003042	Cocaine	SCH 23390 inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]	17303341
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of EIF2AK3 mRNA	19549813
D003375	Coumestrol	Coumestrol results in decreased expression of EIF2AK3 mRNA	19167446
D003513	Cycloheximide	Cycloheximide inhibits the reaction [dimethylarsinous acid results in increased phosphorylation of EIF2AK3 protein]	22425709
D016572	Cyclosporine	Cyclosporine results in increased expression of EIF2AK3 mRNA	20106945\|2163298
C093628	cyproconazole	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EIF2AK3 mRNA	29038839
D003603	Cytotoxins	Cytotoxins results in increased phosphorylation of EIF2AK3 protein	21147958
D003603	Cytotoxins	EIF2AK3 protein affects the reaction [Cytotoxins results in increased phosphorylation of MAPK1 protein]	21147958
D003603	Cytotoxins	EIF2AK3 protein affects the reaction [Cytotoxins results in increased phosphorylation of MAPK3 protein]	21147958
D003603	Cytotoxins	EIF2AK3 protein affects the reaction [Cytotoxins results in increased phosphorylation of MAPK8 protein]	21147958
D003603	Cytotoxins	EIF2AK3 protein affects the reaction [Cytotoxins results in increased phosphorylation of MAPK9 protein]	21147958
D003620	Dantrolene	Dantrolene results in decreased phosphorylation of EIF2AK3 protein	15921666
C107676	deguelin	deguelin results in increased phosphorylation of EIF2AK3 protein	25322282
C050229	demethoxycurcumin	demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]	26264395
C539263	di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone	"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased phosphorylation of EIF2AK3 protein"	24532803
C539263	di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone	"EIF2AK3 protein promotes the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased phosphorylation of EIF2S1 protein]"	24532803
C539263	di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone	"NDRG1 protein inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased phosphorylation of EIF2AK3 protein]"	24532803
D003974	Diatrizoate Meglumine	Diatrizoate Meglumine results in increased phosphorylation of EIF2AK3 protein	20071420
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of EIF2AK3 mRNA	21266533
D004008	Diclofenac	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]"	26609140
D004008	Diclofenac	2-aminoethoxydiphenyl borate inhibits the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]	26609140
D004008	Diclofenac	Calcium promotes the reaction [Diclofenac results in increased phosphorylation of EIF2AK3 protein]	26609140
D004008	Diclofenac	Diclofenac affects the expression of EIF2AK3 mRNA	24752500
D004008	Diclofenac	Diclofenac results in increased activity of EIF2AK3 protein	24752500
D004008	Diclofenac	Diclofenac results in increased phosphorylation of EIF2AK3 protein	26609140
D004008	Diclofenac	Diclofenac results in increased expression of EIF2AK3 mRNA	26934552
D004041	Dietary Fats	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats inhibits the reaction [EPHX2 gene mutant form results in decreased phosphorylation of EIF2AK3 protein]]	23576437
D004041	Dietary Fats	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Dietary Fats results in increased phosphorylation of EIF2AK3 protein]	23576437
D004041	Dietary Fats	Dietary Fats inhibits the reaction [EPHX2 gene mutant form results in decreased phosphorylation of EIF2AK3 protein]	23576437
D004041	Dietary Fats	Dietary Fats results in increased phosphorylation of EIF2AK3 protein	23576437
D004041	Dietary Fats	[PTPN1 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased activity of and results in increased phosphorylation of EIF2AK3 protein	22509299
D004041	Dietary Fats	[resveratrol co-treated with Dietary Fats] results in decreased phosphorylation of EIF2AK3 protein	26055348
D017878	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	"4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased expression of EIF2AK3 protein modified form]"	27638049
C472511	dimethylarsinous acid	Cycloheximide inhibits the reaction [dimethylarsinous acid results in increased phosphorylation of EIF2AK3 protein]	22425709
C472511	dimethylarsinous acid	dimethylarsinous acid results in increased phosphorylation of EIF2AK3 protein	22425709
D004126	Dimethylformamide	[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of EIF2AK3 protein modified form	20097184
D004229	Dithiothreitol	Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein	12486162
D016291	Dizocilpine Maleate	Dizocilpine Maleate inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]	17303341
D004317	Doxorubicin	Doxorubicin results in increased phosphorylation of and results in increased activity of EIF2AK3 protein	20656019
C109476	epoxiconazole	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EIF2AK3 mRNA	29038839
C109476	epoxiconazole	epoxiconazole results in increased expression of EIF2AK3 mRNA	29038839
C078846	epoxomicin	"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2AK3 protein]]"	25639565
D000431	Ethanol	Ethanol results in increased expression of EIF2AK3 protein modified form	24224909
D000431	Ethanol	resveratrol inhibits the reaction [Ethanol results in increased expression of EIF2AK3 protein modified form]	24224909
D000431	Ethanol	Ethanol results in increased phosphorylation of EIF2AK3 protein	28119953
D000431	Ethanol	Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]	26747958
D000431	Ethanol	Ethanol results in increased phosphorylation of EIF2AK3 protein	26747958
D000431	Ethanol	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]	26747958
D000431	Ethanol	[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein	26747958
D000431	Ethanol	zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]	26747958
C024565	ethylene dichloride	ethylene dichloride results in increased expression of EIF2AK3 mRNA	28973639
D005230	Fatty Acids, Nonesterified	"Fatty Acids, Nonesterified results in increased phosphorylation of EIF2AK3 protein"	23527285
C017875	fisetin	"[fisetin co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased expression of EIF2AK3 protein"	28181380
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of EIF2AK3 mRNA	28329830
D005459	Fluorides	Fluorides affects the expression of EIF2AK3 mRNA	20709135
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EIF2AK3 gene	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of EIF2AK3 mRNA	20655997
D005557	Formaldehyde	Formaldehyde results in increased phosphorylation of EIF2AK3 protein	24140967
D005557	Formaldehyde	DDAH1 protein inhibits the reaction [Formaldehyde results in increased phosphorylation of EIF2AK3 protein]	24140967
D005632	Fructose	Fructose results in increased phosphorylation of EIF2AK3 protein	22698815
D005632	Fructose	Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2AK3 protein]	22698815
C056933	fumonisin B1	fumonisin B1 results in increased phosphorylation of EIF2AK3 protein	25925693
C038958	gadolinium chloride	gadolinium chloride results in increased expression of EIF2AK3 protein	21198628
D005944	Glucosamine	Glucosamine results in increased phosphorylation of EIF2AK3 protein	19383982
D005944	Glucosamine	EIF2AK3 gene mutant form inhibits the reaction [Glucosamine results in increased phosphorylation of EIF2S1 protein]	16324875
D005978	Glutathione	Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein]	24515801
D006046	Gold	Gold analog results in increased phosphorylation of EIF2AK3 protein	26551149
D006427	Hemin	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]	26747958
D006427	Hemin	Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]	26747958
D017313	Fenretinide	EIF2AK3 mutant form inhibits the reaction [Fenretinide results in increased phosphorylation of EIF2S1 protein]	20022965
D017313	Fenretinide	EIF2AK3 results in decreased susceptibility to Fenretinide	20022965
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of EIF2AK3 mRNA	20044591
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EIF2AK3 mRNA	25613284
D007545	Isoproterenol	Isoproterenol results in increased expression of EIF2AK3 mRNA	21335049
C544151	jinfukang	jinfukang results in decreased expression of EIF2AK3 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of EIF2AK3 protein	25762632
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein]	16330322
C008261	lead acetate	lead acetate results in increased phosphorylation of EIF2AK3 protein	25088297
C008261	lead acetate	Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2AK3 protein]	25088297
C002385	linsidomine	linsidomine results in increased phosphorylation of EIF2AK3 protein	21703327
D008070	Lipopolysaccharides	4-phenylbutyric acid inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein]	28245985
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein	19675143\|2824598
C025340	manganese chloride	manganese chloride promotes the reaction [EIF2AK3 protein results in increased expression of ATF4 mRNA]	23948121
C025340	manganese chloride	manganese chloride promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2S1 protein]	23948121
C025340	manganese chloride	manganese chloride results in increased expression of and results in increased phosphorylation of EIF2AK3 protein	23934647
C025340	manganese chloride	manganese chloride results in increased expression of EIF2AK3 protein	25732873
C025340	manganese chloride	manganese chloride results in increased phosphorylation of EIF2AK3 protein	23948121
C025340	manganese chloride	SNCA protein promotes the reaction [manganese chloride results in increased expression of and results in increased phosphorylation of EIF2AK3 protein]	23934647
D008464	Mecamylamine	Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]	26803847
D008550	Melatonin	Melatonin inhibits the reaction [Methamphetamine results in increased expression of EIF2AK3 protein modified form]	28070110
D008694	Methamphetamine	EIF2AK3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]	27323860
D008694	Methamphetamine	EIF2AK3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]	27323860
D008694	Methamphetamine	EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of ATF4 protein]	27323860
D008694	Methamphetamine	EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]	27323860
D008694	Methamphetamine	EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]	27323860
D008694	Methamphetamine	Methamphetamine results in increased phosphorylation of EIF2AK3 protein	27323860
D008694	Methamphetamine	Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein]	27323860
D008694	Methamphetamine	norbinaltorphimine inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein]	27323860
D008694	Methamphetamine	Methamphetamine results in increased expression of EIF2AK3 protein	27323860
D008694	Methamphetamine	Melatonin inhibits the reaction [Methamphetamine results in increased expression of EIF2AK3 protein modified form]	28070110
D008694	Methamphetamine	Methamphetamine results in increased expression of EIF2AK3 protein modified form	28070110
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EIF2AK3 gene	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of EIF2AK3 mRNA	28001369
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in increased activity of EIF2AK3 protein	12486162
C008493	methylselenic acid	HSPA5 protein inhibits the reaction [methylselenic acid results in increased phosphorylation of EIF2AK3 protein]	16204082
C008493	methylselenic acid	methylselenic acid results in increased phosphorylation of and results in increased activity of EIF2AK3 protein	16204082\|1620564
C012258	mevastatin	mevastatin results in increased phosphorylation of EIF2AK3 protein	16330322
D008911	Minocycline	Minocycline results in increased phosphorylation of EIF2AK3 protein	22245251
C555916	MitoTEMPO	MitoTEMPO inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]	27784618
D009151	Mustard Gas	Mustard Gas results in increased expression of EIF2AK3 mRNA	15674844
D009271	Naltrexone	Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein]	27323860
C028007	nickel monoxide	nickel monoxide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein	28945320
C028007	nickel monoxide	nickel monoxide results in increased expression of EIF2AK3 mRNA	28945320
D009534	Niclosamide	ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]	26917416
D009534	Niclosamide	Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein	26917416
D009534	Niclosamide	Niclosamide results in increased expression of EIF2AK3 mRNA	26917416
D009538	Nicotine	Mecamylamine inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]	26803847
D009538	Nicotine	Nicotine results in increased phosphorylation of EIF2AK3 protein	26803847
D009538	Nicotine	tauroursodeoxycholic acid inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]	26803847
D009543	Nifedipine	Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]	22226148
D009543	Nifedipine	Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein]	22226148
D009544	Niflumic Acid	ciglitazone promotes the reaction [Niflumic Acid results in increased phosphorylation of EIF2AK3 protein]	21067863
D009544	Niflumic Acid	Niflumic Acid promotes the reaction [ciglitazone results in increased phosphorylation of EIF2AK3 protein]	21067863
D009544	Niflumic Acid	Niflumic Acid results in increased phosphorylation of EIF2AK3 protein	21067863
C051844	norbinaltorphimine	norbinaltorphimine inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein]	27323860
C442478	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide	N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]	17303341
D016627	Oxidopamine	EIF2AK3 protein affects the susceptibility to Oxidopamine	12486162
D016627	Oxidopamine	Oxidopamine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein	12486162
C507134	ON 01910	ON 01910 results in increased expression of EIF2AK3 mRNA	22351695
C055122	orlistat	EIF2AK3 gene mutant form results in increased susceptibility to orlistat	17283163
C055122	orlistat	orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]	17283163
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of EIF2AK3 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased phosphorylation of EIF2AK3 protein	19041636
D010100	Oxygen	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]	22226148\|2327070
D010100	Oxygen	4-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein]	22226148\|2327070
D010100	Oxygen	acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]	23270704
D010100	Oxygen	acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein]	23270704
D010100	Oxygen	AKR1B1 protein inhibits the reaction [Oxygen deficiency results in increased phosphorylation of EIF2AK3 protein]	19041636
D010100	Oxygen	Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]	26747958
D010100	Oxygen	Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]	26747958
D010100	Oxygen	Hemin inhibits the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]	26747958
D010100	Oxygen	Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 mRNA]	22226148
D010100	Oxygen	Nifedipine inhibits the reaction [Oxygen deficiency results in increased expression of EIF2AK3 protein]	22226148
D010100	Oxygen	[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein	26747958
D010100	Oxygen	[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein	26747958
D010100	Oxygen	Oxygen deficiency results in increased expression of EIF2AK3 mRNA	22226148\|2327070
D010100	Oxygen	Oxygen deficiency results in increased expression of EIF2AK3 protein	22226148\|2327070
D010100	Oxygen	zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]	26747958
D010100	Oxygen	zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]	26747958
D017239	Paclitaxel	EIF2AK3 protein affects the susceptibility to Paclitaxel	16217747
D010168	Palmitates	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Palmitates results in increased phosphorylation of EIF2AK3 protein]	23576437
D010168	Palmitates	Palmitates results in increased phosphorylation of EIF2AK3 protein	23576437
D010269	Paraquat	Paraquat results in increased expression of EIF2AK3 protein modified form	28986289
D010269	Paraquat	Paraquat results in increased phosphorylation of EIF2AK3 protein	28986289
D010269	Paraquat	Paraquat results in increased expression of EIF2AK3 protein modified form	27442881
D010269	Paraquat	Paraquat results in increased phosphorylation of EIF2AK3 protein	22245251
D052638	Particulate Matter	Particulate Matter results in increased phosphorylation of EIF2AK3 protein	19675143
C000610380	p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane	"p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in increased phosphorylation of EIF2AK3 protein"	26035713
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of EIF2AK3 mRNA	18593933
D010396	Penicillamine	Penicillamine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein	22843330
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether analog results in increased expression of EIF2AK3 mRNA	19095052
D010654	Phenylbutyrates	Phenylbutyrates inhibits the reaction [Fructose results in increased phosphorylation of EIF2AK3 protein]	22698815
D064209	Phytochemicals	Phytochemicals results in decreased expression of EIF2AK3 protein	22685690
D010862	Pilocarpine	Pilocarpine promotes the reaction [EIF2AK3 protein modified form results in increased phosphorylation of EIF2S1 protein]	16492139
D010862	Pilocarpine	Pilocarpine results in increased activity of EIF2AK3 protein	16492139
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of EIF2AK3 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of EIF2AK3 mRNA	17426115
D010936	Plant Extracts	Plant Extracts results in decreased expression of EIF2AK3 protein	22685690
D010936	Plant Extracts	Plant Extracts results in decreased phosphorylation of EIF2AK3 protein	23955962
D010936	Plant Extracts	Plant Extracts results in increased expression of EIF2AK3 mRNA	23557933
D044945	Proanthocyanidins	Proanthocyanidins inhibits the reaction [lead acetate results in increased phosphorylation of EIF2AK3 protein]	25088297
C045362	prochloraz	[cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of EIF2AK3 mRNA	29038839
C045950	propiconazole	propiconazole results in increased expression of EIF2AK3 mRNA	21278054
C010313	pseudocumene	pseudocumene results in decreased expression of EIF2AK3 protein	17337753
C107773	pterostilbene	2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]	25341683
C107773	pterostilbene	Acetylcysteine inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]	25341683
C107773	pterostilbene	Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]	25341683
C107773	pterostilbene	CAT protein inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]	25341683
C107773	pterostilbene	pterostilbene results in increased phosphorylation of EIF2AK3 protein	25341683
C107773	pterostilbene	Thapsigargin promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]	25341683
D011718	Pyrazinamide	4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]	28063906
D011718	Pyrazinamide	Pyrazinamide results in increased phosphorylation of EIF2AK3 protein	28063906
D011718	Pyrazinamide	4-phenylbutyric acid inhibits the reaction [Pyrazinamide results in increased phosphorylation of EIF2AK3 protein]	28063906
D011718	Pyrazinamide	Pyrazinamide results in increased phosphorylation of EIF2AK3 protein	28063906
D011794	Quercetin	Quercetin results in increased phosphorylation of EIF2AK3 protein	24368982\|2461213
C059514	resveratrol	resveratrol inhibits the reaction [Ethanol results in increased expression of EIF2AK3 protein modified form]	24224909
C059514	resveratrol	resveratrol results in increased phosphorylation of EIF2AK3 protein	24264887
C059514	resveratrol	[resveratrol co-treated with Dietary Fats] results in decreased phosphorylation of EIF2AK3 protein	26055348
D012293	Rifampin	4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 mRNA]	27470132
D012293	Rifampin	4-phenylbutyric acid inhibits the reaction [Rifampin results in increased expression of EIF2AK3 protein]	27470132
D012293	Rifampin	Rifampin results in increased expression of EIF2AK3 mRNA	27470132
D012293	Rifampin	Rifampin results in increased expression of EIF2AK3 protein	27470132
D012293	Rifampin	Rifampin results in increased phosphorylation of EIF2AK3 protein	24638036
D012402	Rotenone	Rotenone results in increased phosphorylation of EIF2AK3 protein	19233273
D012402	Rotenone	Rotenone results in increased phosphorylation of and results in increased activity of EIF2AK3 protein	12486162
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of EIF2AK3 mRNA	21427059
C534628	SCH 23390	SCH 23390 inhibits the reaction [Cocaine results in increased expression of EIF2AK3 protein]	17303341
D020280	Sertraline	MAP4K4 mutant form inhibits the reaction [Sertraline results in increased phosphorylation of EIF2AK3 protein]	24865413
D020280	Sertraline	Sertraline results in increased expression of and results in increased phosphorylation of EIF2AK3 protein	24865413
D020280	Sertraline	Sertraline results in increased expression of EIF2AK3 mRNA	24865413
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of EIF2AK3 mRNA	23221170
D012906	Smoke	Smoke results in increased phosphorylation of EIF2AK3 protein	18206657
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of EIF2AK3 protein	28973481
C017947	sodium arsenite	sodium arsenite results in increased phosphorylation of EIF2AK3 protein	21911445
C016104	sodium bichromate	sodium bichromate results in decreased expression of EIF2AK3 mRNA	22155349
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of EIF2AK3 mRNA	25132241
C471405	sorafenib	EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]	18787411
C471405	sorafenib	EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to FADD protein binds to CASP8 protein]]	18787411
C471405	sorafenib	EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]	18787411
C471405	sorafenib	EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased expression of ATG5 protein]	18787411
C471405	sorafenib	FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein]	18787411
C471405	sorafenib	FAS protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein]	18787411
C471405	sorafenib	[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to EIF2AK3 protein]	18787411
C471405	sorafenib	[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein	18787411
C471405	sorafenib	sorafenib results in increased phosphorylation of EIF2AK3 protein	17548474
C558809	SR1001	SR1001 results in decreased phosphorylation of EIF2AK3 protein	28698385
C559087	SR 1078	SR 1078 results in increased phosphorylation of EIF2AK3 protein	28698385
C016766	sulforafan	sulforafan promotes the reaction [arsenic trioxide results in increased expression of EIF2AK3 protein modified form]	22922937
C016766	sulforafan	sulforafan results in increased expression of EIF2AK3 protein modified form	22922937
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid inhibits the reaction [Nicotine results in increased phosphorylation of EIF2AK3 protein]	26803847
C534735	tetraarsenic tetrasulfide	tetraarsenic tetrasulfide results in increased expression of EIF2AK3 mRNA	19208803
C000591600	tetrachlorobenzoquinone	4-phenylbutyric acid inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form]	27484784
C000591600	tetrachlorobenzoquinone	Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form]	27484784
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased expression of EIF2AK3 protein modified form	27484784
C000591600	tetrachlorobenzoquinone	tetrachlorobenzoquinone results in increased phosphorylation of EIF2AK3 protein	27484784
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of EIF2AK3 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of EIF2AK3 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased phosphorylation of EIF2AK3 protein	24932542
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EIF2AK3 mRNA	25613284
D019284	Thapsigargin	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]	23576437
D019284	Thapsigargin	demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]	26264395
D019284	Thapsigargin	EIF2AK3 mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]	20022965
D019284	Thapsigargin	EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]	27358234
D019284	Thapsigargin	EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]	27358234
D019284	Thapsigargin	Thapsigargin promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein]	25341683
D019284	Thapsigargin	Thapsigargin results in increased expression of EIF2AK3 mRNA	17963750\|2237831
D019284	Thapsigargin	Thapsigargin results in increased expression of EIF2AK3 protein	24865413
D019284	Thapsigargin	Thapsigargin results in increased expression of EIF2AK3 protein modified form	24224909
D019284	Thapsigargin	Thapsigargin results in increased phosphorylation of EIF2AK3 protein	23576437\|2626439
D019284	Thapsigargin	1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]	23576437
D019284	Thapsigargin	EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]	24648495
D019284	Thapsigargin	EIF2AK3 gene mutant form results in increased susceptibility to Thapsigargin	17283163
D019284	Thapsigargin	PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein]	22509299
D019284	Thapsigargin	[Thapsigargin co-treated with HRAS protein] results in increased expression of EIF2AK3 protein	24898257
D019284	Thapsigargin	Thapsigargin promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]	17283163
D019284	Thapsigargin	Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein	22509299
D019284	Thapsigargin	Thapsigargin results in increased phosphorylation of EIF2AK3 protein	23576437
D019284	Thapsigargin	EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]	16324875
D014028	Tobacco Smoke Pollution	EIF2AK3 mutant form inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 mRNA]	21703327
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution analog results in increased phosphorylation of EIF2AK3 protein	21703327
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of EIF2AK3 mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of EIF2AK3 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of EIF2AK3 mRNA	22498432
D014212	Tretinoin	Tretinoin results in increased expression of EIF2AK3 protein	22498432
C011559	tributyltin	tributyltin results in increased expression of EIF2AK3 mRNA	25499138
C012589	trichostatin A	trichostatin A results in increased expression of EIF2AK3 mRNA	24935251
C005865	troxerutin	"epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2AK3 protein]]"	25639565
C005865	troxerutin	"troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2AK3 protein]"	25639565
D014415	Tunicamycin	Tunicamycin results in increased expression of and results in increased phosphorylation of EIF2AK3 protein	26551149
D014415	Tunicamycin	Tunicamycin results in increased expression of EIF2AK3 mRNA	22378314
D014415	Tunicamycin	Tunicamycin results in increased expression of EIF2AK3 protein modified form	24224909
D014415	Tunicamycin	"1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]"	22959925
D014415	Tunicamycin	"benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]]"	22959925
D014415	Tunicamycin	"Bortezomib inhibits the reaction [1,2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of EIF2AK3 mRNA]]"	22959925
D014415	Tunicamycin	EIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of ATF4 mRNA]	24648495
D014415	Tunicamycin	EIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of ATF4 protein]	24648495
D014415	Tunicamycin	EIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of ATF6 protein]	24648495
D014415	Tunicamycin	EIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]	24648495
D014415	Tunicamycin	EIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of EIF2S1 protein]	24648495
D014415	Tunicamycin	EIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of IBTK mRNA]	24648495
D014415	Tunicamycin	EIF2AK3 gene mutant form inhibits the reaction [Tunicamycin results in increased expression of IBTK protein]	24648495
D014415	Tunicamycin	EIF2AK3 gene mutant form results in increased susceptibility to Tunicamycin	24648495
D014415	Tunicamycin	Ketoconazole inhibits the reaction [Tunicamycin results in increased phosphorylation of EIF2AK3 protein]	16330322
D014415	Tunicamycin	PTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein]	22509299
D014415	Tunicamycin	[Tunicamycin co-treated with HRAS protein] results in increased expression of EIF2AK3 protein	24898257
D014415	Tunicamycin	Tunicamycin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein	22509299
D014415	Tunicamycin	Tunicamycin results in increased expression of EIF2AK3 mRNA	22959925
D014415	Tunicamycin	Tunicamycin results in increased phosphorylation of EIF2AK3 protein	16330322\|2200196
D014520	Urethane	Urethane results in increased expression of EIF2AK3 mRNA	28818685
C005466	ursolic acid	EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased expression of DDIT3 protein]	24802810
C005466	ursolic acid	EIF2AK3 mutant form inhibits the reaction [ursolic acid results in increased phosphorylation of EIF2S1 protein]	24802810
C005466	ursolic acid	ursolic acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein]	24802810
C005466	ursolic acid	ursolic acid results in increased phosphorylation of EIF2AK3 protein	24802810
C406224	valdecoxib	valdecoxib results in decreased expression of EIF2AK3 mRNA	24136188
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EIF2AK3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of EIF2AK3 mRNA	26272509\|2800136
D014635	Valproic Acid	Valproic Acid affects the expression of EIF2AK3 mRNA	17963808
D014635	Valproic Acid	Valproic Acid results in increased expression of EIF2AK3 mRNA	19136453\|2142705
C111237	vorinostat	EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]	18787411
C111237	vorinostat	EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to FADD protein binds to CASP8 protein]]	18787411
C111237	vorinostat	EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]	18787411
C111237	vorinostat	EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased expression of ATG5 protein]	18787411
C111237	vorinostat	FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein]	18787411
C111237	vorinostat	FAS protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein]	18787411
C111237	vorinostat	[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to EIF2AK3 protein]	18787411
C111237	vorinostat	[sorafenib co-treated with vorinostat] results in increased phosphorylation of EIF2AK3 protein	18787411
C111237	vorinostat	vorinostat results in increased phosphorylation of EIF2AK3 protein	20962572
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of EIF2AK3 mRNA	18593933
D015034	Zinc Oxide	Zinc Oxide analog results in increased phosphorylation of EIF2AK3 protein	25680694
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased phosphorylation of EIF2AK3 protein]	26747958
C017803	zinc protoporphyrin	zinc protoporphyrin promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased phosphorylation of EIF2AK3 protein]	26747958

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004672	protein kinase activity	-	IBA	21873635
GO:0004672	protein kinase activity	-	TAS	10026192
GO:0004674	protein serine/threonine kinase activity	-	ISS	-
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	-	IBA	21873635
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	-	IDA	10026192 10677345 11907036
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	-	IMP	12086964 25329545
GO:0005515	protein binding	-	IPI	11907036 25393282 26268696 27238082
GO:0005524	ATP binding	-	IEA	-
GO:0019899	enzyme binding	-	IPI	23103912
GO:0019903	protein phosphatase binding	-	IPI	22169477
GO:0042802	identical protein binding	-	IPI	11907036
GO:0042803	protein homodimerization activity	-	TAS	22934019
GO:0051879	Hsp90 protein binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001501	skeletal system development	-	ISS	-
GO:0001503	ossification	-	IMP	12086964
GO:0001525	angiogenesis	-	IMP	22915762
GO:0002063	chondrocyte development	-	ISS	-
GO:0006468	protein phosphorylation	-	ISS	-
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	ISS	-
GO:0006983	ER overload response	-	IDA	10677345 11907036
GO:0007029	endoplasmic reticulum organization	-	ISS	-
GO:0010575	positive regulation of vascular endothelial growth factor production	-	IMP	22915762
GO:0010628	positive regulation of gene expression	-	IMP	22915762
GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	-	ISS	-
GO:0017148	negative regulation of translation	-	TAS	12086964
GO:0018105	peptidyl-serine phosphorylation	-	ISS	-
GO:0019722	calcium-mediated signaling	-	ISS	-
GO:0030282	bone mineralization	-	ISS	-
GO:0030968	endoplasmic reticulum unfolded protein response	-	IDA	10677345 11907036 22169477
GO:0030968	endoplasmic reticulum unfolded protein response	-	TAS	19816510
GO:0031018	endocrine pancreas development	-	IMP	12086964
GO:0031642	negative regulation of myelination	-	ISS	-
GO:0032057	negative regulation of translational initiation in response to stress	-	TAS	10677345 12086964 19816510
GO:0034198	cellular response to amino acid starvation	-	IMP	25329545
GO:0034976	response to endoplasmic reticulum stress	-	IMP	19061639
GO:0036492	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	-	IMP	25329545
GO:0036492	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	-	TAS	22934019
GO:0036499	PERK-mediated unfolded protein response	-	TAS	22934019
GO:0042149	cellular response to glucose starvation	-	IMP	22915762
GO:0045943	positive regulation of transcription by RNA polymerase I	-	IMP	22915762
GO:0046777	protein autophosphorylation	-	IDA	10026192 11907036
GO:0046777	protein autophosphorylation	-	IMP	12086964
GO:0048009	insulin-like growth factor receptor signaling pathway	-	ISS	-
GO:0051260	protein homooligomerization	-	IMP	11907036
GO:0060734	regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	-	ISS	-
GO:0070417	cellular response to cold	-	IMP	25329545
GO:1900182	positive regulation of protein localization to nucleus	-	ISS	-
GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	-	IMP	23000344
GO:1990737	response to manganese-induced endoplasmic reticulum stress	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	ISS	-
GO:0005783	endoplasmic reticulum	-	IC	11907036
GO:0005783	endoplasmic reticulum	-	ISS	-
GO:0005783	endoplasmic reticulum	-	TAS	12086964
GO:0005789	endoplasmic reticulum membrane	-	ISS	-
GO:0005789	endoplasmic reticulum membrane	-	NAS	11907036
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0022626	cytosolic ribosome	-	IBA	21873635
GO:0030176	integral component of endoplasmic reticulum membrane	-	NAS	22013210 22934019
GO:0048471	perinuclear region of cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04141	Protein processing in endoplasmic reticulum
hsa05010	Alzheimer's disease
hsa05160	Hepatitis C

Reactome ID	Reactome Term	Evidence
R-HSA-381042	PERK regulates gene expression	TAS
R-HSA-381119	Unfolded Protein Response (UPR)	TAS
R-HSA-392499	Metabolism of proteins	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28847752	The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells. (2017 Dec)	Lugea A	Gastroenterology
26043790	Cocaine-mediated microglial activation involves the ER stress-autophagy axis. (2015)	Guo ML	Autophagy