Gene: HOMER2

9455
ACPD|CPD|DFNA68|HOMER-2|VESL-2
homer scaffold protein 2
protein-coding
15q25.2
Ensembl:ENSG00000103942 MIM:604799 Vega:OTTHUMG00000172462 UniprotKB:Q9NSB8
NG_029435.1
PubMed
0   ANCO-SNPs
CD|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.590e-1 (AD)  7.386e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf210.878
ATXN10.854
TUB0.85
NCKAP10.845
NF10.841
IDS0.839
SGTB0.838
MCFD20.837
ASH1L0.835
VHL0.834

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.531
OR4F29-0.497
CSAG1-0.452
S100A8-0.375
S100A12-0.362
NFE2-0.34
SPINK8-0.34
ACAP1-0.339
CLEC2B-0.335
PPBP-0.332

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of HOMER2 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HOMER2 mRNA"19114083
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HOMER2 mRNA]"19467301
D000082AcetaminophenAcetaminophen affects the expression of HOMER2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HOMER2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HOMER2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HOMER2 mRNA19770486
C000188alachloralachlor results in increased expression of HOMER2 mRNA12419858
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of HOMER2 mRNA21298039
C015001arsenitearsenite results in increased methylation of HOMER2 promoter23974009
C487081belinostatbelinostat results in decreased expression of HOMER2 mRNA26272509
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HOMER2 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HOMER2 mRNA21715664
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of HOMER2 mRNA20404318
C006780bisphenol Abisphenol A affects the expression of HOMER2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of HOMER2 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of HOMER2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HOMER2 gene28505145
C032036bromobenzenebromobenzene results in increased expression of HOMER2 mRNA12628495
C018475butyraldehydebutyraldehyde results in increased expression of HOMER2 mRNA26079696
D003042CocaineCocaine affects the reaction [HOMER2 mutant form results in decreased secretion of Excitatory Amino Acid Agents]15545022
D003042CocaineCocaine results in decreased expression of HOMER2 mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of HOMER2 mRNA]18355967
D003042CocaineHOMER2 protein results in decreased susceptibility to Cocaine15294147
D003042CocaineHOMER2 results in decreased susceptibility to Cocaine14684444|1554502
D003042CocaineCocaine affects the expression of HOMER2 mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of HOMER2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of HOMER2 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of HOMER2 mRNA25562108|2798913
D002945CisplatinCisplatin results in decreased expression of HOMER2 mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HOMER2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of HOMER2 mRNA18042831|1946730
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of HOMER2 mRNA28412506
D002117CalcitriolCalcitriol results in increased expression of HOMER2 mRNA26485663
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in decreased expression of HOMER2 mRNA16623957
D000431EthanolEthanol results in decreased expression of HOMER2 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HOMER2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HOMER2 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of HOMER2 mRNA28189721
D018683Excitatory Amino Acid AgentsCocaine affects the reaction [HOMER2 mutant form results in decreased secretion of Excitatory Amino Acid Agents]15545022
D018683Excitatory Amino Acid AgentsHOMER2 mutant form results in decreased secretion of Excitatory Amino Acid Agents15545022
D019833GenisteinGenistein results in decreased expression of HOMER2 mRNA15378649
C412815GW 4064GW 4064 results in increased expression of HOMER2 mRNA26655953
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of HOMER2 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of HOMER2 mRNA26752646
C523799MRK 003HOMER2 results in decreased susceptibility to MRK 00319903844
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of HOMER2 mRNA25658374
D010126OzoneOzone results in increased expression of HOMER2 mRNA25658374
D000073878Palm OilPalm Oil results in increased expression of HOMER2 mRNA18042831
C016030pantogabpantogab results in decreased expression of HOMER2 mRNA17379144
D010269ParaquatParaquat results in decreased expression of HOMER2 mRNA21371552
C046012pentanalpentanal results in increased expression of HOMER2 mRNA26079696
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of HOMER2 mRNA26272509
D010705PhosgenePhosgene affects the expression of HOMER2 mRNA16300373
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HOMER2 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of HOMER2 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of HOMER2 mRNA20813756|2381119
C006253pirinixic acidpirinixic acid results in increased expression of HOMER2 mRNA17426115
D011374ProgesteroneProgesterone results in decreased expression of HOMER2 mRNA23018184
D011374ProgesteroneProgesterone results in decreased expression of HOMER2 mRNA22238285
D011374ProgesteroneProgesterone results in increased expression of HOMER2 mRNA19690047
C010313pseudocumenepseudocumene results in decreased expression of HOMER2 protein17337753
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of HOMER2 mRNA14699072
C059514resveratrolresveratrol results in decreased expression of HOMER2 mRNA18586690
D013629TamoxifenTamoxifen affects the expression of HOMER2 mRNA14699072
D013629TamoxifenTamoxifen results in decreased expression of HOMER2 mRNA15590111
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOMER2 mRNA26377647|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HOMER2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HOMER2 mRNA16960034
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOMER2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HOMER2 mRNA16960034
C022884undecaneundecane results in decreased expression of HOMER2 protein17337753
D014635Valproic AcidValproic Acid results in decreased expression of HOMER2 mRNA26272509|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of HOMER2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of HOMER2 mRNA23179753|2915479
D014635Valproic AcidValproic Acid affects the expression of HOMER2 mRNA17963808
D014638VanadatesVanadates results in increased expression of HOMER2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HOMER2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IEA-  
GO:0005515protein binding-IPI18218901  25416956  
GO:0019904protein domain specific binding-IEA-  
GO:0030160GKAP/Homer scaffold activity-IEA-  
GO:0035256G-protein coupled glutamate receptor binding-IBA21873635  
GO:0042803protein homodimerization activity-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007216G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007216G-protein coupled glutamate receptor signaling pathway-TAS9808458  
GO:0007605sensory perception of sound-IMP25816005  
GO:0008277regulation of G-protein coupled receptor protein signaling pathway-IEA-  
GO:0032703negative regulation of interleukin-2 production-IMP18218901  
GO:0035584calcium-mediated signaling using intracellular calcium source-IEA-  
GO:0048148behavioral response to cocaine-IEA-  
GO:0048875chemical homeostasis within a tissue-IEA-  
GO:0070885negative regulation of calcineurin-NFAT signaling cascade-IMP18218901  
GO:2001256regulation of store-operated calcium entry-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA25816005  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0014069postsynaptic density-IBA21873635  
GO:0014069postsynaptic density-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IBA21873635  
GO:0030425dendrite-IEA-  
GO:0032426stereocilium tip-ISS-  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-IEA-  
GO:0045177apical part of cell-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22432643Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. (2012 Sep)Cozzoli DKAlcohol Clin Exp Res
16314758Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. (2005 Dec)Dahl JPPsychiatr Genet
20807241Accumbens Homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking? (2011 Feb)Goulding SPGenes Brain Behav
26254965Homer2 within the nucleus accumbens core bidirectionally regulates alcohol intake by both P and Wistar rats. (2015 Sep)Haider AAlcohol
29249995Homer2 and Alcohol: A Mutual Interaction. (2017)Castelli VFront Psychiatry
25916683Homer2 regulates alcohol and stress cross-sensitization. (2016 May)Quadir SGAddict Biol
19587272Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. (2009 Jul 8)Cozzoli DKJ Neurosci
24467847mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions. (2014 Apr)Lum ENNeuropharmacology
17568396Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice. (2008 May)Szumlinski KKNeuropsychopharmacology
29109058Homer2 within the central nucleus of the amygdala modulates withdrawal-induced anxiety in a mouse model of binge-drinking. (2018 Jan)Lee KMNeuropharmacology
16441286Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure. (2006 Feb)Chandler LJAlcohol Clin Exp Res