Gene: HOMER1

9456
HOMER|HOMER1A|HOMER1B|HOMER1C|SYN47|Ves-1
homer scaffold protein 1
protein-coding
5q14.1
Ensembl:ENSG00000152413 MIM:604798 Vega:OTTHUMG00000134278 UniprotKB:Q86YM7
NC_000005.10
PubMed
0   ANCO-SNPs
CD|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.112e-2 (AD)  1.062e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAL20.94
GABRA40.937
SCAI0.935
RIMBP20.935
KIAA1549L0.933
HCN10.932
GABRB30.931
PLCB10.93
GABRA10.93
MYT1L0.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.58
CSAG1-0.565
HEY2-0.551
COPZ2-0.546
ROM1-0.539
SNHG18-0.538
AGTRAP-0.53
FLT3LG-0.528
RNF135-0.524
RAB13-0.521

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of HOMER1 mRNA"19162173
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased expression of HOMER1 mRNA alternative form]16786172
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HOMER1 mRNA"19114083
C079148(3-aminopropyl)(n-butyl)phosphinic acidHOMER1 mRNA modified form results in decreased susceptibility to (3-aminopropyl)(n-butyl)phosphinic acid17540011
D000082AcetaminophenAcetaminophen results in increased expression of HOMER1 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HOMER1 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HOMER1 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of HOMER1 mRNA19194377
D001151ArsenicArsenic affects the methylation of HOMER1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HOMER1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to HOMER1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HOMER1 mRNA19770486|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HOMER1 mRNA"20018196
D004958EstradiolEstradiol results in decreased expression of HOMER1 mRNA20068009
C095105bexarotenebexarotene results in increased expression of HOMER1 mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of HOMER1 mRNA25594700
C006780bisphenol Abisphenol A results in decreased expression of HOMER1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HOMER1 mRNA19010381
D002110CaffeineHOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
D002118CalciumHOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
D002118CalciumHOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
D003024ClozapineClozapine results in increased expression of HOMER1 mRNA12464447|1586034
D003024ClozapineCycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]12464447
D003042CocaineHOMER1 polymorphism results in increased susceptibility to Cocaine16314758
D003042CocaineCocaine results in increased expression of HOMER1 mRNA18355967
D003042CocaineHOMER1 protein results in decreased susceptibility to Cocaine15294147
D003042CocaineCocaine affects the expression of and affects the localization of HOMER1 protein19105975
D003042CocaineCocaine affects the expression of HOMER1 mRNA20187946
D003042CocaineCocaine affects the expression of HOMER1 protein19118598|2053484
D003042CocaineCocaine results in increased expression of HOMER1 protein19306440
D003042CocaineCocaine affects the expression of HOMER1 protein16160706
D003471CuprizoneCuprizone results in decreased expression of HOMER1 mRNA26577399
D036563Cyclic ADP-RiboseHOMER1 protein alternative form inhibits the reaction [Cyclic ADP-Ribose promotes the reaction [RYR2 protein results in increased secretion of Calcium]]12887973
D003523CycloserineCycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]12464447
D003523CycloserineCycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA]12464447
D016572CyclosporineCyclosporine results in decreased expression of HOMER1 mRNA25562108|2798913
D013759DronabinolDronabinol results in increased expression of HOMER1 mRNA21955143
D003907DexamethasoneDexamethasone results in decreased expression of HOMER1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of HOMER1 mRNA]20032058
D003976DiazinonDiazinon results in increased expression of HOMER1 mRNA29108742
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HOMER1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of HOMER1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of HOMER1 mRNA27392435
D007980LevodopaHOMER1 gene SNP affects the susceptibility to Levodopa24126708
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HOMER1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HOMER1 mRNA22079256
D000431EthanolEthanol results in decreased expression of HOMER1 mRNA21955143
D000431EthanolEthanol results in decreased expression of HOMER1 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HOMER1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HOMER1 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of HOMER1 mRNA23649840
D005473FluoxetineFluoxetine results in decreased expression of HOMER1 mRNA17033635
D005557FormaldehydeFormaldehyde results in decreased expression of HOMER1 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of HOMER1 mRNA22634610
C004312glycidolglycidol results in increased expression of HOMER1 mRNA24915197
D006220HaloperidolCycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA]12464447
D006220HaloperidolHaloperidol results in increased expression of HOMER1 mRNA12464447|1586034
D006582HexachloropheneHexachlorophene results in decreased expression of HOMER1 mRNA29301063
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of HOMER1 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HOMER1 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of HOMER1 mRNA alternative form16786172
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of HOMER1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of HOMER1 mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of HOMER1 protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of HOMER1 mRNA24796395
D007608Kainic AcidKainic Acid results in increased expression of HOMER1 mRNA19700661
C018584linaloollinalool results in increased expression of HOMER1 mRNA20536181
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOMER1 mRNA16415329
D008694MethamphetamineMethamphetamine results in increased expression of HOMER1 mRNA15644446
D008694MethamphetamineMethamphetamine results in increased expression of HOMER1 mRNA alternative form17630046
D008694MethamphetamineMethamphetamine results in increased expression of HOMER1 protein alternative form17630046
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of HOMER1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HOMER1 mRNA"26251327
D008774MethylphenidateMethylphenidate results in increased expression of HOMER1 mRNA16549270
D008774MethylphenidateSCH 23390 inhibits the reaction [Methylphenidate results in increased expression of HOMER1 mRNA]16549270
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium co-treated with ML 9] results in increased expression of HOMER1 mRNA24358303
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium co-treated with ML 9] results in increased expression of HOMER1 protein24358303
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium co-treated with MRS 1845] results in increased expression of HOMER1 mRNA24358303
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium co-treated with MRS 1845] results in increased expression of HOMER1 protein24358303
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium co-treated with STIM1 mutant form] results in increased expression of HOMER1 mRNA24358303
D0156551-Methyl-4-phenylpyridinium[1-Methyl-4-phenylpyridinium co-treated with STIM1 mutant form] results in increased expression of HOMER1 protein24358303
C056218ML 9[1-Methyl-4-phenylpyridinium co-treated with ML 9] results in increased expression of HOMER1 mRNA24358303
C056218ML 9[1-Methyl-4-phenylpyridinium co-treated with ML 9] results in increased expression of HOMER1 protein24358303
D009020MorphineMorphine results in increased expression of HOMER1 mRNA21955143
C503978MRS 1845[1-Methyl-4-phenylpyridinium co-treated with MRS 1845] results in increased expression of HOMER1 mRNA24358303
C503978MRS 1845[1-Methyl-4-phenylpyridinium co-treated with MRS 1845] results in increased expression of HOMER1 protein24358303
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HOMER1 mRNA"25620056
D009281NaphthalenesNaphthalenes results in increased expression of HOMER1 protein17337753
C051752nefazodonenefazodone results in increased expression of HOMER1 mRNA24136188
C029938nickel sulfatenickel sulfate results in increased expression of HOMER1 mRNA22714537
D009538NicotineNicotine results in decreased expression of HOMER1 mRNA21955143
C024713n-tetradecanen-tetradecane results in increased expression of HOMER1 protein17337753
D010098OxycodoneOxycodone results in increased expression of HOMER1 mRNA23439660
D010100OxygenOxygen results in increased expression of HOMER1 mRNA22911455
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of HOMER1 mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of HOMER1 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of HOMER1 mRNA23091169
D010656PhenylephrinePhenylephrine results in increased expression of HOMER1 mRNA alternative form16786172
C006253pirinixic acidpirinixic acid results in increased expression of HOMER1 mRNA19162173
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HOMER1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of HOMER1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HOMER1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of HOMER1 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in decreased expression of HOMER1 mRNA24780913
C010313pseudocumenepseudocumene results in increased expression of HOMER1 protein17337753
D011899Ranitidine[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOMER1 mRNA16415329
D018967RisperidoneRisperidone results in increased expression of HOMER1 mRNA20147574
C534628SCH 23390SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of HOMER1 mRNA]16549270
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in decreased expression of HOMER1 mRNA17540011
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of HOMER1 mRNA19244175
D012643SeleniumSelenium results in decreased expression of HOMER1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of HOMER1 mRNA23806026
C017947sodium arsenitesodium arsenite results in decreased expression of HOMER1 protein19072884
D012999SomanSoman results in increased expression of HOMER1 mRNA19281266
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of HOMER1 mRNA16214533
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of HOMER1 mRNA"26680231
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of HOMER1 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HOMER1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOMER1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HOMER1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HOMER1 mRNA25613284
D014050TolueneToluene results in increased expression of HOMER1 mRNA22967744
C113580U 0126U 0126 inhibits the reaction [EDN1 protein results in increased expression of HOMER1 mRNA alternative form]16786172
C022884undecaneundecane results in increased expression of HOMER1 protein17337753
D014635Valproic AcidValproic Acid results in increased expression of HOMER1 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HOMER1 gene25560391
D014747VinblastineHOMER1 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin affects the expression of HOMER1 mRNA19015723
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of HOMER1 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of HOMER1 mRNA19244175
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of HOMER1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  18218901  19447967  25416956  
GO:0035256G-protein coupled glutamate receptor binding-IBA21873635  
GO:0035591signaling adaptor activity-IC14505576  
GO:0044325ion channel binding-IPI14505576  
GO ID GO Term Qualifier Evidence PubMed
GO:0003009skeletal muscle contraction-IEA-  
GO:0007206phospholipase C-activating G-protein coupled glutamate receptor signaling pathway-TAS9808459  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007268chemical synaptic transmission-TAS9808458  
GO:0009967positive regulation of signal transduction-IC14505576  
GO:0048148behavioral response to cocaine-IEA-  
GO:0048741skeletal muscle fiber development-IEA-  
GO:0048875chemical homeostasis within a tissue-IEA-  
GO:0051262protein tetramerization-ISS-  
GO:0051592response to calcium ion-IDA14505576  
GO:0051928positive regulation of calcium ion transport-IEA-  
GO:0051966regulation of synaptic transmission, glutamatergic-ISS-  
GO:0090279regulation of calcium ion import-IEA-  
GO:1902950regulation of dendritic spine maintenance-ISS-  
GO:2001256regulation of store-operated calcium entry-IBA21873635  
GO:2001256regulation of store-operated calcium entry-TAS14505576  
GO:2001257regulation of cation channel activity-TAS14505576  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0014069postsynaptic density-IBA21873635  
GO:0014069postsynaptic density-IEA-  
GO:0030018Z disc-IEA-  
GO:0030054cell junction-IEA-  
GO:0030424axon-IEA-  
GO:0030425dendrite-IBA21873635  
GO:0043005neuron projection-IBA21873635  
GO:0043034costamere-IEA-  
GO:0044309neuron spine-ISS-  
GO:0045177apical part of cell-IEA-  
GO:0045211postsynaptic membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25743187Ethanol impairment of spontaneous alternation behaviour and associated changes in medial prefrontal glutamatergic gene expression precede putative markers of dependence. (2015 Mar 2)Pickering CPharmacol Biochem Behav
16314758Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. (2005 Dec)Dahl JPPsychiatr Genet