Gene: PICK1

9463
PICK|PRKCABP
protein interacting with PRKCA 1
protein-coding
22q13.1
Ensembl:ENSG00000100151 MIM:605926 Vega:OTTHUMG00000151159 UniprotKB:Q9NRD5
NC_000022.11
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.581e-1 (AD)  1.966e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14938844chr22:38470398PICK1Gene body1.928e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IGSF80.94
HID10.939
LGI30.939
P4HTM0.938
PHKG20.932
KLHL220.929
FOXRED10.929
BRF10.926
ZFYVE270.926
C6orf1360.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.583
OR4F29-0.555
MTRNR2L9-0.473
MTRNR2L6-0.468
MTRNR2L10-0.456
KCNJ15-0.453
PABPC4L-0.439
TFPI2-0.433
FCGR3B-0.432
EBF1-0.429

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PICK1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PICK1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PICK1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of PICK1 mRNA29067470
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PICK1 mRNA16483693
D001151ArsenicArsenic affects the methylation of PICK1 gene25304211
D001280AtrazineAtrazine results in decreased expression of PICK1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PICK1 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of PICK1 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of PICK1 protein28903499
D002118CalciumCalcium affects the reaction [PICK1 protein binds to AGO2 protein]28404816
D002118CalciumCalcium deficiency inhibits the reaction [Excitatory Amino Acid Agonists inhibits the reaction [PICK1 protein binds to AGO2 protein]]28404816
D002118CalciumCalcium promotes the reaction [PICK1 protein binds to GRIA2 protein]28404816
D003976DiazinonDiazinon results in increased methylation of PICK1 gene22964155
D003976DiazinonDiazinon results in increased expression of PICK1 mRNA17452286
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PICK1 mRNA21266533
D002945CisplatinCisplatin results in increased expression of PICK1 mRNA27594783
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PICK1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PICK1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PICK1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PICK1 mRNA17942748
D018690Excitatory Amino Acid AgonistsCalcium deficiency inhibits the reaction [Excitatory Amino Acid Agonists inhibits the reaction [PICK1 protein binds to AGO2 protein]]28404816
D018690Excitatory Amino Acid AgonistsExcitatory Amino Acid Agonists inhibits the reaction [PICK1 protein binds to AGO2 protein]28404816
C492448ICG 001ICG 001 results in increased expression of PICK1 mRNA26191083
D007608Kainic AcidKainic Acid results in decreased expression of PICK1 mRNA17997037
D008694MethamphetaminePICK1 gene SNP results in increased susceptibility to Methamphetamine17606663
D008694MethamphetamineMethamphetamine results in increased expression of PICK1 mRNA26307267
D008727MethotrexateMethotrexate affects the expression of PICK1 mRNA18502557
D009538NicotineNicotine results in decreased expression of PICK1 mRNA17997037
C006253pirinixic acidpirinixic acid results in increased expression of PICK1 mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PICK1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PICK1 mRNA22079256
D013629TamoxifenTamoxifen affects the expression of PICK1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PICK1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PICK1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PICK1 mRNA17942748
D014639VanadiumVanadium results in decreased expression of PICK1 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions affects the expression of PICK1 mRNA23940539

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001664G-protein coupled receptor binding-ISS-  
GO:0005080protein kinase C binding-IBA21873635  
GO:0005080protein kinase C binding-ISS-  
GO:0005102signaling receptor binding-ISS-  
GO:0005515protein binding-IPI11343649  11802773  16713569  
GO:0005543phospholipid binding-IBA21873635  
GO:0008022protein C-terminus binding-IPI11343649  
GO:0019899enzyme binding-IPI16314870  
GO:0019904protein domain specific binding-ISS-  
GO:0042802identical protein binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0051015actin filament binding-ISS-  
GO:0071933Arp2/3 complex binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002092positive regulation of receptor internalization-IBA21873635  
GO:0002092positive regulation of receptor internalization-ISS-  
GO:0006468protein phosphorylation-ISS-  
GO:0006886intracellular protein transport-IBA21873635  
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-NAS10623590  
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-IDA10623590  
GO:0015844monoamine transport-IDA11343649  
GO:0021782glial cell development-ISS-  
GO:0034315regulation of Arp2/3 complex-mediated actin nucleation-IBA21873635  
GO:0034316negative regulation of Arp2/3 complex-mediated actin nucleation-ISS-  
GO:0036294cellular response to decreased oxygen levels-ISS-  
GO:0042149cellular response to glucose starvation-ISS-  
GO:0043045DNA methylation involved in embryo development-NAS12138111  
GO:0043046DNA methylation involved in gamete generation-TAS12138111  
GO:0043113receptor clustering-IBA21873635  
GO:0043113receptor clustering-ISS-  
GO:0045161neuronal ion channel clustering-TAS11343649  
GO:0060292long term synaptic depression-ISS-  
GO:0097061dendritic spine organization-IBA21873635  
GO:0097061dendritic spine organization-ISS-  
GO:0097062dendritic spine maintenance-IBA21873635  
GO:0097062dendritic spine maintenance-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA11343649  16314870  
GO:0005739mitochondrion-IDA-  
GO:0005794Golgi apparatus-ISS-  
GO:0005829cytosol-IDA-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-IDA11343649  
GO:0005886plasma membrane-TAS-  
GO:0008021synaptic vesicle-IBA21873635  
GO:0014069postsynaptic density-IBA21873635  
GO:0014069postsynaptic density-IEA-  
GO:0016235aggresome-IDA-  
GO:0030054cell junction-IEA-  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0032588trans-Golgi network membrane-IBA21873635  
GO:0042734presynaptic membrane-IDA11343649  
GO:0043005neuron projection-IBA21873635  
GO:0043005neuron projection-ISS-  
GO:0045202synapse-IBA21873635  
GO:0045202synapse-ISS-  
GO:0045211postsynaptic membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-ISS-  
GO:0098842postsynaptic early endosome-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-202733Cell surface interactions at the vascular wallIEA
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-416993Trafficking of GluR2-containing AMPA receptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20018661Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. (2010 Jan 5)Thorsen TSProc Natl Acad Sci U S A