Gene: IL27RA

9466
CRL1|IL-27RA|IL27R|TCCR|WSX1|zcytor1
interleukin 27 receptor subunit alpha
protein-coding
19p13.12
Ensembl:ENSG00000104998 MIM:605350 Vega:OTTHUMG00000181990 UniprotKB:Q6UWB1
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.187e-2 (AD)  5.789e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GALNT180.744
TSPAN140.737
HEXB0.736
DHX160.734
BTN2A10.734
MAP3K30.727
FURIN0.725
TMEM1090.724
PPP3CC0.721
ACTN10.719

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.369
OR4F29-0.358
PDE11A-0.343
C5orf64-0.341
ZFHX4-AS1-0.302
REN-0.299
CTNNA3-0.298
SLC22A6-0.297
PON1-0.294
TPPP2-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL27RA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL27RA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL27RA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL27RA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL27RA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL27RA mRNA"27188386
D000111AcetylcysteineAcetylcysteine results in decreased expression of IL27RA mRNA16084531
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of IL27RA mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IL27RA mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of IL27RA mRNA19128835
D001280AtrazineAtrazine results in increased expression of IL27RA mRNA22378314
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IL27RA mRNA19619570
D004958EstradiolEstradiol results in increased expression of IL27RA mRNA19619570|2118537
C006780bisphenol Abisphenol A results in decreased expression of IL27RA mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IL27RA mRNA22079614
D002104CadmiumCadmium results in decreased expression of IL27RA mRNA21120746
D002220CarbamazepineCarbamazepine affects the expression of IL27RA mRNA25979313
D019327Copper SulfateCopper Sulfate results in increased expression of IL27RA mRNA19549813
D003471CuprizoneCuprizone results in increased expression of IL27RA mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of IL27RA mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of IL27RA mRNA22147139
D003609DactinomycinDactinomycin results in increased expression of IL27RA mRNA21527772
C014347decitabinedecitabine affects the expression of IL27RA mRNA23300844
D016264Dextran SulfateIL27RA protein results in decreased susceptibility to Dextran Sulfate16306766
D002945CisplatinCisplatin affects the expression of IL27RA mRNA23300844
D002945CisplatinCisplatin results in increased expression of IL27RA mRNA27594783
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNA15784690
C118739entinostatentinostat results in increased expression of IL27RA mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL27RA mRNA"27188386
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of IL27RA mRNA16084531
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IL27RA mRNA22079256
D005472FluorouracilIL27RA protein affects the susceptibility to Fluorouracil16217747
D005839GentamicinsGentamicins results in increased expression of IL27RA mRNA22061828
D007529IsoflavonesIsoflavones affects the expression of IL27RA mRNA16365062
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IL27RA mRNA24796395|2675264
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of IL27RA mRNA22401849
D009532NickelNickel results in increased expression of IL27RA mRNA25583101
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL27RA mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of IL27RA mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of IL27RA mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of IL27RA mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of IL27RA mRNA22079256
D012524SarinSarin results in increased expression of IL27RA mRNA19522546
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IL27RA mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IL27RA mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IL27RA mRNA21570461|2637764
D013849ThimerosalThimerosal results in decreased expression of IL27RA mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IL27RA mRNA22363418
D014118Toxins, Biological"Toxins, Biological affects the expression of IL27RA mRNA"19682533
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL27RA mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of IL27RA mRNA24935251|2627250
D017974Uranium CompoundsUranium Compounds results in increased expression of IL27RA mRNA19654044
D014635Valproic AcidValproic Acid affects the expression of IL27RA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of IL27RA mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of IL27RA mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IL27RA gene25560391
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of IL27RA mRNA15784690

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS9600072  
GO:0004896cytokine receptor activity-IBA21873635  
GO:0019955cytokine binding-IBA21873635  
GO:0045509interleukin-27 receptor activity-IBA21873635  
GO:0045509interleukin-27 receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002827positive regulation of T-helper 1 type immune response-IEA-  
GO:0002829negative regulation of type 2 immune response-IEA-  
GO:0006955immune response-TAS9600072  
GO:0007166cell surface receptor signaling pathway-TAS9600072  
GO:0032729positive regulation of interferon-gamma production-IEA-  
GO:0048302regulation of isotype switching to IgG isotypes-IEA-  
GO:0050830defense response to Gram-positive bacterium-IEA-  
GO:0070106interleukin-27-mediated signaling pathway-TAS-  
GO:0070757interleukin-35-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9600072  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-447115Interleukin-12 family signalingIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-8984722Interleukin-35 SignallingTAS
R-HSA-9020956Interleukin-27 signalingTAS
R-HSA-9020956Interleukin-27 signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26642056In Utero Cigarette Smoke Affects Allergic Airway Disease But Does Not Alter the Lung Methylome. (2015)Eyring KRPLoS One