Gene: SH3BP5

9467
SAB|SH3BP-5
SH3 domain binding protein 5
protein-coding
3p25.1
Ensembl:ENSG00000131370 MIM:605612 Vega:OTTHUMG00000129859 UniprotKB:O60239
NC_000003.12
PubMed
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.915e-2 (AD)  1.826e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1318937chr3:15253857 (GRCh38.p7)A>Galcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP320.899
TBRG10.898
IDH3A0.892
IQCJ-SCHIP10.887
SLC4A80.886
SOGA30.884
RNASEH10.876
MFSD60.873
SLC9B20.873
FTO0.873

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EYA2-0.508
STON2-0.502
NBPF10-0.476
GPR143-0.47
ZIC2-0.47
AKR1C3-0.467
ACOX2-0.466
PON3-0.462
DDIT4L-0.462
NHSL1-0.46

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SH3BP5 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SH3BP5 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SH3BP5 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SH3BP5 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH3BP5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH3BP5 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SH3BP5 mRNA27761495
D000082AcetaminophenAcetaminophen results in increased expression of SH3BP5 mRNA21420995|2570463
D000082AcetaminophenAcetaminophen affects the expression of SH3BP5 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of SH3BP5 protein27773698
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of SH3BP5 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SH3BP5 mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of SH3BP5 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SH3BP5 protein20106945
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of SH3BP5 protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SH3BP5 protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SH3BP5 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of SH3BP5 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SH3BP5 mRNA19770486|2156981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SH3BP5 mRNA"20018196
D004958EstradiolEstradiol results in increased expression of SH3BP5 mRNA20106945
C006780bisphenol Abisphenol A affects the expression of SH3BP5 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SH3BP5 mRNA28628672
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SH3BP5 mRNA22079614
D002065BuspironeBuspirone results in increased expression of SH3BP5 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of SH3BP5 mRNA26079696
D002211CapsaicinCapsaicin results in decreased expression of SH3BP5 mRNA16278290
D002220CarbamazepineCarbamazepine affects the expression of SH3BP5 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SH3BP5 mRNA23650126
D002737ChloropreneChloroprene results in decreased expression of SH3BP5 mRNA23125180
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of SH3BP5 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of SH3BP5 mRNA23811191
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SH3BP5 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of SH3BP5 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of SH3BP5 mRNA24386269
C009160cyclonitecyclonite results in decreased expression of SH3BP5 mRNA25559034
D016572CyclosporineCyclosporine results in decreased expression of SH3BP5 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of SH3BP5 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SH3BP5 mRNA28628672
D002945CisplatinCisplatin results in increased expression of SH3BP5 mRNA21151649
D004147DioxinsDioxins affects the expression of SH3BP5 mRNA20463971
D004237DiuronDiuron results in decreased expression of SH3BP5 mRNA21551480
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of SH3BP5 mRNA20064776
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SH3BP5 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SH3BP5 mRNA29097150
C082360fipronilfipronil results in increased expression of SH3BP5 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of SH3BP5 mRNA24136188
C039281furanfuran results in increased expression of SH3BP5 mRNA26194646
D005897GlafenineGlafenine results in decreased expression of SH3BP5 mRNA24136188
D017313FenretinideFenretinide results in increased expression of SH3BP5 mRNA28973697
D000068877Imatinib MesylateSH3BP5 protein affects the reaction [Imatinib Mesylate results in increased cleavage of CASP3 protein]28315715
D000068877Imatinib MesylateSH3BP5 protein affects the reaction [Imatinib Mesylate results in increased cleavage of CASP7 protein]28315715
D000068877Imatinib MesylateSH3BP5 protein affects the reaction [Imatinib Mesylate results in increased cleavage of CASP9 protein]28315715
D000068877Imatinib MesylateSH3BP5 protein affects the reaction [Imatinib Mesylate results in increased expression of DDIT3 protein]28315715
D000068877Imatinib MesylateSH3BP5 protein affects the reaction [Imatinib Mesylate results in increased expression of ERO1A protein]28315715
D000068877Imatinib MesylateSH3BP5 protein results in increased susceptibility to Imatinib Mesylate28315715
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SH3BP5 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SH3BP5 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SH3BP5 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SH3BP5 mRNA23086925
C045463leflunomideleflunomide results in increased expression of SH3BP5 mRNA24136188
D064704LevofloxacinLevofloxacin results in increased expression of SH3BP5 mRNA24136188
C008493methylselenic acidmethylselenic acid affects the expression of SH3BP5 mRNA14617803
D016685MitomycinSH3BP5 protein affects the susceptibility to Mitomycin16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SH3BP5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SH3BP5 mRNA"25554681
C119536nickel acetatenickel acetate affects the expression of SH3BP5 mRNA12915101
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SH3BP5 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of SH3BP5 mRNA20880076
D010100OxygenOxygen deficiency results in increased expression of SH3BP5 protein28315715
D010634PhenobarbitalPhenobarbital affects the expression of SH3BP5 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of SH3BP5 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SH3BP5 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SH3BP5 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of SH3BP5 mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of SH3BP5 mRNA21278054
C089730rosiglitazonerosiglitazone results in decreased expression of SH3BP5 mRNA21515302
D012402RotenoneRotenone results in increased expression of SH3BP5 protein28315715
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SH3BP5 mRNA19073995
D018038Sodium SeleniteSodium Selenite results in increased expression of SH3BP5 mRNA18175754
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of SH3BP5 mRNA15885361
C501413tesaglitazartesaglitazar results in decreased expression of SH3BP5 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SH3BP5 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SH3BP5 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SH3BP5 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SH3BP5 mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of SH3BP5 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of SH3BP5 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SH3BP5 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SH3BP5 mRNA25729387
D014212TretinoinTretinoin results in increased expression of SH3BP5 mRNA21934132|2383079
C057693troglitazonetroglitazone results in decreased expression of SH3BP5 mRNA28973697
C080163trovafloxacintrovafloxacin results in increased expression of SH3BP5 mRNA24136188
D014520UrethaneUrethane results in increased expression of SH3BP5 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SH3BP5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SH3BP5 mRNA19101580|2317975
D014638VanadatesVanadates results in increased expression of SH3BP5 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SH3BP5 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004860protein kinase inhibitor activity-IBA21873635  
GO:0004860protein kinase inhibitor activity-IDA10339589  
GO:0005515protein binding-IPI9571151  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS9571151  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0035556intracellular signal transduction-IDA10339589  
GO:0061099negative regulation of protein tyrosine kinase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS9571151  
GO:0005739mitochondrion-IEA-  
GO:0016604nuclear body-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25129674Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. (2014 Sep)McClintick JNAlcohol
22488850Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (2012 Jun)Zuo LAm J Med Genet B Neuropsychiatr Genet