Gene: CHST3

9469
C6ST|C6ST1|HSD
carbohydrate sulfotransferase 3
protein-coding
10q22.1
Ensembl:ENSG00000122863 MIM:603799 Vega:OTTHUMG00000018431 UniprotKB:Q7LGC8
NG_012635.1
SNP Mapped
1   ANCO-SNPs
CD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.012e-1 (AD)  8.215e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7086629chr10:71969470 (GRCh38.p7)T>Ccocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WASF20.877
PLIN30.865
ABHD40.86
TMBIM10.86
SH3PXD2B0.857
CSF10.838
LRP100.836
ITPKB0.835
TIPARP0.833
TTC380.828

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.572
VWC2-0.543
HAPLN1-0.54
LHX6-0.539
CALHM1-0.535
FBLN7-0.533
SMIM18-0.522
NEUROD6-0.52
SLC7A4-0.519
PPEF1-0.518

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CHST3 mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of CHST3 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CHST3 mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHST3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of CHST3 mRNA24449571
C526219apple polyphenol extractapple polyphenol extract results in increased expression of CHST3 mRNA18351577
D001280AtrazineAtrazine results in increased expression of CHST3 mRNA25929836
D001280AtrazineAtrazine results in increased expression of CHST3 mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of CHST3 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CHST3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHST3 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CHST3 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CHST3 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of CHST3 mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of CHST3 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CHST3 gene20938992
D002857ChromiumChromium results in increased expression of CHST3 mRNA17547211
C480342clothianidinclothianidin results in increased expression of CHST3 mRNA29044138
D016572CyclosporineCyclosporine results in decreased expression of CHST3 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of CHST3 mRNA20106945
D002945CisplatinCisplatin results in increased expression of CHST3 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of CHST3 mRNA28302478
D019422Dietary SucroseDietary Sucrose results in increased expression of CHST3 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of CHST3 mRNA16002434
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CHST3 mRNA23649840
C540355fenamidonefenamidone results in increased expression of CHST3 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CHST3 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of CHST3 mRNA23649840
C492448ICG 001ICG 001 results in increased expression of CHST3 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CHST3 mRNA26752646
D007854LeadLead affects the expression of CHST3 mRNA28903495
C045463leflunomideleflunomide results in increased expression of CHST3 mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CHST3 gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CHST3 mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of CHST3 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CHST3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CHST3 mRNA"25554681
D019800PhenolPhenol results in increased expression of CHST3 mRNA17547211
D010936Plant ExtractsPlant Extracts results in increased expression of CHST3 mRNA18351577
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CHST3 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of CHST3 mRNA17547211
C513428pyrachlostrobinpyrachlostrobin results in increased expression of CHST3 mRNA27029645
D011794QuercetinQuercetin results in increased expression of CHST3 mRNA21632981
D012643SeleniumSelenium results in increased expression of CHST3 mRNA19244175
D053260SootSoot results in decreased expression of CHST3 mRNA22461453
C012589trichostatin Atrichostatin A results in increased expression of CHST3 mRNA24935251
D014520UrethaneUrethane results in increased expression of CHST3 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of CHST3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of CHST3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CHST3 gene25560391
D014810Vitamin EVitamin E results in increased expression of CHST3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001517N-acetylglucosamine 6-O-sulfotransferase activity-IBA21873635  
GO:0008146sulfotransferase activity-TAS9883891  
GO:0008459chondroitin 6-sulfotransferase activity-IBA21873635  
GO:0008459chondroitin 6-sulfotransferase activity-IDA9883891  
GO:0008459chondroitin 6-sulfotransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-IEA-  
GO:0006044N-acetylglucosamine metabolic process-IBA21873635  
GO:0006790sulfur compound metabolic process-IBA21873635  
GO:0006790sulfur compound metabolic process-IDA9883891  
GO:0030206chondroitin sulfate biosynthetic process-IBA21873635  
GO:0030206chondroitin sulfate biosynthetic process-IDA9883891  
GO:0030206chondroitin sulfate biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005802trans-Golgi network-IBA21873635  
KEGG ID KEGG Term
hsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-2022870Chondroitin sulfate biosynthesisTAS
R-HSA-3560782Diseases associated with glycosaminoglycan metabolismTAS
R-HSA-3595172Defective CHST3 causes SEDCJDTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal