Gene: ATG5

9474
APG5|APG5-LIKE|APG5L|ASP|SCAR25|hAPG5
autophagy related 5
protein-coding
6q21
Ensembl:ENSG00000057663 MIM:604261 Vega:OTTHUMG00000016193 UniprotKB:Q9H1Y0
NC_000006.12
PubMed
0   ANCO-SNPs
CD|ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.711e-1 (AD)  3.948e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AFTPH0.956
RBM180.955
UBQLN10.95
RANBP60.948
NRBF20.948
NUP500.946
SACM1L0.946
SHOC20.946
PPP2R5E0.945
FBXO280.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.573
OR4F29-0.534
ASB4-0.341
ANPEP-0.337
MYOM1-0.336
CSAG1-0.321
MTRNR2L10-0.314
HEY2-0.311
P2RY14-0.31
OLAH-0.308

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased activity of ATG5 mRNA]19748465
C0005162-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide results in increased expression of ATG5 protein26815770
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ATG5 mRNA"19114083
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]28184909
C0259463-methyladenine3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]28184909
C0259463-methyladenineATG5 protein affects the reaction [3-methyladenine results in increased activity of CASP3 protein]18818525
C0259463-methyladenine3-methyladenine inhibits the reaction [aristolochic acid I results in increased expression of ATG5 protein]23939141
C0259463-methyladenine"3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]"29128638
C5550214-acetylantroquinonol B4-acetylantroquinonol B results in decreased expression of ATG5 protein28408137
C5857454-amino-2-trifluoromethyl-phenyl retinate4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of ATG5 mRNA28130038
C5857454-amino-2-trifluoromethyl-phenyl retinate4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of ATG5 protein28130038
C5857454-amino-2-trifluoromethyl-phenyl retinateATG5 protein promotes the reaction [4-amino-2-trifluoromethyl-phenyl retinate affects the expression of ITGAM protein]28130038
C5857454-amino-2-trifluoromethyl-phenyl retinateATG5 protein promotes the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]28130038
C0415944-nonylphenol4-nonylphenol results in increased expression of ATG5 mRNA28041982
D000082AcetaminophenAcetaminophen affects the expression of ATG5 mRNA17562736
D000082Acetaminophen[ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]22491424
D000082Acetaminophen[ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the susceptibility to Acetaminophen22491424
D000082AcetaminophenATG5 protein affects the reaction [Acetaminophen affects the abundance of Glutathione]22491424
D000082AcetaminophenATG5 protein affects the susceptibility to Acetaminophen22491424
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Butyric Acid results in increased expression of ATG5 protein]28600122
D000111AcetylcysteineAcetylcysteine inhibits the reaction [vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]]20543569
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG5 mRNA]24614525
D012794Sialic AcidsSialic Acids inhibits the reaction [Lipopolysaccharides results in increased cleavage of ATG5 protein]24973090
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ATG5 mRNA21641981
C031143AICA ribonucleotideAICA ribonucleotide inhibits the reaction [Ethanol results in decreased expression of ATG5 protein]24582693
D000924Anticholesteremic AgentsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATG5 mRNA]28275691
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ATG5 mRNA24449571
C000228aristolochic acid I3-methyladenine inhibits the reaction [aristolochic acid I results in increased expression of ATG5 protein]23939141
C000228aristolochic acid Iaristolochic acid I results in increased expression of ATG5 protein23939141
C000228aristolochic acid IATG5 affects the reaction [aristolochic acid I results in increased cleavage of PARP1 protein]23939141
C000228aristolochic acid IATG5 results in increased susceptibility to aristolochic acid I23939141
C006632arsenic trioxidearsenic trioxide results in increased expression of ATG5 protein21594580
D000069059Atorvastatin CalciumATG5 mutant form promotes the reaction [Atorvastatin Calcium results in increased cleavage of CASP3 protein]20876807
D000069059Atorvastatin CalciumATG5 mutant form promotes the reaction [Atorvastatin Calcium results in increased cleavage of PARP1 protein]20876807
D000069059Atorvastatin CalciumATG5 results in increased susceptibility to Atorvastatin Calcium20876807
D001280AtrazineAtrazine results in increased expression of ATG5 mRNA25929836
C426023austenitic steel[Nickel co-treated with austenitic steel analog] results in increased expression of ATG5 mRNA23638002
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ATG5 mRNA"19150397|2001819
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ATG5 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ATG5 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ATG5 mRNA20678512
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ATG5 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ATG5 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ATG5 mRNA26139607|2753935
D000069286BortezomibATG5 gene mutant form inhibits the reaction [Bortezomib results in increased cleavage of and results in increased activity of CASP3 protein]22842577
D000069286BortezomibATG5 gene mutant form inhibits the reaction [HRAS protein promotes the reaction [Bortezomib results in increased cleavage of and results in increased activity of CASP3 protein]]22842577
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ATG5 mRNA15336504
D020148Butyric AcidAcetylcysteine inhibits the reaction [Butyric Acid results in increased expression of ATG5 protein]28600122
D020148Butyric AcidButyric Acid results in increased expression of ATG5 protein28600122
D002104CadmiumATG5 protein affects the reaction [Cadmium results in increased cleavage of CASP3 protein]29111403
D002104CadmiumATG5 protein affects the reaction [Cadmium results in increased cleavage of PARP1 protein]29111403
D002104CadmiumCadmium results in increased expression of ATG5 mRNA27492225
D002104CadmiumATG5 protein affects the reaction [Cadmium results in decreased expression of SQSTM1 protein]27658547
D002104CadmiumATG5 protein affects the reaction [Cadmium results in increased cleavage of PARP1 protein]27658547
D002104CadmiumATG5 protein affects the reaction [Cadmium results in increased expression of DDIT3 protein]27658547
D002166CamptothecinATG5 mutant form inhibits the reaction [Camptothecin results in increased degradation of SQSTM1 protein]22927544
D002211CapsaicinATG5 mutant form inhibits the reaction [Capsaicin results in increased phosphorylation of and results in increased activity of ATM protein]22226932
D002211CapsaicinATG5 mutant form inhibits the reaction [Capsaicin results in increased phosphorylation of PRKDC protein]22226932
D002211CapsaicinCapsaicin results in increased expression of ATG5 protein22226932
D002738ChloroquineChloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]28184909
D002953CitrininCitrinin results in increased expression of ATG5 mRNA22771370
D016572CyclosporineCyclosporine results in increased expression of ATG5 mRNA25562108
C017160cypermethrincypermethrin results in increased expression of ATG5 mRNA27704156
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ATG5 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ATG5 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ATG5 mRNA28628672
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"ATG5 mutant form inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased expression of MAP1LC3B protein]"25301941
D002945CisplatinATG5 affects the reaction [NACC1 affects the susceptibility to Cisplatin]21743489
D002945CisplatinATG5 protein results in decreased susceptibility to Cisplatin21351258
D002945CisplatinCisplatin results in decreased expression of ATG5 protein28408137
D002945CisplatinCisplatin results in increased expression of ATG5 protein24817946
C000944dicrotophosdicrotophos results in decreased expression of ATG5 mRNA28302478
D004041Dietary FatsAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATG5 mRNA]28275691
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATG5 mRNA28275691
D019422Dietary SucroseAnticholesteremic Agents inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATG5 mRNA]28275691
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ATG5 mRNA28275691
D002117Calcitriol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased activity of ATG5 mRNA]19748465
D002117CalcitriolATG5 results in increased susceptibility to Calcitriol19748465
D002117CalcitriolCalcitriol results in increased expression of ATG5 mRNA19748465
D002117CalcitriolCAMP mutant form inhibits the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of CEBPB] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK14] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK1] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117Calcitriol[CAMP results in increased activity of MAPK3] affects the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117CalcitriolCEBPB mutant form inhibits the reaction [Calcitriol results in increased expression of ATG5 mRNA]19748465
D002117CalcitriolSB 203580 inhibits the reaction [Calcitriol results in increased activity of ATG5 mRNA]19748465
D004147DioxinsDioxins affects the expression of ATG5 mRNA20463971
D004155DiphenhydramineATG5 protein affects the susceptibility to Diphenhydramine22310178
D004610Ellagic AcidEllagic Acid results in increased expression of ATG5 mRNA12002526
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATG5 mRNA22079256
D000069347Erlotinib HydrochlorideATG5 protein results in decreased susceptibility to Erlotinib Hydrochloride23917044
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of ATG5 protein21655094
D000431EthanolADIPOQ protein inhibits the reaction [Ethanol results in decreased expression of ATG5 mRNA]24582693
D000431EthanolADIPOQ protein inhibits the reaction [Ethanol results in decreased expression of ATG5 protein]24582693
D000431EthanolAICA ribonucleotide inhibits the reaction [Ethanol results in decreased expression of ATG5 protein]24582693
D000431EthanolATG5 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein]]24582693
D000431EthanolATG5 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]]24582693
D000431EthanolATG5 protein results in decreased susceptibility to Ethanol24582693
D000431EthanolEthanol results in decreased expression of ATG5 mRNA24582693
D000431EthanolEthanol results in decreased expression of ATG5 protein24582693
D000431EthanolEthanol results in increased expression of ATG5 mRNA24095927
D000431EthanolFOXO3 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Ethanol results in decreased expression of ATG5 mRNA]]24582693
D000431EthanolPRKAA1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Ethanol results in decreased expression of ATG5 mRNA]]24582693
D000431EthanolEthanol results in increased expression of ATG5 mRNA24095927|2449248
D000431EthanolEthanol results in increased expression of ATG5 protein24095927
D000431EthanolNR1H4 gene mutant form inhibits the reaction [Ethanol results in increased expression of ATG5 mRNA]25460735
D000431Ethanolresveratrol promotes the reaction [Ethanol results in increased expression of ATG5 mRNA]24095927
D000431EthanolADIPOQ protein inhibits the reaction [Ethanol results in decreased expression of ATG5 protein]24582693
D000431EthanolEthanol results in decreased expression of ATG5 protein24582693
C000499ferric oxideferric oxide analog results in increased expression of ATG5 protein24068039
D000068876Fingolimod HydrochlorideFingolimod Hydrochloride results in increased expression of ATG5 protein25939952
D005485FlutamideFlutamide results in increased expression of ATG5 mRNA24136188
C419708gefitinibgefitinib results in increased expression of ATG5 protein21655094
D019833GenisteinGenistein results in increased expression of ATG5 mRNA15256057
D005947Glucose"3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]"29128638
D005947GlucoseGlucose results in decreased expression of ATG5 protein29128638
D005947Glucose"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]"29128638
D005947Glucose"Sirolimus promotes the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]"29128638
D005947GlucoseULK1 protein affects the reaction [Glucose results in decreased expression of ATG5 protein]29128638
D005947Glucose"ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]"29128638
D005978Glutathione[ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]22491424
D005978Glutathione[ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the abundance of Glutathione22491424
D005978GlutathioneATG5 protein affects the abundance of Glutathione22491424
D005978GlutathioneATG5 protein affects the reaction [Acetaminophen affects the abundance of Glutathione]22491424
C010974glyphosateglyphosate results in increased expression of ATG5 mRNA25636363
C059922gossypetin"gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]]"25622137
C031927hydroquinonehydroquinone results in increased expression of ATG5 mRNA28263894
C031927hydroquinonePARP1 protein promotes the reaction [hydroquinone results in increased expression of ATG5 mRNA]28263894
C031927hydroquinoneSIRT1 protein inhibits the reaction [hydroquinone results in increased expression of ATG5 mRNA]28263894
D0201553-Hydroxybutyric AcidATG5 protein results in increased abundance of 3-Hydroxybutyric Acid25943029
C005044hydroxyethyl methacrylate3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]28184909
C005044hydroxyethyl methacrylate3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]28184909
C005044hydroxyethyl methacrylateChloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]28184909
C005044hydroxyethyl methacrylatehydroxyethyl methacrylate results in increased expression of ATG5 protein28184909
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ATG5 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ATG5 mRNA28628672
D058085Iron CompoundsIron Compounds results in increased expression of ATG5 protein28483490
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ATG5 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ATG5 mRNA28628672
C544151jinfukangjinfukang results in decreased expression of ATG5 mRNA27392435
D008062Lipofuscin[ATG5 protein affects the susceptibility to Paraquat] which affects the abundance of Lipofuscin22982048
D008062Lipofuscin[ATG5 protein affects the susceptibility to Paraquat] which affects the abundance of Lipofuscin22982048
D008070LipopolysaccharidesLipopolysaccharides results in increased cleavage of ATG5 protein24973090
D008070LipopolysaccharidesSialic Acids inhibits the reaction [Lipopolysaccharides results in increased cleavage of ATG5 protein]24973090
D008298MaleatesATG5 mutant form inhibits the reaction [Maleates results in increased expression of MAP1LC3B protein]21976531
C569869malondialdehyde-low density lipoprotein, human"gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]]"25622137
C569869malondialdehyde-low density lipoprotein, human"malondialdehyde-low density lipoprotein, human promotes the reaction [ATG5 protein binds to ATG12 protein]"25622137
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ATG5 mRNA23179753|2718838
C004925methylmercuric chlorideATG5 affects the susceptibility to methylmercuric chloride27667695
C004925methylmercuric chlorideATG5 promotes the reaction [methylmercuric chloride results in increased cleavage of CASP3 protein]27667695
C004925methylmercuric chlorideATG5 promotes the reaction [methylmercuric chloride results in increased cleavage of MAP1LC3B protein]27667695
C004925methylmercuric chlorideATG5 promotes the reaction [methylmercuric chloride results in increased expression of SQSTM1 protein]27667695
D0156551-Methyl-4-phenylpyridiniumATG5 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium23997112
D0156551-Methyl-4-phenylpyridiniumATG5 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of and results in increased activity of CASP3 protein]23997112
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"Sirolimus promotes the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"ULK1 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]"29128638
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ATG5 protein"24929217
C002443neem oilATG5 results in decreased susceptibility to neem oil22915764
D009532Nickel[Nickel co-treated with austenitic steel analog] results in increased expression of ATG5 mRNA23638002
D009532NickelNickel results in increased expression of ATG5 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of ATG5 mRNA19167457
C010615Nonidet P-40Nonidet P-40 results in decreased expression of ATG5 mRNA26552463
D009828Oleanolic AcidOleanolic Acid analog results in increased expression of ATG5 protein26612655
D009842OligopeptidesOligopeptides analog results in increased expression of ATG5 protein24875536
D019308Palmitic AcidATG5 protein promotes the reaction [resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]25943029
C016030pantogabpantogab results in decreased expression of ATG5 mRNA17379144
D010269ParaquatATG5 protein affects the reaction [Paraquat results in increased expression of [ATG5 protein binds to ATG12 protein]]22982048
D010269ParaquatATG5 protein affects the reaction [Paraquat results in increased expression of LAMP1 protein]22982048
D010269ParaquatATG5 protein affects the reaction [Paraquat results in increased expression of MAP1LC3A protein]22982048
D010269ParaquatATG5 protein affects the susceptibility to Paraquat22982048|2399711
D010269Paraquat[ATG5 protein affects the susceptibility to Paraquat] which affects the abundance of Lipofuscin22982048
D010269ParaquatATG5 protein promotes the reaction [Paraquat results in increased cleavage of and results in increased activity of CASP3 protein]23997112
D010269ParaquatParaquat results in increased expression of ATG5 mRNA27220436
D010269ParaquatParaquat results in increased expression of [ATG5 protein binds to ATG12 protein]22982048
D010269ParaquatATG5 protein affects the reaction [Paraquat results in increased expression of LAMP1 protein]22982048
D010269ParaquatATG5 protein affects the susceptibility to Paraquat22982048
D010269Paraquat[ATG5 protein affects the susceptibility to Paraquat] which affects the abundance of Lipofuscin22982048
D010269ParaquatParaquat results in increased expression of ATG5 protein22982048|2724669
D010269ParaquatParaquat results in increased expression of [ATG5 protein binds to ATG12 protein]22982048
D010269ParaquatTLR4 protein affects the reaction [Paraquat results in increased expression of ATG5 protein]27246695
D010269ParaquatATG5 protein affects the susceptibility to Paraquat27324791
D052638Particulate MatterParticulate Matter results in increased expression of ATG5 mRNA23685237|2712597
D052638Particulate Matter[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of ATG5 protein28013216
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ATG5 mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ATG5 mRNA27825932
C023036perfluorooctanoic acidATG5 protein promotes the reaction [perfluorooctanoic acid results in increased expression of MAP1LC3B protein modified form]26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ATG5 mRNA26879310
C006253pirinixic acidpirinixic acid results in increased expression of ATG5 mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATG5 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ATG5 mRNA22079256
C045950propiconazolepropiconazole results in decreased expression of ATG5 mRNA21278054
D011794QuercetinQuercetin results in increased expression of [ATG12 protein binds to ATG5 protein]25293876
C059514resveratrolATG5 protein affects the reaction [resveratrol affects the metabolism of MAP1LC3B protein]23680031
C059514resveratrolATG5 protein affects the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]24145604
C059514resveratrolATG5 protein affects the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]24145604
C059514resveratrolATG5 protein affects the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]24145604
C059514resveratrolATG5 protein affects the reaction [[TNF protein co-treated with resveratrol] results in increased expression of MAP1LC3B protein alternative form]24145604
C059514resveratrolATG5 protein affects the susceptibility to resveratrol23680031
C059514resveratrolATG5 protein promotes the reaction [resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]25943029
C059514resveratrolresveratrol results in increased expression of ATG5 mRNA12002526|1256957
C059514resveratrolresveratrol promotes the reaction [Ethanol results in increased expression of ATG5 mRNA]24095927
C059514resveratrolresveratrol results in increased expression of ATG5 mRNA24095927
D012402RotenoneATG5 protein affects the reaction [Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]19682553
D012402RotenoneATG5 protein affects the susceptibility to Rotenone18032788
D012402RotenoneGAPDH mutant form promotes the reaction [Rotenone results in increased expression of ATG5 protein]25725130
D012402RotenoneRotenone results in increased expression of ATG5 protein25725130
C093642SB 203580SB 203580 inhibits the reaction [Calcitriol results in increased activity of ATG5 mRNA]19748465
D020123SirolimusATG5 protein affects the reaction [Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]19682553
D020123Sirolimus"Sirolimus promotes the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]"29128638
C017947sodium arseniteATG5 protein affects the reaction [sodium arsenite results in increased expression of BECN1 protein]28888487
C017947sodium arsenitesodium arsenite results in increased expression of ATG5 protein28888487
D012969Sodium FluorideSodium Fluoride results in increased expression of ATG5 mRNA24296261
D012969Sodium FluorideSodium Fluoride results in increased expression of ATG5 protein24296261
D012969Sodium FluorideSodium Fluoride results in increased expression of ATG5 mRNA24296261
D012969Sodium FluorideSodium Fluoride results in increased expression of ATG5 protein24296261
D018038Sodium SeleniteSodium Selenite results in increased expression of ATG5 protein25204997
C471405sorafenibATG5 protein inhibits the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]18787411
C471405sorafenibEIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]18787411
C471405sorafenibEIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased expression of ATG5 protein]18787411
C471405sorafenibFADD protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]18787411
C471405sorafenibFADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in decreased expression of ATG5 protein]18787411
C471405sorafenibFAS protein promotes the reaction [[sorafenib co-treated with vorinostat] results in decreased expression of ATG5 protein]18787411
C471405sorafenib[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to CASP8 protein binds to ATG5 protein binds to HSPA5 protein]18787411
C471405sorafenib[sorafenib co-treated with vorinostat] results in increased expression of ATG5 protein18787411
C471405sorafenibsorafenib results in increased expression of ATG5 protein18787411
D013267StilbenesATG5 protein results in decreased susceptibility to Stilbenes23059970
D013311StreptozocinStreptozocin results in increased expression of ATG5 mRNA24889822
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATG5 mRNA21570461
C009438tetrandrinetetrandrine results in decreased expression of ATG5 protein25266202
C009438tetrandrinetetrandrine results in increased expression of ATG5 protein26822499
D013804ThenoyltrifluoroacetoneATG5 protein affects the susceptibility to Thenoyltrifluoroacetone18032788
C025541tri-o-cresyl phosphatetri-o-cresyl phosphate results in increased expression of ATG5 protein25385720
C001899triptolidetriptolide results in increased expression of ATG5 protein26990902
D014635Valproic AcidValproic Acid affects the expression of ATG5 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased expression of ATG5 mRNA27188386
D014635Valproic AcidValproic Acid results in increased expression of ATG5 mRNA23527032
D001335Vehicle Emissions[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of ATG5 protein28013216
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ATG5 gene25560391
D024483Vitamin K 3ATG5 protein affects the susceptibility to Vitamin K 318073215|1831963
D024483Vitamin K 3ATG5 mRNA affects the susceptibility to Vitamin K 320578144
C111237vorinostatAcetylcysteine inhibits the reaction [vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]]20543569
C111237vorinostatATG5 protein inhibits the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]18787411
C111237vorinostatEIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]18787411
C111237vorinostatEIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased expression of ATG5 protein]18787411
C111237vorinostatFADD protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]18787411
C111237vorinostatFADD protein promotes the reaction [[sorafenib co-treated with vorinostat] results in decreased expression of ATG5 protein]18787411
C111237vorinostatFAS protein promotes the reaction [[sorafenib co-treated with vorinostat] results in decreased expression of ATG5 protein]18787411
C111237vorinostat[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to CASP8 protein binds to ATG5 protein binds to HSPA5 protein]18787411
C111237vorinostat[sorafenib co-treated with vorinostat] results in increased expression of ATG5 protein18787411
C111237vorinostatvorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]20543569
C111237vorinostatvorinostat results in increased expression of ATG5 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ATG5 mRNA18593933
C016837zinc chloridezinc chloride results in increased expression of ATG5 mRNA16973896
D015034Zinc OxideAcetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG5 mRNA]24614525
D015034Zinc OxideZinc Oxide analog results in increased expression of ATG5 mRNA24614525

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9852036  11096062  17353931  17709747  20417604  20562859  
21575909  22342342  23202584  23262492  23392225  26812546  
GO:0019776Atg8 ligase activityCONTRIBUTES_TOIBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000045autophagosome assembly-IBA21873635  
GO:0000045autophagosome assembly-ISS-  
GO:0000422autophagy of mitochondrion-IBA21873635  
GO:0001974blood vessel remodeling-IEA-  
GO:0002739regulation of cytokine secretion involved in immune response-IEA-  
GO:0006501C-terminal protein lipidation-IBA21873635  
GO:0006914autophagy-IMP26812546  
GO:0006914autophagy-ISS-  
GO:0006915apoptotic process-IEA-  
GO:0006995cellular response to nitrogen starvation-IBA21873635  
GO:0009620response to fungus-IEA-  
GO:0016236macroautophagy-TAS-  
GO:0019725cellular homeostasis-IEA-  
GO:0019883antigen processing and presentation of endogenous antigen-IEA-  
GO:0031397negative regulation of protein ubiquitination-IEA-  
GO:0035973aggrephagy-IMP22982048  
GO:0039689negative stranded viral RNA replication-IEA-  
GO:0042311vasodilation-IEA-  
GO:0042493response to drug-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043687post-translational protein modification-ISS-  
GO:0044804autophagy of nucleus-IBA21873635  
GO:0045060negative thymic T cell selection-IEA-  
GO:0048840otolith development-IEA-  
GO:0050765negative regulation of phagocytosis-IEA-  
GO:0051279regulation of release of sequestered calcium ion into cytosol-IEA-  
GO:0055015ventricular cardiac muscle cell development-IEA-  
GO:0060047heart contraction-IEA-  
GO:0060548negative regulation of cell death-IMP19273585  
GO:0061739protein lipidation involved in autophagosome assembly-IEA-  
GO:0070257positive regulation of mucus secretion-IEA-  
GO:0071500cellular response to nitrosative stress-IEA-  
GO:0075044autophagy of host cells involved in interaction with symbiont-IGI28389568  
GO:1902017regulation of cilium assembly-ISS-  
GO:2000378negative regulation of reactive oxygen species metabolic process-IEA-  
GO:2000619negative regulation of histone H4-K16 acetylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
GO:0005776autophagosome-IDA15292400  
GO:0005829cytosol-TAS-  
GO:0005930axoneme-ISS-  
GO:0016020membrane-IDA23093945  
GO:0030670phagocytic vesicle membrane-TAS-  
GO:0034045phagophore assembly site membrane-IBA21873635  
GO:0034045phagophore assembly site membrane-ISS-  
GO:0034274Atg12-Atg5-Atg16 complex-IBA21873635  
GO:0044233ER-mitochondrion membrane contact site-IEA-  
KEGG ID KEGG Term
hsa04140Regulation of autophagy
hsa04622RIG-I-like receptor signaling pathway
hsa05131Shigellosis
Reactome ID Reactome Term Evidence
R-HSA-1632852MacroautophagyTAS
R-HSA-1632852MacroautophagyIEA
R-HSA-168249Innate Immune SystemIEA
R-HSA-168256Immune SystemIEA
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaIEA
R-HSA-5205647MitophagyTAS
R-HSA-5205685Pink/Parkin Mediated MitophagyTAS
R-HSA-8934903Receptor Mediated MitophagyTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-8953897Cellular responses to external stimuliIEA
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29515441Autophagy Flux Contributes to Regulation of Components of Eclipta prostrata L. on Cigarette Smoking-Induced Injury of Bronchial Epithelial Cells. (2018)Ding SFront Pharmacol
26043790Cocaine-mediated microglial activation involves the ER stress-autophagy axis. (2015)Guo MLAutophagy
24727585Interaction of caveolin-1 with ATG12-ATG5 system suppresses autophagy in lung epithelial cells. (2014 Jun 1)Chen ZHAm J Physiol Lung Cell Mol Physiol
21676957Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells. (2011 Oct 1)Csordas ACardiovasc Res