Gene: ROCK2

9475
ROCK-II
Rho associated coiled-coil containing protein kinase 2
protein-coding
2p25.1
Ensembl:ENSG00000134318 MIM:604002 Vega:OTTHUMG00000149916 UniprotKB:O75116
NG_029769.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.400e-1 (AD)  1.529e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2A20.949
BRAF0.946
DYRK1A0.941
UBP10.941
RALGAPB0.94
GSK3B0.94
FAM126B0.939
UBE2K0.938
UBE3C0.937
CAND10.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.557
OR4F29-0.519
MYL3-0.439
CSAG1-0.42
COPZ2-0.38
HEY2-0.379
SNHG18-0.377
MYOM1-0.366
ASB4-0.361
ROM1-0.36

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08162FasudilSmall Molecule103745-39-7InvestigationalTarget
DB08756(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDESmall MoleculeExperimentalTarget
DB13165RipasudilSmall Molecule223645-67-8ApprovedTarget
DB13931NetarsudilSmall Molecule1254032-66-0ApprovedTarget
ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ROCK2 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ROCK2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ROCK2 mRNA"18648102
C0806695,7-dihydroxy-6-methoxy-2-phenylchromen-4-one"[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein"26694894
C0806695,7-dihydroxy-6-methoxy-2-phenylchromen-4-one"[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein]"26694894
D000082AcetaminophenAcetaminophen affects the expression of ROCK2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ROCK2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ROCK2 mRNA27153756
D006710HomocysteineHomocysteine results in decreased expression of ROCK2 mRNA17326132
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ROCK2 mRNA16483693
D003913DextroamphetamineDextroamphetamine affects the expression of ROCK2 mRNA12558987
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ROCK2 mRNA24449571
D001151ArsenicROCK2 mRNA results in increased susceptibility to Arsenic17976673
D017638Asbestos, Crocidolite"ROCK2 protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]"24760326
D001280AtrazineAtrazine results in increased expression of ROCK2 mRNA25929836
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ROCK2 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ROCK2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in increased expression of ROCK2 mRNA26314263
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ROCK2 mRNA20106945|2163298
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ROCK2 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ROCK2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ROCK2 mRNA20127859
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ROCK2 mRNA"19150397|2001819
C427308benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketonebenzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein]20661774
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of ROCK2 mRNA19687787
D004958EstradiolEstradiol results in increased expression of ROCK2 mRNA19687787
D004958EstradiolEstradiol affects the expression of ROCK2 mRNA15598610
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ROCK2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ROCK2 mRNA26063408
C006780bisphenol Abisphenol A affects the expression of ROCK2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROCK2 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ROCK2 mRNA26314263
C086539BQ 788"[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein]"26694894
C013418bromfenacoumbromfenacoum results in increased expression of ROCK2 protein28903499
D002101Cacodylic AcidCacodylic Acid results in increased expression of ROCK2 mRNA16122865
D002104CadmiumCadmium results in decreased expression of ROCK2 mRNA18956198
D002220CarbamazepineCarbamazepine affects the expression of ROCK2 mRNA24752500
C100187chloropicrinchloropicrin affects the expression of ROCK2 mRNA26352163
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of ROCK2 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of ROCK2 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of ROCK2 mRNA26314263
D003042CocaineCocaine affects the expression of ROCK2 mRNA20187946
D003300CopperCopper results in increased expression of ROCK2 mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of ROCK2 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ROCK2 mRNA"19167446
C009160cyclonitecyclonite results in decreased expression of ROCK2 mRNA25559034
C072247cyclo(Trp-Asp-Pro-Val-Leu)"[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein]"26694894
D003907DexamethasoneDexamethasone results in increased expression of ROCK2 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ROCK2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROCK2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ROCK2 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ROCK2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ROCK2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ROCK2 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of ROCK2 mRNA24752500
D004041Dietary FatsDietary Fats results in increased expression of ROCK2 mRNA22010203
D004642EmodinEmodin results in decreased expression of ROCK2 mRNA16045814
D004726EndosulfanEndosulfan results in decreased expression of ROCK2 mRNA28108160
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ROCK2 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ROCK2 mRNA22079256
D004967EstrogensEstrogens results in decreased expression of ROCK2 mRNA20970835
C049347fasudilfasudil results in decreased activity of ROCK2 protein10998351
D005557FormaldehydeFormaldehyde results in decreased expression of ROCK2 mRNA23649840
C001277geldanamycingeldanamycin results in increased expression of ROCK2 mRNA26705709
D019833GenisteinGenistein results in decreased expression of ROCK2 protein24552547
D016244Guanosine 5'-O-(3-Thiotriphosphate)Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of ROCK2 protein12960549
D016244Guanosine 5'-O-(3-Thiotriphosphate)sevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of ROCK2 protein]12960549
D017313FenretinideFenretinide results in decreased expression of ROCK2 mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of ROCK2 mRNA16984733
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ROCK2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROCK2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ROCK2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ROCK2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ROCK2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ROCK2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of ROCK2 mRNA27392435
C410337K 7174K 7174 results in increased expression of ROCK2 mRNA24086573
C045463leflunomideleflunomide results in increased expression of ROCK2 mRNA28988120
C108255levormeloxifenelevormeloxifene results in decreased expression of ROCK2 mRNA20970835
D008070Lipopolysaccharides"[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein"26694894
D008070Lipopolysaccharides"[cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein]"26694894
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ROCK2 mRNA23103053
C030957methylmercury IImethylmercury II results in increased expression of ROCK2 mRNA26314263
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ROCK2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ROCK2 mRNA"19285098
C056218ML 9ML 9 results in decreased activity of ROCK2 protein12534346
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of ROCK2 protein10998351
D037742Nanotubes, Carbon"ROCK2 protein promotes the reaction [Nanotubes, Carbon results in increased secretion of IL1B protein]"24760326
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ROCK2 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ROCK2 mRNA19812364
C025589ochratoxin Aochratoxin A metabolite results in increased expression of ROCK2 mRNA26314263
C025589ochratoxin Aochratoxin A results in increased expression of ROCK2 mRNA26314263
D010100OxygenOxygen deficiency results in increased expression of ROCK2 mRNA26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of ROCK2 mRNA]26476374
D010416PentachlorophenolPentachlorophenol results in increased expression of ROCK2 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ROCK2 mRNA27153767
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of ROCK2 mRNA17616710
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital results in increased expression of ROCK2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of ROCK2 mRNA19482888
D010656PhenylephrinePhenylephrine results in increased expression of ROCK2 mRNA18158353
D010936Plant ExtractsPlant Extracts results in increased expression of ROCK2 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ROCK2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ROCK2 mRNA22079256|2271453
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of ROCK2 mRNA19687787
D011794QuercetinQuercetin results in decreased expression of ROCK2 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of ROCK2 mRNA]26476374
D019257QuinpiroleROCK2 protein affects the reaction [Quinpirole results in increased phosphorylation of CFL1 protein]27717053
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of ROCK2 mRNA20970835
C009250sevofluranesevoflurane inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) affects the localization of ROCK2 protein]12960549
C009277sodium arsenatesodium arsenate results in increased expression of ROCK2 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of ROCK2 protein26135927
C025451sodium bisulfidesodium bisulfide results in increased activity of ROCK2 protein23479079
D012969Sodium FluorideSodium Fluoride results in decreased expression of ROCK2 mRNA21340527
D053260SootSoot results in increased expression of ROCK2 mRNA22461453
D010042Ouabainbenzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein]20661774
D010042OuabainOuabain results in increased cleavage of ROCK2 protein20661774
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ROCK2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ROCK2 mRNA25613284
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of ROCK2 protein20109541
D013853ThioacetamideThioacetamide results in increased expression of ROCK2 mRNA23411599
D013917ThrombinThrombin results in increased expression of ROCK2 protein18287881
C402769tipifarnibtipifarnib results in increased expression of ROCK2 mRNA16403772
C011559tributyltintributyltin results in increased expression of ROCK2 mRNA26314263
D014241TrichloroethyleneTrichloroethylene results in increased methylation of ROCK2 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of ROCK2 mRNA24935251|2627250
C001899triptolidetriptolide results in decreased expression of ROCK2 mRNA27554044
D014635Valproic AcidValproic Acid results in increased expression of ROCK2 mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of ROCK2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ROCK2 gene25560391
C025643vinclozolinvinclozolin results in increased expression of ROCK2 mRNA23555832
C108830Y 27632Y 27632 results in decreased activity of ROCK2 protein10686302
C108830Y 27632Y 27632 results in decreased activity of ROCK2 protein10998351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0004674protein serine/threonine kinase activity-IDA16574662  21147781  
GO:0004674protein serine/threonine kinase activity-IMP24305806  
GO:0004674protein serine/threonine kinase activity-ISS24305806  
GO:0004674protein serine/threonine kinase activity-NAS27853422  
GO:0005198structural molecule activity-NAS9933571  
GO:0005515protein binding-IPI17015463  20230755  
GO:0005524ATP binding-IEA-  
GO:0017048Rho GTPase binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0072518Rho-dependent protein serine/threonine kinase activity-IMP24065547  
GO:0072518Rho-dependent protein serine/threonine kinase activity-TAS28679962  
GO ID GO Term Qualifier Evidence PubMed
GO:0001934positive regulation of protein phosphorylation-IMP24065547  
GO:0006468protein phosphorylation-IDA18559669  
GO:0006939smooth muscle contraction-TAS12778124  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IMP25816133  
GO:0007266Rho protein signal transduction-IEA-  
GO:0010595positive regulation of endothelial cell migration-IMP24065547  
GO:0010613positive regulation of cardiac muscle hypertrophy-ISS-  
GO:0010628positive regulation of gene expression-IMP24065547  
GO:0010628positive regulation of gene expression-ISS-  
GO:0010825positive regulation of centrosome duplication-IEA-  
GO:0016525negative regulation of angiogenesis-IMP19181962  
GO:0018105peptidyl-serine phosphorylation-IMP24305806  
GO:0018105peptidyl-serine phosphorylation-ISS24305806  
GO:0018107peptidyl-threonine phosphorylation-IMP24305806  
GO:0030155regulation of cell adhesion-TAS12778124  
GO:0030866cortical actin cytoskeleton organization-IGI25816133  
GO:0030866cortical actin cytoskeleton organization-IMP25816133  
GO:0032723positive regulation of connective tissue growth factor production-ISS-  
GO:0032956regulation of actin cytoskeleton organization-TAS12778124  
GO:0035509negative regulation of myosin-light-chain-phosphatase activity-IGI25816133  
GO:0035509negative regulation of myosin-light-chain-phosphatase activity-IMP25816133  
GO:0039694viral RNA genome replication-IMP19376974  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0043410positive regulation of MAPK cascade-ISS-  
GO:0045616regulation of keratinocyte differentiation-IMP19997641  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0048013ephrin receptor signaling pathway-TAS-  
GO:0048511rhythmic process-IEA-  
GO:0051246regulation of protein metabolic process-ISS24305806  
GO:0051298centrosome duplication-IMP17015463  
GO:0051492regulation of stress fiber assembly-TAS12778124  
GO:0051893regulation of focal adhesion assembly-TAS12778124  
GO:0070168negative regulation of biomineral tissue development-ISS-  
GO:0071394cellular response to testosterone stimulus-IMP24065547  
GO:0071559response to transforming growth factor beta-ISS-  
GO:0072659protein localization to plasma membrane-IGI25816133  
GO:0072659protein localization to plasma membrane-IMP25816133  
GO:0090271positive regulation of fibroblast growth factor production-ISS-  
GO:0110061regulation of angiotensin-activated signaling pathway-ISS-  
GO:0150033negative regulation of protein localization to lysosome-IMP24305806  
GO:1902004positive regulation of amyloid-beta formation-IMP24305806  
GO:1902004positive regulation of amyloid-beta formation-ISS24305806  
GO:1902961positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process-IMP24305806  
GO:1902961positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process-ISS24305806  
GO:1902966positive regulation of protein localization to early endosome-IMP24305806  
GO:1902993positive regulation of amyloid precursor protein catabolic process-IMP24305806  
GO:1902993positive regulation of amyloid precursor protein catabolic process-ISS24305806  
GO:1903140regulation of establishment of endothelial barrier-IGI25816133  
GO:1903140regulation of establishment of endothelial barrier-IMP25816133  
GO:1903347negative regulation of bicellular tight junction assembly-IGI25816133  
GO:1905205positive regulation of connective tissue replacement-ISS-  
GO:1990776response to angiotensin-ISS-  
GO:2000114regulation of establishment of cell polarity-TAS20803696  
GO:2000145regulation of cell motility-TAS12778124  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005813centrosome-IDA17015463  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0036464cytoplasmic ribonucleoprotein granule-IDA15121898  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05130Pathogenic Escherichia coli infection
hsa05131Shigellosis
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-194138Signaling by VEGFTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2682334EPH-Ephrin signalingIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-373755Semaphorin interactionsTAS
R-HSA-373755Semaphorin interactionsIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-3928662EPHB-mediated forward signalingTAS
R-HSA-3928662EPHB-mediated forward signalingIEA
R-HSA-3928663EPHA-mediated growth cone collapseIEA
R-HSA-400685Sema4D in semaphorin signalingTAS
R-HSA-400685Sema4D in semaphorin signalingIEA
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-416572Sema4D induced cell migration and growth-cone collapseTAS
R-HSA-416572Sema4D induced cell migration and growth-cone collapseIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-5627117RHO GTPases Activate ROCKsTAS
R-HSA-5627117RHO GTPases Activate ROCKsIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20139919Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers. (2010 Apr)Hidaka THypertens Res
22093931[Relationship between ROCK2 expression and clinicopathologic characteristics of esophageal squamous cell carcinoma]. (2011 Aug 9)Yibulayin WZhonghua Yi Xue Za Zhi
27123784Atorvastatin Plus Metformin Confer Additive Benefits on Subjects with Dyslipidemia and Overweight/Obese via Reducing ROCK2 Concentration. (2016 Apr)Hao ZExp Clin Endocrinol Diabetes