Gene: MED20

9477
PRO0213|SRB2|TRFP
mediator complex subunit 20
protein-coding
6p21.1
Ensembl:ENSG00000124641 MIM:612915 Vega:OTTHUMG00000014689 UniprotKB:Q9H944
NG_042059.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.047e-1 (AD)  2.717e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALG20.856
C3orf380.842
PDIA60.821
NOL110.816
ZNF4100.813
TARS0.812
CRK0.812
COPB10.808
AP3M10.808
PDIA30.806

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.586
OR4F29-0.528
OR6C74-0.231
TNFRSF13B-0.223
C5orf64-0.201
AKR1B15-0.189
CTNNA3-0.188
RNASE8-0.186
TMEM89-0.179
LCE3A-0.175

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MED20 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MED20 mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of MED20 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MED20 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MED20 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of MED20 mRNA16705744
C006780bisphenol Abisphenol A results in decreased expression of MED20 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of MED20 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MED20 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MED20 mRNA18804290
D002104CadmiumCadmium results in decreased expression of MED20 mRNA23369406
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MED20 mRNA18804290
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MED20 mRNA17602206
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MED20 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MED20 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MED20 mRNA17361019
D002945CisplatinCisplatin results in increased expression of MED20 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MED20 mRNA17602206
D004147DioxinsDioxins affects the expression of MED20 mRNA20463971
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MED20 mRNA23649840
D019833GenisteinGenistein results in decreased expression of MED20 mRNA16705744
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MED20 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of MED20 mRNA28628672
C045463leflunomideleflunomide results in decreased expression of MED20 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MED20 mRNA"18930950
D008713MethimazoleMethimazole results in increased expression of MED20 mRNA22504374
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MED20 mRNA26011545
D009532NickelNickel results in decreased expression of MED20 mRNA23195993
C046012pentanalpentanal results in decreased expression of MED20 mRNA26079696
D010433PentylenetetrazolePentylenetetrazole affects the expression of MED20 mRNA21503142
D010695PhlorhizinPhlorhizin results in decreased expression of MED20 mRNA22538082
C006253pirinixic acidpirinixic acid results in decreased expression of MED20 mRNA18445702
C009041primycinprimycin results in decreased expression of MED20 mRNA28916286
D011441PropylthiouracilPropylthiouracil results in increased expression of MED20 mRNA22504374
C012589trichostatin Atrichostatin A affects the expression of MED20 mRNA28542535
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of MED20 mRNA"18930950
D014520UrethaneUrethane results in increased expression of MED20 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MED20 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MED20 gene25560391
C025643vinclozolinvinclozolin affects the expression of MED20 mRNA23034163
C088658zoledronic acidzoledronic acid results in increased expression of MED20 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activity-IBA21873635  
GO:0003899DNA-directed 5'-3' RNA polymerase activity-NAS9933582  
GO:0005515protein binding-IPI14576168  15175163  25416956  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-NAS9933582  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-TAS9933582  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0016567protein ubiquitination-IEA-  
GO:0035914skeletal muscle cell differentiation-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000151ubiquitin ligase complex-IEA-  
GO:0005654nucleoplasm-TAS-  
GO:0016592mediator complex-IBA21873635  
GO:0016592mediator complex-NAS9933582  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29133146Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population. (2018 Feb 5)Seiki TGene