Gene: SLC25A27

9481
UCP4
solute carrier family 25 member 27
protein-coding
6p12.3
Ensembl:ENSG00000153291 MIM:613725 Vega:OTTHUMG00000014786 UniprotKB:O95847
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
1.260e-2 (AD)  9.322e-1 (ND)   (Frontal_Cortex)
8.702e-2 (AD)  4.225e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10807344chr6:46657898 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPFIA20.922
GDAP10.915
PAFAH1B10.914
BCAP290.914
KLHL420.913
ATP9A0.912
NLK0.912
AK50.911
C2CD50.911
NDRG30.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.525
OR4F29-0.509
MTRNR2L10-0.433
EVC2-0.428
MTRNR2L6-0.421
MTRNR2L9-0.407
MTRNR2L2-0.394
CSAG1-0.391
PDZK1IP1-0.378
MTRNR2L8-0.375

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC25A27 mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of SLC25A27 mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC25A27 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC25A27 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC25A27 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC25A27 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SLC25A27 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC25A27 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SLC25A27 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A27 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A27 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SLC25A27 mRNA20385226
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A27 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A27 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SLC25A27 mRNA21420995
D000393Air PollutantsAir Pollutants analog results in decreased expression of SLC25A27 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC25A27 mRNA16483693
D004958EstradiolEstradiol affects the expression of SLC25A27 mRNA22574217
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of SLC25A27 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of SLC25A27 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of SLC25A27 mRNA27178563
C006780bisphenol Abisphenol A results in increased methylation of SLC25A27 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC25A27 mRNA20938992
D003513CycloheximideCycloheximide results in increased expression of SLC25A27 mRNA20385226
D016572CyclosporineCyclosporine results in decreased expression of SLC25A27 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of SLC25A27 mRNA27989131
D002117CalcitriolCalcitriol results in increased expression of SLC25A27 mRNA16002434
D005485FlutamideFlutamide results in increased expression of SLC25A27 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC25A27 mRNA20938992
C039281furanfuran results in increased methylation of SLC25A27 gene22079235
D005947GlucoseGlucose results in increased expression of SLC25A27 mRNA24349266
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SLC25A27 mRNA24349266
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of SLC25A27 protein17337753
D007854LeadLead affects the expression of SLC25A27 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SLC25A27 mRNA20938992
D008715MethionineMethionine deficiency results in increased expression of SLC25A27 protein17716000
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SLC25A27 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of SLC25A27 mRNA15948157|1976373
D0156551-Methyl-4-phenylpyridiniumSLC25A27 protein affects the susceptibility to 1-Methyl-4-phenylpyridinium20385226
D0156551-Methyl-4-phenylpyridiniumUCP2 protein affects the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A27 mRNA]19763737
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC25A27 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC25A27 mRNA"25554681
D009532NickelNickel results in decreased expression of SLC25A27 mRNA24768652|2558310
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of SLC25A27 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A27 mRNA"27188386
C006253pirinixic acidpirinixic acid results in increased expression of SLC25A27 mRNA20813756
D059808PolyphenolsPolyphenols results in decreased expression of SLC25A27 mRNA16293270
D011441PropylthiouracilPropylthiouracil results in increased expression of SLC25A27 mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of SLC25A27 protein17337753
C009277sodium arsenatesodium arsenate results in increased expression of SLC25A27 mRNA21795629
D019802Succinic AcidSLC25A27 protein results in increased uptake of Succinic Acid21862587
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC25A27 mRNA20399798
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC25A27 mRNA22298810
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC25A27 mRNA27255386
C012589trichostatin Atrichostatin A results in increased expression of SLC25A27 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of SLC25A27 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC25A27 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of SLC25A27 mRNA22378314
C022884undecaneundecane results in decreased expression of SLC25A27 protein17337753
D014520UrethaneUrethane results in increased expression of SLC25A27 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of SLC25A27 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SLC25A27 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SLC25A27 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SLC25A27 mRNA26272509
D014635Valproic AcidValproic Acid results in increased expression of SLC25A27 mRNA24935251|2915479
D014635Valproic AcidValproic Acid results in increased expression of SLC25A27 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SLC25A27 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0009409response to cold-IBA21873635  
GO:0010917negative regulation of mitochondrial membrane potential-IEA-  
GO:0035356cellular triglyceride homeostasis-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0046324regulation of glucose import-IEA-  
GO:0048839inner ear development-IEA-  
GO:0051562negative regulation of mitochondrial calcium ion concentration-IEA-  
GO:0055085transmembrane transport-IEA-  
GO:0070997neuron death-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA10025957  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0031966mitochondrial membrane-IDA10025957  
GO:0043025neuronal cell body-IEA-  
GO:0045177apical part of cell-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-166187Mitochondrial Uncoupling ProteinsTAS
R-HSA-167826The fatty acid cycling modelTAS
R-HSA-167827The proton buffering modelTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal