Gene: STX8

9482
CARB
syntaxin 8
protein-coding
17p13.1
Ensembl:ENSG00000170310 MIM:604203 Vega:OTTHUMG00000177844 UniprotKB:Q9UNK0
NG_047110.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.134e-2 (AD)  4.088e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7216753chr17:9446509 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COMMD10.928
MRPS150.899
METTL50.899
DPY300.897
PSMB60.891
ZNF320.891
NDUFV20.889
SUCLG10.887
MRPL110.887
CWC150.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.664
OR4F29-0.625
MTRNR2L6-0.273
P2RY14-0.266
SLC26A5-0.266
KIAA0754-0.257
C8orf74-0.25
MTRNR2L9-0.249
ZBTB20-0.241
RAET1E-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of STX8 mRNA"19162173
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of STX8 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of STX8 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 affects the expression of STX8 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of STX8 mRNA21641981|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of STX8 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of STX8 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STX8 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STX8 mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of STX8 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of STX8 mRNA"26238291
D004958EstradiolEstradiol results in decreased expression of STX8 mRNA23019147
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of STX8 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of STX8 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of STX8 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of STX8 gene28505145
C006780bisphenol Abisphenol A results in increased methylation of STX8 gene28505145
D003024ClozapineClozapine affects the expression of STX8 mRNA15860345
C018021cobaltous chloridecobaltous chloride results in decreased expression of STX8 mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of STX8 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of STX8 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of STX8 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of STX8 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of STX8 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of STX8 mRNA19561079
D002945CisplatinCisplatin results in increased expression of STX8 mRNA21151649
C000944dicrotophosdicrotophos results in decreased expression of STX8 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of STX8 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of STX8 mRNA]21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of STX8 mRNA28085963
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of STX8 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of STX8 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STX8 mRNA17942748
D005557FormaldehydeFormaldehyde results in decreased expression of STX8 mRNA23649840
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of STX8 gene28505145
D006220HaloperidolHaloperidol affects the expression of STX8 mRNA15860345
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of STX8 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of STX8 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of STX8 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of STX8 mRNA23086925
D008353MannitolMannitol results in decreased expression of STX8 mRNA25270620
D009151Mustard GasMustard Gas results in decreased expression of STX8 mRNA25102026
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of STX8 mRNA25729387
D011441PropylthiouracilPropylthiouracil results in decreased expression of STX8 mRNA24780913
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of STX8 mRNA]21852083
D013629TamoxifenTamoxifen affects the expression of STX8 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STX8 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of STX8 mRNA17942748
D019284ThapsigarginThapsigargin results in decreased expression of STX8 protein24648495
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of STX8 mRNA25729387
D014635Valproic AcidValproic Acid affects the expression of STX8 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of STX8 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of STX8 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO:0005484SNAP receptor activity-IBA21873635  
GO:0005515protein binding-IPI16189514  21516116  25416956  
GO:0019869chloride channel inhibitor activity-IDA18570918  
GO:0019905syntaxin binding-IPI10564279  
GO:0031625ubiquitin protein ligase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0006906vesicle fusion-IBA21873635  
GO:0008333endosome to lysosome transport-IEA-  
GO:0045022early endosome to late endosome transport-IDA10564279  
GO:0048278vesicle docking-IBA21873635  
GO:0071346cellular response to interferon-gamma-IEA-  
GO:1903076regulation of protein localization to plasma membrane-IDA18570918  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-IEA-  
GO:0005768endosome-IDA10564279  
GO:0005769early endosome-IDA10564279  
GO:0005770late endosome-IDA10564279  
GO:0005783endoplasmic reticulum-TAS9852078  
GO:0005802trans-Golgi network-IDA10564279  
GO:0005829cytosol-IEA-  
GO:0005887integral component of plasma membrane-TAS10198254  
GO:0012505endomembrane system-IBA21873635  
GO:0016021integral component of membrane-IBA21873635  
GO:0031201SNARE complex-IBA21873635  
GO:0031902late endosome membrane-IEA-  
GO:0031982vesicle-IDA18570918  
GO:0045335phagocytic vesicle-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA18570918  
GO:0055037recycling endosome-IDA18570918  
KEGG ID KEGG Term
hsa04130SNARE interactions in vesicular transport
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal