Gene: PIGB

9488
GPI-MT-III|PIG-B
phosphatidylinositol glycan anchor biosynthesis class B
protein-coding
15q21.3
Ensembl:ENSG00000069943 MIM:604122 Vega:OTTHUMG00000172654 UniprotKB:Q92521
NC_000015.10
SNP Mapped
1   ANCO-SNPs
CD
0   
9.018e-1 (AD)  8.801e-1 (ND)   (Frontal_Cortex)
2.530e-1 (AD)  2.693e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs678892chr15:55340661 (GRCh38.p7)G>A / G>C / G>Tcocaine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NHLRC30.804
MFSD80.795
CEP570.795
ELMOD20.792
ALG90.791
DNAJC100.789
NAE10.788
SETDB20.785
ORC30.784
ZMYM60.781

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.441
OR4F29-0.409
C7orf61-0.27
NR0B1-0.266
VHLL-0.244
WDR38-0.242
MTRNR2L9-0.241
ANXA13-0.239
MTRNR2L6-0.23
FAM151A-0.229

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PIGB mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of PIGB mRNA29067470
D001151ArsenicArsenic affects the methylation of PIGB gene25304211
D001280AtrazineAtrazine results in increased expression of PIGB mRNA25929836
D001280AtrazineAtrazine results in increased expression of PIGB mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PIGB mRNA17879257
C006780bisphenol Abisphenol A results in decreased expression of PIGB mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PIGB gene20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of PIGB mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of PIGB mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of PIGB mRNA20106945
C000944dicrotophosdicrotophos results in decreased expression of PIGB mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of PIGB mRNA28031460
D019422Dietary SucroseDietary Sucrose results in increased expression of PIGB mRNA26033743
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PIGB gene20938992
D007545IsoproterenolIsoproterenol results in decreased expression of PIGB mRNA21823215
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PIGB mRNA24796395
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PIGB gene20938992
D008727MethotrexateMethotrexate affects the expression of PIGB mRNA18502557
C568376MT19c compoundMT19c compound results in increased expression of PIGB mRNA21781307
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PIGB mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PIGB mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PIGB promoter]19654925
C025643vinclozolinvinclozolin results in decreased expression of PIGB mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000030mannosyltransferase activity-IBA21873635  
GO:0000030mannosyltransferase activity-IDA8861954  
GO:0004376glycolipid mannosyltransferase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006506GPI anchor biosynthetic process-IBA21873635  
GO:0006506GPI anchor biosynthetic process-IDA8861954  
GO:0016254preassembly of GPI anchor in ER membrane-TAS-  
GO:0097502mannosylation-IDA8861954  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005789endoplasmic reticulum membrane-IBA21873635  
GO:0005789endoplasmic reticulum membrane-IDA8861954  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-NAS8861954  
KEGG ID KEGG Term
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-162710Synthesis of glycosylphosphatidylinositol (GPI)TAS
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal