Gene info: ID 949

Gene: SCARB1

GENE ID: 949

Synonyms: CD36L1|CLA-1|CLA1|HDLQTL6|SR-BI|SRB1

Description: scavenger receptor class B member 1

Gene type: protein-coding

Location: 12q24.31

dbXrefs: Ensembl:ENSG00000073060 MIM:601040 Vega:OTTHUMG00000168544 UniprotKB:Q8WTV0

RefSeq: NG_028199.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 10

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.670e-1 (AD) 4.549e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg17057702	chr12:125262508	SCARB1	3'UTR	1.254e-4	Alcohol use disorders	26763658
cg27180443	chr12:125348871	SCARB1		2.200e-8	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MGAT1	0.798
PPT2	0.783
TYK2	0.782
SLC7A5	0.778
TMEM109	0.774
RGL2	0.773
BSG	0.759
ACIN1	0.748
GRN	0.747
CTSZ	0.746

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.645
OR4F5	-0.634
HMX2	-0.192
FOXB1	-0.189
OTP	-0.181
C22orf42	-0.181
MYZAP	-0.18
MYL1	-0.175
UNCX	-0.174
LHX5	-0.174

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00144	Phosphatidyl serine	Small Molecule	1446756-47-3	Approved\|Investigational\|Nutraceutical	Target

ID	Drug Name	Action	PubMed
C495626	14-deoxy-11,12-didehydroandrographolide	"14-deoxy-11,12-didehydroandrographolide results in increased expression of SCARB1 mRNA"	22101062
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SCARB1 mRNA"	25614096
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SCARB1 mRNA"	27291303
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of SCARB1 mRNA"	19114083
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SCARB1 mRNA"	19167446
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of SCARB1 mRNA"	21346803
C044563	24-hydroxycholesterol	24-hydroxycholesterol affects the localization of SCARB1 protein	16530456
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in decreased expression of SCARB1 protein	14614521
C076996	27-hydroxycholesterol	27-hydroxycholesterol results in increased expression of SCARB1 protein	14614521
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SCARB1 mRNA"	12376462
C526651	2-hexyl-1-cyclopentanone thiosemicarbazone	2-hexyl-1-cyclopentanone thiosemicarbazone results in decreased activity of SCARB1 protein	17890024
C000598200	4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid	"4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of SCARB1 mRNA"	22918042
C000598200	4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid	"NR1H4 gene mutant form inhibits the reaction [4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of SCARB1 mRNA]"	22918042
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in decreased expression of SCARB1 mRNA"	22504055
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in decreased expression of SCARB1 protein"	22504055
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCARB1 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal binds to SCARB1 protein	22442701
C027576	4-hydroxy-2-nonenal	Tobacco Smoke Pollution promotes the reaction [4-hydroxy-2-nonenal binds to SCARB1 protein]	22442701
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCARB1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of SCARB1 mRNA	21420995
D020106	Acrylamide	Acrylamide results in increased expression of SCARB1 protein	20025956
D020106	Acrylamide	Acrylamide results in decreased expression of SCARB1 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of SCARB1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of SCARB1 mRNA	27153756
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of SCARB1 mRNA	21757418
C103303	alitretinoin	alitretinoin results in increased expression of SCARB1 mRNA	16142410
D000537	Aluminum Oxide	Aluminum Oxide results in decreased expression of SCARB1 mRNA	19464052
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SCARB1 mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of SCARB1 gene	25304211
D001241	Aspirin	Aspirin affects the expression of SCARB1 mRNA	16816107
D001241	Aspirin	[Aspirin co-treated with Fenofibrate] results in increased expression of SCARB1 protein	16816107
D001241	Aspirin	Aspirin inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]	15037193
D001241	Aspirin	Aspirin results in decreased expression of and results in decreased activity of SCARB1 protein	16816107
D001241	Aspirin	Aspirin results in decreased expression of SCARB1 mRNA	15037193
D001241	Aspirin	Aspirin results in increased expression of and results in increased activity of SCARB1 protein	16816107
D001241	Aspirin	Aspirin results in increased expression of SCARB1 mRNA	20137092
D001241	Aspirin	Aspirin results in increased expression of SCARB1 protein	20137092
D001241	Aspirin	Aspirin affects the expression of SCARB1 protein	16816107
D000069059	Atorvastatin Calcium	[rosiglitazone co-treated with Atorvastatin Calcium] results in increased expression of SCARB1 protein	15183127
D001280	Atrazine	Atrazine results in decreased expression of SCARB1 mRNA	24632104
D001280	Atrazine	Atrazine results in decreased expression of SCARB1 mRNA	19541795
D001280	Atrazine	Atrazine results in increased expression of SCARB1 mRNA	21427058
D001280	Atrazine	Atrazine results in increased expression of SCARB1 protein	21427058
D001280	Atrazine	[CGA protein affects the susceptibility to Atrazine] which results in increased expression of SCARB1 mRNA	27554787
C547126	AZM551248	AZM551248 results in decreased expression of SCARB1 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SCARB1 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SCARB1 mRNA	22228805
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]	22442701
D019207	beta Carotene	SCARB1 protein results in increased transport of beta Carotene	16177187
D004958	Estradiol	Estradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein]	17879945
D004958	Estradiol	Estradiol results in increased expression of SCARB1 mRNA	23019147
D004958	Estradiol	Estradiol results in decreased expression of SCARB1 protein	17673517
D001629	Bezafibrate	Bezafibrate affects the localization of SCARB1 protein	16530456
D001629	Bezafibrate	Bezafibrate results in increased expression of SCARB1 mRNA	16530456
C099952	bifenthrin	bifenthrin results in decreased expression of SCARB1 mRNA	23994515
C006780	bisphenol A	bisphenol A results in decreased expression of SCARB1 mRNA	15901920
C006780	bisphenol A	bisphenol A results in increased expression of SCARB1 mRNA	25181051
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SCARB1 mRNA	22079614
D001971	Bromocriptine	Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of SCARB1 mRNA]	21427058
D002065	Buspirone	Buspirone results in decreased expression of SCARB1 mRNA	24136188
C027561	butylbenzyl phthalate	butylbenzyl phthalate results in decreased expression of SCARB1 mRNA	26472102
D002110	Caffeine	Caffeine results in decreased expression of SCARB1 mRNA	25868845
D002110	Caffeine	Caffeine results in decreased expression of SCARB1 protein	25868845
D002110	Caffeine	Caffeine results in increased methylation of SCARB1 promoter	25868845
D002186	Cannabinoids	Cannabinoids results in increased expression of SCARB1 mRNA	17205118
D002273	Carcinogens	Carcinogens results in decreased expression of SCARB1 mRNA	22269147
C070295	catalase-polyethylene glycol	catalase-polyethylene glycol inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]	22442701
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SCARB1 mRNA	24763279
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of SCARB1 mRNA	22540009
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of SCARB1 mRNA	29208485
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of SCARB1 protein	29208485
D002738	Chloroquine	[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]	20404351
D002738	Chloroquine	Chloroquine results in decreased expression of SCARB1 mRNA	19393257
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of SCARB1 mRNA	21356183
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in decreased expression of SCARB1 mRNA	21356183
D002784	Cholesterol	[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA	18302760
D002784	Cholesterol	Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA]	18302760
D002784	Cholesterol	SCARB1 protein affects the transport of Cholesterol	26651060
D002784	Cholesterol	SCARB1 protein affects the transport of Cholesterol	15883047\|2304539
D002784	Cholesterol	SCARB1 protein affects the uptake of Cholesterol	22442701
D002784	Cholesterol	SCARB1 protein results in increased transport of Cholesterol	16530456
D002791	Cholesterol, Dietary	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of SCARB1 mRNA"	19509184
D002788	Cholesterol Esters	SCARB1 protein affects the uptake of Cholesterol Esters	23045399
D008076	Cholesterol, HDL	"Niacin promotes the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"	21291703
D008076	Cholesterol, HDL	"SCARB1 protein results in increased export of Cholesterol, HDL"	21291703
D008076	Cholesterol, HDL	"Fenofibrate inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"	17533223
D008076	Cholesterol, HDL	"SCARB1 protein results in increased export of Cholesterol, HDL"	17533223
D008076	Cholesterol, HDL	"SDZ HDL 376 analog inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"	17533223
D008076	Cholesterol, HDL	"SDZ HDL 376 inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"	17533223
C023511	cholesteryl oleyl ether	Fenofibrate inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]	17533223
C023511	cholesteryl oleyl ether	SCARB1 protein results in increased uptake of cholesteryl oleyl ether	17533223
C023511	cholesteryl oleyl ether	SDZ HDL 376 analog inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]	17533223
C023511	cholesteryl oleyl ether	SDZ HDL 376 inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]	17533223
D019826	Cholic Acid	[Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA	22540009
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SCARB1 mRNA	27344345
D002793	Cholic Acids	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of SCARB1 mRNA	27344345
D002793	Cholic Acids	[Methyltestosterone co-treated with Cholic Acids] affects the expression of SCARB1 mRNA	27344345
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SCARB1 gene	20938992
D002994	Clofibrate	Clofibrate results in decreased expression of SCARB1 mRNA	17585979\|2381119
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SCARB1 mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SCARB1 mRNA	19320972\|2294125
D003042	Cocaine	Cocaine results in increased expression of SCARB1 mRNA	17205118
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in decreased expression of SCARB1 mRNA	21356183
D003300	Copper	Copper results in decreased expression of SCARB1 mRNA	21356183
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of SCARB1 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of SCARB1 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SCARB1 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of SCARB1 mRNA	19167446
D003474	Curcumin	Curcumin affects the expression of SCARB1 mRNA	27208389
D016572	Cyclosporine	Cyclosporine results in decreased expression of SCARB1 mRNA	20106945\|2556210
C093628	cyproconazole	cyproconazole results in increased expression of SCARB1 mRNA	22045034
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of SCARB1 mRNA	23640034
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of SCARB1 mRNA	22540009
D003907	Dexamethasone	Dexamethasone results in increased expression of SCARB1 mRNA	21041162
D003907	Dexamethasone	Dexamethasone results in decreased expression of SCARB1 protein	12475377
C526766	diaminochlorotriazine	diaminochlorotriazine results in decreased expression of SCARB1 mRNA	24632104
D003976	Diazinon	Diazinon results in increased methylation of SCARB1 gene	22964155
C016366	dibenzothiophene	dibenzothiophene results in increased expression of SCARB1 mRNA	23656968
D003993	Dibutyl Phthalate	Dibutyl Phthalate affects the expression of SCARB1 protein	21745491
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of SCARB1 mRNA	14617579\|1514109
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of SCARB1 protein	14617579\|1514109
D003994	Bucladesine	Bucladesine results in increased expression of SCARB1 mRNA	23045399\|2336226
D003994	Bucladesine	LIPE protein affects the reaction [Bucladesine results in increased expression of SCARB1 mRNA]	23362264
D003994	Bucladesine	Bucladesine results in increased expression of SCARB1 mRNA	23045399
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of SCARB1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of SCARB1 mRNA	27594783
D002945	Cisplatin	Cisplatin results in increased expression of SCARB1 mRNA	21151649
C000944	dicrotophos	dicrotophos results in increased expression of SCARB1 mRNA	28302478
D004026	Dieldrin	Dieldrin results in increased expression of SCARB1 mRNA	20438755\|2304172
D004040	Dietary Carbohydrates	Dietary Carbohydrates results in decreased expression of SCARB1 mRNA	20110567
D004041	Dietary Fats	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of SCARB1 mRNA"	19509184
D004041	Dietary Fats	[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA	18302760
D004041	Dietary Fats	[Dietary Fats co-treated with rosiglitazone] results in decreased expression of SCARB1 mRNA	18276752
D004041	Dietary Fats	Dietary Fats promotes the reaction [NR1H4 protein binds to SCARB1 intron]	22540009
D004041	Dietary Fats	Dietary Fats promotes the reaction [[NR1H4 protein binds to SCARB1 intron] which results in increased expression of SCARB1 mRNA]	22540009\|2254000
D004041	Dietary Fats	Dietary Fats results in decreased expression of SCARB1 mRNA	18457598\|1903023
D004041	Dietary Fats	Dietary Fats results in increased expression of SCARB1 mRNA	22540009
D004041	Dietary Fats	Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA]	18302760
D004041	Dietary Fats	NR1H4 protein affects the reaction [Dietary Fats results in increased expression of SCARB1 mRNA]	22540009
D004041	Dietary Fats	[Oligosaccharides co-treated with Dietary Fats] results in increased expression of SCARB1 mRNA	28549616
D004041	Dietary Fats	[Oligosaccharides co-treated with Dietary Fats] results in increased expression of SCARB1 protein	28549616
D004041	Dietary Fats	resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA]	23127599
D004041	Dietary Fats	resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein]	23127599
D004041	Dietary Fats	[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA	23127599
D004041	Dietary Fats	[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein	23127599
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of SCARB1 mRNA	19245819
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of SCARB1 mRNA	19000923
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of SCARB1 mRNA	16690193\|2647210
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SCARB1 mRNA	17602206
C089799	diheptyl phthalate	diheptyl phthalate results in decreased expression of SCARB1 mRNA	22112501
C025605	diisobutyl phthalate	diisobutyl phthalate results in decreased expression of SCARB1 mRNA	22112501\|2865564
C012125	diisononyl phthalate	diisononyl phthalate results in decreased expression of SCARB1 mRNA	22112501
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SCARB1 mRNA"	12376462
C024629	dimethyl phthalate	dimethyl phthalate results in decreased expression of SCARB1 mRNA	26472102
C027387	di-n-hexyl phthalate	di-n-hexyl phthalate results in decreased expression of SCARB1 mRNA	22112501\|2693418
C034171	di-n-pentyl phthalate	di-n-pentyl phthalate results in decreased expression of SCARB1 mRNA	19560483\|2211250
C034171	di-n-pentyl phthalate	[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of SCARB1 mRNA	25055962
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]	22442701
D004237	Diuron	Diuron results in increased expression of SCARB1 mRNA	21551480
D004391	Dust	Dust results in decreased expression of SCARB1 mRNA	17805423
C118739	entinostat	entinostat results in increased expression of SCARB1 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCARB1 mRNA"	27188386
D000431	Ethanol	Ethanol results in increased expression of SCARB1 mRNA	15353170
D004997	Ethinyl Estradiol	ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of SCARB1 protein modified form]	17673517
D004997	Ethinyl Estradiol	[Ethinyl Estradiol affects the expression of TRA2B protein] which affects the splicing of SCARB1 mRNA	17673517
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the splicing of SCARB1 mRNA	17673517
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of SCARB1 mRNA	27344345
D004997	Ethinyl Estradiol	[Ethinyl Estradiol affects the expression of TRA2B protein] which affects the splicing of SCARB1 mRNA	17673517
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the splicing of SCARB1 mRNA	17673517
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of SCARB1 mRNA	12475377\|1583489
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of SCARB1 protein	12475377\|1767351
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SCARB1 protein	12475377
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SCARB1 protein modified form	17673517
C024565	ethylene dichloride	ethylene dichloride results in increased expression of SCARB1 mRNA	28189721
D000069438	Ezetimibe	Ezetimibe results in decreased expression of SCARB1 mRNA	16177187
D011345	Fenofibrate	[Aspirin co-treated with Fenofibrate] results in increased expression of SCARB1 protein	16816107
D011345	Fenofibrate	Fenofibrate results in increased expression of SCARB1 protein	16816107
D011345	Fenofibrate	"Fenofibrate inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"	17533223
D011345	Fenofibrate	Fenofibrate inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]	17533223
D011345	Fenofibrate	Fenofibrate results in decreased activity of SCARB1 protein	17533223
D011345	Fenofibrate	Fenofibrate affects the localization of SCARB1 protein	16530456
C024555	ferric chloride	ferric chloride results in increased expression of SCARB1 protein	20025956
D005395	Fish Oils	Fish Oils results in decreased expression of SCARB1 mRNA	29329427
D005411	Flame Retardants	Flame Retardants results in decreased expression of SCARB1 mRNA	23347875
D005419	Flavonoids	Flavonoids results in increased expression of SCARB1 mRNA	18035473
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SCARB1 gene	20938992
D005632	Fructose	"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of SCARB1 mRNA"	19509184
D005632	Fructose	Fructose results in decreased expression of SCARB1 mRNA	19193814
D019833	Genistein	[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of SCARB1 mRNA	27181934
D005897	Glafenine	Glafenine results in increased expression of SCARB1 mRNA	24136188
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SCARB1 mRNA	24763279
C412815	GW 4064	[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA	22540009
C412815	GW 4064	[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA	22540009
C412815	GW 4064	GW 4064 promotes the reaction [NR1H4 protein binds to SCARB1 intron]	22540009
C059714	HDL cholesteryl ester	SCARB1 protein promotes the reaction [LIPC protein results in increased uptake of HDL cholesteryl ester]	12611911
C059714	HDL cholesteryl ester	SCARB1 protein results in increased uptake of HDL cholesteryl ester	12611911
C059714	HDL cholesteryl ester	SCARB1 protein results in increased transport of HDL cholesteryl ester	16816107
C089796	hexabromocyclododecane	[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of SCARB1 mRNA	25447410
C089796	hexabromocyclododecane	hexabromocyclododecane results in decreased expression of SCARB1 mRNA	23347875\|2544741
C409722	hexaconazole	hexaconazole results in increased expression of SCARB1 mRNA	22045034
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of SCARB1 protein	22442701
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of SCARB1 mRNA	27392435
C410337	K 7174	K 7174 results in decreased expression of SCARB1 mRNA	24086573
C011890	kojic acid	kojic acid results in increased expression of SCARB1 mRNA	19000923
D007854	Lead	Lead affects the expression of SCARB1 mRNA	28903495
C008261	lead acetate	lead acetate results in increased expression of SCARB1 mRNA	21829687
C045463	leflunomide	leflunomide results in increased expression of SCARB1 mRNA	24136188
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 mRNA"	12010990
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 protein"	12010990
C440499	lipopolysaccharide, Escherichia coli O111 B4	"Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 mRNA]"	12010990
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [rosiglitazone results in increased expression of SCARB1 protein]	22240665
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of SCARB1 mRNA	22240665
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of SCARB1 protein	22240665
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of SCARB1 mRNA	15883047
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of SCARB1 protein	15883047
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of SCARB1 mRNA	19000923
D019808	Losartan	Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA]	18302760
D008148	Lovastatin	[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]	20404351
D008148	Lovastatin	Lovastatin affects the expression of SCARB1 mRNA	27208389
D008628	Mercury	Mercury results in increased expression of SCARB1 mRNA	19937285
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SCARB1 gene	20938992
D008731	Methoxychlor	Methoxychlor results in increased expression of SCARB1 mRNA	27663972
C005219	methyl cellosolve	Bromocriptine inhibits the reaction [methyl cellosolve results in increased expression of SCARB1 mRNA]	21427058
C005219	methyl cellosolve	methyl cellosolve results in increased expression of SCARB1 mRNA	21427058
C005219	methyl cellosolve	methyl cellosolve results in increased expression of SCARB1 protein	21427058
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SCARB1 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SCARB1 mRNA"	20188158
D008777	Methyltestosterone	[Methyltestosterone co-treated with Cholic Acids] affects the expression of SCARB1 mRNA	27344345
C011309	mezerein	mezerein results in increased expression of SCARB1 mRNA	19000923
C016599	mono-(2-ethylhexyl)phthalate	[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of SCARB1 mRNA	27181934
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in decreased expression of SCARB1 mRNA	22401849
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of SCARB1 mRNA	22087261
D009153	Mutagens	Mutagens results in decreased expression of SCARB1 mRNA	22269147
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SCARB1 mRNA"	25448806
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SCARB1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SCARB1 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SCARB1 mRNA	27344345
D009525	Niacin	Aspirin inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]	15037193
D009525	Niacin	"Niacin promotes the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"	21291703
D009525	Niacin	Niacin results in increased expression of SCARB1 mRNA	15037193
D009525	Niacin	Ro 31-8220 inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]	15037193
D009525	Niacin	Niacin results in decreased expression of SCARB1 protein	19878707
D009532	Nickel	Nickel results in decreased expression of SCARB1 mRNA	24768652\|2558310
C028007	nickel monoxide	nickel monoxide results in increased expression of SCARB1 mRNA	19167457
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of SCARB1 mRNA	20971185
C464660	obeticholic acid	obeticholic acid results in increased expression of SCARB1 mRNA	27939613
D019319	Okadaic Acid	Okadaic Acid results in increased expression of SCARB1 mRNA	19000923
C108709	oleoyl-estrone	oleoyl-estrone results in increased expression of SCARB1 mRNA	19793540
D009844	Oligosaccharides	[Oligosaccharides co-treated with Dietary Fats] results in increased expression of SCARB1 mRNA	28549616
D009844	Oligosaccharides	[Oligosaccharides co-treated with Dietary Fats] results in increased expression of SCARB1 protein	28549616
D015525	Fatty Acids, Omega-3	"Fatty Acids, Omega-3 results in decreased expression of SCARB1 mRNA"	23333450
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of SCARB1 mRNA	25729387
D052638	Particulate Matter	Particulate Matter results in increased expression of SCARB1 mRNA	22861003
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of SCARB1 mRNA	24642059
D010416	Pentachlorophenol	Pentachlorophenol results in decreased expression of SCARB1 mRNA	23892564
C522391	perfluorododecanoic acid	perfluorododecanoic acid results in decreased expression of SCARB1 mRNA	17400581
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in decreased expression of SCARB1 mRNA	21705711
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of SCARB1 mRNA	21705711
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of SCARB1 mRNA	17681415
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of SCARB1 mRNA	19162173
D010622	Phencyclidine	Phencyclidine results in increased expression of SCARB1 mRNA	17205118
D010634	Phenobarbital	Phenobarbital affects the expression of SCARB1 mRNA	19136022\|2309116
D010672	Phenytoin	Phenytoin results in decreased expression of SCARB1 mRNA	15136057
D010795	Phthalic Acids	Phthalic Acids inhibits the reaction [LHB protein results in increased expression of SCARB1 mRNA]	19699292
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of SCARB1 mRNA	15728792
C060836	pioglitazone	pioglitazone results in decreased expression of SCARB1 mRNA	20503262
C060836	pioglitazone	pioglitazone affects the localization of SCARB1 protein	16530456
C060836	pioglitazone	pioglitazone results in increased expression of SCARB1 mRNA	16530456
C006253	pirinixic acid	pirinixic acid affects the expression of SCARB1 mRNA	19136022
C006253	pirinixic acid	pirinixic acid results in decreased expression of SCARB1 mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of SCARB1 mRNA	16985257\|1742611
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls results in increased expression of SCARB1 mRNA	21334430
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of SCARB1 mRNA	22714537
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SCARB1 mRNA	15883047\|1916217
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of SCARB1 protein	15883047
D011374	Progesterone	[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]	20404351
D011374	Progesterone	Progesterone results in increased expression of SCARB1 mRNA	19000923
D011374	Progesterone	SCARB1 protein results in increased abundance of Progesterone	20404351
C045950	propiconazole	propiconazole results in decreased expression of SCARB1 mRNA	21278054
C030984	pyrene	pyrene results in increased expression of SCARB1 mRNA	23656968
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of SCARB1 mRNA	19167446
C059514	resveratrol	resveratrol inhibits the reaction [Smoke analog results in decreased expression of SCARB1 protein]	24423486
C059514	resveratrol	resveratrol results in increased expression of SCARB1 mRNA	23041272
C059514	resveratrol	resveratrol results in increased expression of SCARB1 protein	24423486
C059514	resveratrol	resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA]	23127599
C059514	resveratrol	resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein]	23127599
C014794	retinol palmitate	retinol palmitate results in increased expression of SCARB1 mRNA	17299104
D012293	Rifampin	Rifampin results in decreased expression of SCARB1 mRNA	15883047
D012293	Rifampin	Rifampin results in decreased expression of SCARB1 protein	15883047
C089032	rimonabant	rimonabant results in increased expression of SCARB1 mRNA	20110567
D019438	Ritonavir	Estradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein]	17879945
D019438	Ritonavir	Ritonavir results in increased expression of SCARB1 mRNA	17879945
C064758	Ro 31-8220	Ro 31-8220 inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]	15037193
C089730	rosiglitazone	[rosiglitazone co-treated with Atorvastatin Calcium] results in increased expression of SCARB1 protein	15183127
C089730	rosiglitazone	rosiglitazone results in increased expression of SCARB1 mRNA	16386711
C089730	rosiglitazone	rosiglitazone results in increased expression of SCARB1 protein	15183127\|1638671
C089730	rosiglitazone	rosiglitazone inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of SCARB1 mRNA]	20926582
C089730	rosiglitazone	[Dietary Fats co-treated with rosiglitazone] results in decreased expression of SCARB1 mRNA	18276752
C089730	rosiglitazone	Lipopolysaccharides inhibits the reaction [rosiglitazone results in increased expression of SCARB1 protein]	22240665
C089730	rosiglitazone	rosiglitazone results in increased expression of SCARB1 protein	22240665
D012439	Saccharin	Saccharin results in increased expression of SCARB1 mRNA	19000923
C108967	SDZ HDL 376	"SDZ HDL 376 analog inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"	17533223
C108967	SDZ HDL 376	SDZ HDL 376 analog inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]	17533223
C108967	SDZ HDL 376	SDZ HDL 376 analog results in decreased activity of SCARB1 protein	17533223
C108967	SDZ HDL 376	"SDZ HDL 376 inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"	17533223
C108967	SDZ HDL 376	SDZ HDL 376 inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]	17533223
C108967	SDZ HDL 376	SDZ HDL 376 results in decreased activity of SCARB1 protein	17533223
D012645	Selenomethionine	Selenomethionine affects the expression of SCARB1 mRNA	17222674
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in increased expression of SCARB1 mRNA	18514395
D012834	Silver	SCARB1 protein results in increased uptake of and results in increased susceptibility to Silver	25458489
D019821	Simvastatin	PPARA mutant form inhibits the reaction [Simvastatin results in increased expression of SCARB1]	18981156
D019821	Simvastatin	RHOA inhibits the reaction [Simvastatin results in increased expression of SCARB1]	18981156
D019821	Simvastatin	Simvastatin results in increased expression of SCARB1	18981156
D019821	Simvastatin	Simvastatin results in increased expression of SCARB1	18981156
D019821	Simvastatin	Simvastatin results in increased expression of SCARB1 mRNA	21241519
D019821	Simvastatin	Simvastatin results in increased expression of SCARB1 protein	20025956\|2124151
D019821	Simvastatin	[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of SCARB1 mRNA	25055962
D012906	Smoke	resveratrol inhibits the reaction [Smoke analog results in decreased expression of SCARB1 protein]	24423486
D012906	Smoke	Smoke analog results in decreased expression of SCARB1 protein	24423486
C016104	sodium bichromate	sodium bichromate results in decreased expression of SCARB1 mRNA	22155349
D012980	Sodium Salicylate	Sodium Salicylate results in decreased expression of SCARB1 protein	16816107
D012980	Sodium Salicylate	Sodium Salicylate results in increased expression of SCARB1 protein	16816107
D018038	Sodium Selenite	Sodium Selenite results in increased expression of SCARB1 mRNA	18514395
D053260	Soot	Soot results in increased expression of SCARB1 mRNA	26551751
C023599	stannous chloride	stannous chloride results in increased expression of SCARB1 mRNA	19000923
D013395	Sucrose	resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA]	23127599
D013395	Sucrose	resveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein]	23127599
D013395	Sucrose	[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA	23127599
D013395	Sucrose	[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein	23127599
D013412	Sulfadimethoxine	Sulfadimethoxine results in increased expression of SCARB1 mRNA	19000923
D013469	Sulpiride	Sulpiride results in increased expression of SCARB1 mRNA	21427058
D013469	Sulpiride	Sulpiride results in increased expression of SCARB1 protein	21427058
C004648	testosterone enanthate	testosterone enanthate results in decreased expression of SCARB1 mRNA	21427060
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SCARB1 mRNA	16443690
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SCARB1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SCARB1 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SCARB1 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SCARB1 mRNA	28213091\|2823826
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SCARB1 mRNA	18796159
C009495	titanium dioxide	titanium dioxide results in increased expression of SCARB1 mRNA	23131501
C423915	TO-901317	TO-901317 results in increased expression of SCARB1 mRNA	16142410
C423915	TO-901317	TO-901317 inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of SCARB1 mRNA]	20926582
D014028	Tobacco Smoke Pollution	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]	22442701
D014028	Tobacco Smoke Pollution	catalase-polyethylene glycol inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]	22442701
D014028	Tobacco Smoke Pollution	CAT protein inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]	22442701
D014028	Tobacco Smoke Pollution	diphenyleneiodonium inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]	22442701
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution promotes the reaction [4-hydroxy-2-nonenal binds to SCARB1 protein]	22442701
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of and affects the localization of SCARB1 protein	22442701
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased ubiquitination of SCARB1 protein	22442701
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of SCARB1 mRNA	25729387
D014108	Tosylphenylalanyl Chloromethyl Ketone	"Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 mRNA]"	12010990
D014212	Tretinoin	Tretinoin results in decreased expression of SCARB1 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of SCARB1 protein	20025956
C012589	trichostatin A	trichostatin A results in increased expression of SCARB1 mRNA	15901671
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of SCARB1 mRNA	26049154
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SCARB1 mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of SCARB1 mRNA	12732648\|2897369
C057693	troglitazone	troglitazone affects the localization of SCARB1 protein	16530456
C022884	undecane	undecane results in increased expression of SCARB1 protein	17337753
D014635	Valproic Acid	Valproic Acid results in increased expression of SCARB1 mRNA	15901671
D014635	Valproic Acid	Valproic Acid affects the expression of SCARB1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SCARB1 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased expression of SCARB1 mRNA	22045034
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of SCARB1 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of SCARB1 mRNA	22861003
C025643	vinclozolin	vinclozolin results in increased expression of SCARB1 mRNA	20566332
C540004	WAY-362450	NR1H4 gene mutant form inhibits the reaction [WAY-362450 results in increased expression of SCARB1 mRNA]	22918042
C540004	WAY-362450	WAY-362450 results in increased expression of SCARB1 mRNA	19136377\|2291804
C016837	zinc chloride	zinc chloride results in increased expression of SCARB1 mRNA	19000923
D015039	Ziram	Ziram results in decreased expression of SCARB1 mRNA	28973382
D015039	Ziram	Ziram results in decreased expression of SCARB1 protein	28973382

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001530	lipopolysaccharide binding	-	IDA	12651854
GO:0001540	amyloid-beta binding	-	IEA	-
GO:0001618	virus receptor activity	-	IEA	-
GO:0001786	phosphatidylserine binding	-	ISS	-
GO:0001875	lipopolysaccharide receptor activity	-	IDA	12651854
GO:0005044	scavenger receptor activity	-	TAS	11240025
GO:0005215	transporter activity	-	TAS	9211901
GO:0005515	protein binding	-	IPI	12356718 25416956
GO:0005545	1-phosphatidylinositol binding	-	TAS	9211901
GO:0008035	high-density lipoprotein particle binding	-	IEA	-
GO:0030169	low-density lipoprotein particle binding	-	IDA	9211901
GO:0034185	apolipoprotein binding	-	IPI	10764676
GO:0034186	apolipoprotein A-I binding	-	IPI	10764676 12651854
GO:0042803	protein homodimerization activity	-	IEA	-
GO:0070506	high-density lipoprotein particle receptor activity	-	IDA	9211901
GO:0070506	high-density lipoprotein particle receptor activity	-	IMP	11208913

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001935	endothelial cell proliferation	-	IEA	-
GO:0006702	androgen biosynthetic process	-	IEA	-
GO:0006707	cholesterol catabolic process	-	IEA	-
GO:0006898	receptor-mediated endocytosis	-	TAS	-
GO:0010595	positive regulation of endothelial cell migration	-	TAS	17574123
GO:0010867	positive regulation of triglyceride biosynthetic process	-	ISS	-
GO:0010886	positive regulation of cholesterol storage	-	IDA	9211901
GO:0010899	regulation of phosphatidylcholine catabolic process	-	ISS	-
GO:0015914	phospholipid transport	-	ISS	-
GO:0015920	lipopolysaccharide transport	-	IDA	12651854
GO:0031663	lipopolysaccharide-mediated signaling pathway	-	IEA	-
GO:0032497	detection of lipopolysaccharide	-	IDA	12651854
GO:0033344	cholesterol efflux	-	IMP	12202492
GO:0033344	cholesterol efflux	-	ISS	14718538
GO:0034375	high-density lipoprotein particle remodeling	-	ISS	-
GO:0034383	low-density lipoprotein particle clearance	-	ISS	-
GO:0034384	high-density lipoprotein particle clearance	-	IDA	9211901
GO:0034384	high-density lipoprotein particle clearance	-	TAS	-
GO:0035461	vitamin transmembrane transport	-	IMP	11208913
GO:0042060	wound healing	-	TAS	17574123
GO:0042632	cholesterol homeostasis	-	ISS	-
GO:0043534	blood vessel endothelial cell migration	-	IEA	-
GO:0043654	recognition of apoptotic cell	-	IDA	9211901
GO:0043691	reverse cholesterol transport	-	IEP	9211901
GO:0044406	adhesion of symbiont to host	-	IMP	19087225
GO:0046718	viral entry into host cell	-	IEA	-
GO:0050764	regulation of phagocytosis	-	IC	9211901
GO:0050892	intestinal absorption	-	IEA	-
GO:0051000	positive regulation of nitric-oxide synthase activity	-	IDA	11792700
GO:0070328	triglyceride homeostasis	-	ISS	-
GO:0070508	cholesterol import	-	IMP	11208913 26965621
GO:0070508	cholesterol import	-	ISS	14718538

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005765	lysosomal membrane	-	HDA	17897319
GO:0005886	plasma membrane	-	IDA	9211901
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IEA	-
GO:0005901	caveola	-	TAS	12651854
GO:0009986	cell surface	-	ISS	21481393
GO:0030666	endocytic vesicle membrane	-	TAS	-
GO:0031528	microvillus membrane	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	20458337

KEGG ID	KEGG Term
hsa04145	Phagosome
hsa04975	Fat digestion and absorption
hsa04976	Bile secretion
hsa04977	Vitamin digestion and absorption
hsa05160	Hepatitis C

Reactome ID	Reactome Term	Evidence
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	TAS
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	TAS
R-HSA-3000471	Scavenging by Class B Receptors	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS
R-HSA-8964011	HDL clearance	TAS
R-HSA-8964043	Plasma lipoprotein clearance	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25993026	Association of the Lipoprotein Receptor SCARB1 Common Missense Variant rs4238001 with Incident Coronary Heart Disease. (2015)	Manichaikul A	PLoS One
28889112	Interplay between cigarette smoking and pulmonary reverse lipid transport. (2017 Sep)	Jubinville E	Eur Respir J
27428740	SCARB1 rs5888 is associated with the risk of age-related macular degeneration susceptibility and an impaired macular area. (2017 May-Jun)	Stanislovaitiene D	Ophthalmic Genet
20442857	Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. (2010 Apr 29)	Suchindran S	PLoS Genet
22606049	Interactions of several lipid-related gene polymorphisms and cigarette smoking on blood pressure levels. (2012)	Yin RX	Int J Biol Sci
26092999	Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells. (2015 Aug 15)	Lockett AD	Am J Physiol Lung Cell Mol Physiol
28209224	Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. (2017 Feb 21)	Webb TR	J Am Coll Cardiol
22003152	Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. (2012 Jan)	Grallert H	Eur Heart J
24346170	Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). (2014 Jan 29)	Meyers KJ	Invest Ophthalmol Vis Sci
23562302	Investigation of genetic variation in scavenger receptor class B, member 1 (SCARB1) and association with serum carotenoids. (2013 Aug)	McKay GJ	Ophthalmology