Gene: SCARB1

949
CD36L1|CLA-1|CLA1|HDLQTL6|SR-BI|SRB1
scavenger receptor class B member 1
protein-coding
12q24.31
Ensembl:ENSG00000073060 MIM:601040 Vega:OTTHUMG00000168544 UniprotKB:Q8WTV0
NG_028199.1
PubMed
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.670e-1 (AD)  4.549e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17057702chr12:125262508SCARB13'UTR1.254e-4Alcohol use disorders26763658
cg27180443chr12:125348871SCARB12.200e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MGAT10.798
PPT20.783
TYK20.782
SLC7A50.778
TMEM1090.774
RGL20.773
BSG0.759
ACIN10.748
GRN0.747
CTSZ0.746

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.645
OR4F5-0.634
HMX2-0.192
FOXB1-0.189
OTP-0.181
C22orf42-0.181
MYZAP-0.18
MYL1-0.175
UNCX-0.174
LHX5-0.174

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00144Phosphatidyl serineSmall Molecule1446756-47-3Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in increased expression of SCARB1 mRNA"22101062
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SCARB1 mRNA"25614096
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of SCARB1 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of SCARB1 mRNA"19114083
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SCARB1 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SCARB1 mRNA"21346803
C04456324-hydroxycholesterol24-hydroxycholesterol affects the localization of SCARB1 protein16530456
C07699627-hydroxycholesterol27-hydroxycholesterol results in decreased expression of SCARB1 protein14614521
C07699627-hydroxycholesterol27-hydroxycholesterol results in increased expression of SCARB1 protein14614521
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of SCARB1 mRNA"12376462
C5266512-hexyl-1-cyclopentanone thiosemicarbazone2-hexyl-1-cyclopentanone thiosemicarbazone results in decreased activity of SCARB1 protein17890024
C0005982004-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid"4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of SCARB1 mRNA"22918042
C0005982004-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid"NR1H4 gene mutant form inhibits the reaction [4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid results in increased expression of SCARB1 mRNA]"22918042
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of SCARB1 mRNA"22504055
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of SCARB1 protein"22504055
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCARB1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal binds to SCARB1 protein22442701
C0275764-hydroxy-2-nonenalTobacco Smoke Pollution promotes the reaction [4-hydroxy-2-nonenal binds to SCARB1 protein]22442701
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCARB1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SCARB1 mRNA21420995
D020106AcrylamideAcrylamide results in increased expression of SCARB1 protein20025956
D020106AcrylamideAcrylamide results in decreased expression of SCARB1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SCARB1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SCARB1 mRNA27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of SCARB1 mRNA21757418
C103303alitretinoinalitretinoin results in increased expression of SCARB1 mRNA16142410
D000537Aluminum OxideAluminum Oxide results in decreased expression of SCARB1 mRNA19464052
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SCARB1 mRNA16483693
D001151ArsenicArsenic affects the methylation of SCARB1 gene25304211
D001241AspirinAspirin affects the expression of SCARB1 mRNA16816107
D001241Aspirin[Aspirin co-treated with Fenofibrate] results in increased expression of SCARB1 protein16816107
D001241AspirinAspirin inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]15037193
D001241AspirinAspirin results in decreased expression of and results in decreased activity of SCARB1 protein16816107
D001241AspirinAspirin results in decreased expression of SCARB1 mRNA15037193
D001241AspirinAspirin results in increased expression of and results in increased activity of SCARB1 protein16816107
D001241AspirinAspirin results in increased expression of SCARB1 mRNA20137092
D001241AspirinAspirin results in increased expression of SCARB1 protein20137092
D001241AspirinAspirin affects the expression of SCARB1 protein16816107
D000069059Atorvastatin Calcium[rosiglitazone co-treated with Atorvastatin Calcium] results in increased expression of SCARB1 protein15183127
D001280AtrazineAtrazine results in decreased expression of SCARB1 mRNA24632104
D001280AtrazineAtrazine results in decreased expression of SCARB1 mRNA19541795
D001280AtrazineAtrazine results in increased expression of SCARB1 mRNA21427058
D001280AtrazineAtrazine results in increased expression of SCARB1 protein21427058
D001280Atrazine[CGA protein affects the susceptibility to Atrazine] which results in increased expression of SCARB1 mRNA27554787
C547126AZM551248AZM551248 results in decreased expression of SCARB1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SCARB1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SCARB1 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]22442701
D019207beta CaroteneSCARB1 protein results in increased transport of beta Carotene16177187
D004958EstradiolEstradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein]17879945
D004958EstradiolEstradiol results in increased expression of SCARB1 mRNA23019147
D004958EstradiolEstradiol results in decreased expression of SCARB1 protein17673517
D001629BezafibrateBezafibrate affects the localization of SCARB1 protein16530456
D001629BezafibrateBezafibrate results in increased expression of SCARB1 mRNA16530456
C099952bifenthrinbifenthrin results in decreased expression of SCARB1 mRNA23994515
C006780bisphenol Abisphenol A results in decreased expression of SCARB1 mRNA15901920
C006780bisphenol Abisphenol A results in increased expression of SCARB1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SCARB1 mRNA22079614
D001971BromocriptineBromocriptine inhibits the reaction [methyl cellosolve results in increased expression of SCARB1 mRNA]21427058
D002065BuspironeBuspirone results in decreased expression of SCARB1 mRNA24136188
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of SCARB1 mRNA26472102
D002110CaffeineCaffeine results in decreased expression of SCARB1 mRNA25868845
D002110CaffeineCaffeine results in decreased expression of SCARB1 protein25868845
D002110CaffeineCaffeine results in increased methylation of SCARB1 promoter25868845
D002186CannabinoidsCannabinoids results in increased expression of SCARB1 mRNA17205118
D002273CarcinogensCarcinogens results in decreased expression of SCARB1 mRNA22269147
C070295catalase-polyethylene glycolcatalase-polyethylene glycol inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]22442701
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SCARB1 mRNA24763279
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in increased expression of SCARB1 mRNA22540009
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SCARB1 mRNA29208485
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SCARB1 protein29208485
D002738Chloroquine[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]20404351
D002738ChloroquineChloroquine results in decreased expression of SCARB1 mRNA19393257
D004390ChlorpyrifosChlorpyrifos results in decreased expression of SCARB1 mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of SCARB1 mRNA21356183
D002784Cholesterol[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA18302760
D002784CholesterolLosartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA]18302760
D002784CholesterolSCARB1 protein affects the transport of Cholesterol26651060
D002784CholesterolSCARB1 protein affects the transport of Cholesterol15883047|2304539
D002784CholesterolSCARB1 protein affects the uptake of Cholesterol22442701
D002784CholesterolSCARB1 protein results in increased transport of Cholesterol16530456
D002791Cholesterol, Dietary"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of SCARB1 mRNA"19509184
D002788Cholesterol EstersSCARB1 protein affects the uptake of Cholesterol Esters23045399
D008076Cholesterol, HDL"Niacin promotes the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"21291703
D008076Cholesterol, HDL"SCARB1 protein results in increased export of Cholesterol, HDL"21291703
D008076Cholesterol, HDL"Fenofibrate inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"17533223
D008076Cholesterol, HDL"SCARB1 protein results in increased export of Cholesterol, HDL"17533223
D008076Cholesterol, HDL"SDZ HDL 376 analog inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"17533223
D008076Cholesterol, HDL"SDZ HDL 376 inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"17533223
C023511cholesteryl oleyl etherFenofibrate inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]17533223
C023511cholesteryl oleyl etherSCARB1 protein results in increased uptake of cholesteryl oleyl ether17533223
C023511cholesteryl oleyl etherSDZ HDL 376 analog inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]17533223
C023511cholesteryl oleyl etherSDZ HDL 376 inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]17533223
D019826Cholic Acid[Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA22540009
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SCARB1 mRNA27344345
D002793Cholic Acids[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of SCARB1 mRNA27344345
D002793Cholic Acids[Methyltestosterone co-treated with Cholic Acids] affects the expression of SCARB1 mRNA27344345
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SCARB1 gene20938992
D002994ClofibrateClofibrate results in decreased expression of SCARB1 mRNA17585979|2381119
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SCARB1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of SCARB1 mRNA19320972|2294125
D003042CocaineCocaine results in increased expression of SCARB1 mRNA17205118
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of SCARB1 mRNA21356183
D003300CopperCopper results in decreased expression of SCARB1 mRNA21356183
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SCARB1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of SCARB1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SCARB1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of SCARB1 mRNA19167446
D003474CurcuminCurcumin affects the expression of SCARB1 mRNA27208389
D016572CyclosporineCyclosporine results in decreased expression of SCARB1 mRNA20106945|2556210
C093628cyproconazolecyproconazole results in increased expression of SCARB1 mRNA22045034
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SCARB1 mRNA23640034
D003840Deoxycholic AcidDeoxycholic Acid results in increased expression of SCARB1 mRNA22540009
D003907DexamethasoneDexamethasone results in increased expression of SCARB1 mRNA21041162
D003907DexamethasoneDexamethasone results in decreased expression of SCARB1 protein12475377
C526766diaminochlorotriazinediaminochlorotriazine results in decreased expression of SCARB1 mRNA24632104
D003976DiazinonDiazinon results in increased methylation of SCARB1 gene22964155
C016366dibenzothiophenedibenzothiophene results in increased expression of SCARB1 mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate affects the expression of SCARB1 protein21745491
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SCARB1 mRNA14617579|1514109
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SCARB1 protein14617579|1514109
D003994BucladesineBucladesine results in increased expression of SCARB1 mRNA23045399|2336226
D003994BucladesineLIPE protein affects the reaction [Bucladesine results in increased expression of SCARB1 mRNA]23362264
D003994BucladesineBucladesine results in increased expression of SCARB1 mRNA23045399
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SCARB1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SCARB1 mRNA27594783
D002945CisplatinCisplatin results in increased expression of SCARB1 mRNA21151649
C000944dicrotophosdicrotophos results in increased expression of SCARB1 mRNA28302478
D004026DieldrinDieldrin results in increased expression of SCARB1 mRNA20438755|2304172
D004040Dietary CarbohydratesDietary Carbohydrates results in decreased expression of SCARB1 mRNA20110567
D004041Dietary Fats"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of SCARB1 mRNA"19509184
D004041Dietary Fats[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA18302760
D004041Dietary Fats[Dietary Fats co-treated with rosiglitazone] results in decreased expression of SCARB1 mRNA18276752
D004041Dietary FatsDietary Fats promotes the reaction [NR1H4 protein binds to SCARB1 intron]22540009
D004041Dietary FatsDietary Fats promotes the reaction [[NR1H4 protein binds to SCARB1 intron] which results in increased expression of SCARB1 mRNA]22540009|2254000
D004041Dietary FatsDietary Fats results in decreased expression of SCARB1 mRNA18457598|1903023
D004041Dietary FatsDietary Fats results in increased expression of SCARB1 mRNA22540009
D004041Dietary FatsLosartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA]18302760
D004041Dietary FatsNR1H4 protein affects the reaction [Dietary Fats results in increased expression of SCARB1 mRNA]22540009
D004041Dietary Fats[Oligosaccharides co-treated with Dietary Fats] results in increased expression of SCARB1 mRNA28549616
D004041Dietary Fats[Oligosaccharides co-treated with Dietary Fats] results in increased expression of SCARB1 protein28549616
D004041Dietary Fatsresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA]23127599
D004041Dietary Fatsresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein]23127599
D004041Dietary Fats[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA23127599
D004041Dietary Fats[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein23127599
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SCARB1 mRNA19245819
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of SCARB1 mRNA19000923
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SCARB1 mRNA16690193|2647210
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SCARB1 mRNA17602206
C089799diheptyl phthalatediheptyl phthalate results in decreased expression of SCARB1 mRNA22112501
C025605diisobutyl phthalatediisobutyl phthalate results in decreased expression of SCARB1 mRNA22112501|2865564
C012125diisononyl phthalatediisononyl phthalate results in decreased expression of SCARB1 mRNA22112501
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of SCARB1 mRNA"12376462
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of SCARB1 mRNA26472102
C027387di-n-hexyl phthalatedi-n-hexyl phthalate results in decreased expression of SCARB1 mRNA22112501|2693418
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of SCARB1 mRNA19560483|2211250
C034171di-n-pentyl phthalate[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of SCARB1 mRNA25055962
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]22442701
D004237DiuronDiuron results in increased expression of SCARB1 mRNA21551480
D004391DustDust results in decreased expression of SCARB1 mRNA17805423
C118739entinostatentinostat results in increased expression of SCARB1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SCARB1 mRNA"27188386
D000431EthanolEthanol results in increased expression of SCARB1 mRNA15353170
D004997Ethinyl EstradiolESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of SCARB1 protein modified form]17673517
D004997Ethinyl Estradiol[Ethinyl Estradiol affects the expression of TRA2B protein] which affects the splicing of SCARB1 mRNA17673517
D004997Ethinyl EstradiolEthinyl Estradiol affects the splicing of SCARB1 mRNA17673517
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of SCARB1 mRNA27344345
D004997Ethinyl Estradiol[Ethinyl Estradiol affects the expression of TRA2B protein] which affects the splicing of SCARB1 mRNA17673517
D004997Ethinyl EstradiolEthinyl Estradiol affects the splicing of SCARB1 mRNA17673517
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SCARB1 mRNA12475377|1583489
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SCARB1 protein12475377|1767351
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SCARB1 protein12475377
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SCARB1 protein modified form17673517
C024565ethylene dichlorideethylene dichloride results in increased expression of SCARB1 mRNA28189721
D000069438EzetimibeEzetimibe results in decreased expression of SCARB1 mRNA16177187
D011345Fenofibrate[Aspirin co-treated with Fenofibrate] results in increased expression of SCARB1 protein16816107
D011345FenofibrateFenofibrate results in increased expression of SCARB1 protein16816107
D011345Fenofibrate"Fenofibrate inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"17533223
D011345FenofibrateFenofibrate inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]17533223
D011345FenofibrateFenofibrate results in decreased activity of SCARB1 protein17533223
D011345FenofibrateFenofibrate affects the localization of SCARB1 protein16530456
C024555ferric chlorideferric chloride results in increased expression of SCARB1 protein20025956
D005395Fish OilsFish Oils results in decreased expression of SCARB1 mRNA29329427
D005411Flame RetardantsFlame Retardants results in decreased expression of SCARB1 mRNA23347875
D005419FlavonoidsFlavonoids results in increased expression of SCARB1 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SCARB1 gene20938992
D005632Fructose"[Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of SCARB1 mRNA"19509184
D005632FructoseFructose results in decreased expression of SCARB1 mRNA19193814
D019833Genistein[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of SCARB1 mRNA27181934
D005897GlafenineGlafenine results in increased expression of SCARB1 mRNA24136188
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SCARB1 mRNA24763279
C412815GW 4064[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA22540009
C412815GW 4064[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA22540009
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to SCARB1 intron]22540009
C059714HDL cholesteryl esterSCARB1 protein promotes the reaction [LIPC protein results in increased uptake of HDL cholesteryl ester]12611911
C059714HDL cholesteryl esterSCARB1 protein results in increased uptake of HDL cholesteryl ester12611911
C059714HDL cholesteryl esterSCARB1 protein results in increased transport of HDL cholesteryl ester16816107
C089796hexabromocyclododecane[hexabromocyclododecane co-treated with CGA protein] results in decreased expression of SCARB1 mRNA25447410
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of SCARB1 mRNA23347875|2544741
C409722hexaconazolehexaconazole results in increased expression of SCARB1 mRNA22045034
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of SCARB1 protein22442701
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SCARB1 mRNA27392435
C410337K 7174K 7174 results in decreased expression of SCARB1 mRNA24086573
C011890kojic acidkojic acid results in increased expression of SCARB1 mRNA19000923
D007854LeadLead affects the expression of SCARB1 mRNA28903495
C008261lead acetatelead acetate results in increased expression of SCARB1 mRNA21829687
C045463leflunomideleflunomide results in increased expression of SCARB1 mRNA24136188
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 mRNA"12010990
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 protein"12010990
C440499lipopolysaccharide, Escherichia coli O111 B4"Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 mRNA]"12010990
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [rosiglitazone results in increased expression of SCARB1 protein]22240665
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SCARB1 mRNA22240665
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SCARB1 protein22240665
D008095Lithocholic AcidLithocholic Acid results in decreased expression of SCARB1 mRNA15883047
D008095Lithocholic AcidLithocholic Acid results in decreased expression of SCARB1 protein15883047
D008095Lithocholic AcidLithocholic Acid results in increased expression of SCARB1 mRNA19000923
D019808LosartanLosartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA]18302760
D008148Lovastatin[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]20404351
D008148LovastatinLovastatin affects the expression of SCARB1 mRNA27208389
D008628MercuryMercury results in increased expression of SCARB1 mRNA19937285
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SCARB1 gene20938992
D008731MethoxychlorMethoxychlor results in increased expression of SCARB1 mRNA27663972
C005219methyl cellosolveBromocriptine inhibits the reaction [methyl cellosolve results in increased expression of SCARB1 mRNA]21427058
C005219methyl cellosolvemethyl cellosolve results in increased expression of SCARB1 mRNA21427058
C005219methyl cellosolvemethyl cellosolve results in increased expression of SCARB1 protein21427058
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SCARB1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SCARB1 mRNA"20188158
D008777Methyltestosterone[Methyltestosterone co-treated with Cholic Acids] affects the expression of SCARB1 mRNA27344345
C011309mezereinmezerein results in increased expression of SCARB1 mRNA19000923
C016599mono-(2-ethylhexyl)phthalate[Genistein co-treated with mono-(2-ethylhexyl)phthalate] results in increased expression of SCARB1 mRNA27181934
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of SCARB1 mRNA22401849
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of SCARB1 mRNA22087261
D009153MutagensMutagens results in decreased expression of SCARB1 mRNA22269147
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SCARB1 mRNA"25448806
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SCARB1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SCARB1 mRNA"25620056
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of SCARB1 mRNA27344345
D009525NiacinAspirin inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]15037193
D009525Niacin"Niacin promotes the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"21291703
D009525NiacinNiacin results in increased expression of SCARB1 mRNA15037193
D009525NiacinRo 31-8220 inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]15037193
D009525NiacinNiacin results in decreased expression of SCARB1 protein19878707
D009532NickelNickel results in decreased expression of SCARB1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of SCARB1 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SCARB1 mRNA20971185
C464660obeticholic acidobeticholic acid results in increased expression of SCARB1 mRNA27939613
D019319Okadaic AcidOkadaic Acid results in increased expression of SCARB1 mRNA19000923
C108709oleoyl-estroneoleoyl-estrone results in increased expression of SCARB1 mRNA19793540
D009844Oligosaccharides[Oligosaccharides co-treated with Dietary Fats] results in increased expression of SCARB1 mRNA28549616
D009844Oligosaccharides[Oligosaccharides co-treated with Dietary Fats] results in increased expression of SCARB1 protein28549616
D015525Fatty Acids, Omega-3"Fatty Acids, Omega-3 results in decreased expression of SCARB1 mRNA"23333450
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SCARB1 mRNA25729387
D052638Particulate MatterParticulate Matter results in increased expression of SCARB1 mRNA22861003
D010416PentachlorophenolPentachlorophenol results in increased expression of SCARB1 mRNA24642059
D010416PentachlorophenolPentachlorophenol results in decreased expression of SCARB1 mRNA23892564
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of SCARB1 mRNA17400581
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of SCARB1 mRNA21705711
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of SCARB1 mRNA21705711
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SCARB1 mRNA17681415
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SCARB1 mRNA19162173
D010622PhencyclidinePhencyclidine results in increased expression of SCARB1 mRNA17205118
D010634PhenobarbitalPhenobarbital affects the expression of SCARB1 mRNA19136022|2309116
D010672PhenytoinPhenytoin results in decreased expression of SCARB1 mRNA15136057
D010795Phthalic AcidsPhthalic Acids inhibits the reaction [LHB protein results in increased expression of SCARB1 mRNA]19699292
D010795Phthalic AcidsPhthalic Acids results in decreased expression of SCARB1 mRNA15728792
C060836pioglitazonepioglitazone results in decreased expression of SCARB1 mRNA20503262
C060836pioglitazonepioglitazone affects the localization of SCARB1 protein16530456
C060836pioglitazonepioglitazone results in increased expression of SCARB1 mRNA16530456
C006253pirinixic acidpirinixic acid affects the expression of SCARB1 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of SCARB1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of SCARB1 mRNA16985257|1742611
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls results in increased expression of SCARB1 mRNA21334430
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of SCARB1 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SCARB1 mRNA15883047|1916217
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SCARB1 protein15883047
D011374Progesterone[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]20404351
D011374ProgesteroneProgesterone results in increased expression of SCARB1 mRNA19000923
D011374ProgesteroneSCARB1 protein results in increased abundance of Progesterone20404351
C045950propiconazolepropiconazole results in decreased expression of SCARB1 mRNA21278054
C030984pyrenepyrene results in increased expression of SCARB1 mRNA23656968
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of SCARB1 mRNA19167446
C059514resveratrolresveratrol inhibits the reaction [Smoke analog results in decreased expression of SCARB1 protein]24423486
C059514resveratrolresveratrol results in increased expression of SCARB1 mRNA23041272
C059514resveratrolresveratrol results in increased expression of SCARB1 protein24423486
C059514resveratrolresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA]23127599
C059514resveratrolresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein]23127599
C014794retinol palmitateretinol palmitate results in increased expression of SCARB1 mRNA17299104
D012293RifampinRifampin results in decreased expression of SCARB1 mRNA15883047
D012293RifampinRifampin results in decreased expression of SCARB1 protein15883047
C089032rimonabantrimonabant results in increased expression of SCARB1 mRNA20110567
D019438RitonavirEstradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein]17879945
D019438RitonavirRitonavir results in increased expression of SCARB1 mRNA17879945
C064758Ro 31-8220Ro 31-8220 inhibits the reaction [Niacin results in increased expression of SCARB1 mRNA]15037193
C089730rosiglitazone[rosiglitazone co-treated with Atorvastatin Calcium] results in increased expression of SCARB1 protein15183127
C089730rosiglitazonerosiglitazone results in increased expression of SCARB1 mRNA16386711
C089730rosiglitazonerosiglitazone results in increased expression of SCARB1 protein15183127|1638671
C089730rosiglitazonerosiglitazone inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of SCARB1 mRNA]20926582
C089730rosiglitazone[Dietary Fats co-treated with rosiglitazone] results in decreased expression of SCARB1 mRNA18276752
C089730rosiglitazoneLipopolysaccharides inhibits the reaction [rosiglitazone results in increased expression of SCARB1 protein]22240665
C089730rosiglitazonerosiglitazone results in increased expression of SCARB1 protein22240665
D012439SaccharinSaccharin results in increased expression of SCARB1 mRNA19000923
C108967SDZ HDL 376"SDZ HDL 376 analog inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"17533223
C108967SDZ HDL 376SDZ HDL 376 analog inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]17533223
C108967SDZ HDL 376SDZ HDL 376 analog results in decreased activity of SCARB1 protein17533223
C108967SDZ HDL 376"SDZ HDL 376 inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]"17533223
C108967SDZ HDL 376SDZ HDL 376 inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]17533223
C108967SDZ HDL 376SDZ HDL 376 results in decreased activity of SCARB1 protein17533223
D012645SelenomethionineSelenomethionine affects the expression of SCARB1 mRNA17222674
C002979selenomethylselenocysteineselenomethylselenocysteine results in increased expression of SCARB1 mRNA18514395
D012834SilverSCARB1 protein results in increased uptake of and results in increased susceptibility to Silver25458489
D019821SimvastatinPPARA mutant form inhibits the reaction [Simvastatin results in increased expression of SCARB1]18981156
D019821SimvastatinRHOA inhibits the reaction [Simvastatin results in increased expression of SCARB1]18981156
D019821SimvastatinSimvastatin results in increased expression of SCARB118981156
D019821SimvastatinSimvastatin results in increased expression of SCARB118981156
D019821SimvastatinSimvastatin results in increased expression of SCARB1 mRNA21241519
D019821SimvastatinSimvastatin results in increased expression of SCARB1 protein20025956|2124151
D019821Simvastatin[Simvastatin co-treated with di-n-pentyl phthalate] results in decreased expression of SCARB1 mRNA25055962
D012906Smokeresveratrol inhibits the reaction [Smoke analog results in decreased expression of SCARB1 protein]24423486
D012906SmokeSmoke analog results in decreased expression of SCARB1 protein24423486
C016104sodium bichromatesodium bichromate results in decreased expression of SCARB1 mRNA22155349
D012980Sodium SalicylateSodium Salicylate results in decreased expression of SCARB1 protein16816107
D012980Sodium SalicylateSodium Salicylate results in increased expression of SCARB1 protein16816107
D018038Sodium SeleniteSodium Selenite results in increased expression of SCARB1 mRNA18514395
D053260SootSoot results in increased expression of SCARB1 mRNA26551751
C023599stannous chloridestannous chloride results in increased expression of SCARB1 mRNA19000923
D013395Sucroseresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA]23127599
D013395Sucroseresveratrol inhibits the reaction [[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein]23127599
D013395Sucrose[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 mRNA23127599
D013395Sucrose[Sucrose co-treated with Dietary Fats] results in decreased expression of SCARB1 protein23127599
D013412SulfadimethoxineSulfadimethoxine results in increased expression of SCARB1 mRNA19000923
D013469SulpirideSulpiride results in increased expression of SCARB1 mRNA21427058
D013469SulpirideSulpiride results in increased expression of SCARB1 protein21427058
C004648testosterone enanthatetestosterone enanthate results in decreased expression of SCARB1 mRNA21427060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCARB1 mRNA16443690
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SCARB1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of SCARB1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SCARB1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCARB1 mRNA28213091|2823826
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SCARB1 mRNA18796159
C009495titanium dioxidetitanium dioxide results in increased expression of SCARB1 mRNA23131501
C423915TO-901317TO-901317 results in increased expression of SCARB1 mRNA16142410
C423915TO-901317TO-901317 inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of SCARB1 mRNA]20926582
D014028Tobacco Smoke Pollutionbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]22442701
D014028Tobacco Smoke Pollutioncatalase-polyethylene glycol inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]22442701
D014028Tobacco Smoke PollutionCAT protein inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]22442701
D014028Tobacco Smoke Pollutiondiphenyleneiodonium inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein]22442701
D014028Tobacco Smoke PollutionTobacco Smoke Pollution promotes the reaction [4-hydroxy-2-nonenal binds to SCARB1 protein]22442701
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of and affects the localization of SCARB1 protein22442701
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased ubiquitination of SCARB1 protein22442701
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SCARB1 mRNA25729387
D014108Tosylphenylalanyl Chloromethyl Ketone"Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SCARB1 mRNA]"12010990
D014212TretinoinTretinoin results in decreased expression of SCARB1 mRNA23724009
D014212TretinoinTretinoin results in increased expression of SCARB1 protein20025956
C012589trichostatin Atrichostatin A results in increased expression of SCARB1 mRNA15901671
C005445triphenyl phosphatetriphenyl phosphate results in decreased expression of SCARB1 mRNA26049154
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SCARB1 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of SCARB1 mRNA12732648|2897369
C057693troglitazonetroglitazone affects the localization of SCARB1 protein16530456
C022884undecaneundecane results in increased expression of SCARB1 protein17337753
D014635Valproic AcidValproic Acid results in increased expression of SCARB1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of SCARB1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of SCARB1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of SCARB1 mRNA22045034
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SCARB1 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of SCARB1 mRNA22861003
C025643vinclozolinvinclozolin results in increased expression of SCARB1 mRNA20566332
C540004WAY-362450NR1H4 gene mutant form inhibits the reaction [WAY-362450 results in increased expression of SCARB1 mRNA]22918042
C540004WAY-362450WAY-362450 results in increased expression of SCARB1 mRNA19136377|2291804
C016837zinc chloridezinc chloride results in increased expression of SCARB1 mRNA19000923
D015039ZiramZiram results in decreased expression of SCARB1 mRNA28973382
D015039ZiramZiram results in decreased expression of SCARB1 protein28973382

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001530lipopolysaccharide binding-IDA12651854  
GO:0001540amyloid-beta binding-IEA-  
GO:0001618virus receptor activity-IEA-  
GO:0001786phosphatidylserine binding-ISS-  
GO:0001875lipopolysaccharide receptor activity-IDA12651854  
GO:0005044scavenger receptor activity-TAS11240025  
GO:0005215transporter activity-TAS9211901  
GO:0005515protein binding-IPI12356718  25416956  
GO:00055451-phosphatidylinositol binding-TAS9211901  
GO:0008035high-density lipoprotein particle binding-IEA-  
GO:0030169low-density lipoprotein particle binding-IDA9211901  
GO:0034185apolipoprotein binding-IPI10764676  
GO:0034186apolipoprotein A-I binding-IPI10764676  12651854  
GO:0042803protein homodimerization activity-IEA-  
GO:0070506high-density lipoprotein particle receptor activity-IDA9211901  
GO:0070506high-density lipoprotein particle receptor activity-IMP11208913  
GO ID GO Term Qualifier Evidence PubMed
GO:0001935endothelial cell proliferation-IEA-  
GO:0006702androgen biosynthetic process-IEA-  
GO:0006707cholesterol catabolic process-IEA-  
GO:0006898receptor-mediated endocytosis-TAS-  
GO:0010595positive regulation of endothelial cell migration-TAS17574123  
GO:0010867positive regulation of triglyceride biosynthetic process-ISS-  
GO:0010886positive regulation of cholesterol storage-IDA9211901  
GO:0010899regulation of phosphatidylcholine catabolic process-ISS-  
GO:0015914phospholipid transport-ISS-  
GO:0015920lipopolysaccharide transport-IDA12651854  
GO:0031663lipopolysaccharide-mediated signaling pathway-IEA-  
GO:0032497detection of lipopolysaccharide-IDA12651854  
GO:0033344cholesterol efflux-IMP12202492  
GO:0033344cholesterol efflux-ISS14718538  
GO:0034375high-density lipoprotein particle remodeling-ISS-  
GO:0034383low-density lipoprotein particle clearance-ISS-  
GO:0034384high-density lipoprotein particle clearance-IDA9211901  
GO:0034384high-density lipoprotein particle clearance-TAS-  
GO:0035461vitamin transmembrane transport-IMP11208913  
GO:0042060wound healing-TAS17574123  
GO:0042632cholesterol homeostasis-ISS-  
GO:0043534blood vessel endothelial cell migration-IEA-  
GO:0043654recognition of apoptotic cell-IDA9211901  
GO:0043691reverse cholesterol transport-IEP9211901  
GO:0044406adhesion of symbiont to host-IMP19087225  
GO:0046718viral entry into host cell-IEA-  
GO:0050764regulation of phagocytosis-IC9211901  
GO:0050892intestinal absorption-IEA-  
GO:0051000positive regulation of nitric-oxide synthase activity-IDA11792700  
GO:0070328triglyceride homeostasis-ISS-  
GO:0070508cholesterol import-IMP11208913  26965621  
GO:0070508cholesterol import-ISS14718538  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-HDA17897319  
GO:0005886plasma membrane-IDA9211901  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0005901caveola-TAS12651854  
GO:0009986cell surface-ISS21481393  
GO:0030666endocytic vesicle membrane-TAS-  
GO:0031528microvillus membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04145Phagosome
hsa04975Fat digestion and absorption
hsa04976Bile secretion
hsa04977Vitamin digestion and absorption
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsTAS
R-HSA-3000471Scavenging by Class B ReceptorsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8964011HDL clearanceTAS
R-HSA-8964043Plasma lipoprotein clearanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25993026Association of the Lipoprotein Receptor SCARB1 Common Missense Variant rs4238001 with Incident Coronary Heart Disease. (2015)Manichaikul APLoS One
28889112Interplay between cigarette smoking and pulmonary reverse lipid transport. (2017 Sep)Jubinville EEur Respir J
27428740SCARB1 rs5888 is associated with the risk of age-related macular degeneration susceptibility and an impaired macular area. (2017 May-Jun)Stanislovaitiene DOphthalmic Genet
20442857Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. (2010 Apr 29)Suchindran SPLoS Genet
22606049Interactions of several lipid-related gene polymorphisms and cigarette smoking on blood pressure levels. (2012)Yin RXInt J Biol Sci
26092999Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells. (2015 Aug 15)Lockett ADAm J Physiol Lung Cell Mol Physiol
28209224Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. (2017 Feb 21)Webb TRJ Am Coll Cardiol
22003152Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. (2012 Jan)Grallert HEur Heart J
24346170Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS). (2014 Jan 29)Meyers KJInvest Ophthalmol Vis Sci
23562302Investigation of genetic variation in scavenger receptor class B, member 1 (SCARB1) and association with serum carotenoids. (2013 Aug)McKay GJOphthalmology