Gene: AKAP5

9495
AKAP75|AKAP79|H21
A-kinase anchoring protein 5
protein-coding
14q23.3
Ensembl:ENSG00000179841 MIM:604688 Vega:OTTHUMG00000029634 UniprotKB:P24588
NG_033983.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.187e-1 (AD)  3.703e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DGKB0.956
CAMK40.946
GABRA40.946
NDST30.937
MAL20.937
ARPP210.93
HOMER10.927
CDH90.926
ANO30.926
PTPRO0.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.607
CSAG1-0.562
HEY2-0.557
SNHG18-0.55
ROM1-0.545
TGFB3-0.528
COPZ2-0.527
FLT3LG-0.521
CNN2-0.517
RAB13-0.516

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of AKAP5 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of AKAP5 mRNA]"27071940
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of AKAP5 mRNA"25710175
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of AKAP5 mRNA"23196670
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of AKAP5 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of AKAP5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AKAP5 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AKAP5 mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of AKAP5 mRNA22323515
C006780bisphenol Abisphenol A results in decreased expression of AKAP5 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of AKAP5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of AKAP5 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of AKAP5 mRNA25993096
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of AKAP5 gene20938992
D003471CuprizoneCuprizone results in decreased expression of AKAP5 mRNA26577399
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AKAP5 mRNA]11007951
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of AKAP5 mRNA21266533
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of AKAP5 gene20938992
C039281furanfuran results in decreased expression of AKAP5 mRNA26194646
C016517indole-3-carbinolindole-3-carbinol affects the expression of AKAP5 mRNA21396975
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of AKAP5 gene20938992
D008731MethoxychlorMethoxychlor results in increased methylation of AKAP5 gene23303685
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of AKAP5 mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of AKAP5 mRNA16507463
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AKAP5 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of AKAP5 mRNA19167457
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of AKAP5 mRNA26705709
D010862PilocarpineAKAP5 protein mutant form results in increased susceptibility to Pilocarpine18711127
D011374ProgesteroneProgesterone results in increased expression of AKAP5 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in decreased expression of AKAP5 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in increased expression of AKAP5 mRNA22431001
C016104sodium bichromatesodium bichromate results in decreased expression of AKAP5 mRNA25993096
D012999SomanSoman results in increased expression of AKAP5 mRNA19281266
D053260SootSoot results in decreased expression of AKAP5 mRNA26551751
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AKAP5 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AKAP5 mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AKAP5 mRNA19465110
C009495titanium dioxidetitanium dioxide results in increased expression of AKAP5 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of AKAP5 mRNA20133372
D014635Valproic AcidValproic Acid results in decreased palmitoylation of AKAP5 protein26348896
D014635Valproic AcidValproic Acid results in increased expression of AKAP5 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of AKAP5 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased palmitoylation of AKAP5 protein26348896
D014635Valproic AcidAKAP5 protein modified form results in decreased susceptibility to Valproic Acid26348896
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of AKAP5 gene25487561
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of AKAP5 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of AKAP5 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of AKAP5 mRNA22615374

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11287423  16642035  20664520  22343722  26496610  
GO:0005516calmodulin binding-IEA-  
GO:0008179adenylate cyclase binding-IBA21873635  
GO:0008179adenylate cyclase binding-IPI17081159  
GO:0017124SH3 domain binding-IPI10939335  
GO:0030346protein phosphatase 2B binding-IDA10939335  
GO:0031698beta-2 adrenergic receptor binding-IBA21873635  
GO:0032947protein-containing complex scaffold activity-IBA21873635  
GO:0034237protein kinase A regulatory subunit binding-IBA21873635  
GO:0034237protein kinase A regulatory subunit binding-IPI17911601  
GO:0035254glutamate receptor binding-IBA21873635  
GO:0035254glutamate receptor binding-IDA10939335  
GO:0050811GABA receptor binding-IBA21873635  
GO:0051018protein kinase A binding-TAS1512224  
GO:0097110scaffold protein binding-IPI10939335  
GO ID GO Term Qualifier Evidence PubMed
GO:0006605protein targeting-IEA-  
GO:0007165signal transduction-NAS1512224  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IMP17081159  
GO:0007268chemical synaptic transmission-TAS1512224  
GO:0010738regulation of protein kinase A signaling-IMP17081159  
GO:0045762positive regulation of adenylate cyclase activity-IBA21873635  
GO:1903078positive regulation of protein localization to plasma membrane-IMP22343722  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0009898cytoplasmic side of plasma membrane-IDA22343722  
GO:0014069postsynaptic density-IBA21873635  
GO:0032590dendrite membrane-IBA21873635  
GO:0043197dendritic spine-IBA21873635  
GO:0060076excitatory synapse-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismIEA
R-HSA-163685Integration of energy metabolismIEA
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretionIEA
R-HSA-399719Trafficking of AMPA receptorsTAS
R-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticityTAS
R-HSA-422356Regulation of insulin secretionIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-9010642ROBO receptors bind AKAP5TAS
R-HSA-9010642ROBO receptors bind AKAP5IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24452374A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke. (2014 Mar 15)Oldenburger AAm J Physiol Cell Physiol