Gene: TBX4

9496
ICPPS|SPS
T-box 4
protein-coding
17q23.2
Ensembl:ENSG00000121075 MIM:601719 Vega:OTTHUMG00000180078 UniprotKB:P57082
NG_008080.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.272e-1 (AD)  1.083e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MROH90.636
TAS2R130.63
CD1600.629
KRT730.627
OR13C30.624
ILDR10.622
OR4K30.618
HOXC90.604
IGF2BP30.604
GPR180.603

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HDDC3-0.412
BOLA1-0.404
TMEM53-0.394
HAGHL-0.389
SAC3D1-0.383
CCDC24-0.38
ABHD14A-0.379
KPTN-0.379
NTHL1-0.379
MIF-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of TBX4 mRNA"26377693
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of TBX4 mRNA"25670856
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TBX4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TBX4 gene28458013
D000638AmiodaroneAmiodarone results in increased expression of TBX4 mRNA19774075
C006780bisphenol Abisphenol A affects the expression of TBX4 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of TBX4 promoter27334623
C006780bisphenol Abisphenol A affects the methylation of TBX4 promoter27415467
C006780bisphenol Abisphenol A results in decreased expression of TBX4 mRNA25181051
D002104CadmiumCadmium results in decreased expression of TBX4 mRNA24376830
C074283estradiol 3-benzoateestradiol 3-benzoate results in decreased methylation of TBX4 promoter27415467
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TBX4 mRNA17606305
C069837fullerene C60fullerene C60 results in increased expression of TBX4 mRNA19167457
C004312glycidolglycidol results in decreased expression of TBX4 mRNA24915197
C045463leflunomideleflunomide results in increased expression of TBX4 mRNA28988120
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TBX4 mRNA"25554681
C007350nitrofennitrofen results in decreased expression of TBX4 mRNA27833996
C007350nitrofennitrofen results in decreased expression of TBX4 protein27833996
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TBX4 mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of TBX4 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of TBX4 mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of TBX4 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of TBX4 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TBX4 mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of TBX4 mRNA21795629
D053260SootSoot results in decreased expression of TBX4 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBX4 mRNA24058054

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-NAS15106123  
GO:0003700DNA-binding transcription factor activity-TAS10945475  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0002009morphogenesis of an epithelium-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-NAS10945475  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0007275multicellular organism development-NAS10945475  
GO:0030324lung development-IEA-  
GO:0030326embryonic limb morphogenesis-IEA-  
GO:0035108limb morphogenesis-IMP15106123  
GO:0048705skeletal system morphogenesis-IMP15106123  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24932901Etiopathogenesis of equinovarus foot malformations. (2014 Aug)Bacino CAEur J Med Genet
22497478Application of a novel hybrid study design to explore gene-environment interactions in orofacial clefts. (2012 May)Skare OAnn Hum Genet