Gene: SLC4A7

9497
NBC2|NBC3|NBCN1|SBC2|SLC4A6
solute carrier family 4 member 7
protein-coding
3p24.1
Ensembl:ENSG00000033867 MIM:603353 Vega:OTTHUMG00000155679 UniprotKB:Q9Y6M7
NG_032673.1
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.672e-1 (AD)  7.943e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTBP30.82
CTTNBP2NL0.801
ATP13A30.789
SCAF110.781
SLC30A70.771
BRWD30.765
RBMS10.763
EML40.762
NCOA30.762
HIPK30.76

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.335
APOA1-0.296
HES5-0.291
OR4F29-0.291
HES6-0.289
NEU4-0.275
OLIG1-0.252
BTBD17-0.252
C16orf74-0.241
SPRR2A-0.231

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01390Sodium bicarbonateSmall Molecule144-55-8ApprovedTransporter
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SLC4A7 mRNA19933214
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC4A7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC4A7 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SLC4A7 mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of SLC4A7 mRNA26497421|2906747
D000082AcetaminophenAcetaminophen affects the expression of SLC4A7 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC4A7 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC4A7 mRNA16483693
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of SLC4A7 mRNA"18687144
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC4A7 mRNA21871943
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SLC4A7 mRNA20660070
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SLC4A7 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of SLC4A7 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC4A7 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SLC4A7 mRNA28628672
D002220CarbamazepineCarbamazepine affects the expression of SLC4A7 mRNA25979313
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of SLC4A7 mRNA16197558
C018021cobaltous chloridecobaltous chloride results in decreased expression of SLC4A7 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of SLC4A7 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SLC4A7 mRNA22147139
D016572CyclosporineCyclosporine results in increased expression of SLC4A7 mRNA20106945|2556210
D013759DronabinolDronabinol results in increased expression of SLC4A7 mRNA16597638
D003703DemecolcineDemecolcine results in decreased expression of SLC4A7 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SLC4A7 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SLC4A7 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SLC4A7 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SLC4A7 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of SLC4A7 mRNA16002434|2648566
C118739entinostatentinostat results in decreased expression of SLC4A7 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLC4A7 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC4A7 mRNA29097150
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of SLC4A7 mRNA23649840
C026098etiracetametiracetam results in increased expression of SLC4A7 mRNA20345932
D005419FlavonoidsFlavonoids results in decreased expression of SLC4A7 mRNA18035473
D005557FormaldehydeFormaldehyde results in decreased expression of SLC4A7 mRNA23649840
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of SLC4A7 mRNA22634610
D017313FenretinideFenretinide results in increased expression of SLC4A7 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of SLC4A7 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SLC4A7 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SLC4A7 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of SLC4A7 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC4A7 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SLC4A7 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of SLC4A7 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SLC4A7 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SLC4A7 mRNA27392435
D007854LeadSLC4A7 affects the abundance of and affects the transport of Lead17687451
C008261lead acetatelead acetate results in decreased expression of SLC4A7 mRNA22641619
C045463leflunomideleflunomide results in increased expression of SLC4A7 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC4A7 mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of SLC4A7 mRNA28001369
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC4A7 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SLC4A7 mRNA23649840
D008917MirexMirex results in increased expression of SLC4A7 mRNA23153324
C031721naphthalenenaphthalene analog results in increased expression of SLC4A7 mRNA24976557
C022838nickel chloridenickel chloride results in decreased expression of SLC4A7 mRNA17312168
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SLC4A7 protein26879310
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of SLC4A7 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of SLC4A7 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC4A7 mRNA18489776
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of SLC4A7 mRNA21334430
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLC4A7 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SLC4A7 mRNA22079256|2271453
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SLC4A7 mRNA20660070
D011794QuercetinQuercetin results in increased expression of SLC4A7 mRNA21632981
D012643SeleniumSelenium results in decreased expression of SLC4A7 mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of SLC4A7 mRNA29191790
C009277sodium arsenatesodium arsenate results in decreased expression of SLC4A7 mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of SLC4A7 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in decreased expression of SLC4A7 mRNA27257137
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC4A7 mRNA21641980
C061133tamibarotenetamibarotene affects the expression of SLC4A7 mRNA15498508
C004648testosterone enanthatetestosterone enanthate affects the expression of SLC4A7 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC4A7 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC4A7 mRNA20106945|2163298
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLC4A7 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of SLC4A7 protein24648495
D014212TretinoinTretinoin affects the expression of SLC4A7 mRNA15498508
C012589trichostatin Atrichostatin A results in decreased expression of SLC4A7 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SLC4A7 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of SLC4A7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SLC4A7 mRNA23179753|2519280
C025643vinclozolinvinclozolin results in increased expression of SLC4A7 mRNA23034163
D014750VincristineVincristine results in decreased expression of SLC4A7 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in increased expression of SLC4A7 mRNA26682919
D014810Vitamin EVitamin E results in decreased expression of SLC4A7 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of SLC4A7 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005452inorganic anion exchanger activity-IEA-  
GO:0005515protein binding-IPI15324660  17353931  
GO:0008509anion transmembrane transporter activity-IBA21873635  
GO:0008510sodium:bicarbonate symporter activity-IBA21873635  
GO:0008510sodium:bicarbonate symporter activity-NAS10347222  
GO:0008510sodium:bicarbonate symporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006814sodium ion transport-IEA-  
GO:0015698inorganic anion transport-IEA-  
GO:0015701bicarbonate transport-IBA21873635  
GO:0015701bicarbonate transport-NAS10347222  
GO:0015701bicarbonate transport-TAS-  
GO:0051453regulation of intracellular pH-IBA21873635  
GO:0060117auditory receptor cell development-IBA21873635  
GO:0098656anion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-NAS10347222  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0032420stereocilium-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425381Bicarbonate transportersTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24895409Post-GWAS gene-environment interplay in breast cancer: results from the Breast and Prostate Cancer Cohort Consortium and a meta-analysis on 79,000 women. (2014 Oct 1)Barrdahl MHum Mol Genet
17624982Variation in a bicarbonate co-transporter gene family member SLC4A7 is associated with propensity to addictions: a study using fine-mapping and three samples. (2007 Aug)Ishiguro HAddiction
17687451Evidence of genetic effects on blood lead concentration. (2007 Aug)Whitfield JBEnviron Health Perspect
21791674Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. (2011 Aug 17)Campa DJ Natl Cancer Inst