Gene: ADAMTS4

9507
ADAMTS-2|ADAMTS-4|ADMP-1
ADAM metallopeptidase with thrombospondin type 1 motif 4
protein-coding
1q23.3
Ensembl:ENSG00000158859 MIM:603876 Vega:OTTHUMG00000034349 UniprotKB:O75173
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.327e-1 (AD)  1.082e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EFNA10.8
ICOSLG0.794
LITAF0.784
SPATA130.777
CDC42EP10.765
REEP30.763
WIPF10.761
SYNGR20.754
SLC35D20.753
RHOG0.751

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WTIP-0.483
VIP-0.481
CUX2-0.478
DLX1-0.476
CHRNA2-0.474
KCNQ4-0.47
KCNG1-0.469
SSTR4-0.467
PCDH8-0.466
DLX5-0.465

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06822TinzaparinSmall Molecule9041-08-1ApprovedEnzyme
ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ADAMTS4 mRNA28329830
C0109142,4-diaminotoluene"2,4-diaminotoluene results in increased expression of ADAMTS4 mRNA"20713471
D000082AcetaminophenAcetaminophen results in increased expression of ADAMTS4 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of ADAMTS4 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADAMTS4 mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of ADAMTS4 mRNA"22863853
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of ADAMTS4 mRNA15894607
C015001arsenitearsenite results in decreased expression of ADAMTS4 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of ADAMTS4 mRNA]18929588
C547126AZM551248AZM551248 results in increased expression of ADAMTS4 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ADAMTS4 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of ADAMTS4 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADAMTS4 mRNA27195522
D004958EstradiolEstradiol results in increased expression of ADAMTS4 mRNA25321415
D004958EstradiolEstradiol results in decreased expression of ADAMTS4 mRNA19484750
C006780bisphenol Abisphenol A results in increased expression of ADAMTS4 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of ADAMTS4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ADAMTS4 gene28505145
D002330CarmustineCarmustine results in decreased expression of ADAMTS4 mRNA15980968
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADAMTS4 mRNA24386269
D003300CopperCopper deficiency results in increased expression of ADAMTS4 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of ADAMTS4 mRNA26577399|2752363
D003474CurcuminCurcumin results in increased expression of ADAMTS4 mRNA18321735
D003907DexamethasoneDexamethasone results in decreased expression of ADAMTS4 mRNA22733784
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] affects the expression of ADAMTS4 mRNA20705681
D019422Dietary SucroseDietary Sucrose results in increased expression of ADAMTS4 mRNA26033743
D004298DopamineDopamine results in increased expression of ADAMTS4 mRNA21983523
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [IL1B protein results in increased expression of ADAMTS4 mRNA]16206353
D018818FenoldopamFenoldopam results in decreased expression of ADAMTS4 mRNA21983523
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ADAMTS4 mRNA28329830
D005944GlucosamineGlucosamine results in increased expression of ADAMTS4 mRNA17109745
D017313FenretinideFenretinide results in increased expression of ADAMTS4 mRNA28973697
C008261lead acetatelead acetate results in increased expression of ADAMTS4 mRNA22641619
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ADAMTS4 mRNA20713471
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ADAMTS4 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ADAMTS4 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ADAMTS4 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADAMTS4 mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ADAMTS4 mRNA19812364
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ADAMTS4 mRNA25729387
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of ADAMTS4 mRNA25658374
D010126OzoneOzone results in increased expression of ADAMTS4 mRNA17460151|1955522
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] affects the expression of ADAMTS4 mRNA20705681
D010936Plant ExtractsPlant Extracts results in decreased expression of ADAMTS4 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of ADAMTS4 mRNA23012394
C005556propionaldehydepropionaldehyde results in increased expression of ADAMTS4 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADAMTS4 mRNA24780913
C059514resveratrolresveratrol inhibits the reaction [IL1B protein results in increased expression of ADAMTS4 mRNA]19011540
D012645SelenomethionineSelenomethionine inhibits the reaction [IL1B protein results in increased expression of ADAMTS4 mRNA]16206353
D012822Silicon DioxideSilicon Dioxide results in increased expression of ADAMTS4 mRNA23221170
D053260SootSoot results in increased expression of ADAMTS4 mRNA26551751
D012460SulfasalazineSulfasalazine inhibits the reaction [[IL1A protein co-treated with OSM protein] results in increased expression of ADAMTS4 mRNA]19690126
D013605T-2 ToxinT-2 Toxin results in increased expression of ADAMTS4 mRNA22800716
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADAMTS4 mRNA21570461
D019284ThapsigarginThapsigargin results in decreased expression of ADAMTS4 mRNA22378314
C009495titanium dioxidetitanium dioxide results in decreased expression of ADAMTS4 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of ADAMTS4 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ADAMTS4 mRNA25729387
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of ADAMTS4 mRNA15894607
D014212TretinoinTretinoin results in decreased expression of ADAMTS4 mRNA23724009
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ADAMTS4 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ADAMTS4 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ADAMTS4 mRNA29024780
D014520UrethaneUrethane results in increased expression of ADAMTS4 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of ADAMTS4 gene29154799
D014639VanadiumVanadium results in decreased expression of ADAMTS4 mRNA19000753
D015016YohimbineYohimbine results in increased expression of ADAMTS4 mRNA21983523

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI14744861  
GO:0004222metalloendopeptidase activity-TAS-  
GO:0005515protein binding-IPI18718938  
GO:0008233peptidase activity-TAS10751421  
GO:0008237metallopeptidase activity-TAS10356395  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS10356395  
GO:0006508proteolysis-IEA-  
GO:0022617extracellular matrix disassembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA14744861  
GO:0016607nuclear speck-IDA-  
GO:0031012extracellular matrix-HDA23658023  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26503507Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. (2015 Oct 26)Steele MPBMC Genomics