Gene info: ID 9509

Gene: ADAMTS2

GENE ID: 9509

Description: ADAM metallopeptidase with thrombospondin type 1 motif 2

Gene type: protein-coding

Location: 5q35.3

dbXrefs: Ensembl:ENSG00000087116 MIM:604539 Vega:OTTHUMG00000130915 UniprotKB:O95450

RefSeq: NG_023212.2

Retrived from: SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: AD

# Publications: 0

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.497e-1 (AD) 2.023e-2 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs166031	chr5:179293967 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg17359265	chr5:178567126	ADAMTS2		8.900e-15	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ELK1	0.715
HTR1A	0.711
EPN3	0.679
GPR83	0.659
SOSTDC1	0.653
ESYT3	0.652
ARL4A	0.65
TIAM2	0.648
TUBA8	0.645
HSD11B2	0.645

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SOX3	-0.396
RBP1	-0.356
C5orf64	-0.331
PON1	-0.307
FZD10	-0.305
LRRCC1	-0.304
PAQR6	-0.301
APOM	-0.298
LRAT	-0.295
ENDOU	-0.294

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ADAMTS2 mRNA	19933214
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ADAMTS2 mRNA	16788091
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of ADAMTS2 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of ADAMTS2 mRNA	17562736
D020106	Acrylamide	Acrylamide affects the expression of ADAMTS2 mRNA	28959563
D001151	Arsenic	Arsenic affects the methylation of ADAMTS2 gene	25304211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ADAMTS2 mRNA	20458559
C547126	AZM551248	AZM551248 results in increased expression of ADAMTS2 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ADAMTS2 mRNA	20504355\|2071347
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ADAMTS2 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ADAMTS2 mRNA	21839799
D004958	Estradiol	Estradiol results in increased expression of ADAMTS2 mRNA	19484750
C006780	bisphenol A	bisphenol A results in decreased expression of ADAMTS2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ADAMTS2 gene	28505145
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of ADAMTS2 mRNA	18974090
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ADAMTS2 mRNA	17484886
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS2 mRNA	20938992
D004041	Dietary Fats	Dietary Fats results in decreased expression of ADAMTS2 mRNA	18042831\|2501614
D004041	Dietary Fats	Dietary Fats results in increased expression of ADAMTS2 mRNA	22609946
D004051	Diethylhexyl Phthalate	[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of ADAMTS2 mRNA	25031359
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ADAMTS2 mRNA	22129741
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS2 mRNA	20938992
C039281	furan	furan results in decreased methylation of ADAMTS2 gene	27387713
C039281	furan	furan results in increased expression of ADAMTS2 mRNA	27387713
D019833	Genistein	[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of ADAMTS2 mRNA	25031359
D017313	Fenretinide	Fenretinide results in decreased expression of ADAMTS2 mRNA	28973697
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ADAMTS2 mRNA	22129741
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAMTS2 mRNA	25613284
D007854	Lead	Lead affects the expression of ADAMTS2 mRNA	28903495
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS2 mRNA	20938992
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of ADAMTS2 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ADAMTS2 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ADAMTS2 mRNA	26011545
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of ADAMTS2 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ADAMTS2 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ADAMTS2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ADAMTS2 mRNA"	25554681
D000073878	Palm Oil	Palm Oil results in decreased expression of ADAMTS2 mRNA	18042831
D010634	Phenobarbital	Phenobarbital affects the expression of ADAMTS2 mRNA	23091169
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of ADAMTS2 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ADAMTS2 mRNA	19710929
D010936	Plant Extracts	Plant Extracts results in decreased expression of ADAMTS2 mRNA	23557933
D010938	Plant Oils	Plant Oils results in increased expression of ADAMTS2 mRNA	23370395
D011374	Progesterone	Progesterone results in increased expression of ADAMTS2 mRNA	20864642
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of ADAMTS2 mRNA	24780913
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of ADAMTS2 mRNA"	21514415
D017632	Asbestos, Serpentine	"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of ADAMTS2 mRNA]"	21514415
D012834	Silver	Silver results in decreased expression of ADAMTS2 mRNA	27131904
D013739	Testosterone	Testosterone results in increased expression of ADAMTS2 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ADAMTS2 mRNA	19933214
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAMTS2 mRNA	25613284
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of ADAMTS2 mRNA	19042947
D014635	Valproic Acid	Valproic Acid affects the expression of ADAMTS2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased methylation of ADAMTS2 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of ADAMTS2 mRNA	17292431
C029297	vinylidene chloride	vinylidene chloride results in increased expression of ADAMTS2 mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004222	metalloendopeptidase activity	-	TAS	-
GO:0008237	metallopeptidase activity	-	TAS	10417273
GO:0008270	zinc ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007283	spermatogenesis	-	IEA	-
GO:0016485	protein processing	-	IEA	-
GO:0030199	collagen fibril organization	-	IEA	-
GO:0030324	lung development	-	IEA	-
GO:0030574	collagen catabolic process	-	IEA	-
GO:0043588	skin development	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0062023	collagen-containing extracellular matrix	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474290	Collagen formation	TAS
R-HSA-1643685	Disease	TAS
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	TAS
R-HSA-3781865	Diseases of glycosylation	TAS
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-5083635	Defective B3GALTL causes Peters-plus syndrome (PpS)	TAS
R-HSA-5173105	O-linked glycosylation	TAS
R-HSA-5173214	O-glycosylation of TSR domain-containing proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal