Gene: ADAMTS2

9509
ADAM-TS2|ADAMTS-2|ADAMTS-3|EDSDERMS|NPI|PC I-NP|PCI-NP|PCINP|PCPNI|PNPI
ADAM metallopeptidase with thrombospondin type 1 motif 2
protein-coding
5q35.3
Ensembl:ENSG00000087116 MIM:604539 Vega:OTTHUMG00000130915 UniprotKB:O95450
NG_023212.2
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.497e-1 (AD)  2.023e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs166031chr5:179293967 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17359265chr5:178567126ADAMTS28.900e-15Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELK10.715
HTR1A0.711
EPN30.679
GPR830.659
SOSTDC10.653
ESYT30.652
ARL4A0.65
TIAM20.648
TUBA80.645
HSD11B20.645

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOX3-0.396
RBP1-0.356
C5orf64-0.331
PON1-0.307
FZD10-0.305
LRRCC1-0.304
PAQR6-0.301
APOM-0.298
LRAT-0.295
ENDOU-0.294

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ADAMTS2 mRNA19933214
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of ADAMTS2 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ADAMTS2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ADAMTS2 mRNA17562736
D020106AcrylamideAcrylamide affects the expression of ADAMTS2 mRNA28959563
D001151ArsenicArsenic affects the methylation of ADAMTS2 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of ADAMTS2 mRNA20458559
C547126AZM551248AZM551248 results in increased expression of ADAMTS2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADAMTS2 mRNA20504355|2071347
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADAMTS2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ADAMTS2 mRNA21839799
D004958EstradiolEstradiol results in increased expression of ADAMTS2 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of ADAMTS2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ADAMTS2 gene28505145
D019256Cadmium ChlorideCadmium Chloride affects the expression of ADAMTS2 mRNA18974090
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ADAMTS2 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS2 mRNA20938992
D004041Dietary FatsDietary Fats results in decreased expression of ADAMTS2 mRNA18042831|2501614
D004041Dietary FatsDietary Fats results in increased expression of ADAMTS2 mRNA22609946
D004051Diethylhexyl Phthalate[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of ADAMTS2 mRNA25031359
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ADAMTS2 mRNA22129741
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS2 mRNA20938992
C039281furanfuran results in decreased methylation of ADAMTS2 gene27387713
C039281furanfuran results in increased expression of ADAMTS2 mRNA27387713
D019833Genistein[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of ADAMTS2 mRNA25031359
D017313FenretinideFenretinide results in decreased expression of ADAMTS2 mRNA28973697
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ADAMTS2 mRNA22129741
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAMTS2 mRNA25613284
D007854LeadLead affects the expression of ADAMTS2 mRNA28903495
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ADAMTS2 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ADAMTS2 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ADAMTS2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ADAMTS2 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of ADAMTS2 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADAMTS2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ADAMTS2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADAMTS2 mRNA"25554681
D000073878Palm OilPalm Oil results in decreased expression of ADAMTS2 mRNA18042831
D010634PhenobarbitalPhenobarbital affects the expression of ADAMTS2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADAMTS2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ADAMTS2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ADAMTS2 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of ADAMTS2 mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of ADAMTS2 mRNA23370395
D011374ProgesteroneProgesterone results in increased expression of ADAMTS2 mRNA20864642
D011441PropylthiouracilPropylthiouracil results in decreased expression of ADAMTS2 mRNA24780913
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of ADAMTS2 mRNA"21514415
D017632Asbestos, Serpentine"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of ADAMTS2 mRNA]"21514415
D012834SilverSilver results in decreased expression of ADAMTS2 mRNA27131904
D013739TestosteroneTestosterone results in increased expression of ADAMTS2 mRNA19693291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADAMTS2 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ADAMTS2 mRNA25613284
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ADAMTS2 mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of ADAMTS2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of ADAMTS2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ADAMTS2 mRNA17292431
C029297vinylidene chloridevinylidene chloride results in increased expression of ADAMTS2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0008237metallopeptidase activity-TAS10417273  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007283spermatogenesis-IEA-  
GO:0016485protein processing-IEA-  
GO:0030199collagen fibril organization-IEA-  
GO:0030324lung development-IEA-  
GO:0030574collagen catabolic process-IEA-  
GO:0043588skin development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0062023collagen-containing extracellular matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474290Collagen formationTAS
R-HSA-1643685DiseaseTAS
R-HSA-1650814Collagen biosynthesis and modifying enzymesTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal