Gene: STXBP5L

9515
LLGL4
syntaxin binding protein 5 like
protein-coding
3q13.33
Ensembl:ENSG00000145087 MIM:609381 Vega:OTTHUMG00000159426 UniprotKB:Q9Y2K9
NG_052890.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.618e-2 (AD)  9.234e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12491742chr3:120971356 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HECW10.977
ATP8A20.973
FRMPD40.972
FAXC0.97
DLGAP10.968
AAK10.968
HCN10.967
OLFM30.967
SV2B0.966
PTPN30.966

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.644
HEY2-0.618
YES1-0.611
ROM1-0.608
MYL3-0.598
RNF135-0.598
AGTRAP-0.595
CHST14-0.594
EMP3-0.591
REST-0.59

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STXBP5L mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STXBP5L mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STXBP5L mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STXBP5L mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STXBP5L mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of STXBP5L mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STXBP5L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STXBP5L mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of STXBP5L gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of STXBP5L mRNA21298039
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STXBP5L mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of STXBP5L mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of STXBP5L mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of STXBP5L protein28903499
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STXBP5L mRNA28628672
D004041Dietary FatsDietary Fats results in decreased expression of STXBP5L mRNA25016146
D000431EthanolEthanol results in decreased expression of STXBP5L mRNA29018328
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of STXBP5L mRNA29097150
C039281furanfuran results in decreased expression of STXBP5L mRNA25539665
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STXBP5L mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of STXBP5L mRNA28628672
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of STXBP5L mRNA"24972896
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of STXBP5L mRNA27935865
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of STXBP5L mRNA19074003
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of STXBP5L mRNA"25510870
D011441PropylthiouracilPropylthiouracil results in decreased expression of STXBP5L mRNA24780913
C502851quinocetonequinocetone results in increased expression of STXBP5L mRNA27046791
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of STXBP5L mRNA25895662
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of STXBP5L mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of STXBP5L mRNA19074003
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of STXBP5L mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of STXBP5L mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of STXBP5L mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of STXBP5L gene25560391
C111237vorinostatvorinostat results in increased expression of STXBP5L mRNA27188386
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of STXBP5L mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0017137Rab GTPase binding-IBA21873635  
GO:0019905syntaxin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006887exocytosis-IEA-  
GO:0015031protein transport-IEA-  
GO:0017157regulation of exocytosis-IBA21873635  
GO:0042593glucose homeostasis-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0046676negative regulation of insulin secretion-IEA-  
GO:0050708regulation of protein secretion-IBA21873635  
GO:0050714positive regulation of protein secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23223146A genome-wide association study in Caucasian women points out a putative role of the STXBP5L gene in facial photoaging. (2013 Apr)Le Clerc SJ Invest Dermatol